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Fusion gene ID: 22610 |
FusionGeneSummary for MSH2_TTC7A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MSH2_TTC7A | Fusion gene ID: 22610 | Hgene | Tgene | Gene symbol | MSH2 | TTC7A | Gene ID | 4436 | 57217 |
| Gene name | mutS homolog 2 | tetratricopeptide repeat domain 7A | |
| Synonyms | COCA1|FCC1|HNPCC|HNPCC1|LCFS2 | GIDID|MINAT|TTC7 | |
| Cytomap | 2p21-p16.3 | 2p21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA mismatch repair protein Msh2hMSH2mutS homolog 2, colon cancer, nonpolyposis type 1 | tetratricopeptide repeat protein 7ATPR repeat protein 7A | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P43246 | Q9ULT0 | |
| Ensembl transtripts involved in fusion gene | ENST00000233146, ENST00000543555, ENST00000406134, ENST00000461394, | ENST00000409245, ENST00000319190, ENST00000461601, ENST00000394850, ENST00000263737, ENST00000536057, | |
| Fusion gene scores | * DoF score | 8 X 6 X 8=384 | 5 X 4 X 4=80 |
| # samples | 10 | 5 | |
| ** MAII score | log2(10/384*10)=-1.94110631094643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MSH2 [Title/Abstract] AND TTC7A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MSH2 | GO:0006281 | DNA repair | 8942985 |
| Hgene | MSH2 | GO:0006298 | mismatch repair | 7923193|11555625 |
| Hgene | MSH2 | GO:0006301 | postreplication repair | 7923193 |
| Hgene | MSH2 | GO:0045910 | negative regulation of DNA recombination | 17715146 |
| Hgene | MSH2 | GO:0051096 | positive regulation of helicase activity | 17715146 |
| Tgene | TTC7A | GO:0072659 | protein localization to plasma membrane | 23229899 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-KK-A5A1-01A | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000233146 | ENST00000409245 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| In-frame | ENST00000233146 | ENST00000319190 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| 5CDS-3UTR | ENST00000233146 | ENST00000461601 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| 5CDS-3UTR | ENST00000233146 | ENST00000394850 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| 5CDS-5UTR | ENST00000233146 | ENST00000263737 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| 5CDS-5UTR | ENST00000233146 | ENST00000536057 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| In-frame | ENST00000543555 | ENST00000409245 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| In-frame | ENST00000543555 | ENST00000319190 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| 5CDS-3UTR | ENST00000543555 | ENST00000461601 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| 5CDS-3UTR | ENST00000543555 | ENST00000394850 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| 5CDS-5UTR | ENST00000543555 | ENST00000263737 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| 5CDS-5UTR | ENST00000543555 | ENST00000536057 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| In-frame | ENST00000406134 | ENST00000409245 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| In-frame | ENST00000406134 | ENST00000319190 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| 5CDS-3UTR | ENST00000406134 | ENST00000461601 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| 5CDS-3UTR | ENST00000406134 | ENST00000394850 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| 5CDS-5UTR | ENST00000406134 | ENST00000263737 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| 5CDS-5UTR | ENST00000406134 | ENST00000536057 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| intron-3CDS | ENST00000461394 | ENST00000409245 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| intron-3CDS | ENST00000461394 | ENST00000319190 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| intron-3UTR | ENST00000461394 | ENST00000461601 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| intron-3UTR | ENST00000461394 | ENST00000394850 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| intron-5UTR | ENST00000461394 | ENST00000263737 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
| intron-5UTR | ENST00000461394 | ENST00000536057 | MSH2 | chr2 | 47630541 | + | TTC7A | chr2 | 47177502 | + |
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FusionProtFeatures for MSH2_TTC7A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MSH2 | TTC7A |
| Component of the post-replicative DNA mismatch repairsystem (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) whichbinds to DNA mismatches thereby initiating DNA repair. When bound,heterodimers bend the DNA helix and shields approximately 20 basepairs. MutS alpha recognizes single base mismatches anddinucleotide insertion-deletion loops (IDL) in the DNA. MutS betarecognizes larger insertion-deletion loops up to 13 nucleotideslong. After mismatch binding, MutS alpha or beta forms a ternarycomplex with the MutL alpha heterodimer, which is thought to beresponsible for directing the downstream MMR events, includingstrand discrimination, excision, and resynthesis. ATP binding andhydrolysis play a pivotal role in mismatch repair functions. TheATPase activity associated with MutS alpha regulates bindingsimilar to a molecular switch: mismatched DNA provokes ADP-->ATPexchange, resulting in a discernible conformational transitionthat converts MutS alpha into a sliding clamp capable ofhydrolysis-independent diffusion along the DNA backbone. Thistransition is crucial for mismatch repair. MutS alpha may alsoplay a role in DNA homologous recombination repair. In melanocytesmay modulate both UV-B-induced cell cycle regulation andapoptosis. {ECO:0000269|PubMed:10078208,ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730,ECO:0000269|PubMed:17611581, ECO:0000269|PubMed:21120944,ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679,ECO:0000269|PubMed:9822680}. | Component of a complex required to localizephosphatidylinositol 4-kinase (PI4K) to the plasma membrane(PubMed:23229899, PubMed:24417819). The complex acts as aregulator of phosphatidylinositol 4-phosphate (PtdIns(4)P)synthesis (Probable). In the complex, plays a central role inbridging PI4KA to EFR3B and FAM126A, via direct interactions (Bysimilarity). {ECO:0000250|UniProtKB:Q86TV6,ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000319190 | + | 0 | 20 | 121_157 | 61 | 859 | Repeat | TPR 1 |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000319190 | + | 0 | 20 | 177_210 | 61 | 859 | Repeat | TPR 2 |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000319190 | + | 0 | 20 | 414_447 | 61 | 859 | Repeat | TPR 3 |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000319190 | + | 0 | 20 | 497_531 | 61 | 859 | Repeat | TPR 4 |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000319190 | + | 0 | 20 | 533_565 | 61 | 859 | Repeat | TPR 5 |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000319190 | + | 0 | 20 | 566_599 | 61 | 859 | Repeat | TPR 6 |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000319190 | + | 0 | 20 | 745_778 | 61 | 859 | Repeat | TPR 7 |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000319190 | + | 0 | 20 | 780_812 | 61 | 859 | Repeat | TPR 8 |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000319190 | + | 0 | 20 | 813_846 | 61 | 859 | Repeat | TPR 9 |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000536057 | + | 0 | 3 | 121_157 | 61 | 147 | Repeat | TPR 1 |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000536057 | + | 0 | 3 | 177_210 | 61 | 147 | Repeat | TPR 2 |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000536057 | + | 0 | 3 | 414_447 | 61 | 147 | Repeat | TPR 3 |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000536057 | + | 0 | 3 | 497_531 | 61 | 147 | Repeat | TPR 4 |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000536057 | + | 0 | 3 | 533_565 | 61 | 147 | Repeat | TPR 5 |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000536057 | + | 0 | 3 | 566_599 | 61 | 147 | Repeat | TPR 6 |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000536057 | + | 0 | 3 | 745_778 | 61 | 147 | Repeat | TPR 7 |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000536057 | + | 0 | 3 | 780_812 | 61 | 147 | Repeat | TPR 8 |
| Tgene | >TTC7A | chr2:47630541 | chr2:47177502 | ENST00000536057 | + | 0 | 3 | 813_846 | 61 | 147 | Repeat | TPR 9 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MSH2 | chr2:47630541 | chr2:47177502 | ENST00000233146 | + | 1 | 16 | 669_676 | 70 | 935 | Nucleotide binding | ATP |
| Hgene | >MSH2 | chr2:47630541 | chr2:47177502 | ENST00000543555 | + | 2 | 17 | 669_676 | 4 | 869 | Nucleotide binding | ATP |
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FusionGeneSequence for MSH2_TTC7A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MSH2_ENST00000233146_chr2_47630541_+_TTC7A_ENST00000409245_chr2_47177502_+_868aa MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPADDFGKLLLAEALLEQCLKEN HAKIKDSMPLLEKNEPKMSEAKNYLSSILNHGRLSPQYMCEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLSEAFVI KGLSLERLPNSIASRFRLTEREEEVITCFERASWIAQVFLQELEKTTNNSTSRHLKGCHPLDYELTYFLEAALQSAYVKNLKKGNIVKGM RELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWSPLSHPLPEFMGKEESSFATQALRKPHLYEGDNLYCPKDNIEEALLLLLI SESMATRDVVLSRVPEQEEDRTVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAYAVSLLRECV KLRPSDPTVPLMAAKVCIGSLRWLEEAEHFAMMVISLGEEAGEFLPKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPSD PQVILYVSLQLALVRQISSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENFNLMFTKVKLEQVLKGPEEALV TCRQVLRLWQTLYSFSQLGGLEKDGSFGEGLTMKKQSGMHLTLPDAHDADSGSRRASSIAASRLEEAMSELTMPSSVLKQGPMQLWTTLE QIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKV >In-frame_MSH2_ENST00000233146_chr2_47630541_+_TTC7A_ENST00000319190_chr2_47177502_+_868aa MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPADDFGKLLLAEALLEQCLKEN HAKIKDSMPLLEKNEPKMSEAKNYLSSILNHGRLSPQYMCEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLSEAFVI KGLSLERLPNSIASRFRLTEREEEVITCFERASWIAQVFLQELEKTTNNSTSRHLKGCHPLDYELTYFLEAALQSAYVKNLKKGNIVKGM RELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWSPLSHPLPEFMGKEESSFATQALRKPHLYEGDNLYCPKDNIEEALLLLLI SESMATRDVVLSRVPEQEEDRTVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAYAVSLLRECV KLRPSDPTVPLMAAKVCIGSLRWLEEAEHFAMMVISLGEEAGEFLPKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPSD PQVILYVSLQLALVRQISSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENFNLMFTKVKLEQVLKGPEEALV TCRQVLRLWQTLYSFSQLGGLEKDGSFGEGLTMKKQSGMHLTLPDAHDADSGSRRASSIAASRLEEAMSELTMPSSVLKQGPMQLWTTLE QIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKV >In-frame_MSH2_ENST00000543555_chr2_47630541_+_TTC7A_ENST00000409245_chr2_47177502_+_802aa MGPADDFGKLLLAEALLEQCLKENHAKIKDSMPLLEKNEPKMSEAKNYLSSILNHGRLSPQYMCEAMLILGKLHYVEGSYRDAISMYARA GIDDMSMENKPLYQMRLLSEAFVIKGLSLERLPNSIASRFRLTEREEEVITCFERASWIAQVFLQELEKTTNNSTSRHLKGCHPLDYELT YFLEAALQSAYVKNLKKGNIVKGMRELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWSPLSHPLPEFMGKEESSFATQALRKP HLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRVPEQEEDRTVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLW YQVALSMVACGKSAYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLRWLEEAEHFAMMVISLGEEAGEFLPKGYLALGLTYSLQATDATLK SKQDELHRKALQTLERAQQLAPSDPQVILYVSLQLALVRQISSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHP ENFNLMFTKVKLEQVLKGPEEALVTCRQVLRLWQTLYSFSQLGGLEKDGSFGEGLTMKKQSGMHLTLPDAHDADSGSRRASSIAASRLEE AMSELTMPSSVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPD >In-frame_MSH2_ENST00000543555_chr2_47630541_+_TTC7A_ENST00000319190_chr2_47177502_+_802aa MGPADDFGKLLLAEALLEQCLKENHAKIKDSMPLLEKNEPKMSEAKNYLSSILNHGRLSPQYMCEAMLILGKLHYVEGSYRDAISMYARA GIDDMSMENKPLYQMRLLSEAFVIKGLSLERLPNSIASRFRLTEREEEVITCFERASWIAQVFLQELEKTTNNSTSRHLKGCHPLDYELT YFLEAALQSAYVKNLKKGNIVKGMRELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWSPLSHPLPEFMGKEESSFATQALRKP HLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRVPEQEEDRTVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLW YQVALSMVACGKSAYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLRWLEEAEHFAMMVISLGEEAGEFLPKGYLALGLTYSLQATDATLK SKQDELHRKALQTLERAQQLAPSDPQVILYVSLQLALVRQISSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHP ENFNLMFTKVKLEQVLKGPEEALVTCRQVLRLWQTLYSFSQLGGLEKDGSFGEGLTMKKQSGMHLTLPDAHDADSGSRRASSIAASRLEE AMSELTMPSSVLKQGPMQLWTTLEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPD >In-frame_MSH2_ENST00000406134_chr2_47630541_+_TTC7A_ENST00000409245_chr2_47177502_+_868aa MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPADDFGKLLLAEALLEQCLKEN HAKIKDSMPLLEKNEPKMSEAKNYLSSILNHGRLSPQYMCEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLSEAFVI KGLSLERLPNSIASRFRLTEREEEVITCFERASWIAQVFLQELEKTTNNSTSRHLKGCHPLDYELTYFLEAALQSAYVKNLKKGNIVKGM RELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWSPLSHPLPEFMGKEESSFATQALRKPHLYEGDNLYCPKDNIEEALLLLLI SESMATRDVVLSRVPEQEEDRTVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAYAVSLLRECV KLRPSDPTVPLMAAKVCIGSLRWLEEAEHFAMMVISLGEEAGEFLPKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPSD PQVILYVSLQLALVRQISSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENFNLMFTKVKLEQVLKGPEEALV TCRQVLRLWQTLYSFSQLGGLEKDGSFGEGLTMKKQSGMHLTLPDAHDADSGSRRASSIAASRLEEAMSELTMPSSVLKQGPMQLWTTLE QIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKV >In-frame_MSH2_ENST00000406134_chr2_47630541_+_TTC7A_ENST00000319190_chr2_47177502_+_868aa MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPADDFGKLLLAEALLEQCLKEN HAKIKDSMPLLEKNEPKMSEAKNYLSSILNHGRLSPQYMCEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLYQMRLLSEAFVI KGLSLERLPNSIASRFRLTEREEEVITCFERASWIAQVFLQELEKTTNNSTSRHLKGCHPLDYELTYFLEAALQSAYVKNLKKGNIVKGM RELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWSPLSHPLPEFMGKEESSFATQALRKPHLYEGDNLYCPKDNIEEALLLLLI SESMATRDVVLSRVPEQEEDRTVSLQNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAYAVSLLRECV KLRPSDPTVPLMAAKVCIGSLRWLEEAEHFAMMVISLGEEAGEFLPKGYLALGLTYSLQATDATLKSKQDELHRKALQTLERAQQLAPSD PQVILYVSLQLALVRQISSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENFNLMFTKVKLEQVLKGPEEALV TCRQVLRLWQTLYSFSQLGGLEKDGSFGEGLTMKKQSGMHLTLPDAHDADSGSRRASSIAASRLEEAMSELTMPSSVLKQGPMQLWTTLE QIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MSH2_ENST00000233146_chr2_47630541_+_TTC7A_ENST00000409245_chr2_47177502_+_2604nt ATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCG ACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACC CAGGGGGTGATCAAGTACATGGGGCCGGCAGATGACTTTGGGAAATTGCTGCTGGCTGAGGCCCTCCTGGAGCAGTGTTTGAAGGAGAAC CATGCCAAAATAAAAGACTCCATGCCTTTGCTGGAGAAGAATGAGCCGAAGATGAGCGAAGCCAAAAATTATCTAAGCAGTATCCTTAAC CATGGGAGGCTCTCGCCACAGTACATGTGTGAGGCCATGCTGATCCTGGGCAAACTGCATTACGTGGAGGGCTCATACCGAGATGCCATC AGCATGTACGCACGGGCCGGGATTGATGACATGTCCATGGAGAACAAGCCCCTGTATCAGATGCGGCTGCTGTCGGAGGCTTTTGTCATC AAAGGCCTCTCTCTGGAACGCCTACCCAACTCCATCGCCTCCCGCTTCCGCCTGACAGAGAGGGAGGAGGAAGTGATCACCTGTTTTGAG AGGGCCTCCTGGATCGCTCAGGTGTTCCTGCAGGAATTGGAGAAGACCACAAATAACAGCACGTCGAGGCATCTGAAAGGCTGTCACCCG CTTGACTATGAGCTCACCTACTTCCTGGAAGCTGCCCTCCAGAGCGCCTATGTGAAAAACCTGAAGAAGGGGAACATCGTGAAGGGCATG AGAGAGCTCCGGGAGGTGCTGCGGACTGTGGAGACCAAAGCAACTCAGAACTTCAAAGTGATGGCGGCCAAGCACCTGGCGGGGGTCCTG CTGCACTCCCTGAGTGAGGAGTGCTACTGGAGCCCCCTGTCCCACCCTCTGCCTGAGTTCATGGGCAAGGAGGAGAGTTCTTTCGCCACT CAGGCCCTGCGGAAACCTCACCTCTATGAAGGAGACAACCTCTACTGCCCCAAGGACAACATCGAGGAAGCCCTCCTGCTCCTCCTCATC AGCGAATCCATGGCAACTCGAGATGTGGTGCTGAGCCGGGTGCCGGAGCAGGAGGAGGACCGGACAGTGAGCTTGCAGAATGCCGCAGCC ATCTATGACCTCCTGAGCATCACGTTGGGCAGAAGGGGACAGTACGTCATGCTCTCGGAGTGCCTGGAGCGAGCCATGAAGTTTGCGTTT GGAGAATTTCACCTTTGGTACCAGGTGGCCCTCTCCATGGTGGCTTGTGGGAAGTCAGCCTACGCTGTGTCCCTGCTGCGGGAGTGTGTG AAGTTGCGGCCCTCGGACCCCACCGTGCCCCTGATGGCCGCGAAGGTCTGCATCGGGTCCCTTCGCTGGCTAGAGGAAGCAGAGCACTTT GCCATGATGGTGATCAGCCTCGGAGAGGAAGCCGGGGAGTTCCTCCCCAAGGGCTACCTGGCTCTGGGTCTCACCTATAGCCTGCAGGCC ACCGACGCCACCCTGAAGTCCAAGCAAGATGAATTGCACCGGAAGGCACTGCAGACGCTGGAGAGGGCTCAGCAGCTGGCGCCCAGTGAC CCCCAGGTCATCCTCTATGTCTCGCTGCAGCTGGCCCTCGTCCGACAGATCTCCAGTGCCATGGAGCAGCTGCAGGAGGCCCTGAAGGTA CGCAAGGATGATGCCCACGCCCTCCACCTGCTGGCACTGCTCTTCTCTGCCCAGAAGCACCACCAGCATGCCCTGGATGTTGTCAACATG GCCATCACCGAGCACCCTGAGAACTTCAACCTGATGTTCACCAAGGTGAAGCTGGAGCAGGTGCTGAAAGGCCCAGAGGAAGCCCTCGTG ACCTGCAGACAAGTGCTGAGGCTGTGGCAGACCCTGTACAGCTTCTCCCAGCTGGGAGGCCTAGAAAAGGATGGCAGCTTCGGTGAGGGC CTCACCATGAAGAAGCAGAGTGGCATGCACCTGACTTTGCCTGATGCCCATGATGCAGACTCTGGCTCCCGGCGGGCTTCGTCCATCGCC GCCTCCCGGCTGGAGGAGGCCATGTCAGAGCTGACTATGCCCTCTTCGGTCCTGAAGCAGGGCCCCATGCAGCTGTGGACCACGCTGGAA CAGATCTGGCTGCAGGCTGCTGAGCTGTTCATGGAGCAGCAGCACCTCAAGGAAGCAGGTTTCTGCATCCAGGAGGCGGCGGGCCTCTTC CCCACTTCTCACTCAGTACTCTATATGCGGGGCCGGCTGGCTGAGGTGAAGGGCAACCTGGAGGAGGCCAAGCAGCTGTACAAGGAGGCG CTCACGGTGAACCCAGATGGCGTGCGCATCATGCATAGCCTGGGTCTGATGCTGAGTCGGCTGGGCCACAAGAGCTTGGCCCAGAAGGTG CTTCGTGATGCCGTGGAGAGGCAGAGTACGTGCCACGAGGCGTGGCAGGGCCTGGGCGAGGTGCTGCAGGCCCAGGGCCAGAACGAGGCT >In-frame_MSH2_ENST00000233146_chr2_47630541_+_TTC7A_ENST00000319190_chr2_47177502_+_2604nt ATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCG ACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACC CAGGGGGTGATCAAGTACATGGGGCCGGCAGATGACTTTGGGAAATTGCTGCTGGCTGAGGCCCTCCTGGAGCAGTGTTTGAAGGAGAAC CATGCCAAAATAAAAGACTCCATGCCTTTGCTGGAGAAGAATGAGCCGAAGATGAGCGAAGCCAAAAATTATCTAAGCAGTATCCTTAAC CATGGGAGGCTCTCGCCACAGTACATGTGTGAGGCCATGCTGATCCTGGGCAAACTGCATTACGTGGAGGGCTCATACCGAGATGCCATC AGCATGTACGCACGGGCCGGGATTGATGACATGTCCATGGAGAACAAGCCCCTGTATCAGATGCGGCTGCTGTCGGAGGCTTTTGTCATC AAAGGCCTCTCTCTGGAACGCCTACCCAACTCCATCGCCTCCCGCTTCCGCCTGACAGAGAGGGAGGAGGAAGTGATCACCTGTTTTGAG AGGGCCTCCTGGATCGCTCAGGTGTTCCTGCAGGAATTGGAGAAGACCACAAATAACAGCACGTCGAGGCATCTGAAAGGCTGTCACCCG CTTGACTATGAGCTCACCTACTTCCTGGAAGCTGCCCTCCAGAGCGCCTATGTGAAAAACCTGAAGAAGGGGAACATCGTGAAGGGCATG AGAGAGCTCCGGGAGGTGCTGCGGACTGTGGAGACCAAAGCAACTCAGAACTTCAAAGTGATGGCGGCCAAGCACCTGGCGGGGGTCCTG CTGCACTCCCTGAGTGAGGAGTGCTACTGGAGCCCCCTGTCCCACCCTCTGCCTGAGTTCATGGGCAAGGAGGAGAGTTCTTTCGCCACT CAGGCCCTGCGGAAACCTCACCTCTATGAAGGAGACAACCTCTACTGCCCCAAGGACAACATCGAGGAAGCCCTCCTGCTCCTCCTCATC AGCGAATCCATGGCAACTCGAGATGTGGTGCTGAGCCGGGTGCCGGAGCAGGAGGAGGACCGGACAGTGAGCTTGCAGAATGCCGCAGCC ATCTATGACCTCCTGAGCATCACGTTGGGCAGAAGGGGACAGTACGTCATGCTCTCGGAGTGCCTGGAGCGAGCCATGAAGTTTGCGTTT GGAGAATTTCACCTTTGGTACCAGGTGGCCCTCTCCATGGTGGCTTGTGGGAAGTCAGCCTACGCTGTGTCCCTGCTGCGGGAGTGTGTG AAGTTGCGGCCCTCGGACCCCACCGTGCCCCTGATGGCCGCGAAGGTCTGCATCGGGTCCCTTCGCTGGCTAGAGGAAGCAGAGCACTTT GCCATGATGGTGATCAGCCTCGGAGAGGAAGCCGGGGAGTTCCTCCCCAAGGGCTACCTGGCTCTGGGTCTCACCTATAGCCTGCAGGCC ACCGACGCCACCCTGAAGTCCAAGCAAGATGAATTGCACCGGAAGGCACTGCAGACGCTGGAGAGGGCTCAGCAGCTGGCGCCCAGTGAC CCCCAGGTCATCCTCTATGTCTCGCTGCAGCTGGCCCTCGTCCGACAGATCTCCAGTGCCATGGAGCAGCTGCAGGAGGCCCTGAAGGTA CGCAAGGATGATGCCCACGCCCTCCACCTGCTGGCACTGCTCTTCTCTGCCCAGAAGCACCACCAGCATGCCCTGGATGTTGTCAACATG GCCATCACCGAGCACCCTGAGAACTTCAACCTGATGTTCACCAAGGTGAAGCTGGAGCAGGTGCTGAAAGGCCCAGAGGAAGCCCTCGTG ACCTGCAGACAAGTGCTGAGGCTGTGGCAGACCCTGTACAGCTTCTCCCAGCTGGGAGGCCTAGAAAAGGATGGCAGCTTCGGTGAGGGC CTCACCATGAAGAAGCAGAGTGGCATGCACCTGACTTTGCCTGATGCCCATGATGCAGACTCTGGCTCCCGGCGGGCTTCGTCCATCGCC GCCTCCCGGCTGGAGGAGGCCATGTCAGAGCTGACTATGCCCTCTTCGGTCCTGAAGCAGGGCCCCATGCAGCTGTGGACCACGCTGGAA CAGATCTGGCTGCAGGCTGCTGAGCTGTTCATGGAGCAGCAGCACCTCAAGGAAGCAGGTTTCTGCATCCAGGAGGCGGCGGGCCTCTTC CCCACTTCTCACTCAGTACTCTATATGCGGGGCCGGCTGGCTGAGGTGAAGGGCAACCTGGAGGAGGCCAAGCAGCTGTACAAGGAGGCG CTCACGGTGAACCCAGATGGCGTGCGCATCATGCATAGCCTGGGTCTGATGCTGAGTCGGCTGGGCCACAAGAGCTTGGCCCAGAAGGTG CTTCGTGATGCCGTGGAGAGGCAGAGTACGTGCCACGAGGCGTGGCAGGGCCTGGGCGAGGTGCTGCAGGCCCAGGGCCAGAACGAGGCT >In-frame_MSH2_ENST00000543555_chr2_47630541_+_TTC7A_ENST00000409245_chr2_47177502_+_2406nt ATGGGGCCGGCAGATGACTTTGGGAAATTGCTGCTGGCTGAGGCCCTCCTGGAGCAGTGTTTGAAGGAGAACCATGCCAAAATAAAAGAC TCCATGCCTTTGCTGGAGAAGAATGAGCCGAAGATGAGCGAAGCCAAAAATTATCTAAGCAGTATCCTTAACCATGGGAGGCTCTCGCCA CAGTACATGTGTGAGGCCATGCTGATCCTGGGCAAACTGCATTACGTGGAGGGCTCATACCGAGATGCCATCAGCATGTACGCACGGGCC GGGATTGATGACATGTCCATGGAGAACAAGCCCCTGTATCAGATGCGGCTGCTGTCGGAGGCTTTTGTCATCAAAGGCCTCTCTCTGGAA CGCCTACCCAACTCCATCGCCTCCCGCTTCCGCCTGACAGAGAGGGAGGAGGAAGTGATCACCTGTTTTGAGAGGGCCTCCTGGATCGCT CAGGTGTTCCTGCAGGAATTGGAGAAGACCACAAATAACAGCACGTCGAGGCATCTGAAAGGCTGTCACCCGCTTGACTATGAGCTCACC TACTTCCTGGAAGCTGCCCTCCAGAGCGCCTATGTGAAAAACCTGAAGAAGGGGAACATCGTGAAGGGCATGAGAGAGCTCCGGGAGGTG CTGCGGACTGTGGAGACCAAAGCAACTCAGAACTTCAAAGTGATGGCGGCCAAGCACCTGGCGGGGGTCCTGCTGCACTCCCTGAGTGAG GAGTGCTACTGGAGCCCCCTGTCCCACCCTCTGCCTGAGTTCATGGGCAAGGAGGAGAGTTCTTTCGCCACTCAGGCCCTGCGGAAACCT CACCTCTATGAAGGAGACAACCTCTACTGCCCCAAGGACAACATCGAGGAAGCCCTCCTGCTCCTCCTCATCAGCGAATCCATGGCAACT CGAGATGTGGTGCTGAGCCGGGTGCCGGAGCAGGAGGAGGACCGGACAGTGAGCTTGCAGAATGCCGCAGCCATCTATGACCTCCTGAGC ATCACGTTGGGCAGAAGGGGACAGTACGTCATGCTCTCGGAGTGCCTGGAGCGAGCCATGAAGTTTGCGTTTGGAGAATTTCACCTTTGG TACCAGGTGGCCCTCTCCATGGTGGCTTGTGGGAAGTCAGCCTACGCTGTGTCCCTGCTGCGGGAGTGTGTGAAGTTGCGGCCCTCGGAC CCCACCGTGCCCCTGATGGCCGCGAAGGTCTGCATCGGGTCCCTTCGCTGGCTAGAGGAAGCAGAGCACTTTGCCATGATGGTGATCAGC CTCGGAGAGGAAGCCGGGGAGTTCCTCCCCAAGGGCTACCTGGCTCTGGGTCTCACCTATAGCCTGCAGGCCACCGACGCCACCCTGAAG TCCAAGCAAGATGAATTGCACCGGAAGGCACTGCAGACGCTGGAGAGGGCTCAGCAGCTGGCGCCCAGTGACCCCCAGGTCATCCTCTAT GTCTCGCTGCAGCTGGCCCTCGTCCGACAGATCTCCAGTGCCATGGAGCAGCTGCAGGAGGCCCTGAAGGTACGCAAGGATGATGCCCAC GCCCTCCACCTGCTGGCACTGCTCTTCTCTGCCCAGAAGCACCACCAGCATGCCCTGGATGTTGTCAACATGGCCATCACCGAGCACCCT GAGAACTTCAACCTGATGTTCACCAAGGTGAAGCTGGAGCAGGTGCTGAAAGGCCCAGAGGAAGCCCTCGTGACCTGCAGACAAGTGCTG AGGCTGTGGCAGACCCTGTACAGCTTCTCCCAGCTGGGAGGCCTAGAAAAGGATGGCAGCTTCGGTGAGGGCCTCACCATGAAGAAGCAG AGTGGCATGCACCTGACTTTGCCTGATGCCCATGATGCAGACTCTGGCTCCCGGCGGGCTTCGTCCATCGCCGCCTCCCGGCTGGAGGAG GCCATGTCAGAGCTGACTATGCCCTCTTCGGTCCTGAAGCAGGGCCCCATGCAGCTGTGGACCACGCTGGAACAGATCTGGCTGCAGGCT GCTGAGCTGTTCATGGAGCAGCAGCACCTCAAGGAAGCAGGTTTCTGCATCCAGGAGGCGGCGGGCCTCTTCCCCACTTCTCACTCAGTA CTCTATATGCGGGGCCGGCTGGCTGAGGTGAAGGGCAACCTGGAGGAGGCCAAGCAGCTGTACAAGGAGGCGCTCACGGTGAACCCAGAT GGCGTGCGCATCATGCATAGCCTGGGTCTGATGCTGAGTCGGCTGGGCCACAAGAGCTTGGCCCAGAAGGTGCTTCGTGATGCCGTGGAG AGGCAGAGTACGTGCCACGAGGCGTGGCAGGGCCTGGGCGAGGTGCTGCAGGCCCAGGGCCAGAACGAGGCTGCCGTTGACTGCTTCCTC >In-frame_MSH2_ENST00000543555_chr2_47630541_+_TTC7A_ENST00000319190_chr2_47177502_+_2406nt ATGGGGCCGGCAGATGACTTTGGGAAATTGCTGCTGGCTGAGGCCCTCCTGGAGCAGTGTTTGAAGGAGAACCATGCCAAAATAAAAGAC TCCATGCCTTTGCTGGAGAAGAATGAGCCGAAGATGAGCGAAGCCAAAAATTATCTAAGCAGTATCCTTAACCATGGGAGGCTCTCGCCA CAGTACATGTGTGAGGCCATGCTGATCCTGGGCAAACTGCATTACGTGGAGGGCTCATACCGAGATGCCATCAGCATGTACGCACGGGCC GGGATTGATGACATGTCCATGGAGAACAAGCCCCTGTATCAGATGCGGCTGCTGTCGGAGGCTTTTGTCATCAAAGGCCTCTCTCTGGAA CGCCTACCCAACTCCATCGCCTCCCGCTTCCGCCTGACAGAGAGGGAGGAGGAAGTGATCACCTGTTTTGAGAGGGCCTCCTGGATCGCT CAGGTGTTCCTGCAGGAATTGGAGAAGACCACAAATAACAGCACGTCGAGGCATCTGAAAGGCTGTCACCCGCTTGACTATGAGCTCACC TACTTCCTGGAAGCTGCCCTCCAGAGCGCCTATGTGAAAAACCTGAAGAAGGGGAACATCGTGAAGGGCATGAGAGAGCTCCGGGAGGTG CTGCGGACTGTGGAGACCAAAGCAACTCAGAACTTCAAAGTGATGGCGGCCAAGCACCTGGCGGGGGTCCTGCTGCACTCCCTGAGTGAG GAGTGCTACTGGAGCCCCCTGTCCCACCCTCTGCCTGAGTTCATGGGCAAGGAGGAGAGTTCTTTCGCCACTCAGGCCCTGCGGAAACCT CACCTCTATGAAGGAGACAACCTCTACTGCCCCAAGGACAACATCGAGGAAGCCCTCCTGCTCCTCCTCATCAGCGAATCCATGGCAACT CGAGATGTGGTGCTGAGCCGGGTGCCGGAGCAGGAGGAGGACCGGACAGTGAGCTTGCAGAATGCCGCAGCCATCTATGACCTCCTGAGC ATCACGTTGGGCAGAAGGGGACAGTACGTCATGCTCTCGGAGTGCCTGGAGCGAGCCATGAAGTTTGCGTTTGGAGAATTTCACCTTTGG TACCAGGTGGCCCTCTCCATGGTGGCTTGTGGGAAGTCAGCCTACGCTGTGTCCCTGCTGCGGGAGTGTGTGAAGTTGCGGCCCTCGGAC CCCACCGTGCCCCTGATGGCCGCGAAGGTCTGCATCGGGTCCCTTCGCTGGCTAGAGGAAGCAGAGCACTTTGCCATGATGGTGATCAGC CTCGGAGAGGAAGCCGGGGAGTTCCTCCCCAAGGGCTACCTGGCTCTGGGTCTCACCTATAGCCTGCAGGCCACCGACGCCACCCTGAAG TCCAAGCAAGATGAATTGCACCGGAAGGCACTGCAGACGCTGGAGAGGGCTCAGCAGCTGGCGCCCAGTGACCCCCAGGTCATCCTCTAT GTCTCGCTGCAGCTGGCCCTCGTCCGACAGATCTCCAGTGCCATGGAGCAGCTGCAGGAGGCCCTGAAGGTACGCAAGGATGATGCCCAC GCCCTCCACCTGCTGGCACTGCTCTTCTCTGCCCAGAAGCACCACCAGCATGCCCTGGATGTTGTCAACATGGCCATCACCGAGCACCCT GAGAACTTCAACCTGATGTTCACCAAGGTGAAGCTGGAGCAGGTGCTGAAAGGCCCAGAGGAAGCCCTCGTGACCTGCAGACAAGTGCTG AGGCTGTGGCAGACCCTGTACAGCTTCTCCCAGCTGGGAGGCCTAGAAAAGGATGGCAGCTTCGGTGAGGGCCTCACCATGAAGAAGCAG AGTGGCATGCACCTGACTTTGCCTGATGCCCATGATGCAGACTCTGGCTCCCGGCGGGCTTCGTCCATCGCCGCCTCCCGGCTGGAGGAG GCCATGTCAGAGCTGACTATGCCCTCTTCGGTCCTGAAGCAGGGCCCCATGCAGCTGTGGACCACGCTGGAACAGATCTGGCTGCAGGCT GCTGAGCTGTTCATGGAGCAGCAGCACCTCAAGGAAGCAGGTTTCTGCATCCAGGAGGCGGCGGGCCTCTTCCCCACTTCTCACTCAGTA CTCTATATGCGGGGCCGGCTGGCTGAGGTGAAGGGCAACCTGGAGGAGGCCAAGCAGCTGTACAAGGAGGCGCTCACGGTGAACCCAGAT GGCGTGCGCATCATGCATAGCCTGGGTCTGATGCTGAGTCGGCTGGGCCACAAGAGCTTGGCCCAGAAGGTGCTTCGTGATGCCGTGGAG AGGCAGAGTACGTGCCACGAGGCGTGGCAGGGCCTGGGCGAGGTGCTGCAGGCCCAGGGCCAGAACGAGGCTGCCGTTGACTGCTTCCTC >In-frame_MSH2_ENST00000406134_chr2_47630541_+_TTC7A_ENST00000409245_chr2_47177502_+_2604nt ATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCG ACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACC CAGGGGGTGATCAAGTACATGGGGCCGGCAGATGACTTTGGGAAATTGCTGCTGGCTGAGGCCCTCCTGGAGCAGTGTTTGAAGGAGAAC CATGCCAAAATAAAAGACTCCATGCCTTTGCTGGAGAAGAATGAGCCGAAGATGAGCGAAGCCAAAAATTATCTAAGCAGTATCCTTAAC CATGGGAGGCTCTCGCCACAGTACATGTGTGAGGCCATGCTGATCCTGGGCAAACTGCATTACGTGGAGGGCTCATACCGAGATGCCATC AGCATGTACGCACGGGCCGGGATTGATGACATGTCCATGGAGAACAAGCCCCTGTATCAGATGCGGCTGCTGTCGGAGGCTTTTGTCATC AAAGGCCTCTCTCTGGAACGCCTACCCAACTCCATCGCCTCCCGCTTCCGCCTGACAGAGAGGGAGGAGGAAGTGATCACCTGTTTTGAG AGGGCCTCCTGGATCGCTCAGGTGTTCCTGCAGGAATTGGAGAAGACCACAAATAACAGCACGTCGAGGCATCTGAAAGGCTGTCACCCG CTTGACTATGAGCTCACCTACTTCCTGGAAGCTGCCCTCCAGAGCGCCTATGTGAAAAACCTGAAGAAGGGGAACATCGTGAAGGGCATG AGAGAGCTCCGGGAGGTGCTGCGGACTGTGGAGACCAAAGCAACTCAGAACTTCAAAGTGATGGCGGCCAAGCACCTGGCGGGGGTCCTG CTGCACTCCCTGAGTGAGGAGTGCTACTGGAGCCCCCTGTCCCACCCTCTGCCTGAGTTCATGGGCAAGGAGGAGAGTTCTTTCGCCACT CAGGCCCTGCGGAAACCTCACCTCTATGAAGGAGACAACCTCTACTGCCCCAAGGACAACATCGAGGAAGCCCTCCTGCTCCTCCTCATC AGCGAATCCATGGCAACTCGAGATGTGGTGCTGAGCCGGGTGCCGGAGCAGGAGGAGGACCGGACAGTGAGCTTGCAGAATGCCGCAGCC ATCTATGACCTCCTGAGCATCACGTTGGGCAGAAGGGGACAGTACGTCATGCTCTCGGAGTGCCTGGAGCGAGCCATGAAGTTTGCGTTT GGAGAATTTCACCTTTGGTACCAGGTGGCCCTCTCCATGGTGGCTTGTGGGAAGTCAGCCTACGCTGTGTCCCTGCTGCGGGAGTGTGTG AAGTTGCGGCCCTCGGACCCCACCGTGCCCCTGATGGCCGCGAAGGTCTGCATCGGGTCCCTTCGCTGGCTAGAGGAAGCAGAGCACTTT GCCATGATGGTGATCAGCCTCGGAGAGGAAGCCGGGGAGTTCCTCCCCAAGGGCTACCTGGCTCTGGGTCTCACCTATAGCCTGCAGGCC ACCGACGCCACCCTGAAGTCCAAGCAAGATGAATTGCACCGGAAGGCACTGCAGACGCTGGAGAGGGCTCAGCAGCTGGCGCCCAGTGAC CCCCAGGTCATCCTCTATGTCTCGCTGCAGCTGGCCCTCGTCCGACAGATCTCCAGTGCCATGGAGCAGCTGCAGGAGGCCCTGAAGGTA CGCAAGGATGATGCCCACGCCCTCCACCTGCTGGCACTGCTCTTCTCTGCCCAGAAGCACCACCAGCATGCCCTGGATGTTGTCAACATG GCCATCACCGAGCACCCTGAGAACTTCAACCTGATGTTCACCAAGGTGAAGCTGGAGCAGGTGCTGAAAGGCCCAGAGGAAGCCCTCGTG ACCTGCAGACAAGTGCTGAGGCTGTGGCAGACCCTGTACAGCTTCTCCCAGCTGGGAGGCCTAGAAAAGGATGGCAGCTTCGGTGAGGGC CTCACCATGAAGAAGCAGAGTGGCATGCACCTGACTTTGCCTGATGCCCATGATGCAGACTCTGGCTCCCGGCGGGCTTCGTCCATCGCC GCCTCCCGGCTGGAGGAGGCCATGTCAGAGCTGACTATGCCCTCTTCGGTCCTGAAGCAGGGCCCCATGCAGCTGTGGACCACGCTGGAA CAGATCTGGCTGCAGGCTGCTGAGCTGTTCATGGAGCAGCAGCACCTCAAGGAAGCAGGTTTCTGCATCCAGGAGGCGGCGGGCCTCTTC CCCACTTCTCACTCAGTACTCTATATGCGGGGCCGGCTGGCTGAGGTGAAGGGCAACCTGGAGGAGGCCAAGCAGCTGTACAAGGAGGCG CTCACGGTGAACCCAGATGGCGTGCGCATCATGCATAGCCTGGGTCTGATGCTGAGTCGGCTGGGCCACAAGAGCTTGGCCCAGAAGGTG CTTCGTGATGCCGTGGAGAGGCAGAGTACGTGCCACGAGGCGTGGCAGGGCCTGGGCGAGGTGCTGCAGGCCCAGGGCCAGAACGAGGCT >In-frame_MSH2_ENST00000406134_chr2_47630541_+_TTC7A_ENST00000319190_chr2_47177502_+_2604nt ATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCG ACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACC CAGGGGGTGATCAAGTACATGGGGCCGGCAGATGACTTTGGGAAATTGCTGCTGGCTGAGGCCCTCCTGGAGCAGTGTTTGAAGGAGAAC CATGCCAAAATAAAAGACTCCATGCCTTTGCTGGAGAAGAATGAGCCGAAGATGAGCGAAGCCAAAAATTATCTAAGCAGTATCCTTAAC CATGGGAGGCTCTCGCCACAGTACATGTGTGAGGCCATGCTGATCCTGGGCAAACTGCATTACGTGGAGGGCTCATACCGAGATGCCATC AGCATGTACGCACGGGCCGGGATTGATGACATGTCCATGGAGAACAAGCCCCTGTATCAGATGCGGCTGCTGTCGGAGGCTTTTGTCATC AAAGGCCTCTCTCTGGAACGCCTACCCAACTCCATCGCCTCCCGCTTCCGCCTGACAGAGAGGGAGGAGGAAGTGATCACCTGTTTTGAG AGGGCCTCCTGGATCGCTCAGGTGTTCCTGCAGGAATTGGAGAAGACCACAAATAACAGCACGTCGAGGCATCTGAAAGGCTGTCACCCG CTTGACTATGAGCTCACCTACTTCCTGGAAGCTGCCCTCCAGAGCGCCTATGTGAAAAACCTGAAGAAGGGGAACATCGTGAAGGGCATG AGAGAGCTCCGGGAGGTGCTGCGGACTGTGGAGACCAAAGCAACTCAGAACTTCAAAGTGATGGCGGCCAAGCACCTGGCGGGGGTCCTG CTGCACTCCCTGAGTGAGGAGTGCTACTGGAGCCCCCTGTCCCACCCTCTGCCTGAGTTCATGGGCAAGGAGGAGAGTTCTTTCGCCACT CAGGCCCTGCGGAAACCTCACCTCTATGAAGGAGACAACCTCTACTGCCCCAAGGACAACATCGAGGAAGCCCTCCTGCTCCTCCTCATC AGCGAATCCATGGCAACTCGAGATGTGGTGCTGAGCCGGGTGCCGGAGCAGGAGGAGGACCGGACAGTGAGCTTGCAGAATGCCGCAGCC ATCTATGACCTCCTGAGCATCACGTTGGGCAGAAGGGGACAGTACGTCATGCTCTCGGAGTGCCTGGAGCGAGCCATGAAGTTTGCGTTT GGAGAATTTCACCTTTGGTACCAGGTGGCCCTCTCCATGGTGGCTTGTGGGAAGTCAGCCTACGCTGTGTCCCTGCTGCGGGAGTGTGTG AAGTTGCGGCCCTCGGACCCCACCGTGCCCCTGATGGCCGCGAAGGTCTGCATCGGGTCCCTTCGCTGGCTAGAGGAAGCAGAGCACTTT GCCATGATGGTGATCAGCCTCGGAGAGGAAGCCGGGGAGTTCCTCCCCAAGGGCTACCTGGCTCTGGGTCTCACCTATAGCCTGCAGGCC ACCGACGCCACCCTGAAGTCCAAGCAAGATGAATTGCACCGGAAGGCACTGCAGACGCTGGAGAGGGCTCAGCAGCTGGCGCCCAGTGAC CCCCAGGTCATCCTCTATGTCTCGCTGCAGCTGGCCCTCGTCCGACAGATCTCCAGTGCCATGGAGCAGCTGCAGGAGGCCCTGAAGGTA CGCAAGGATGATGCCCACGCCCTCCACCTGCTGGCACTGCTCTTCTCTGCCCAGAAGCACCACCAGCATGCCCTGGATGTTGTCAACATG GCCATCACCGAGCACCCTGAGAACTTCAACCTGATGTTCACCAAGGTGAAGCTGGAGCAGGTGCTGAAAGGCCCAGAGGAAGCCCTCGTG ACCTGCAGACAAGTGCTGAGGCTGTGGCAGACCCTGTACAGCTTCTCCCAGCTGGGAGGCCTAGAAAAGGATGGCAGCTTCGGTGAGGGC CTCACCATGAAGAAGCAGAGTGGCATGCACCTGACTTTGCCTGATGCCCATGATGCAGACTCTGGCTCCCGGCGGGCTTCGTCCATCGCC GCCTCCCGGCTGGAGGAGGCCATGTCAGAGCTGACTATGCCCTCTTCGGTCCTGAAGCAGGGCCCCATGCAGCTGTGGACCACGCTGGAA CAGATCTGGCTGCAGGCTGCTGAGCTGTTCATGGAGCAGCAGCACCTCAAGGAAGCAGGTTTCTGCATCCAGGAGGCGGCGGGCCTCTTC CCCACTTCTCACTCAGTACTCTATATGCGGGGCCGGCTGGCTGAGGTGAAGGGCAACCTGGAGGAGGCCAAGCAGCTGTACAAGGAGGCG CTCACGGTGAACCCAGATGGCGTGCGCATCATGCATAGCCTGGGTCTGATGCTGAGTCGGCTGGGCCACAAGAGCTTGGCCCAGAAGGTG CTTCGTGATGCCGTGGAGAGGCAGAGTACGTGCCACGAGGCGTGGCAGGGCCTGGGCGAGGTGCTGCAGGCCCAGGGCCAGAACGAGGCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MSH2_ENST00000233146_chr2_47630541_+_TTC7A_ENST00000409245_chr2_47177502_+_2952nt GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGATGACTTTGGGAAATT GCTGCTGGCTGAGGCCCTCCTGGAGCAGTGTTTGAAGGAGAACCATGCCAAAATAAAAGACTCCATGCCTTTGCTGGAGAAGAATGAGCC GAAGATGAGCGAAGCCAAAAATTATCTAAGCAGTATCCTTAACCATGGGAGGCTCTCGCCACAGTACATGTGTGAGGCCATGCTGATCCT GGGCAAACTGCATTACGTGGAGGGCTCATACCGAGATGCCATCAGCATGTACGCACGGGCCGGGATTGATGACATGTCCATGGAGAACAA GCCCCTGTATCAGATGCGGCTGCTGTCGGAGGCTTTTGTCATCAAAGGCCTCTCTCTGGAACGCCTACCCAACTCCATCGCCTCCCGCTT CCGCCTGACAGAGAGGGAGGAGGAAGTGATCACCTGTTTTGAGAGGGCCTCCTGGATCGCTCAGGTGTTCCTGCAGGAATTGGAGAAGAC CACAAATAACAGCACGTCGAGGCATCTGAAAGGCTGTCACCCGCTTGACTATGAGCTCACCTACTTCCTGGAAGCTGCCCTCCAGAGCGC CTATGTGAAAAACCTGAAGAAGGGGAACATCGTGAAGGGCATGAGAGAGCTCCGGGAGGTGCTGCGGACTGTGGAGACCAAAGCAACTCA GAACTTCAAAGTGATGGCGGCCAAGCACCTGGCGGGGGTCCTGCTGCACTCCCTGAGTGAGGAGTGCTACTGGAGCCCCCTGTCCCACCC TCTGCCTGAGTTCATGGGCAAGGAGGAGAGTTCTTTCGCCACTCAGGCCCTGCGGAAACCTCACCTCTATGAAGGAGACAACCTCTACTG CCCCAAGGACAACATCGAGGAAGCCCTCCTGCTCCTCCTCATCAGCGAATCCATGGCAACTCGAGATGTGGTGCTGAGCCGGGTGCCGGA GCAGGAGGAGGACCGGACAGTGAGCTTGCAGAATGCCGCAGCCATCTATGACCTCCTGAGCATCACGTTGGGCAGAAGGGGACAGTACGT CATGCTCTCGGAGTGCCTGGAGCGAGCCATGAAGTTTGCGTTTGGAGAATTTCACCTTTGGTACCAGGTGGCCCTCTCCATGGTGGCTTG TGGGAAGTCAGCCTACGCTGTGTCCCTGCTGCGGGAGTGTGTGAAGTTGCGGCCCTCGGACCCCACCGTGCCCCTGATGGCCGCGAAGGT CTGCATCGGGTCCCTTCGCTGGCTAGAGGAAGCAGAGCACTTTGCCATGATGGTGATCAGCCTCGGAGAGGAAGCCGGGGAGTTCCTCCC CAAGGGCTACCTGGCTCTGGGTCTCACCTATAGCCTGCAGGCCACCGACGCCACCCTGAAGTCCAAGCAAGATGAATTGCACCGGAAGGC ACTGCAGACGCTGGAGAGGGCTCAGCAGCTGGCGCCCAGTGACCCCCAGGTCATCCTCTATGTCTCGCTGCAGCTGGCCCTCGTCCGACA GATCTCCAGTGCCATGGAGCAGCTGCAGGAGGCCCTGAAGGTACGCAAGGATGATGCCCACGCCCTCCACCTGCTGGCACTGCTCTTCTC TGCCCAGAAGCACCACCAGCATGCCCTGGATGTTGTCAACATGGCCATCACCGAGCACCCTGAGAACTTCAACCTGATGTTCACCAAGGT GAAGCTGGAGCAGGTGCTGAAAGGCCCAGAGGAAGCCCTCGTGACCTGCAGACAAGTGCTGAGGCTGTGGCAGACCCTGTACAGCTTCTC CCAGCTGGGAGGCCTAGAAAAGGATGGCAGCTTCGGTGAGGGCCTCACCATGAAGAAGCAGAGTGGCATGCACCTGACTTTGCCTGATGC CCATGATGCAGACTCTGGCTCCCGGCGGGCTTCGTCCATCGCCGCCTCCCGGCTGGAGGAGGCCATGTCAGAGCTGACTATGCCCTCTTC GGTCCTGAAGCAGGGCCCCATGCAGCTGTGGACCACGCTGGAACAGATCTGGCTGCAGGCTGCTGAGCTGTTCATGGAGCAGCAGCACCT CAAGGAAGCAGGTTTCTGCATCCAGGAGGCGGCGGGCCTCTTCCCCACTTCTCACTCAGTACTCTATATGCGGGGCCGGCTGGCTGAGGT GAAGGGCAACCTGGAGGAGGCCAAGCAGCTGTACAAGGAGGCGCTCACGGTGAACCCAGATGGCGTGCGCATCATGCATAGCCTGGGTCT GATGCTGAGTCGGCTGGGCCACAAGAGCTTGGCCCAGAAGGTGCTTCGTGATGCCGTGGAGAGGCAGAGTACGTGCCACGAGGCGTGGCA GGGCCTGGGCGAGGTGCTGCAGGCCCAGGGCCAGAACGAGGCTGCCGTTGACTGCTTCCTCACCGCCCTTGAGCTGGAGGCCAGCAGCCC TGTACTGCCCTTCTCCATCATCCCCAGAGAGCTCTGACGACGCTGCAGCCGCAGGGAGGGAGGGGCTGGCCAGAGGGAGAGGCAGCAGGG >In-frame_MSH2_ENST00000233146_chr2_47630541_+_TTC7A_ENST00000319190_chr2_47177502_+_5039nt GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGATGACTTTGGGAAATT GCTGCTGGCTGAGGCCCTCCTGGAGCAGTGTTTGAAGGAGAACCATGCCAAAATAAAAGACTCCATGCCTTTGCTGGAGAAGAATGAGCC GAAGATGAGCGAAGCCAAAAATTATCTAAGCAGTATCCTTAACCATGGGAGGCTCTCGCCACAGTACATGTGTGAGGCCATGCTGATCCT GGGCAAACTGCATTACGTGGAGGGCTCATACCGAGATGCCATCAGCATGTACGCACGGGCCGGGATTGATGACATGTCCATGGAGAACAA GCCCCTGTATCAGATGCGGCTGCTGTCGGAGGCTTTTGTCATCAAAGGCCTCTCTCTGGAACGCCTACCCAACTCCATCGCCTCCCGCTT CCGCCTGACAGAGAGGGAGGAGGAAGTGATCACCTGTTTTGAGAGGGCCTCCTGGATCGCTCAGGTGTTCCTGCAGGAATTGGAGAAGAC CACAAATAACAGCACGTCGAGGCATCTGAAAGGCTGTCACCCGCTTGACTATGAGCTCACCTACTTCCTGGAAGCTGCCCTCCAGAGCGC CTATGTGAAAAACCTGAAGAAGGGGAACATCGTGAAGGGCATGAGAGAGCTCCGGGAGGTGCTGCGGACTGTGGAGACCAAAGCAACTCA GAACTTCAAAGTGATGGCGGCCAAGCACCTGGCGGGGGTCCTGCTGCACTCCCTGAGTGAGGAGTGCTACTGGAGCCCCCTGTCCCACCC TCTGCCTGAGTTCATGGGCAAGGAGGAGAGTTCTTTCGCCACTCAGGCCCTGCGGAAACCTCACCTCTATGAAGGAGACAACCTCTACTG CCCCAAGGACAACATCGAGGAAGCCCTCCTGCTCCTCCTCATCAGCGAATCCATGGCAACTCGAGATGTGGTGCTGAGCCGGGTGCCGGA GCAGGAGGAGGACCGGACAGTGAGCTTGCAGAATGCCGCAGCCATCTATGACCTCCTGAGCATCACGTTGGGCAGAAGGGGACAGTACGT CATGCTCTCGGAGTGCCTGGAGCGAGCCATGAAGTTTGCGTTTGGAGAATTTCACCTTTGGTACCAGGTGGCCCTCTCCATGGTGGCTTG TGGGAAGTCAGCCTACGCTGTGTCCCTGCTGCGGGAGTGTGTGAAGTTGCGGCCCTCGGACCCCACCGTGCCCCTGATGGCCGCGAAGGT CTGCATCGGGTCCCTTCGCTGGCTAGAGGAAGCAGAGCACTTTGCCATGATGGTGATCAGCCTCGGAGAGGAAGCCGGGGAGTTCCTCCC CAAGGGCTACCTGGCTCTGGGTCTCACCTATAGCCTGCAGGCCACCGACGCCACCCTGAAGTCCAAGCAAGATGAATTGCACCGGAAGGC ACTGCAGACGCTGGAGAGGGCTCAGCAGCTGGCGCCCAGTGACCCCCAGGTCATCCTCTATGTCTCGCTGCAGCTGGCCCTCGTCCGACA GATCTCCAGTGCCATGGAGCAGCTGCAGGAGGCCCTGAAGGTACGCAAGGATGATGCCCACGCCCTCCACCTGCTGGCACTGCTCTTCTC TGCCCAGAAGCACCACCAGCATGCCCTGGATGTTGTCAACATGGCCATCACCGAGCACCCTGAGAACTTCAACCTGATGTTCACCAAGGT GAAGCTGGAGCAGGTGCTGAAAGGCCCAGAGGAAGCCCTCGTGACCTGCAGACAAGTGCTGAGGCTGTGGCAGACCCTGTACAGCTTCTC CCAGCTGGGAGGCCTAGAAAAGGATGGCAGCTTCGGTGAGGGCCTCACCATGAAGAAGCAGAGTGGCATGCACCTGACTTTGCCTGATGC CCATGATGCAGACTCTGGCTCCCGGCGGGCTTCGTCCATCGCCGCCTCCCGGCTGGAGGAGGCCATGTCAGAGCTGACTATGCCCTCTTC GGTCCTGAAGCAGGGCCCCATGCAGCTGTGGACCACGCTGGAACAGATCTGGCTGCAGGCTGCTGAGCTGTTCATGGAGCAGCAGCACCT CAAGGAAGCAGGTTTCTGCATCCAGGAGGCGGCGGGCCTCTTCCCCACTTCTCACTCAGTACTCTATATGCGGGGCCGGCTGGCTGAGGT GAAGGGCAACCTGGAGGAGGCCAAGCAGCTGTACAAGGAGGCGCTCACGGTGAACCCAGATGGCGTGCGCATCATGCATAGCCTGGGTCT GATGCTGAGTCGGCTGGGCCACAAGAGCTTGGCCCAGAAGGTGCTTCGTGATGCCGTGGAGAGGCAGAGTACGTGCCACGAGGCGTGGCA GGGCCTGGGCGAGGTGCTGCAGGCCCAGGGCCAGAACGAGGCTGCCGTTGACTGCTTCCTCACCGCCCTTGAGCTGGAGGCCAGCAGCCC TGTACTGCCCTTCTCCATCATCCCCAGAGAGCTCTGACGACGCTGCAGCCGCAGGGAGGGAGGGGCTGGCCAGAGGGAGAGGCAGCAGGG AACGTGGGTCAGGGTGGGGCAACAGTGGCATCAGGTGCGGGGCCTCAGGGAAATACATCTTTAGTGAACGCCTCTGCAGCTGCAGCCCTC GTTCTCTTGGCTGGGCCAAGAGGGCCTTCCTGGATTTCTTTGTTGGTGCCTTGGGAAACAGTCTGACTTGAACCCTAAGTGCCTTTGGAG AGTTTTGTGGTGACCAGACTTGCTCCCCAAGAGCTGGGCAGCGGGGAGCCTCACAGCTGTCCTTCACCCTCACCCATGCCTCTGGCTTGG AGTCTGGGTGGGGGGTTCTCACTCCCCACTCTCAGCACAGTACAGACTTCTGGATCTCTCTCAGGTCTTGCCCAGGGCGGTCACAATGTG AAGAAACTGCGGGCAAGTGGGAAGACTATGAGATTTCTGGGTTCCCTTCTCAGACTTGGAGTTAGTAGATGATTCCTGCATTGCCCCTGC TTGCCCTCTGAGACCAGCTGGGCCCCACCTTGCTCTTTCCCCCTGCTACCAAGTGCCTTTGGGGTCTGACCAGGGGTACTGAGCACCGGC CCTAACACTTCCATCTCCACCCACCCCATCTCCCTGGCGATGTGCTCCAGCCCAAGCAGCCTCCGTAGGCTTTAGATCCTGTGGTTGCTA GATCCAGTCCTTTCTAATACCCTGAGTCAACACATTACTCCTGCAGGTCTTAGGCTACAATGCAGGTCCCTTGAGGGCCACCAACATGGA GGTAGGCAGTTTCTAGGACTGTCCCCAGTACATCTCACCACCCACAGCCCTTTTTTTGCCTTGATTCGAGCCTCACCCTGGCCTTTTGGC TTCCCCTGCCTGAGAGAGACCTGAGGAGGGGACAGAGCCCAGCCCCTCTCCTGTGGCTGAGCAGGCCTCTGTGTCCATGACACCTGTCTT CCGGGCCTGGGGGCTGTGGGTGTATGTCCTCCCTACTGGCTTCCCCGGCCCCTGCTGCATGATGCTCTTGGAACTCTTCTCCAAGGAGTC AGTCCCCCAGGCCTATCAGGGGATCCTTTTGTATCTGCACTTTGGGTTTTAGTTTCAAAGCTCCATCAGGTACAGCTTGCATTTCAGGAT GTGTGGAAAGCTCGGGTGAGGGCTGCCCTGGTTCATCATAGCTCCACCTTCCTCGGAAGGAGTGGGCTGTTGGAGACCCCCCATCCATGG CACACTAGCTCAGCACTGCATTTCCCGAGATGATTCCCAAGACAGCTGGTGCCTCCTGGCTTTCCTGTGCCAGGCCAAGGGGCACCACAG AGGACCCTGGATCCTTTGCCTCTTCTTGGTTGAAGGATCTCTATGTATGTGTGTATATAAATATAGTTTTTTATCTATATATATAAAATA GAGATCTATTTTTTTTCTGGAATTCTGTTAGAAAAGTAAAGAAAAAGCAAATGCTGTTGGTTTATCTCAGGGTGCCCAAAGTGGTTATAG TCAATTTTTGGTACTAGGAAAGGCACCCAATGCATTTCCTGACTTTTAAGCATTTCCTTGTTGGAAGCAGCAGAGGGCCAGGCCAAGTTG CTGACAGTGACTTTGCAGGTTGAATAAAGAAACCCTTGGAGGGGAAGCAGGCTTGTCTGAAGCAGCATGTATATTCACTGGGCATGTAGC TCCCACACCAGCCTTGAGCCAGGCCCTGGACAGGAGGGGCTGTTGCAGGATGAGGGAGGCCAGAGAAGGCATCGAAGCCAAGACCTGGGC CCACCTGGGGAGGGATGTGGGAAAGGAAGGATGGGAGGGAGGACCCTCTGGGAAAATGTGGATTTGAGCTGGTGAGAGTGTTGCTAAGGC TGGGCTAAAGCCTGGAGAGGGTAGGAGGAGGCAAGAGGGGTCCAGGCAGGGCTGATCCTGGCCTCTGACCTGTCCAGGGCGACCCCTGAA GCCCCTGCTGCCTCTGGGCATTGCTGGGAGAGGCCAAGGCAGGACTCACGTCTGAACAGAGATCCCCTCGGGCATTGCTGATGGGCCACC TTCAGCTGCAGGGAAGAAGCCTAGGAGAGGAGGCATGGGAGGGACCTGGGCCTTGTTCAGATTGGCCACCTCTGCTGAGAAGTCCATACC >In-frame_MSH2_ENST00000543555_chr2_47630541_+_TTC7A_ENST00000409245_chr2_47177502_+_2670nt AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGATGACTTTGGGAAATTGCTGCTGGCTGA