|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 2263 |
FusionGeneSummary for APP_ITM2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: APP_ITM2B | Fusion gene ID: 2263 | Hgene | Tgene | Gene symbol | APP | ITM2B | Gene ID | 351 | 9445 |
| Gene name | amyloid beta precursor protein | integral membrane protein 2B | |
| Synonyms | AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4 | ABRI|BRI|BRI2|BRICD2B|E25B|E3-16|FBD|RDGCA|imBRI2 | |
| Cytomap | 21q21.3 | 13q14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | amyloid-beta A4 proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor proteincereb | integral membrane protein 2BABri/ADan amyloid peptideBRICHOS domain containing 2Bimmature BRI2transmembrane protein BRI | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P05067 | Q9Y287 | |
| Ensembl transtripts involved in fusion gene | ENST00000346798, ENST00000354192, ENST00000348990, ENST00000357903, ENST00000358918, ENST00000359726, ENST00000448388, ENST00000440126, ENST00000439274, ENST00000474136, | ENST00000378565, ENST00000378549, | |
| Fusion gene scores | * DoF score | 15 X 15 X 9=2025 | 5 X 4 X 3=60 |
| # samples | 19 | 5 | |
| ** MAII score | log2(19/2025*10)=-3.4138505843284 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: APP [Title/Abstract] AND ITM2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | APP | GO:0001934 | positive regulation of protein phosphorylation | 11404397 |
| Hgene | APP | GO:0008285 | negative regulation of cell proliferation | 22944668 |
| Tgene | ITM2B | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process | 16027166|18524908 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRP | TCGA-UZ-A9PR-01A | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000346798 | ENST00000378565 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000346798 | ENST00000378549 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000354192 | ENST00000378565 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000354192 | ENST00000378549 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000348990 | ENST00000378565 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000348990 | ENST00000378549 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000357903 | ENST00000378565 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000357903 | ENST00000378549 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000358918 | ENST00000378565 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000358918 | ENST00000378549 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000359726 | ENST00000378565 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000359726 | ENST00000378549 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000448388 | ENST00000378565 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000448388 | ENST00000378549 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000440126 | ENST00000378565 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000440126 | ENST00000378549 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000439274 | ENST00000378565 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000439274 | ENST00000378549 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| intron-3CDS | ENST00000474136 | ENST00000378565 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
| intron-3CDS | ENST00000474136 | ENST00000378549 | APP | chr21 | 27347383 | - | ITM2B | chr13 | 48827944 | + |
Top |
FusionProtFeatures for APP_ITM2B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| APP | ITM2B |
| Plays a regulatory role in the processing of theamyloid-beta A4 precursor protein (APP) and acts as an inhibitorof the amyloid-beta peptide aggregation and fibrils deposition.Plays a role in the induction of neurite outgrowth. Functions as aprotease inhibitor by blocking access of secretases to APPcleavage sites. Mature BRI2 (mBRI2) functions as a modulator of theamyloid-beta A4 precursor protein (APP) processing leading to astrong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42. Bri23 peptide prevents aggregation of APP amyloid-betaprotein 42 into toxic oligomers. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000346798 | - | 11 | 18 | 230_260 | 486 | 771 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000346798 | - | 11 | 18 | 274_280 | 486 | 771 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000348990 | - | 9 | 16 | 230_260 | 411 | 696 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000348990 | - | 9 | 16 | 274_280 | 411 | 696 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000354192 | - | 8 | 15 | 230_260 | 355 | 640 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000354192 | - | 8 | 15 | 274_280 | 355 | 640 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000357903 | - | 10 | 17 | 230_260 | 467 | 752 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000357903 | - | 10 | 17 | 274_280 | 467 | 752 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000358918 | - | 11 | 17 | 230_260 | 486 | 753 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000358918 | - | 11 | 17 | 274_280 | 486 | 753 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000359726 | - | 10 | 17 | 230_260 | 430 | 715 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000359726 | - | 10 | 17 | 274_280 | 430 | 715 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000440126 | - | 10 | 17 | 230_260 | 462 | 747 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000440126 | - | 10 | 17 | 274_280 | 462 | 747 | Compositional bias | Note=Poly-Thr |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000346798 | - | 11 | 18 | 181_188 | 486 | 771 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000346798 | - | 11 | 18 | 391_423 | 486 | 771 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000346798 | - | 11 | 18 | 96_110 | 486 | 771 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000348990 | - | 9 | 16 | 181_188 | 411 | 696 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000348990 | - | 9 | 16 | 96_110 | 411 | 696 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000354192 | - | 8 | 15 | 181_188 | 355 | 640 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000354192 | - | 8 | 15 | 96_110 | 355 | 640 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000357903 | - | 10 | 17 | 181_188 | 467 | 752 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000357903 | - | 10 | 17 | 391_423 | 467 | 752 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000357903 | - | 10 | 17 | 96_110 | 467 | 752 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000358918 | - | 11 | 17 | 181_188 | 486 | 753 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000358918 | - | 11 | 17 | 391_423 | 486 | 753 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000358918 | - | 11 | 17 | 96_110 | 486 | 753 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000359726 | - | 10 | 17 | 181_188 | 430 | 715 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000359726 | - | 10 | 17 | 391_423 | 430 | 715 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000359726 | - | 10 | 17 | 96_110 | 430 | 715 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000440126 | - | 10 | 17 | 181_188 | 462 | 747 | Region | Note=Zinc-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000440126 | - | 10 | 17 | 391_423 | 462 | 747 | Region | Note=Heparin-binding |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000440126 | - | 10 | 17 | 96_110 | 462 | 747 | Region | Note=Heparin-binding |
| Tgene | >ITM2B | chr21:27347383 | chr13:48827944 | ENST00000378565 | + | 0 | 6 | 137_231 | 39 | 267 | Domain | BRICHOS |
| Tgene | >ITM2B | chr21:27347383 | chr13:48827944 | ENST00000378565 | + | 0 | 6 | 76_266 | 39 | 267 | Topological domain | Lumenal |
| Tgene | >ITM2B | chr21:27347383 | chr13:48827944 | ENST00000378565 | + | 0 | 6 | 55_75 | 39 | 267 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000346798 | - | 11 | 18 | 724_734 | 486 | 771 | Motif | Note=Basolateral sorting signal |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000346798 | - | 11 | 18 | 759_762 | 486 | 771 | Motif | Note=NPXY motif%3B contains endocytosis signal |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000348990 | - | 9 | 16 | 724_734 | 411 | 696 | Motif | Note=Basolateral sorting signal |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000348990 | - | 9 | 16 | 759_762 | 411 | 696 | Motif | Note=NPXY motif%3B contains endocytosis signal |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000354192 | - | 8 | 15 | 724_734 | 355 | 640 | Motif | Note=Basolateral sorting signal |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000354192 | - | 8 | 15 | 759_762 | 355 | 640 | Motif | Note=NPXY motif%3B contains endocytosis signal |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000357903 | - | 10 | 17 | 724_734 | 467 | 752 | Motif | Note=Basolateral sorting signal |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000357903 | - | 10 | 17 | 759_762 | 467 | 752 | Motif | Note=NPXY motif%3B contains endocytosis signal |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000358918 | - | 11 | 17 | 724_734 | 486 | 753 | Motif | Note=Basolateral sorting signal |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000358918 | - | 11 | 17 | 759_762 | 486 | 753 | Motif | Note=NPXY motif%3B contains endocytosis signal |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000359726 | - | 10 | 17 | 724_734 | 430 | 715 | Motif | Note=Basolateral sorting signal |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000359726 | - | 10 | 17 | 759_762 | 430 | 715 | Motif | Note=NPXY motif%3B contains endocytosis signal |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000440126 | - | 10 | 17 | 724_734 | 462 | 747 | Motif | Note=Basolateral sorting signal |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000440126 | - | 10 | 17 | 759_762 | 462 | 747 | Motif | Note=NPXY motif%3B contains endocytosis signal |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000346798 | - | 11 | 18 | 491_522 | 486 | 771 | Region | Note=Heparin-binding |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000346798 | - | 11 | 18 | 523_540 | 486 | 771 | Region | Note=Collagen-binding |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000348990 | - | 9 | 16 | 391_423 | 411 | 696 | Region | Note=Heparin-binding |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000348990 | - | 9 | 16 | 491_522 | 411 | 696 | Region | Note=Heparin-binding |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000348990 | - | 9 | 16 | 523_540 | 411 | 696 | Region | Note=Collagen-binding |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000354192 | - | 8 | 15 | 391_423 | 355 | 640 | Region | Note=Heparin-binding |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000354192 | - | 8 | 15 | 491_522 | 355 | 640 | Region | Note=Heparin-binding |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000354192 | - | 8 | 15 | 523_540 | 355 | 640 | Region | Note=Collagen-binding |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000357903 | - | 10 | 17 | 491_522 | 467 | 752 | Region | Note=Heparin-binding |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000357903 | - | 10 | 17 | 523_540 | 467 | 752 | Region | Note=Collagen-binding |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000358918 | - | 11 | 17 | 491_522 | 486 | 753 | Region | Note=Heparin-binding |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000358918 | - | 11 | 17 | 523_540 | 486 | 753 | Region | Note=Collagen-binding |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000359726 | - | 10 | 17 | 491_522 | 430 | 715 | Region | Note=Heparin-binding |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000359726 | - | 10 | 17 | 523_540 | 430 | 715 | Region | Note=Collagen-binding |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000440126 | - | 10 | 17 | 491_522 | 462 | 747 | Region | Note=Heparin-binding |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000440126 | - | 10 | 17 | 523_540 | 462 | 747 | Region | Note=Collagen-binding |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000346798 | - | 11 | 18 | 18_699 | 486 | 771 | Topological domain | Extracellular |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000346798 | - | 11 | 18 | 724_770 | 486 | 771 | Topological domain | Cytoplasmic |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000348990 | - | 9 | 16 | 18_699 | 411 | 696 | Topological domain | Extracellular |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000348990 | - | 9 | 16 | 724_770 | 411 | 696 | Topological domain | Cytoplasmic |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000354192 | - | 8 | 15 | 18_699 | 355 | 640 | Topological domain | Extracellular |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000354192 | - | 8 | 15 | 724_770 | 355 | 640 | Topological domain | Cytoplasmic |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000357903 | - | 10 | 17 | 18_699 | 467 | 752 | Topological domain | Extracellular |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000357903 | - | 10 | 17 | 724_770 | 467 | 752 | Topological domain | Cytoplasmic |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000358918 | - | 11 | 17 | 18_699 | 486 | 753 | Topological domain | Extracellular |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000358918 | - | 11 | 17 | 724_770 | 486 | 753 | Topological domain | Cytoplasmic |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000359726 | - | 10 | 17 | 18_699 | 430 | 715 | Topological domain | Extracellular |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000359726 | - | 10 | 17 | 724_770 | 430 | 715 | Topological domain | Cytoplasmic |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000440126 | - | 10 | 17 | 18_699 | 462 | 747 | Topological domain | Extracellular |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000440126 | - | 10 | 17 | 724_770 | 462 | 747 | Topological domain | Cytoplasmic |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000346798 | - | 11 | 18 | 700_723 | 486 | 771 | Transmembrane | Helical |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000348990 | - | 9 | 16 | 700_723 | 411 | 696 | Transmembrane | Helical |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000354192 | - | 8 | 15 | 700_723 | 355 | 640 | Transmembrane | Helical |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000357903 | - | 10 | 17 | 700_723 | 467 | 752 | Transmembrane | Helical |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000358918 | - | 11 | 17 | 700_723 | 486 | 753 | Transmembrane | Helical |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000359726 | - | 10 | 17 | 700_723 | 430 | 715 | Transmembrane | Helical |
| Hgene | >APP | chr21:27347383 | chr13:48827944 | ENST00000440126 | - | 10 | 17 | 700_723 | 462 | 747 | Transmembrane | Helical |
| Tgene | ITM2B | chr21:27347383 | chr13:48827944 | ENST00000378565 | + | 0 | 6 | 1_54 | 39 | 267 | Topological domain | Cytoplasmic |
Top |
FusionGeneSequence for APP_ITM2B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_APP_ENST00000346798_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_714aa MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANER QQLVETHMARVEAMLNDRRRLALENYITALQAVPPRDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKY IKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLEL >In-frame_APP_ENST00000346798_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_608aa MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANER QQLVETHMARVEAMLNDRRRLALENYITALQAVPPRDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQAGTYLPQSYLI >In-frame_APP_ENST00000354192_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_583aa MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAK HRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRDPDDV VPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPV PEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCH >In-frame_APP_ENST00000354192_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_477aa MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAK HRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRDPDDV VPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGI >In-frame_APP_ENST00000348990_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_639aa MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHF QEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKY FALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIP LNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFENKF >In-frame_APP_ENST00000348990_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_533aa MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHF QEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKY >In-frame_APP_ENST00000357903_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_695aa MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYL ETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRR RLALENYITALQAVPPRDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALY QTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEH >In-frame_APP_ENST00000357903_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_589aa MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYL ETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRR RLALENYITALQAVPPRDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQAGTYLPQSYLIHEHMVITDRIENIDHLGFF >In-frame_APP_ENST00000358918_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_714aa MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANER QQLVETHMARVEAMLNDRRRLALENYITALQAVPPRDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKY IKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLEL >In-frame_APP_ENST00000358918_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_608aa MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANER QQLVETHMARVEAMLNDRRRLALENYITALQAVPPRDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQAGTYLPQSYLI >In-frame_APP_ENST00000359726_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_658aa MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVRVSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRDPDDVVPVGQRRAWCWCMCF GLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDF NKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKG >In-frame_APP_ENST00000359726_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_552aa MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTT SIATTTTTTTESVEEVVRVSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRDPDDVVPVGQRRAWCWCMCF GLAFMLAGVILGGAYLYKYFALQAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFE >In-frame_APP_ENST00000448388_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_604aa MFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSD ALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADT DYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLE TPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRR LALENYITALQAVPPRDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQ TIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHM >In-frame_APP_ENST00000448388_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_498aa MFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSD ALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADT DYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLE TPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRR LALENYITALQAVPPRDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQAGTYLPQSYLIHEHMVITDRIENIDHLGFFI >In-frame_APP_ENST00000440126_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_690aa MDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQ NWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFV CCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATT TTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYLETPGD ENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALE NYITALQAVPPRDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEE NIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITD >In-frame_APP_ENST00000440126_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_584aa MDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQ NWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFV CCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATT TTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDAVDKYLETPGD ENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALE NYITALQAVPPRDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLC >In-frame_APP_ENST00000439274_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_658aa MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGG NRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRDPDDVVPVGQRRAWCWCMCF GLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDF NKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKG >In-frame_APP_ENST00000439274_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_552aa MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGG NRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRDPDDVVPVGQRRAWCWCMCF GLAFMLAGVILGGAYLYKYFALQAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_APP_ENST00000346798_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_2142nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCT GAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAA ACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAA CCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGT GAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGG CACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGA GGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGG GGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAA GAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACC AGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAAC TTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGAT CCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCAT TTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCA AAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGA CAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTG CAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTT ATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACTGTGGAATAAAGTAC ATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATATTAAAATCTTTGAA GAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACTTTAACAAGAAACTT ACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAAACCTACTGGAGTTA CTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGAT CACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGT >In-frame_APP_ENST00000346798_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_1824nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCT GAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAA ACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAA CCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGT GAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGG CACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGA GGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGG GGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAA GAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACC AGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAAC TTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGAT CCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCAT TTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCA AAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGA CAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTG CAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTT ATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAAGCTGGAACCTATTTGCCTCAGTCCTATCTGATT CATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTAC AAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCC >In-frame_APP_ENST00000354192_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_1749nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTA GAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGC TGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACT CATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATT GACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCG GATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAG GTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACA GAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACC CCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAG CACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTT ATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTG GAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTG GTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATAC TTGTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCT GCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTC CCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGC TATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCT CAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCAT GACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTT >In-frame_APP_ENST00000354192_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_1431nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTA GAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGC TGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACT CATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATT GACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCG GATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAG GTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACA GAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACC CCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAG CACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTT ATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTG GAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTG GTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATAC TTGTACAAATATTTTGCACTTCAAGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAA AACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATT >In-frame_APP_ENST00000348990_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_1917nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCT GAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAA ACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAA CCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGT GAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGG CACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGA GGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGG GGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAA GAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACC AGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTT GACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGA ATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTC CAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTC AATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGC CAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATAT TTTGCACTTCAACCAGATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCA GCTGCTCTCTACCAGACAATTGAAGAAAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCA GATAGTGATCCTGCCAACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCT CTGAACACTTCCATTGTTATGCCACCCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTG ATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACT TACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTT >In-frame_APP_ENST00000348990_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_1599nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCT GAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAA ACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAA CCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGT GAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGG CACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGA GGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGG GGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAA GAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACC AGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTT GACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGA ATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTC CAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTC AATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGC CAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATAT TTTGCACTTCAAGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCAC CTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAA >In-frame_APP_ENST00000357903_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_2085nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCT GAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAA ACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAA CCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGT GAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGG CACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGA GGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGG GGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAA GAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACC AGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAAC TTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTC GAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTC ATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTG GAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGC CGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCC TGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAA CCAGATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTAC CAGACAATTGAAGAAAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCT GCCAACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCC ATTGTTATGCCACCCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCAC ATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAA CGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACT >In-frame_APP_ENST00000357903_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_1767nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCT GAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAA ACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAA CCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGT GAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGG CACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGA GGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGG GGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAA GAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACC AGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAAC TTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTC GAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTC ATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTG GAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGC CGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCC TGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAA GCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTT ATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGT >In-frame_APP_ENST00000358918_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_2142nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCT GAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAA ACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAA CCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGT GAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGG CACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGA GGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGG GGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAA GAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACC AGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAAC TTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGAT CCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCAT TTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCA AAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGA CAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTG CAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTT ATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACTGTGGAATAAAGTAC ATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATATTAAAATCTTTGAA GAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACTTTAACAAGAAACTT ACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAAACCTACTGGAGTTA CTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGAT CACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGT >In-frame_APP_ENST00000358918_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_1824nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCT GAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAA ACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAA CCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGT GAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGG CACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGA GGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGG GGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAA GAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACC AGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAAC TTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGAT CCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCAT TTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCA AAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGA CAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTG CAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTT ATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAAGCTGGAACCTATTTGCCTCAGTCCTATCTGATT CATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTAC AAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCC >In-frame_APP_ENST00000359726_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_1974nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCT GAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAA ACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAA CCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGT GAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGG CACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGA GGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGG GGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAA GAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACC AGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTGTCCCAAAGTTTACTCAAGACTACCCAGGAACCT CTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAAT GAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCA GAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCA GCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTAC ATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTT GGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACTGT GGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATATT AAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACTTT AACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAAAC CTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATT GAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGT >In-frame_APP_ENST00000359726_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_1656nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCT GAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAA ACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAA CCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGT GAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGG CACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGA GGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGG GGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAA GAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACC AGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTGTCCCAAAGTTTACTCAAGACTACCCAGGAACCT CTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAAT GAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCA GAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCA GCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTAC ATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTT GGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAAGCTGGAACCTATTTGCCTCAG TCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGAC AAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAA >In-frame_APP_ENST00000448388_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_1812nt ATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACC AAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAG AACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGAT GCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAA GAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTG TGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACA GACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGAC GAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACC ACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAG ACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATG AGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAA TCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGC CTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGG TGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAACCA GATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAG ACAATTGAAGAAAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCTGCC AACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATT GTTATGCCACCCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATG GTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGC AGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTA >In-frame_APP_ENST00000448388_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_1494nt ATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACC AAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAG AACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGAT GCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAA GAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTG TGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACA GACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGAC GAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACC ACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAG ACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATG AGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAA TCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGC CTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGG TGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAAGCT GGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATT TATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTC >In-frame_APP_ENST00000440126_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_2070nt ATGGACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCC ATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACC AAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAG AACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGAT GCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAA GAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTG TGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACA GACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGAC GAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACC ACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCC CGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAG TACTGCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGAT GAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAA GAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAG GAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAG AACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATG TGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAACCAGATGACGTGTAC TACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAA AATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCAT GACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCC AGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGAT CGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATT AAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGA >In-frame_APP_ENST00000440126_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_1752nt ATGGACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCC ATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACC AAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAG AACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGAT GCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAA GAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTG TGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACA GACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGAC GAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACC ACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCC CGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAG TACTGCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGAT GAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAA GAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAG GAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAG AACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATG TGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAAGCTGGAACCTATTTG CCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGT CATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCAT >In-frame_APP_ENST00000439274_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_1974nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTA GAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGC TGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACT CATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATT GACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCG GATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAG GTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACA GAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAG ACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGC AACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCT CTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAAT GAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCA GAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCA GCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTAC ATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTT GGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACTGT GGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATATT AAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACTTT AACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAAAC CTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATT GAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGT >In-frame_APP_ENST00000439274_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_1656nt ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTA GAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGC TGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACT CATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATT GACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCG GATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAG GTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACA GAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAG ACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGC AACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCT CTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAAT GAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCA GAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCA GCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTAC ATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTT GGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAAGCTGGAACCTATTTGCCTCAG TCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGAC AAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_APP_ENST00000346798_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_3276nt CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGA ACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCC CCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGA GAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGG CATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGC TGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGC AGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGA GGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGA GGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATT CTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTT ACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCT CGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGT CATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGT GGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCG CCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGC CTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCA ACCAGATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTA CCAGACAATTGAAGAAAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCC TGCCAACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTC CATTGTTATGCCACCCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCA CATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCA ACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAAC TTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGAT TATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCAATTAAAACCATTACCTTAAAA TTTTTTTCTTTCGAAGTGTGGTGTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATAGATAATAGTACATGTCACCTTAGGTAGTAG GAAGAATTACAATTTCTTTAAATCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGACGGATTATCTAGAGAATAATCATA TATATGCATACGTAAAAATGGACCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTTTGTTAGTGCATTTGAGCACACAT TTTAATTTTCCTCTAATTAAAATGTGCAGTATTTTCAGTGTCAAATATATTTAACTATTTAGAGAATGATTTCCACCTTTATGTTTTAAT ATCCTAGGCATCTGCTGTAATAATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACTAATTTGTATAACCCATATCTGTG CAATGGAATATAAATATCACAAAGTTGTTTAACTAGACTGCGTGTTGTTTTTCCCGTATAATAAAACCAAAGAATAGTTTGGTTCTTCAA ATCTTAAGAGAATCCACATAAAAGAAGAAACTATTTTTTAAAAATTCACTTCTATATATACAATGAGTAAAATCACAGATTTTTTCTTTA AATAAAAATAAGTCATTTTAATAACTAAACCAGATTCTTTGTGGATACTATTAAAGTAACATTTAAGCCTCAACCTTGAATGATGTTGTT TAATATAAAATGCTTTTATTTTTGATGGAAAGGCAATCAAAGCCTAAAGTTTCCAAGGAACGTAAAATAACTGTGCTTCTCTGAGAATGC CCGCCTCACAAGTGGAACATTTTGAGTTAATAATGATGATTTTTATGTTTCTAAGGTTGCTTCCTCTCTGAAATAATTCAGAATCCACCC >In-frame_APP_ENST00000346798_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_2022nt CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA GGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAA TGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGA ACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCC CCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGA GAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGG CATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGC TGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGC AGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGA GGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGA GGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATT CTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTT ACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCT CGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGT CATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGT GGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCG CCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGC CTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCA AGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTT TATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTG TTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTA ATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTA >In-frame_APP_ENST00000354192_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_2976nt GCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTC GCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCT GGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCA GTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAA ATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAA CTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGA CAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAA AGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGT AGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGA AGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGC CCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCA AGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGA GAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGC TCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGC ATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACTGTGGAATAAA GTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATATTAAAATCTT TGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACTTTAACAAGAA ACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAAACCTACTGGA GTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACAT TGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAA ACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAA CATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTA GCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCAATTAAAACCATTACCTTAAAATTTTTTTCTTTCGAAGTGTGGTGTCTTTTA TATTTGAATTAGTAACTGTATGAAGTCATAGATAATAGTACATGTCACCTTAGGTAGTAGGAAGAATTACAATTTCTTTAAATCATTTAT CTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGACGGATTATCTAGAGAATAATCATATATATGCATACGTAAAAATGGACCACAGTG ACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTTTGTTAGTGCATTTGAGCACACATTTTAATTTTCCTCTAATTAAAATGTGCAGT ATTTTCAGTGTCAAATATATTTAACTATTTAGAGAATGATTTCCACCTTTATGTTTTAATATCCTAGGCATCTGCTGTAATAATATTTTA GAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACTAATTTGTATAACCCATATCTGTGCAATGGAATATAAATATCACAAAGTTGTTT AACTAGACTGCGTGTTGTTTTTCCCGTATAATAAAACCAAAGAATAGTTTGGTTCTTCAAATCTTAAGAGAATCCACATAAAAGAAGAAA CTATTTTTTAAAAATTCACTTCTATATATACAATGAGTAAAATCACAGATTTTTTCTTTAAATAAAAATAAGTCATTTTAATAACTAAAC CAGATTCTTTGTGGATACTATTAAAGTAACATTTAAGCCTCAACCTTGAATGATGTTGTTTAATATAAAATGCTTTTATTTTTGATGGAA AGGCAATCAAAGCCTAAAGTTTCCAAGGAACGTAAAATAACTGTGCTTCTCTGAGAATGCCCGCCTCACAAGTGGAACATTTTGAGTTAA TAATGATGATTTTTATGTTTCTAAGGTTGCTTCCTCTCTGAAATAATTCAGAATCCACCCCCATTTAATAAAATACCTATGATTCATTTC >In-frame_APP_ENST00000354192_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_1722nt GCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTC GCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCT GGAGGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCA GTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAA ATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAA CTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGA CAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAA AGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGT AGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGA AGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGC CCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCA AGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGA GAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGC TCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGC ATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAAGCTGGAACCTATTTGCCTCAGTCCTATCT GATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAAC TTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATT TGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATT TTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCAATTAAAACC >In-frame_APP_ENST00000348990_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_3164nt AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG TATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGC CGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGAC AAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAG AGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAA GAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGT GAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGT GATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAG TCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAAT GAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCA GAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCA GCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTAC ATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTT GGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACTGT GGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATATT AAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACTTT AACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAAAC CTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATT GAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGT ATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTC AAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCA TGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCAATTAAAACCATTACCTTAAAATTTTTTTCTTTCGAAGTGTGGT GTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATAGATAATAGTACATGTCACCTTAGGTAGTAGGAAGAATTACAATTTCTTTAAA TCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGACGGATTATCTAGAGAATAATCATATATATGCATACGTAAAAATGGA CCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTTTGTTAGTGCATTTGAGCACACATTTTAATTTTCCTCTAATTAAAA TGTGCAGTATTTTCAGTGTCAAATATATTTAACTATTTAGAGAATGATTTCCACCTTTATGTTTTAATATCCTAGGCATCTGCTGTAATA ATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACTAATTTGTATAACCCATATCTGTGCAATGGAATATAAATATCACAA AGTTGTTTAACTAGACTGCGTGTTGTTTTTCCCGTATAATAAAACCAAAGAATAGTTTGGTTCTTCAAATCTTAAGAGAATCCACATAAA AGAAGAAACTATTTTTTAAAAATTCACTTCTATATATACAATGAGTAAAATCACAGATTTTTTCTTTAAATAAAAATAAGTCATTTTAAT AACTAAACCAGATTCTTTGTGGATACTATTAAAGTAACATTTAAGCCTCAACCTTGAATGATGTTGTTTAATATAAAATGCTTTTATTTT TGATGGAAAGGCAATCAAAGCCTAAAGTTTCCAAGGAACGTAAAATAACTGTGCTTCTCTGAGAATGCCCGCCTCACAAGTGGAACATTT TGAGTTAATAATGATGATTTTTATGTTTCTAAGGTTGCTTCCTCTCTGAAATAATTCAGAATCCACCCCCATTTAATAAAATACCTATGA >In-frame_APP_ENST00000348990_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_1910nt AGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAA GGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCC GCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTG AACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAG TATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGC CGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGAC AAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAG AGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAA GAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGT GAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGT GATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAG TCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAAT GAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCA GAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCA GCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTAC ATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTT GGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAAGCTGGAACCTATTTGCCTCAG TCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGAC AAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAA AACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCC TTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCAA >In-frame_APP_ENST00000357903_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_3352nt CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA CCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCC AGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTG ATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCA AAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTG TGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACA CAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATG ACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCA CCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCT CCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAG AGTACTGCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGG ATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGG AAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAAC AGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGG AGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCA TGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAACCAGATGACGTGT ACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAG AAAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTC ATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTATGCCAC CCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTG ATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTA TTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTT GAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTC TTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCAATTAAAACCATTACCTTAAAATTTTTTTCTTTCGA AGTGTGGTGTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATAGATAATAGTACATGTCACCTTAGGTAGTAGGAAGAATTACAATT TCTTTAAATCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGACGGATTATCTAGAGAATAATCATATATATGCATACGTA AAAATGGACCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTTTGTTAGTGCATTTGAGCACACATTTTAATTTTCCTCT AATTAAAATGTGCAGTATTTTCAGTGTCAAATATATTTAACTATTTAGAGAATGATTTCCACCTTTATGTTTTAATATCCTAGGCATCTG CTGTAATAATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACTAATTTGTATAACCCATATCTGTGCAATGGAATATAAA TATCACAAAGTTGTTTAACTAGACTGCGTGTTGTTTTTCCCGTATAATAAAACCAAAGAATAGTTTGGTTCTTCAAATCTTAAGAGAATC CACATAAAAGAAGAAACTATTTTTTAAAAATTCACTTCTATATATACAATGAGTAAAATCACAGATTTTTTCTTTAAATAAAAATAAGTC ATTTTAATAACTAAACCAGATTCTTTGTGGATACTATTAAAGTAACATTTAAGCCTCAACCTTGAATGATGTTGTTTAATATAAAATGCT TTTATTTTTGATGGAAAGGCAATCAAAGCCTAAAGTTTCCAAGGAACGTAAAATAACTGTGCTTCTCTGAGAATGCCCGCCTCACAAGTG GAACATTTTGAGTTAATAATGATGATTTTTATGTTTCTAAGGTTGCTTCCTCTCTGAAATAATTCAGAATCCACCCCCATTTAATAAAAT >In-frame_APP_ENST00000357903_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_2098nt CGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGGAGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGG TGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTT TGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTG CCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATA CCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCC AGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTG ATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCA AAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTG TGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACA CAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATG ACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCA CCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCT CCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAG AGTACTGCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGG ATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGG AAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAAC AGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGG AGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCA TGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAAGCTGGAACCTATT TGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGT GTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGC ATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAA CCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCAT >In-frame_APP_ENST00000358918_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_3442nt GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAG AAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAAC AAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGAT GTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCC AGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGG ATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGG AAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAAC AGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGG AGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCA TGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAACCAGATGACGTGT ACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAG AAAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTC ATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTATGCCAC CCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTG ATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTA TTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTT GAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTC TTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCAATTAAAACCATTACCTTAAAATTTTTTTCTTTCGA AGTGTGGTGTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATAGATAATAGTACATGTCACCTTAGGTAGTAGGAAGAATTACAATT TCTTTAAATCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGACGGATTATCTAGAGAATAATCATATATATGCATACGTA AAAATGGACCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTTTGTTAGTGCATTTGAGCACACATTTTAATTTTCCTCT AATTAAAATGTGCAGTATTTTCAGTGTCAAATATATTTAACTATTTAGAGAATGATTTCCACCTTTATGTTTTAATATCCTAGGCATCTG CTGTAATAATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACTAATTTGTATAACCCATATCTGTGCAATGGAATATAAA TATCACAAAGTTGTTTAACTAGACTGCGTGTTGTTTTTCCCGTATAATAAAACCAAAGAATAGTTTGGTTCTTCAAATCTTAAGAGAATC CACATAAAAGAAGAAACTATTTTTTAAAAATTCACTTCTATATATACAATGAGTAAAATCACAGATTTTTTCTTTAAATAAAAATAAGTC ATTTTAATAACTAAACCAGATTCTTTGTGGATACTATTAAAGTAACATTTAAGCCTCAACCTTGAATGATGTTGTTTAATATAAAATGCT TTTATTTTTGATGGAAAGGCAATCAAAGCCTAAAGTTTCCAAGGAACGTAAAATAACTGTGCTTCTCTGAGAATGCCCGCCTCACAAGTG GAACATTTTGAGTTAATAATGATGATTTTTATGTTTCTAAGGTTGCTTCCTCTCTGAAATAATTCAGAATCCACCCCCATTTAATAAAAT >In-frame_APP_ENST00000358918_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_2188nt GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAG AAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAAC AAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGAT GTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCC AGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGG ATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGG AAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAAC AGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGG AGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCA TGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAAGCTGGAACCTATT TGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGT GTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGC ATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAA CCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCAT >In-frame_APP_ENST00000359726_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_3274nt GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAG AAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTGTCCCAAAGTTTAC TCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCG AGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCA TGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGG AATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCC GCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCT GGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAAC CAGATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACC AGACAATTGAAGAAAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCTG CCAACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCA TTGTTATGCCACCCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACA TGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAAC GCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTT TAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTA TTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCAATTAAAACCATTACCTTAAAATT TTTTTCTTTCGAAGTGTGGTGTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATAGATAATAGTACATGTCACCTTAGGTAGTAGGA AGAATTACAATTTCTTTAAATCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGACGGATTATCTAGAGAATAATCATATA TATGCATACGTAAAAATGGACCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTTTGTTAGTGCATTTGAGCACACATTT TAATTTTCCTCTAATTAAAATGTGCAGTATTTTCAGTGTCAAATATATTTAACTATTTAGAGAATGATTTCCACCTTTATGTTTTAATAT CCTAGGCATCTGCTGTAATAATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACTAATTTGTATAACCCATATCTGTGCA ATGGAATATAAATATCACAAAGTTGTTTAACTAGACTGCGTGTTGTTTTTCCCGTATAATAAAACCAAAGAATAGTTTGGTTCTTCAAAT CTTAAGAGAATCCACATAAAAGAAGAAACTATTTTTTAAAAATTCACTTCTATATATACAATGAGTAAAATCACAGATTTTTTCTTTAAA TAAAAATAAGTCATTTTAATAACTAAACCAGATTCTTTGTGGATACTATTAAAGTAACATTTAAGCCTCAACCTTGAATGATGTTGTTTA ATATAAAATGCTTTTATTTTTGATGGAAAGGCAATCAAAGCCTAAAGTTTCCAAGGAACGTAAAATAACTGTGCTTCTCTGAGAATGCCC GCCTCACAAGTGGAACATTTTGAGTTAATAATGATGATTTTTATGTTTCTAAGGTTGCTTCCTCTCTGAAATAATTCAGAATCCACCCCC >In-frame_APP_ENST00000359726_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_2020nt GGATCAGCTGACTCGCCTGGCTCTGAGCCCCGCCGCCGCGCTCGGGCTCCGTCAGTTTCCTCGGCAGCGGTAGGCGAGAGCACGCGGAGG AGCGTGCGCGGGGGCCCCGGGAGACGGCGGCGGTGGCGGCGCGGGCAGAGCAAGGACGCGGCGGATCCCACTCGCACAGCAGCGCACTCG GTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGAGGTACCCACTGATG GTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATT CAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCA ATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTC CCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTT GCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCT GCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGG ATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAG TGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAG AAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTGTCCCAAAGTTTAC TCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCG AGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCA TGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGG AATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCC GCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCT GGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAAG CTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTA TTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTT TCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAAT ATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATC >In-frame_APP_ENST00000448388_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_3104nt GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCA GTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAG TTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCAC ACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGG GTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGC GGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAA GCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGC ATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGAC AAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATG TCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAG GAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAAT GACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAA AGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTT GCACTTCAACCAGATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCT GCTCTCTACCAGACAATTGAAGAAAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGAT AGTGATCCTGCCAACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTG AACACTTCCATTGTTATGCCACCCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATT CATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTAC AAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCC GTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGT GCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCAATTAAAACCATTA CCTTAAAATTTTTTTCTTTCGAAGTGTGGTGTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATAGATAATAGTACATGTCACCTTA GGTAGTAGGAAGAATTACAATTTCTTTAAATCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGACGGATTATCTAGAGAA TAATCATATATATGCATACGTAAAAATGGACCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTTTGTTAGTGCATTTGA GCACACATTTTAATTTTCCTCTAATTAAAATGTGCAGTATTTTCAGTGTCAAATATATTTAACTATTTAGAGAATGATTTCCACCTTTAT GTTTTAATATCCTAGGCATCTGCTGTAATAATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACTAATTTGTATAACCCA TATCTGTGCAATGGAATATAAATATCACAAAGTTGTTTAACTAGACTGCGTGTTGTTTTTCCCGTATAATAAAACCAAAGAATAGTTTGG TTCTTCAAATCTTAAGAGAATCCACATAAAAGAAGAAACTATTTTTTAAAAATTCACTTCTATATATACAATGAGTAAAATCACAGATTT TTTCTTTAAATAAAAATAAGTCATTTTAATAACTAAACCAGATTCTTTGTGGATACTATTAAAGTAACATTTAAGCCTCAACCTTGAATG ATGTTGTTTAATATAAAATGCTTTTATTTTTGATGGAAAGGCAATCAAAGCCTAAAGTTTCCAAGGAACGTAAAATAACTGTGCTTCTCT GAGAATGCCCGCCTCACAAGTGGAACATTTTGAGTTAATAATGATGATTTTTATGTTTCTAAGGTTGCTTCCTCTCTGAAATAATTCAGA >In-frame_APP_ENST00000448388_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_1850nt GTCGGATGATTCAAGCTCACGGGGACGAGCAGGAGCGCTCTCGACTTTTCTAGAGCCTCAGCGTCCTAGGACTCACCTTTCCCTGATCCT GCACCGTCCCTCTCCTGGCCCCAGACTCTCCCTCCCACTGTTCACGAAGCCCAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAA CCCCAGATTGCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACC TGCATTGATACCAAGGAAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCA GTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAG TTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCAC ACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGG GTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGC GGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAA GCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGC ATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGAC AAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATG TCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAG GAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAAT GACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAA AGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTT GCACTTCAAGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTG GGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCC AGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAG GAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGG >In-frame_APP_ENST00000440126_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_3436nt AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG AAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACT GGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCC TTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGA CATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTT GCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACT ATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGG ACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCA CCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCT GGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACT GCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGA ATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGG CAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAG CAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACT ACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCT TTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACT GTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATA TTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACT TTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAA ACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCA TTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAG GTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAG TCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTT CATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCAATTAAAACCATTACCTTAAAATTTTTTTCTTTCGAAGTGTG GTGTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATAGATAATAGTACATGTCACCTTAGGTAGTAGGAAGAATTACAATTTCTTTA AATCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGACGGATTATCTAGAGAATAATCATATATATGCATACGTAAAAATG GACCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTTTGTTAGTGCATTTGAGCACACATTTTAATTTTCCTCTAATTAA AATGTGCAGTATTTTCAGTGTCAAATATATTTAACTATTTAGAGAATGATTTCCACCTTTATGTTTTAATATCCTAGGCATCTGCTGTAA TAATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACTAATTTGTATAACCCATATCTGTGCAATGGAATATAAATATCAC AAAGTTGTTTAACTAGACTGCGTGTTGTTTTTCCCGTATAATAAAACCAAAGAATAGTTTGGTTCTTCAAATCTTAAGAGAATCCACATA AAAGAAGAAACTATTTTTTAAAAATTCACTTCTATATATACAATGAGTAAAATCACAGATTTTTTCTTTAAATAAAAATAAGTCATTTTA ATAACTAAACCAGATTCTTTGTGGATACTATTAAAGTAACATTTAAGCCTCAACCTTGAATGATGTTGTTTAATATAAAATGCTTTTATT TTTGATGGAAAGGCAATCAAAGCCTAAAGTTTCCAAGGAACGTAAAATAACTGTGCTTCTCTGAGAATGCCCGCCTCACAAGTGGAACAT TTTGAGTTAATAATGATGATTTTTATGTTTCTAAGGTTGCTTCCTCTCTGAAATAATTCAGAATCCACCCCCATTTAATAAAATACCTAT >In-frame_APP_ENST00000440126_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_2182nt AGAGTTCCGGAGGCTTTGGTTGTCCATTGTTAGCTTAGAAGTTGGCGCAGTGTGCGTGTGATCCACGCCTAAATAGCACAGCCTTGCTGT GCGTGGTAGAAGTTGGGTTAGTGTTGACATGCTGTTGACTCACCCTCCCGAGGATGGAAGCTCTGGCCTGGGTCAAGTTGTGGTCACTGC AGTTAACAGTTTGTTGATCTCAGGGAGTATTCCACAGTTGCTGATGTAATTGACAATGATTGGAGCCAGCTCTTCCCCAGATTCAAATGG ACCAATTAGAGGACTTGTTGGTTCTGTTTATCAACTATGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATTGCCATGT TCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAGTGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGG AAGGCATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACT GGTGCAAGCGGGGCCGCAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCC TTCTCGTTCCTGACAAGTGCAAATTCTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGA CATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTT GCCCACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACT ATGCAGATGGGAGTGAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGG ACGATGAGGATGGTGATGAGGTAGAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCA CCACCACCACAGAGTCTGTGGAAGAGGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCT GGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACT GCATGGCCGTGTGTGGCAGCGCCATTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGA ATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGG CAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAG CAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACT ACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCT TTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAAGCTGGAACCTATTTGCCTC AGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATG ACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTG AAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCAC CCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTC >In-frame_APP_ENST00000439274_chr21_27347383_-_ITM2B_ENST00000378565_chr13_48827944_+_3108nt CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA GGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTG CAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATT CTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTT GCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAA TGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGT AGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGA GGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGA GGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAA GTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCAT GTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGT TGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAG AATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTT CCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCT CAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGG CCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATA TTTTGCACTTCAACCAGATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCC AGCTGCTCTCTACCAGACAATTGAAGAAAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGC AGATAGTGATCCTGCCAACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCC TCTGAACACTTCCATTGTTATGCCACCCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCT GATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAAC TTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATT TGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATT TTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCAATTAAAACC ATTACCTTAAAATTTTTTTCTTTCGAAGTGTGGTGTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATAGATAATAGTACATGTCAC CTTAGGTAGTAGGAAGAATTACAATTTCTTTAAATCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGACGGATTATCTAG AGAATAATCATATATATGCATACGTAAAAATGGACCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTTTGTTAGTGCAT TTGAGCACACATTTTAATTTTCCTCTAATTAAAATGTGCAGTATTTTCAGTGTCAAATATATTTAACTATTTAGAGAATGATTTCCACCT TTATGTTTTAATATCCTAGGCATCTGCTGTAATAATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACTAATTTGTATAA CCCATATCTGTGCAATGGAATATAAATATCACAAAGTTGTTTAACTAGACTGCGTGTTGTTTTTCCCGTATAATAAAACCAAAGAATAGT TTGGTTCTTCAAATCTTAAGAGAATCCACATAAAAGAAGAAACTATTTTTTAAAAATTCACTTCTATATATACAATGAGTAAAATCACAG ATTTTTTCTTTAAATAAAAATAAGTCATTTTAATAACTAAACCAGATTCTTTGTGGATACTATTAAAGTAACATTTAAGCCTCAACCTTG AATGATGTTGTTTAATATAAAATGCTTTTATTTTTGATGGAAAGGCAATCAAAGCCTAAAGTTTCCAAGGAACGTAAAATAACTGTGCTT CTCTGAGAATGCCCGCCTCACAAGTGGAACATTTTGAGTTAATAATGATGATTTTTATGTTTCTAAGGTTGCTTCCTCTCTGAAATAATT >In-frame_APP_ENST00000439274_chr21_27347383_-_ITM2B_ENST00000378549_chr13_48827944_+_1854nt CAGCAGCGCACTCGGTGCCCCGCGCAGGGTCGCGATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCGCTGGA GGTCTACCCTGAACTGCAGATCACCAATGTGGTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTG CAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTTGGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATT CTTACACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGTGAGAAGAGTACCAACTT GCATGACTACGGCATGTTGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCCCACTGGCTGAAGAAAGTGACAA TGTGGATTCTGCTGATGCGGAGGAGGATGACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGTGAAGACAAAGT AGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGGAAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTAGA GGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAGCATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGA GGTGGTTCGAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAA GTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCAT GTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGT TGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCATTTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAG AATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTT CCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCT CAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGGACCCAGATGATGTGGTACCAGTTGG CCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATA TTTTGCACTTCAAGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCA CCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGA AGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTAT TGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAAC |
Top |
FusionGenePPI for APP_ITM2B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| APP | APPBP2, CLSTN1, APBB2, APBA2, FBLN1, APBA1, APBA3, DAB2, CALR, COL25A1, HSD17B10, CAV1, KLC1, NCSTN, BGN, APBB1, SNCA, SNCB, DAB1, ACHE, SHC1, NAE1, GSN, BLMH, APBB3, HGS, BCAP31, SET, PARK2, STUB1, HSPD1, HSPA4, HSP90AA1, SYVN1, NOTCH1, FBXL2, YWHAG, KAT5, GSK3B, UBQLN1, NAPG, UBB, MAPK8IP1, MAPRE1, GGA1, CLU, LRP2, CRYAB, HSPA8, UBE2M, TPPP, NOS3, DMTN, TCEANC, WIBG, MRPL19, C17orf85, PRR16, HOMER2, VIM, NSRP1, RPL30, RTF1, E2F8, SMTNL2, SLAIN2, GABARAPL2, PLK1, IGBP1, MAP2, KCNAB1, EIF4E2, TPRXL, MPG, DDX19B, ENY2, WDR5, AKNAD1, ZNF706, ADAP2, KIF3B, PDAP1, RAD51AP1, TCP10L, TPT1, GIMAP4, C1orf131, STAC, FAM114A2, UBXN10, RASL11B, CDK16, TSLP, RPAP3, YY1, BOD1, TOX2, TMA16, NTMT1, ATP6V1G1, AURKA, ELK1, PNMAL1, CTNNA1, MCM10, TCEAL2, FGF12, PRR15, MZT2A, TRPT1, DCX, HMCES, MRPL1, SLIT1-AS1, RGS3, PSRC1, C7orf50, TOP1, KIFC3, RPS19, C11orf63, ERMN, IRS1, SERBP1, TRUB1, TBC1D10C, C1orf87, POGZ, TMA7, C19orf57, COASY, G3BP1, FEN1, RPL12, ARID3A, LMCD1, CWF19L2, ZFYVE27, NOLC1, ZMYM5, ARGLU1, DDX54, GCC1, C9orf41, LIMCH1, CENPB, PTBP1, PPID, NKIRAS1, WHSC1, TOM1L2, CSAG1, ASPSCR1, CLIP4, PPP1R32, POLD3, MOB3A, RGS10, SCEL, SH3GLB1, PLIN3, RPS10, BRWD1, FANCM, CAT, UBXN6, TAF1B, PP2D1, NOP16, SNRNP70, DDX47, EIF1AX, SOCS3, TRIM41, LSM6, DIRAS1, RGS14, ARL4C, ZAP70, ARFGAP1, RSRC2, STXBP1, DDX55, HINT2, C9orf43, PHF7, C12orf65, TCEA1, SOX5, SEPT9, PATL1, RITA1, KLC4, ACO2, FLOT2, CIRH1A, IER3, ODF2, EIF1, HK1, SECISBP2, CDK17, ANKZF1, PTTG2, APRT, ATAT1, PYCR2, FAM126B, C1orf35, TPH1, VPS33B, STK25, MLLT6, NUAK1, C1orf110, HMGB2, PTPN7, DDX18, IFRD2, HERPUD1, CASZ1, LRRC59, FMNL1, QKI, TTLL7, CCNB1IP1, BLOC1S1, TAF9B, OAS2, LATS1, NMT2, APEX2, EPB41L2, CWC15, SSB, TACO1, AICDA, NAT6, RPS20, SENP2, TCF19, KIF2C, ECI2, TARBP2, C6orf201, MAPK13, PRDX5, RP9, FDX1L, RNPC3, LIG3, MOB3C, NPM1, MRPL34, TCP10, KLC2, SPATA2, PRRC2B, LCP2, SURF2, ZW10, TSSC4, MYL5, BUD31, TRIM52, CCDC149, FAM53A, CELF2, CEP57, TRMT2A, GAK, STOML2, PPFIBP2, AVPI1, GAPDH, TAB2, SERPIND1, ING2, DEF6, EIF5, NOB1, KCTD18, BCL7C, CTF1, ZC3HAV1L, FAM64A, C9orf78, ALDOB, ZC2HC1A, TIGD1, HP1BP3, THAP3, EIF3G, ARFIP2, KIAA0930, CXorf56, SCYL1, ASXL1, SASH3, ANXA9, POP7, GRB10, SH3RF2, CRIP2, TASP1, IKBIP, LRRC8D, PSMC1, ARL4D, GOLGA4, FAM32A, RASL10B, RASL12, TOB1, MXI1, EIF2S2, KRAS, EME1, DNM2, C1orf115, COPS7B, ZGRF1, APLF, MRPS24, CDKL3, EPB41L5, GADD45GIP1, TRIM63, RPL31, LACRT, RASA1, UNG, SPZ1, OR2W1, RPUSD2, BBX, NUAK2, ACSL4, RPF2, DLGAP1-AS2, C11orf52, USE1, CDKN1A, HIST1H2BM, EPB41L4A, ZADH2, GYG2, PAK4, ARHGAP24, DCLK1, PCBD2, C19orf40, PDZD4, DHX58, MAPKAPK3, DFFB, DYRK2, RPS9, NFKBIB, LNX1, CD74, ECH1, RPS12, GPANK1, CPLX2, BCAR3, GALK1, PADI4, PAK6, RPS16, BIN1, COIL, TLE3, PDE6H, GPT2, ANKRD50, AIMP1, PPP1R14A, MPP3, GORAB, C2orf49, MKNK1, ETV3, PAPSS2, SMAD3, MTG1, TSPYL1, CLEC3B, ACTR1B, SPANXN3, MCM7, BLOC1S2, GTF2E2, GTPBP1, FANCI, MESDC2, GBA2, MRPL49, PRRC1, MLX, BTF3, DDX43, CSNK1G2, ADRM1, RPL36, HSPBP1, DDX42, PLEKHG2, BIK, AMOT, TCP11, AFAP1L2, ADD2, CUL3, GOSR2, MED8, SH3GL2, SMAP1, DDRGK1, PAK2, RPL41, MRPL10, ZNF622, NR1D1, DDX17, DNAJC8, SP2, ZFYVE1, ZNF365, ABLIM1, AURKB, RASGRP3, IQCH, ASXL2, FNDC3A, KCNAB3, C19orf43, C1orf174, RGS5, OSBPL11, LYRM7, MSL3, TRAF3IP1, LOC541472, BLOC1S5, PNKD, SEPT5, CRADD, EEPD1, CLK3, BAIAP2, LARP4, SART1, MRPS18A, SOCS5, RGL1, AGPAT3, ZHX2, STK40, ARHGEF40, MRPL28, KIF3A, TAF6, DYNLRB2, LAP3, ABCF1, CCNB3, ARMC1, FUBP3, ISL1, GLRX5, PTP4A1, BYSL, PCIF1, RPL23, UTP23, UCHL5, TRAPPC2L, ORC6, RNF32, ROPN1L, RAP1B, ITGB3BP, SHOC2, ZNF684, LIMA1, PRKCI, NFYA, TTPA, SMIM11, NBPF3, LARP1B, POGK, RBM42, DEDD, IMP4, MAGEH1, BCKDK, HADH, TPD52L3, PLEKHO2, TGFBR2, ADH5, CDK3, ZNF22, TBCC, SERP1, MED24, SF3B6, HS3ST1, CCDC106, AIFM3, FIP1L1, ATF2, DPY19L2P1, NEDD9, PHYH, LUC7L2, CSNK1D, RAB40B, MRPL35, CCSER2, TFPT, CCDC59, MRPL11, ZNF2, IFIH1, TRIM40, SETBP1, DMD, ZNF410, ATP5H, ERG, RSRP1, HBG1, GJB1, ATG16L1, UBE2E2, HIST2H2AA3, POLE3, DENND6B, PPP1R8, FAM133B, TK1, GYS1, SIVA1, LMNTD1, BMX, HNRNPA1, UBE2S, COL14A1, COX6A2, HOMER3, HBS1L, ZNF574, MND1, GABPA, SDC1, KLF12, ALDH4A1, LARP6, DDHD2, ULK4, MOB1A, BMPR1B, ATF6, PHF20L1, TIPIN, ENTHD2, GNL2, CHGB, TBPL1, PRSS23, EIF2B5, ECHDC2, ARPC1B, WASH2P, DUS3L, SLC4A1AP, SPX, ZSCAN1, CCDC60, ACBD6, KCNN3, NUSAP1, PDE4D, NECAP1, PIP4K2C, DCDC2, NOL7, ADAT2, TWF1, BCAT2, SIRT7, OLFML2A, TBC1D7, RNF41, MAP1LC3A, ANKS6, SMAD1, CAPNS2, PHGDH, ECHDC1, HDAC4, VPS37C, PPAN, PSMA1, PCK1, ENKD1, ARNT2, CACNB1, PSMD11, MAPK7, ZMAT4, CSNK1E, HSPB7, GPKOW, ELK3, DCTN6, POLR2K, XAF1, CDC20, OCEL1, MX1, MORF4L1, GFAP, MYBBP1A, IL15, CTNND1, VCY1B, PTPN12, CCDC115, SRRT, RNMTL1, RUSC1, TSPY2, ACAD10, FGF16, CCDC15, SYCP2L, ACLY, ENO3, ATP5C1, FKBP1A, OTX2, SAMHD1, PNKP, HEYL, RPS6KB1, CCNL1, HDDC3, PLA2G4D, RPS11, MTURN, CHKA, FCHO1, PACRG, TTK, DNAJB1, C3orf36, STK17B, AAMDC, DPY19L2P4, STAU1, RRP15, BRD3, SIRT5, DDX1, CAAP1, RBM8A, CSNK2A1, LARP7, HIST1H2BA, NME3, ZNF740, SYK, TCP11L1, EMG1, PPHLN1, PLEKHJ1, KRTCAP2, AK4, BEND5, CMAS, ZMYM3, PRR14, CARF, PLSCR1, RPL34, KIAA1191, ITGB1BP1, TSSK2, FGFR2, LOC254896, MMGT1, SYT6, LINC00982, ATP5A1, SPG20, FSD1L, DRAP1, ZRSR2, HRASLS5, SRSF3, SKA3, GAS2, KCNK5, NELFA, USP2, YWHAB, HMBS, C14orf93, RCAN1, LETM2, BLOC1S6, LMX1B, TSSK6, CMTM2, CAMKK2, DIDO1, NAA25, SGK2, SRSF8, HIC2, SPATA4, ZFC3H1, PHYHD1, SYNCRIP, ABR, NECAB3, CDCA7, PSMA5, SND1, ASS1, THAP4, CAMK1D, PHACTR4, FBXO38, ARAP1, LOC401068, SIK2, SETD3, ZNF343, MARCH10, HBZ, CDK5R1, RGS1, SRR, LAD1, MURC, ADARB1, MYOZ1, KANSL2, SUPT4H1, ZSCAN5A, CHRAC1, PAIP2, PAGR1, UPF3A, EXOC3, HMGCS2, SNX1, LOC554207, TBC1D9B, PDPK1, ZCCHC17, FKBPL, TOM1, CLDN16, ABHD11, URI1, SP140L, RLBP1, TARP, WARS, EXOSC3, DKFZP434K028, MAT2B, SAE1, DYRK1A, ELF2, PRKCD, MB, TBCD, FAM90A1, HELLS, NUMB, DNAJC4, STIP1, CENPI, CSNK1G1, TICRR, CINP, ZNF35, TPI1, GNAZ, STK33, E2F6, TMOD2, NOL12, ICK, TTC23, PAK1, DECR1, HAGH, RPL37A, SULF1, GPAM, DDX10, YWHAZ, CCZ1B, DPCR1, ANKS4B, MAK, DZIP1L, ABCB7, UBAC1, NIM1K, TFPI, SLC7A1, AGFG1, VAC14, NNMT, PPP3CC, NR1H3, ZSCAN16, NEIL1, CFDP1, RAB39A, DECR2, CPEB1, PRSS33, FILIP1, PRPSAP2, ACO1, OARD1, WASL, PPIL2, KIFC1, CCDC88C, SLFNL1, SSTR2, FAM184A, C18orf21, SF3B2, CFAP58, H1F0, PHF8, DUSP12, UBL4A, GIMAP5, POMZP3, BEGAIN, AKT1, SOX7, BEND2, SPSB2, GPN2, FIBP, TNIP2, SPATS2, KLHL32, ZCCHC8, C2orf57, ING3, WWC3, METTL2B, RPL37, IFI16, LETMD1, NUDT16L1, SSBP3, EFS, TSKS, ATPAF2, TRAIP, MAPRE2, MAPK11, EIF2B2, C22orf46, ANKRD36BP1, ETNPPL, DUSP4, SAR1A, LIN7A, PSMD4, VPS41, BCL2L13, MRPL24, FAM212B, ARL6IP6, TMEM53, SLCO2B1, DLGAP5, CENPQ, RPS26, MEF2D, USP39, KLF8, DYNC1LI2, ERH, INIP, MLLT3, CHEK1, CCL26, PCDHGA12, RCOR3, ACSL3, ODF2L, COPZ1, METAP2, MARS2, PLBD1, PCK2, YTHDF2, C4orf46, RBX1, SUSD3, METTL16, LIMD1, MRPL27, POLH, POMC, C19orf33, BCL2L11, BHLHB9, ACY1, PPP2R5C, NEK11, PLEKHF2, IL26, IGSF10, HOXC6, CDC7, PPP1R17, STK26, TARDBP, OLFM1, SRPK2, SIGIRR, KLF6, PWP1, LENG1, RASGRP2, VWA5A, FAAH2, RIOK2, CAPRIN1, RSU1, ZMAT3, GNAT2, TP53TG1, MCC, FAM50A, RASA3, ARHGAP9, BHMT2, RIT2, CHTOP, CCNG1, IFT81, MRPS6, TXNDC5, OR7A5, PRKRIP1, LOC142937, DGCR6, SLX4, LRRC42, FBF1, NDUFB1, PARD6B, FRMD8, CDC25A, RAB14, TAF9, C3orf33, TRIM44, GIMAP8, AHDC1, ECI1, NPL, MRPL53, C11orf71, IK, QARS, FAM19A4, C11orf53, DTWD1, NDUFB6, CDK2AP2, GSTA3, AGO4, ZFAND5, FTSJ1, SMURF1, SNRNP35, MTMR14, ZXDC, SCD, PTK2, CDC42EP4, NXT2, FRG1B, MBD1, DSN1, RUFY3, PUSL1, VAMP3, ORC3, KLF4, C11orf45, FBXL7, ZCCHC12, IL18RAP, NDP, MROH8, AGAP1, CDKN2B, SERPINB2, TEX2, PROSER2, CLP1, FHL2, MOBP, NOVA1, TET3, PKM, ZC3HAV1, PRPF4, RPS6KA6, OR4D6, LOC403312, TCL1B, TOMM5, IRF2, CCT7, ZNF720, MEOX1, HBD, IGSF6, NMNAT1, TBC1D3P2, CDK5, LURAP1L, AIMP2, ZNF839, HIST1H4I, RBM4B, ARHGAP17, DNAJB6, TRAP1, PSME1, MRPL3, ATG12, GPR78, VPS29, S100A16, CHURC1, EIF6, LIPT1, LGALS2, HIGD2A, HOXB7, C15orf43, ASB6, MVB12A, LIMS2, DNALI1, CCDC33, EOGT, HIST2H2AB, EPB41L1, LMAN1, FAM212A, EAF1, OSM, IGHM, MEIS2, MICU1, SENP1, LAMC1, GPATCH1, RPL3L, PCYT1B, ATP6V1E1, ZNF23, CHCHD6, SLC35B1, SRSF1, ESRRG, PRICKLE2, CXCL16, RTKN, TRAM1, DPCD, RAI2, POLI, DENND1C, PTBP3, CLUAP1, HINT3, FAM47B, OXSR1, ARMC9, HMBOX1, PHLDA1, C8orf33, EP400NL, TAF7L, HMG20B, VHL, NARF, MCFD2, CTSB, SCAMP3, STRIP2, MCM5, QPCTL, USP6, TP53TG5, AGR2, SLC41A3, CELF4, OLFM3, CD36, ICT1, C3orf20, PIBF1, COPB1, GSPT2, CENPT, TAGLN2, RAB43, CCNE2, MRPS2, TGIF1, USP12, CD58, USP6NL, TCN2, GABRA4, PDSS2, APOA1, COPS5, IARS2, AHSA1, OPA1, SGK3, LPL, MED19, TNNT2, RPS14, UBE2G1, PSME2, CDIPT, KIAA1143, RNF183, CD300LF, TMEM126B, DGCR8, ALKBH7, AAK1, FOXI1, FMNL2, GALE, PARVG, FERMT3, WARS2, ZWINT, C21orf33, LFNG, TRDMT1, COL4A6, SOD2, CCDC144NL, DERL1, SRPK1, AK1, KCNMB2, TCEANC2, NECAP2, KLF7, DCTPP1, RAB11B, ARMC7, IDO1, POLL, SDCCAG3, MRPL20, MSMB, CCDC40, LY86, VAPA, WDR45B, CRACR2B, RAB10, COMMD2, RNF115, SYF2, ACTL7B, IL7, SULT1A3, GSTA1, ANKRD39, CIART, DDX20, MCM2, GPR61, H2AFV, WDR88, PTGDR, CGB, TIMM17B, CMTM3, DGUOK, TPRA1, ERVFRD-1, LINC00341, PSAT1, ORC4, NDEL1, ORMDL1, BAALC-AS2, PPP5C, TRAPPC3, MTFMT, S100A8, VTA1, USF1, PPP1R3C, GAL3ST1, SMARCB1, BNIP1, TBX22, PLRG1, NME8, MDM4, IPO4, EXOSC1, RALGPS1, DIMT1, GTDC1, COX4I2, RETSAT, RXFP3, MPV17L, NDUFA2, POLR2F, SEPT1, SKAP2, RUVBL2, AFG3L1P, ALDH8A1, ARHGDIB, RAB1B, C21orf59, KIAA0825, NRIP1, MRAP2, HAPLN1, CAMKK1, TGM2, CELF1, TNFSF14, DSCR9, RAB8B, ANXA8, CDK18, PIP5K1A, SRSF9, RIMS4, THAP7, C15orf39, GAGE1, POMGNT2, DEFA6, IREB2, PCDHGC3, CERK, WASH3P, PARP3, SH3BP5, HSPA9, UGCG, CLASRP, CCDC28B, MITF, RAB7B, SNX21, GNLY, PCDHA7, MAP2K3, SERAC1, DNAJB14, WDR45, SHMT2, KRT36, TRMT1L, TPMT, DIEXF, GEMIN8, RAB5C, GTF2E1, NAPA, CDK4, STOML1, FAM131C, ANKRA2, GUCD1, AGER, SUB1, C19orf18, DNAJC12, RPA4, GRAMD4, ALDH2, PGM3, ETFB, COLEC12, PPP6R2, ACKR2, PCDHGC5, MAPK10, RAB38, KIAA1841, PPAP2B, ETHE1, NMNAT2, PIKFYVE, GUCY1B3, OPA3, PLA2G4C, CD300LB, ZDHHC23, PFKL, NXF2, SPINT2, PUS7L, TRIM69, ZNF483, CUL4B, RNF34, EIF4E, SNAI2, ASCL3, C7orf31, HMGB4, NECAB1, REG1A, PIK3R5, ADAD2, CAPSL, MYOT, BIN3-IT1, ASGR1, C1D, APOBEC3G, GSTO1, RPS27A, ARF6, SEC24C, PPP2R4, CRHR2, SPAG6, RAB26, HCFC1R1, RBM39, CCL13, NAT2, NDUFS4, RPS18, ZC3HC1, FMNL3, KIF4A, VIPR2, KLK7, ZKSCAN1, NUDT9, CBFA2T2, PPIA, SYNJ2BP, IFNW1, TRAF6, MIER1, C3orf62, UBE3A, WDR89, MXD1, EBF4, SPIC, KCNE1L, SRSF6, ZCCHC6, L3MBTL4, YAE1D1, ANXA2, PLK2, ANKS1B, ZSCAN18, GGA2, DCUN1D2, SH2D1B, CDPF1, GSDMB, SLC1A1, FERMT2, VPS37A, TSNAXIP1, P2RX6, MRRF, GAPDHS, INTS12, C1orf64, EIF3M, OBFC1, ASPH, KAT7, ETV5, HYPK, EPHA2, LGALS3, SPC24, SLC48A1, VASH2, KPNA2, CLDN3, TMEM97, ARRDC1, ACAA2, ANKRD13D, CDK7, LANCL2, YPEL3, DYNLT1, C12orf5, RWDD2B, PDE1A, C6orf118, ADH4, ALB, GNB5, EIF2A, PSMD5, CFAP53, PGM1, SERF1A, AEBP2, TBC1D20, ARCN1, USP5, RSPH3, CDKL2, CCDC107, RD3, UGGT2, TSPAN5, TMX3, FUCA1, AP2A2, ARPP19, C19orf12, MPI, GRHL2, CCIN, RSPH10B2, SUN5, EEF1B2, C16orf70, PYROXD1, TNFAIP8L1, CLDN20, PIK3R2, POLDIP2, TCEA2, NLRP2, LRRC1, NOL11, RAB35, FGFBP2, CHEK2, NARFL, ISOC2, UBE3C, BRMS1, TANK, BET1L, SRRM2, PLCD4, C17orf70, CSTF2, IFI6, R3HDML, FKBP5, NGLY1, OXSM, MKKS, FOXJ2, MCTP2, MAD2L1, RBPJ, ARL5A, FAM151A, CAMKV, AFG3L2, TEX37, MEST, PARVA, GLOD4, PTMS, MCEE, MED11, BDH1, FAM127B, FAM127A, INPP5B, LLPH, DNAH14, SDF4, GNRH2, CSRP1, NAV1, DEPTOR, CTBP2, NDUFA4, EMC8, ASMTL, HBG2, BCL11A, TSPAN13, CYB561D2, PEX2, MMP12, OSTF1, CHMP3, MTERF4, RRAGB, UBL3, DHRS7B, PDS5B, CDCA3, RBPJL, HAVCR2, TUBB, TAF11, UBXN7, C11orf54, CISD2, HIST1H2BB, STK11, STX11, LINGO2, HIRIP3, CXXC4, MARCH3, NOC2L, SMYD3, AKT2, RAB28, UXT, ACSBG1, RGS18, NNAT, DUSP21, ST3GAL6, SKAP1, C1orf112, FITM1, NAGA, FAM122A, CLIC3, ZDHHC7, MAP2K4, IRGC, STAT5B, FAM160B2, KIAA0513, TMEM175, ATL3, MOB1B, SSH3, DAPK2, ERC1, COA5, IL1B, PELI3, PRPF38A, GORASP2, FAM214B, BRF1, PDZK1, RING1, GTF3C6, RASSF8, RPA2, TEK, LOC90768, PFKFB1, POLR3C, HCK, ARL8B, SYT17, FN3KRP, MAGEA4, FAM213A, ROR1, KLK9, HSPA2, JAGN1, H2AFY, IGF1R, WAC, ETS1, BDNF, STARD10, TMCC2, CIAO1, CNPY2, TRIM16, MAB21L2, LAIR1, EFHD2, SPATA7, DNAAF2, KISS1, PRKAB1, GLB1L, TLL1, ART4, GNA12, CCDC14, METTL8, NUP50, KPNA4, FAM3B, RPS6KA5, RFWD3, SNURF, CAMK1, SMG5, FYCO1, TIMMDC1, SIX2, OTUB2, CHID1, GGCT, CCND3, ARID3B, EXOSC7, MRPL52, UBE2DNL, ODAM, NME6, PHLDA3, VPS35, NDUFA5, SNAP25, DCXR, INTS3, CALCOCO1, TBCK, PAEP, RNASE11, MYL10, TNFRSF14, PABPC3, CNOT7, ALOX5, TMEM35, TTLL6, GNA15, RABL3, METTL25, LYPLA2, LOC554223, ORMDL3, INS, TMOD4, GALNT12, CFHR2, TCP11L2, ZNF75A, PPP2R5E, SNRNP40, FCGR3A, NTM, AP4S1, SH3BGRL3, PRKCG, NOS1AP, ZNF581, KPTN, SLC17A5, MAST2, ALDH7A1, VAT1L, MTERF3, ANXA5, CASP4, PARP15, EPS8L2, WNT4, GADD45G, BTK, PCBP1, CASC4, HAUS6, ZFP36, RNF11, PTK6, CARS, TAP2, C1orf111, ZEB2, FLCN, MINA, MSTN, GPR12, TBC1D21, NUDT16P1, DPP3, TCEAL8, PIGG, UGT1A10, RNF138, CXCL14, DTD2, PTGIS, GTPBP8, PTPRO, NDUFAF7, MED9, CIRBP, AGFG2, SPINK6, RNF185, ARHGEF5, TMEM255A, SCO2, MS4A2, IFNA16, RPS21, TIPRL, PQBP1, RIOK1, CACNG2, EIF3F, MSI1, C6orf106, RBCK1, CYP20A1, ANKRD45, NMRK1, RAD51C, CACNG3, NXPE3, APITD1, HCP5, CYB5B, OSBPL5, ACAD11, MBNL1, RASSF3, SLC2A2, ABHD10, ANP32B, DHRSX, ACYP1, C14orf159, MAG, TNFSF13B, MOGAT3, OSTCP1, KRTAP10-7, RCBTB1, DIO3, TRIB3, PNPO, BCL2A1, RAB27A, RAPGEFL1, ZFYVE16, KLK2, PLS3, DRAM1, SF3A3, CAMKMT, ACTL7A, HPGD, ARFGAP3, RAB2B, PDK3, CCBL1, P2RY2, CATIP, TRIM47, DCAF7, C9orf72, SEPT12, SGCG, GIMAP6, MTCP1, OCIAD2, APEX1, POU2F1, CHAC2, NDUFB3, AIDA, CNDP1, ACTL6B, TRIM39, DIXDC1, EBP, LIMK1, RNF151, SLC38A2, ITGA6, C9orf142, OLFM4, NLN, AREG, DUSP3, PDCD7, VTN, NTRK3, C6orf203, ICAM3, FAM200A, FOXS1, ACBD4, AKAP1, SPEG, PSMB4, SLC22A6, IPO9, ATG13, CCT8, HAUS8, TRIB2, ODF4, ADI1, LSMEM2, MRPL48, HRASLS, IFNA5, MAPK8, DMKN, CDKN2D, PRDX2, C10orf88, RAB3D, C5orf28, FSIP1, MYL1, VSIG4, ATXN3, CEACAM6, IL1RL1, ATRAID, MED30, ETV4, TRIML1, PPARG, IFNA8, KCNIP4, TMEM261, NAAA, CEP250, ATG7, C11orf73, NMRK2, NUP62CL, PASD1, ZNF322, RPS25, ARMCX3, POLA2, ATF4, CHAF1B, PDZD9, KCNJ10, BSND, KIR2DL3, SERTM1, FAM134B, LSMEM1, C4orf22, PIGO, CLEC2B, C5orf15, TMEM183A, SCAND2P, LPAR3, LINC00663, CST2, PLCD1, COX4I1, CTNNB1, JTB, C1orf105, GOSR1, VDAC2, BOLA1, C2orf47, IARS, EVI2A, USP48, PDIA3, EPHB4, ATCAY, TBK1, PBRM1, COQ6, PDYN, TRAPPC4, FBXW9, SPRR4, TMUB1, DNAJC19, TMEM180, RMND5A, PLA1A, HERC2P9, PPP1CC, DHX16, PIM1, PKNOX1, NDUFS2, STOML3, GNPTAB, FAM3A, PDDC1, ANGPTL7, NAALADL2, DLK2, PSMA7, A2M, PSEN1, IFIT3, AP1M2, PRAM1, CDC37, EXOC6, MAST1, PAXIP1, PI4K2A, PSEN2, RAB3A, ECSIT, CFL1, APP, TM2D1, MAP3K11, MAPK8IP2, KIF1B, TPD52L2, TIRAP, FOS, PCBD1, JUN, MDM2, RANBP9, LRP1, BACE1, SNX17, SNX27, CUL7, MAPT, QRICH1, RNF2, EGFR, UBE2I, GSAP, SORL1, TMEM30A, USP25, FBXW11, SRP19, FAM27E3, RBM11, VCY, KIAA0020, LTV1, OR6B3, TUBG1, PINX1, ABT1, AGO1, TYMSOS, ZNF747, FGF13, UTP14A, MYC, RBM34, ZC3H3, HIST2H2AC, ADAM22, ERCC1, PES1, ATXN7L3, APOBEC3H, DDX49, RPL11, ZNF486, TBC1D26, ZNF385B, AKAP13, DNAJB7, PARD6A, RSL1D1, C1orf116, C16orf78, PURG, ALKBH8, FCF1, PNRC2, EHF, GLRB, CPED1, GPATCH2L, RAG1, ROBO3, FES, NCR1, THAP1, GRAMD1C, ST6GALNAC6, ZSCAN21, DNAJC30, ZNF449, PPP1R10, HDGF, ATP5O, S1PR1, GPR15, EEF1D, ZKSCAN8, TRAPPC9, TRIM46, HMGA1, THBS4, RFX5, HOXC4, ARHGAP15, TMCC1, ZNF641, LMF2, KATNA1, SGIP1, TMEM216, XRCC3, CASP3, CASP6, MAP3K5, NEFL, TGFB1, TGFB2, UCHL1, PTGS2, SRC, NF1, KDR, PTPN2, CES2, FRMD6, UTP11L, ZNF107, INHBE, ZNF431, SULF2, ZNF92, ZNF724P, ACADL, NME2, GSG2, CES3, GDF11, DNAJB9, TMEM30B, MAP7, OBSL1, F11, IL20RB, TIMP3, KEAP1, MAP7D1, ZNF445, AARS2, CBX6, COL18A1, CKAP2, C3orf17, CLEC12A, HS2ST1, PTCD2, QTRT1, TRIM25, TES | ITM2B | BCL2, RYK, CCDC155, SYNE4, NAALADL2, HLA-A, UBR1, DCBLD2, MR1, BTN2A2, SEMA4F, ATF6B, CHST12, TMEM59L, TMEM219, HS6ST1, PGAP1, GLG1, SEMA6A, CACNA2D1, B4GALNT1, TGFBR3, LRFN3, KIAA1467, AMIGO1, UNK, TMEM17, CREB3, KIF18A, POU5F1, FCGRT, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000346798 | - | 11 | 18 | 732_751 | 486 | 771 | G(o)-alpha |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000348990 | - | 9 | 16 | 732_751 | 411 | 696 | G(o)-alpha |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000354192 | - | 8 | 15 | 732_751 | 355 | 640 | G(o)-alpha |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000357903 | - | 10 | 17 | 732_751 | 467 | 752 | G(o)-alpha |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000358918 | - | 11 | 17 | 732_751 | 486 | 753 | G(o)-alpha |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000359726 | - | 10 | 17 | 732_751 | 430 | 715 | G(o)-alpha |
| Hgene | APP | chr21:27347383 | chr13:48827944 | ENST00000440126 | - | 10 | 17 | 732_751 | 462 | 747 | G(o)-alpha |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for APP_ITM2B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | APP | P05067 | DB06782 | Dimercaprol | Amyloid-beta A4 protein | small molecule | approved |
| Hgene | APP | P05067 | DB09148 | Florbetaben (18F) | Amyloid-beta A4 protein | small molecule | approved |
| Hgene | APP | P05067 | DB00746 | Deferoxamine | Amyloid-beta A4 protein | small molecule | approved|investigational |
| Hgene | APP | P05067 | DB01370 | Aluminium | Amyloid-beta A4 protein | small molecule | approved|investigational |
| Hgene | APP | P05067 | DB01593 | Zinc | Amyloid-beta A4 protein | small molecule | approved|investigational |
| Hgene | APP | P05067 | DB09149 | Florbetapir (18F) | Amyloid-beta A4 protein | small molecule | approved|investigational |
| Hgene | APP | P05067 | DB09151 | Flutemetamol (18F) | Amyloid-beta A4 protein | small molecule | approved|investigational |
Top |
RelatedDiseases for APP_ITM2B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | APP | C0002395 | Alzheimer's Disease | 55 | CTD_human;HPO;ORPHANET;UNIPROT |
| Hgene | APP | C0025261 | Memory Disorders | 12 | CTD_human |
| Hgene | APP | C0027746 | Nerve Degeneration | 11 | CTD_human |
| Hgene | APP | C0023186 | Learning Disorders | 6 | CTD_human |
| Hgene | APP | C0011570 | Mental Depression | 5 | PSYGENET |
| Hgene | APP | C0011581 | Depressive disorder | 5 | PSYGENET |
| Hgene | APP | C2751536 | CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED | 5 | ORPHANET;UNIPROT |
| Hgene | APP | C0009241 | Cognition Disorders | 4 | CTD_human |
| Hgene | APP | C0522224 | Paralysed | 4 | CTD_human |
| Hgene | APP | C0524851 | Neurodegenerative Disorders | 2 | CTD_human |
| Hgene | APP | C0600467 | Neurogenic Inflammation | 2 | CTD_human |
| Hgene | APP | C2931672 | Cerebral hemorrhage with amyloidosis, hereditary, Dutch type | 2 | CTD_human;ORPHANET |
| Hgene | APP | C0002622 | Amnesia | 1 | CTD_human |
| Hgene | APP | C0002726 | Amyloidosis | 1 | CTD_human |
| Hgene | APP | C0003469 | Anxiety Disorders | 1 | CTD_human |
| Hgene | APP | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | APP | C0006111 | Brain Diseases | 1 | CTD_human |
| Hgene | APP | C0011573 | Endogenous depression | 1 | PSYGENET |
| Hgene | APP | C0016667 | Fragile X Syndrome | 1 | CTD_human |
| Hgene | APP | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | APP | C0027540 | Necrosis | 1 | CTD_human |
| Hgene | APP | C0037928 | Spinal Cord Diseases | 1 | CTD_human |
| Hgene | APP | C0038002 | Splenomegaly | 1 | CTD_human |
| Hgene | APP | C0043094 | Weight Gain | 1 | CTD_human |
| Hgene | APP | C0085220 | Cerebral Amyloid Angiopathy | 1 | CTD_human;HPO |
| Hgene | APP | C0231341 | Premature aging syndrome | 1 | CTD_human |
| Hgene | APP | C0338656 | Impaired cognition | 1 | CTD_human |
| Hgene | APP | C0497327 | Dementia | 1 | CTD_human;HPO |
| Hgene | APP | C2936349 | Plaque, Amyloid | 1 | CTD_human |
| Tgene | ITM2B | C0020538 | Hypertensive disease | 1 | CTD_human |
| Tgene | ITM2B | C4015146 | RETINAL DYSTROPHY WITH INNER RETINAL DYSFUNCTION AND GANGLION CELL ABNORMALITIES | 1 | ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|