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Fusion gene ID: 22670 |
FusionGeneSummary for MSN_ALK |
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Fusion gene information | Fusion gene name: MSN_ALK | Fusion gene ID: 22670 | Hgene | Tgene | Gene symbol | MSN | ALK | Gene ID | 4478 | 238 |
Gene name | moesin | ALK receptor tyrosine kinase | |
Synonyms | HEL70|IMD50 | CD246|NBLST3 | |
Cytomap | Xq12 | 2p23.2-p23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | moesinepididymis luminal protein 70membrane-organizing extension spike protein | ALK tyrosine kinase receptorCD246 antigenanaplastic lymphoma receptor tyrosine kinasemutant anaplastic lymphoma kinase | |
Modification date | 20180527 | 20180527 | |
UniProtAcc | P26038 | Q9UM73 | |
Ensembl transtripts involved in fusion gene | ENST00000609205, ENST00000360270, | ENST00000389048, ENST00000431873, ENST00000498037, | |
Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 24 X 23 X 10=5520 |
# samples | 8 | 46 | |
** MAII score | log2(8/147*10)=-0.877744249949002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(46/5520*10)=-3.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MSN [Title/Abstract] AND ALK [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MSN | GO:0001771 | immunological synapse formation | 27405666 |
Hgene | MSN | GO:0042098 | T cell proliferation | 27405666 |
Hgene | MSN | GO:0070489 | T cell aggregation | 27405666 |
Hgene | MSN | GO:0071394 | cellular response to testosterone stimulus | 24065547 |
Hgene | MSN | GO:0072678 | T cell migration | 27405666 |
Tgene | ALK | GO:0016310 | phosphorylation | 9174053 |
Tgene | ALK | GO:0046777 | protein autophosphorylation | 9174053 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AF295356 | MSN | chrX | 64958479 | + | ALK | chr2 | 29446377 | - | ||
ChiTaRS3.1 | AF295078 | MSN | chrX | 64958831 | + | ALK | chr2 | 29446377 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000609205 | ENST00000389048 | MSN | chrX | 64958479 | + | ALK | chr2 | 29446377 | - |
intron-intron | ENST00000609205 | ENST00000431873 | MSN | chrX | 64958479 | + | ALK | chr2 | 29446377 | - |
intron-intron | ENST00000609205 | ENST00000498037 | MSN | chrX | 64958479 | + | ALK | chr2 | 29446377 | - |
Frame-shift | ENST00000360270 | ENST00000389048 | MSN | chrX | 64958479 | + | ALK | chr2 | 29446377 | - |
5CDS-intron | ENST00000360270 | ENST00000431873 | MSN | chrX | 64958479 | + | ALK | chr2 | 29446377 | - |
5CDS-intron | ENST00000360270 | ENST00000498037 | MSN | chrX | 64958479 | + | ALK | chr2 | 29446377 | - |
intron-3CDS | ENST00000609205 | ENST00000389048 | MSN | chrX | 64958831 | + | ALK | chr2 | 29446377 | - |
intron-intron | ENST00000609205 | ENST00000431873 | MSN | chrX | 64958831 | + | ALK | chr2 | 29446377 | - |
intron-intron | ENST00000609205 | ENST00000498037 | MSN | chrX | 64958831 | + | ALK | chr2 | 29446377 | - |
intron-3CDS | ENST00000360270 | ENST00000389048 | MSN | chrX | 64958831 | + | ALK | chr2 | 29446377 | - |
intron-intron | ENST00000360270 | ENST00000431873 | MSN | chrX | 64958831 | + | ALK | chr2 | 29446377 | - |
intron-intron | ENST00000360270 | ENST00000498037 | MSN | chrX | 64958831 | + | ALK | chr2 | 29446377 | - |
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FusionProtFeatures for MSN_ALK |
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Hgene | Tgene |
MSN | ALK |
Probably involved in connections of major cytoskeletalstructures to the plasma membrane. May inhibit herpes simplexvirus 1 infection at an early stage. Plays a role in regulatingthe proliferation, migration, and adhesion of human lymphoid cellsand participates in immunologic synapse formation(PubMed:27405666). {ECO:0000269|PubMed:21549406,ECO:0000269|PubMed:27405666}. | Neuronal receptor tyrosine kinase that is essentiallyand transiently expressed in specific regions of the central andperipheral nervous systems and plays an important role in thegenesis and differentiation of the nervous system. Transducessignals from ligands at the cell surface, through specificactivation of the mitogen-activated protein kinase (MAPK) pathway.Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK inducestyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well asof the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptorfor ligands pleiotrophin (PTN), a secreted growth factor, andmidkine (MDK), a PTN-related factor, thus participating in PTN andMDK signal transduction. PTN-binding induces MAPK pathwayactivation, which is important for the anti-apoptotic signaling ofPTN and regulation of cell proliferation. MDK-binding inducesphosphorylation of the ALK target insulin receptor substrate(IRS1), activates mitogen-activated protein kinases (MAPKs) andPI3-kinase, resulting also in cell proliferation induction. DrivesNF-kappa-B activation, probably through IRS1 and the activation ofthe AKT serine/threonine kinase. Recruitment of IRS1 to activatedALK and the activation of NF-kappa-B are essential for theautocrine growth and survival signaling of MDK.{ECO:0000269|PubMed:11121404, ECO:0000269|PubMed:11278720,ECO:0000269|PubMed:11387242, ECO:0000269|PubMed:11809760,ECO:0000269|PubMed:12107166, ECO:0000269|PubMed:12122009,ECO:0000269|PubMed:15226403, ECO:0000269|PubMed:15908427,ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:16878150,ECO:0000269|PubMed:17274988}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MSN_ALK |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MSN_ALK |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MSN_ALK |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | ALK | Q9UM73 | DB08865 | Crizotinib | ALK tyrosine kinase receptor | small molecule | approved |
Tgene | ALK | Q9UM73 | DB09063 | Ceritinib | ALK tyrosine kinase receptor | small molecule | approved |
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RelatedDiseases for MSN_ALK |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MSN | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | MSN | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Hgene | MSN | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | MSN | C3495559 | Juvenile arthritis | 1 | CTD_human |
Tgene | ALK | C0007131 | Non-Small Cell Lung Carcinoma | 28 | CTD_human |
Tgene | ALK | C0027819 | Neuroblastoma | 12 | CTD_human;ORPHANET |
Tgene | ALK | C0152013 | Adenocarcinoma of lung (disorder) | 8 | CTD_human |
Tgene | ALK | C0206180 | Ki-1+ Anaplastic Large Cell Lymphoma | 6 | CTD_human |
Tgene | ALK | C2751681 | NEUROBLASTOMA, SUSCEPTIBILITY TO, 3 | 4 | UNIPROT |
Tgene | ALK | C0018199 | Granuloma, Plasma Cell | 3 | CTD_human |
Tgene | ALK | C0007621 | Neoplastic Cell Transformation | 2 | CTD_human |
Tgene | ALK | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
Tgene | ALK | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Tgene | ALK | C0006118 | Brain Neoplasms | 1 | CTD_human |
Tgene | ALK | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | ALK | C0011570 | Mental Depression | 1 | PSYGENET |
Tgene | ALK | C0011581 | Depressive disorder | 1 | PSYGENET |
Tgene | ALK | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
Tgene | ALK | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | ALK | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
Tgene | ALK | C0085269 | Plasma Cell Granuloma, Pulmonary | 1 | CTD_human |
Tgene | ALK | C0278601 | Inflammatory Breast Carcinoma | 1 | CTD_human |