![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 22651 |
FusionGeneSummary for MSL1_PPP3CA |
![]() |
Fusion gene information | Fusion gene name: MSL1_PPP3CA | Fusion gene ID: 22651 | Hgene | Tgene | Gene symbol | MSL1 | PPP3CA | Gene ID | 339287 | 5530 |
Gene name | male specific lethal 1 homolog | protein phosphatase 3 catalytic subunit alpha | |
Synonyms | MSL-1|hMSL1 | CALN|CALNA|CALNA1|CCN1|CNA1|IECEE|IECEE1|PPP2B | |
Cytomap | 17q21.1 | 4q24 | |
Type of gene | protein-coding | protein-coding | |
Description | male-specific lethal 1 homologMSL1-like 1male-specific lethal 1-like 1male-specific lethal-1 homolog 1 | serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformCAM-PRP catalytic subunitcalcineurin A alphacalmodulin-dependent calcineurin A subunit alpha isoformprotein phosphatase 2B, catalytic subunit, alpha isoformprotein phosphatase 3 ( | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q68DK7 | Q08209 | |
Ensembl transtripts involved in fusion gene | ENST00000398532, ENST00000577454, ENST00000578648, ENST00000579565, | ENST00000512215, ENST00000394854, ENST00000323055, ENST00000394853, ENST00000507176, ENST00000523694, ENST00000510292, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 8 X 5 X 3=120 |
# samples | 4 | 8 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MSL1 [Title/Abstract] AND PPP3CA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MSL1 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
Tgene | PPP3CA | GO:0006470 | protein dephosphorylation | 18815128|19154138 |
Tgene | PPP3CA | GO:0033173 | calcineurin-NFAT signaling cascade | 19154138|22688515 |
Tgene | PPP3CA | GO:0035690 | cellular response to drug | 11005320 |
Tgene | PPP3CA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22688515 |
Tgene | PPP3CA | GO:0051592 | response to calcium ion | 18815128 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE896062 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000398532 | ENST00000512215 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
3UTR-3UTR | ENST00000398532 | ENST00000394854 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
3UTR-3UTR | ENST00000398532 | ENST00000323055 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
3UTR-3UTR | ENST00000398532 | ENST00000394853 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
3UTR-3UTR | ENST00000398532 | ENST00000507176 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
3UTR-intron | ENST00000398532 | ENST00000523694 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
3UTR-intron | ENST00000398532 | ENST00000510292 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-3UTR | ENST00000577454 | ENST00000512215 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-3UTR | ENST00000577454 | ENST00000394854 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-3UTR | ENST00000577454 | ENST00000323055 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-3UTR | ENST00000577454 | ENST00000394853 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-3UTR | ENST00000577454 | ENST00000507176 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-intron | ENST00000577454 | ENST00000523694 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-intron | ENST00000577454 | ENST00000510292 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-3UTR | ENST00000578648 | ENST00000512215 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-3UTR | ENST00000578648 | ENST00000394854 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-3UTR | ENST00000578648 | ENST00000323055 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-3UTR | ENST00000578648 | ENST00000394853 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-3UTR | ENST00000578648 | ENST00000507176 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-intron | ENST00000578648 | ENST00000523694 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-intron | ENST00000578648 | ENST00000510292 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-3UTR | ENST00000579565 | ENST00000512215 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-3UTR | ENST00000579565 | ENST00000394854 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-3UTR | ENST00000579565 | ENST00000323055 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-3UTR | ENST00000579565 | ENST00000394853 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-3UTR | ENST00000579565 | ENST00000507176 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-intron | ENST00000579565 | ENST00000523694 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
intron-intron | ENST00000579565 | ENST00000510292 | MSL1 | chr17 | 38291327 | + | PPP3CA | chr4 | 101946829 | - |
Top |
FusionProtFeatures for MSL1_PPP3CA |
![]() |
Hgene | Tgene |
MSL1 | PPP3CA |
Component of histone acetyltransferase complexresponsible for the majority of histone H4 acetylation at 'Lys-16'(H4K16ac) which is implicated in the formation of higher-orderchromatin structure. Greatly enhances MSL2 E3 ubiquitin ligaseactivity, promoting monoubiquitination of histone H2B at 'Lys-34'(H2BK34Ub). This modification in turn stimulates histone H3methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leadsto gene activation, including that of HOXA9 and MEIS1. In the MSLcomplex, acts as a scaffold to tether MSL3 and KAT8 together forenzymatic activity regulation. {ECO:0000269|PubMed:16227571,ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026}. | Calcium-dependent, calmodulin-stimulated proteinphosphatase which plays an essential role in the transduction ofintracellular Ca(2+)-mediated signals (PubMed:15671020,PubMed:18838687, PubMed:19154138, PubMed:23468591). Many of thesubstrates contain a PxIxIT motif and/or a LxVP motif(PubMed:17498738, PubMed:17502104, PubMed:23468591,PubMed:27974827, PubMed:22343722). In response to increased Ca(2+)levels, dephosphorylates and activates phosphatase SSH1 whichresults in cofilin dephosphorylation (PubMed:15671020). Inresponse to increased Ca(2+) levels following mitochondrialdepolarization, dephosphorylates DNM1L inducing DNM1Ltranslocation to the mitochondrion (PubMed:18838687).Dephosphorylates heat shock protein HSPB1 (By similarity).Dephosphorylates and activates transcription factor NFATC1(PubMed:19154138). In response to increased Ca(2+) levels,regulates NFAT-mediated transcription probably bydephosphorylating NFAT and promoting its nuclear translocation(PubMed:26248042). Dephosphorylates and inactivates transcriptionfactor ELK1 (PubMed:19154138). Dephosphorylates DARPP32(PubMed:19154138). {ECO:0000250|UniProtKB:P48452,ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:17498738,ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:18838687,ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:22343722,ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042,ECO:0000269|PubMed:27974827}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MSL1_PPP3CA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for MSL1_PPP3CA |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MSL1_PPP3CA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MSL1_PPP3CA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PPP3CA | C0019202 | Hepatolenticular Degeneration | 1 | CTD_human |
Tgene | PPP3CA | C0030305 | Pancreatitis | 1 | CTD_human |
Tgene | PPP3CA | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | PPP3CA | C0039584 | Testicular Diseases | 1 | CTD_human |
Tgene | PPP3CA | C0149721 | Left Ventricular Hypertrophy | 1 | CTD_human |
Tgene | PPP3CA | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |