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Fusion gene ID: 22652 |
FusionGeneSummary for MSL1_RBM28 |
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Fusion gene information | Fusion gene name: MSL1_RBM28 | Fusion gene ID: 22652 | Hgene | Tgene | Gene symbol | MSL1 | RBM28 | Gene ID | 339287 | 55131 |
Gene name | male specific lethal 1 homolog | RNA binding motif protein 28 | |
Synonyms | MSL-1|hMSL1 | ANES | |
Cytomap | 17q21.1 | 7q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | male-specific lethal 1 homologMSL1-like 1male-specific lethal 1-like 1male-specific lethal-1 homolog 1 | RNA-binding protein 282810480G15Rik | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q68DK7 | Q9NW13 | |
Ensembl transtripts involved in fusion gene | ENST00000398532, ENST00000577454, ENST00000578648, ENST00000579565, | ENST00000223073, ENST00000481788, ENST00000415472, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 3 X 3 X 3=27 |
# samples | 4 | 3 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MSL1 [Title/Abstract] AND RBM28 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MSL1 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ336160 | MSL1 | chr17 | 38292795 | + | RBM28 | chr7 | 127979769 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000398532 | ENST00000223073 | MSL1 | chr17 | 38292795 | + | RBM28 | chr7 | 127979769 | + |
3UTR-intron | ENST00000398532 | ENST00000481788 | MSL1 | chr17 | 38292795 | + | RBM28 | chr7 | 127979769 | + |
3UTR-intron | ENST00000398532 | ENST00000415472 | MSL1 | chr17 | 38292795 | + | RBM28 | chr7 | 127979769 | + |
intron-3CDS | ENST00000577454 | ENST00000223073 | MSL1 | chr17 | 38292795 | + | RBM28 | chr7 | 127979769 | + |
intron-intron | ENST00000577454 | ENST00000481788 | MSL1 | chr17 | 38292795 | + | RBM28 | chr7 | 127979769 | + |
intron-intron | ENST00000577454 | ENST00000415472 | MSL1 | chr17 | 38292795 | + | RBM28 | chr7 | 127979769 | + |
intron-3CDS | ENST00000578648 | ENST00000223073 | MSL1 | chr17 | 38292795 | + | RBM28 | chr7 | 127979769 | + |
intron-intron | ENST00000578648 | ENST00000481788 | MSL1 | chr17 | 38292795 | + | RBM28 | chr7 | 127979769 | + |
intron-intron | ENST00000578648 | ENST00000415472 | MSL1 | chr17 | 38292795 | + | RBM28 | chr7 | 127979769 | + |
intron-3CDS | ENST00000579565 | ENST00000223073 | MSL1 | chr17 | 38292795 | + | RBM28 | chr7 | 127979769 | + |
intron-intron | ENST00000579565 | ENST00000481788 | MSL1 | chr17 | 38292795 | + | RBM28 | chr7 | 127979769 | + |
intron-intron | ENST00000579565 | ENST00000415472 | MSL1 | chr17 | 38292795 | + | RBM28 | chr7 | 127979769 | + |
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FusionProtFeatures for MSL1_RBM28 |
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Hgene | Tgene |
MSL1 | RBM28 |
Component of histone acetyltransferase complexresponsible for the majority of histone H4 acetylation at 'Lys-16'(H4K16ac) which is implicated in the formation of higher-orderchromatin structure. Greatly enhances MSL2 E3 ubiquitin ligaseactivity, promoting monoubiquitination of histone H2B at 'Lys-34'(H2BK34Ub). This modification in turn stimulates histone H3methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leadsto gene activation, including that of HOXA9 and MEIS1. In the MSLcomplex, acts as a scaffold to tether MSL3 and KAT8 together forenzymatic activity regulation. {ECO:0000269|PubMed:16227571,ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026}. | Nucleolar component of the spliceosomalribonucleoprotein complexes. {ECO:0000269|PubMed:17081119}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MSL1_RBM28 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MSL1_RBM28 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MSL1_RBM28 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MSL1_RBM28 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | RBM28 | C2677535 | Alopecia, Neurologic Defects, and Endocrinopathy Syndrome | 1 | CTD_human;ORPHANET;UNIPROT |