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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22668

FusionGeneSummary for MSMO1_DDX60

check button Fusion gene summary
Fusion gene informationFusion gene name: MSMO1_DDX60
Fusion gene ID: 22668
HgeneTgene
Gene symbol

MSMO1

DDX60

Gene ID

6307

55601

Gene namemethylsterol monooxygenase 1DExD/H-box helicase 60
SynonymsDESP4|ERG25|MCCPD|SC4MOL-
Cytomap

4q32.3

4q32.3

Type of geneprotein-codingprotein-coding
Descriptionmethylsterol monooxygenase 1C-4 methylsterol oxidaseprobable ATP-dependent RNA helicase DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 60DEAD box protein 60DEAD-box helicase 60
Modification date2018052320180519
UniProtAcc

Q15800

Q8IY21

Ensembl transtripts involved in fusion geneENST00000261507, ENST00000393766, 
ENST00000504317, 
ENST00000393743, 
ENST00000505393, 
Fusion gene scores* DoF score2 X 1 X 2=42 X 2 X 1=4
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: MSMO1 [Title/Abstract] AND DDX60 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDDX60

GO:0009615

response to virus

21791617


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0B2-01AMSMO1chr4

166248916

+DDX60chr4

169143032

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000261507ENST00000393743MSMO1chr4

166248916

+DDX60chr4

169143032

-
5UTR-intronENST00000261507ENST00000505393MSMO1chr4

166248916

+DDX60chr4

169143032

-
5UTR-3CDSENST00000393766ENST00000393743MSMO1chr4

166248916

+DDX60chr4

169143032

-
5UTR-intronENST00000393766ENST00000505393MSMO1chr4

166248916

+DDX60chr4

169143032

-
5UTR-3CDSENST00000504317ENST00000393743MSMO1chr4

166248916

+DDX60chr4

169143032

-
5UTR-intronENST00000504317ENST00000505393MSMO1chr4

166248916

+DDX60chr4

169143032

-

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FusionProtFeatures for MSMO1_DDX60


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MSMO1

Q15800

DDX60

Q8IY21

Catalyzes the first step in the removal of the two C-4methyl groups of 4,4-dimethylzymosterol.{ECO:0000250|UniProtKB:P53045}. Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible geneexpression in response to viral infection. Binds ssRNA, dsRNA anddsDNA and can promote the binding of DDX58/RIG-I to dsRNA.Exhibits antiviral activity against hepatitis C virus andvesicular stomatitis virus (VSV). {ECO:0000269|PubMed:21478870,ECO:0000269|PubMed:21791617}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MSMO1_DDX60


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MSMO1_DDX60


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MSMO1ELAVL1, ATXN1, EIF3F, PDHA2, EIF3A, DDRGK1, IMMT, VKORC1, GPR52, TMPRSS11B, C3AR1, P2RX5DDX60EGFR, SORT1, CDK2AP1, FYCO1, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MSMO1_DDX60


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MSMO1_DDX60


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMSMO1C4225189MICROCEPHALY, CONGENITAL CATARACT, AND PSORIASIFORM DERMATITIS1UNIPROT
TgeneDDX60C0021400Influenza1CTD_human