GGCCCTCCTGGAGCAGTGTTTGAAGGAGAACCATGCCAAAATAAAAGACTCCATGCCTTTGCTGGAGAAGAATGAGCCGAAGATGAGCGA AGCCAAAAATTATCTAAGCAGTATCCTTAACCATGGGAGGCTCTCGCCACAGTACATGTGTGAGGCCATGCTGATCCTGGGCAAACTGCA TTACGTGGAGGGCTCATACCGAGATGCCATCAGCATGTACGCACGGGCCGGGATTGATGACATGTCCATGGAGAACAAGCCCCTGTATCA GATGCGGCTGCTGTCGGAGGCTTTTGTCATCAAAGGCCTCTCTCTGGAACGCCTACCCAACTCCATCGCCTCCCGCTTCCGCCTGACAGA GAGGGAGGAGGAAGTGATCACCTGTTTTGAGAGGGCCTCCTGGATCGCTCAGGTGTTCCTGCAGGAATTGGAGAAGACCACAAATAACAG CACGTCGAGGCATCTGAAAGGCTGTCACCCGCTTGACTATGAGCTCACCTACTTCCTGGAAGCTGCCCTCCAGAGCGCCTATGTGAAAAA CCTGAAGAAGGGGAACATCGTGAAGGGCATGAGAGAGCTCCGGGAGGTGCTGCGGACTGTGGAGACCAAAGCAACTCAGAACTTCAAAGT GATGGCGGCCAAGCACCTGGCGGGGGTCCTGCTGCACTCCCTGAGTGAGGAGTGCTACTGGAGCCCCCTGTCCCACCCTCTGCCTGAGTT CATGGGCAAGGAGGAGAGTTCTTTCGCCACTCAGGCCCTGCGGAAACCTCACCTCTATGAAGGAGACAACCTCTACTGCCCCAAGGACAA CATCGAGGAAGCCCTCCTGCTCCTCCTCATCAGCGAATCCATGGCAACTCGAGATGTGGTGCTGAGCCGGGTGCCGGAGCAGGAGGAGGA CCGGACAGTGAGCTTGCAGAATGCCGCAGCCATCTATGACCTCCTGAGCATCACGTTGGGCAGAAGGGGACAGTACGTCATGCTCTCGGA GTGCCTGGAGCGAGCCATGAAGTTTGCGTTTGGAGAATTTCACCTTTGGTACCAGGTGGCCCTCTCCATGGTGGCTTGTGGGAAGTCAGC CTACGCTGTGTCCCTGCTGCGGGAGTGTGTGAAGTTGCGGCCCTCGGACCCCACCGTGCCCCTGATGGCCGCGAAGGTCTGCATCGGGTC CCTTCGCTGGCTAGAGGAAGCAGAGCACTTTGCCATGATGGTGATCAGCCTCGGAGAGGAAGCCGGGGAGTTCCTCCCCAAGGGCTACCT GGCTCTGGGTCTCACCTATAGCCTGCAGGCCACCGACGCCACCCTGAAGTCCAAGCAAGATGAATTGCACCGGAAGGCACTGCAGACGCT GGAGAGGGCTCAGCAGCTGGCGCCCAGTGACCCCCAGGTCATCCTCTATGTCTCGCTGCAGCTGGCCCTCGTCCGACAGATCTCCAGTGC CATGGAGCAGCTGCAGGAGGCCCTGAAGGTACGCAAGGATGATGCCCACGCCCTCCACCTGCTGGCACTGCTCTTCTCTGCCCAGAAGCA CCACCAGCATGCCCTGGATGTTGTCAACATGGCCATCACCGAGCACCCTGAGAACTTCAACCTGATGTTCACCAAGGTGAAGCTGGAGCA GGTGCTGAAAGGCCCAGAGGAAGCCCTCGTGACCTGCAGACAAGTGCTGAGGCTGTGGCAGACCCTGTACAGCTTCTCCCAGCTGGGAGG CCTAGAAAAGGATGGCAGCTTCGGTGAGGGCCTCACCATGAAGAAGCAGAGTGGCATGCACCTGACTTTGCCTGATGCCCATGATGCAGA CTCTGGCTCCCGGCGGGCTTCGTCCATCGCCGCCTCCCGGCTGGAGGAGGCCATGTCAGAGCTGACTATGCCCTCTTCGGTCCTGAAGCA GGGCCCCATGCAGCTGTGGACCACGCTGGAACAGATCTGGCTGCAGGCTGCTGAGCTGTTCATGGAGCAGCAGCACCTCAAGGAAGCAGG TTTCTGCATCCAGGAGGCGGCGGGCCTCTTCCCCACTTCTCACTCAGTACTCTATATGCGGGGCCGGCTGGCTGAGGTGAAGGGCAACCT GGAGGAGGCCAAGCAGCTGTACAAGGAGGCGCTCACGGTGAACCCAGATGGCGTGCGCATCATGCATAGCCTGGGTCTGATGCTGAGTCG GCTGGGCCACAAGAGCTTGGCCCAGAAGGTGCTTCGTGATGCCGTGGAGAGGCAGAGTACGTGCCACGAGGCGTGGCAGGGCCTGGGCGA GGTGCTGCAGGCCCAGGGCCAGAACGAGGCTGCCGTTGACTGCTTCCTCACCGCCCTTGAGCTGGAGGCCAGCAGCCCTGTACTGCCCTT CTCCATCATCCCCAGAGAGCTCTGACGACGCTGCAGCCGCAGGGAGGGAGGGGCTGGCCAGAGGGAGAGGCAGCAGGGAACGTGGGTCAG >In-frame_MSH2_ENST00000543555_chr2_47630541_+_TTC7A_ENST00000319190_chr2_47177502_+_4757nt AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGATGACTTTGGGAAATTGCTGCTGGCTGA GGCCCTCCTGGAGCAGTGTTTGAAGGAGAACCATGCCAAAATAAAAGACTCCATGCCTTTGCTGGAGAAGAATGAGCCGAAGATGAGCGA AGCCAAAAATTATCTAAGCAGTATCCTTAACCATGGGAGGCTCTCGCCACAGTACATGTGTGAGGCCATGCTGATCCTGGGCAAACTGCA TTACGTGGAGGGCTCATACCGAGATGCCATCAGCATGTACGCACGGGCCGGGATTGATGACATGTCCATGGAGAACAAGCCCCTGTATCA GATGCGGCTGCTGTCGGAGGCTTTTGTCATCAAAGGCCTCTCTCTGGAACGCCTACCCAACTCCATCGCCTCCCGCTTCCGCCTGACAGA GAGGGAGGAGGAAGTGATCACCTGTTTTGAGAGGGCCTCCTGGATCGCTCAGGTGTTCCTGCAGGAATTGGAGAAGACCACAAATAACAG CACGTCGAGGCATCTGAAAGGCTGTCACCCGCTTGACTATGAGCTCACCTACTTCCTGGAAGCTGCCCTCCAGAGCGCCTATGTGAAAAA CCTGAAGAAGGGGAACATCGTGAAGGGCATGAGAGAGCTCCGGGAGGTGCTGCGGACTGTGGAGACCAAAGCAACTCAGAACTTCAAAGT GATGGCGGCCAAGCACCTGGCGGGGGTCCTGCTGCACTCCCTGAGTGAGGAGTGCTACTGGAGCCCCCTGTCCCACCCTCTGCCTGAGTT CATGGGCAAGGAGGAGAGTTCTTTCGCCACTCAGGCCCTGCGGAAACCTCACCTCTATGAAGGAGACAACCTCTACTGCCCCAAGGACAA CATCGAGGAAGCCCTCCTGCTCCTCCTCATCAGCGAATCCATGGCAACTCGAGATGTGGTGCTGAGCCGGGTGCCGGAGCAGGAGGAGGA CCGGACAGTGAGCTTGCAGAATGCCGCAGCCATCTATGACCTCCTGAGCATCACGTTGGGCAGAAGGGGACAGTACGTCATGCTCTCGGA GTGCCTGGAGCGAGCCATGAAGTTTGCGTTTGGAGAATTTCACCTTTGGTACCAGGTGGCCCTCTCCATGGTGGCTTGTGGGAAGTCAGC CTACGCTGTGTCCCTGCTGCGGGAGTGTGTGAAGTTGCGGCCCTCGGACCCCACCGTGCCCCTGATGGCCGCGAAGGTCTGCATCGGGTC CCTTCGCTGGCTAGAGGAAGCAGAGCACTTTGCCATGATGGTGATCAGCCTCGGAGAGGAAGCCGGGGAGTTCCTCCCCAAGGGCTACCT GGCTCTGGGTCTCACCTATAGCCTGCAGGCCACCGACGCCACCCTGAAGTCCAAGCAAGATGAATTGCACCGGAAGGCACTGCAGACGCT GGAGAGGGCTCAGCAGCTGGCGCCCAGTGACCCCCAGGTCATCCTCTATGTCTCGCTGCAGCTGGCCCTCGTCCGACAGATCTCCAGTGC CATGGAGCAGCTGCAGGAGGCCCTGAAGGTACGCAAGGATGATGCCCACGCCCTCCACCTGCTGGCACTGCTCTTCTCTGCCCAGAAGCA CCACCAGCATGCCCTGGATGTTGTCAACATGGCCATCACCGAGCACCCTGAGAACTTCAACCTGATGTTCACCAAGGTGAAGCTGGAGCA GGTGCTGAAAGGCCCAGAGGAAGCCCTCGTGACCTGCAGACAAGTGCTGAGGCTGTGGCAGACCCTGTACAGCTTCTCCCAGCTGGGAGG CCTAGAAAAGGATGGCAGCTTCGGTGAGGGCCTCACCATGAAGAAGCAGAGTGGCATGCACCTGACTTTGCCTGATGCCCATGATGCAGA CTCTGGCTCCCGGCGGGCTTCGTCCATCGCCGCCTCCCGGCTGGAGGAGGCCATGTCAGAGCTGACTATGCCCTCTTCGGTCCTGAAGCA GGGCCCCATGCAGCTGTGGACCACGCTGGAACAGATCTGGCTGCAGGCTGCTGAGCTGTTCATGGAGCAGCAGCACCTCAAGGAAGCAGG TTTCTGCATCCAGGAGGCGGCGGGCCTCTTCCCCACTTCTCACTCAGTACTCTATATGCGGGGCCGGCTGGCTGAGGTGAAGGGCAACCT GGAGGAGGCCAAGCAGCTGTACAAGGAGGCGCTCACGGTGAACCCAGATGGCGTGCGCATCATGCATAGCCTGGGTCTGATGCTGAGTCG GCTGGGCCACAAGAGCTTGGCCCAGAAGGTGCTTCGTGATGCCGTGGAGAGGCAGAGTACGTGCCACGAGGCGTGGCAGGGCCTGGGCGA GGTGCTGCAGGCCCAGGGCCAGAACGAGGCTGCCGTTGACTGCTTCCTCACCGCCCTTGAGCTGGAGGCCAGCAGCCCTGTACTGCCCTT CTCCATCATCCCCAGAGAGCTCTGACGACGCTGCAGCCGCAGGGAGGGAGGGGCTGGCCAGAGGGAGAGGCAGCAGGGAACGTGGGTCAG GGTGGGGCAACAGTGGCATCAGGTGCGGGGCCTCAGGGAAATACATCTTTAGTGAACGCCTCTGCAGCTGCAGCCCTCGTTCTCTTGGCT GGGCCAAGAGGGCCTTCCTGGATTTCTTTGTTGGTGCCTTGGGAAACAGTCTGACTTGAACCCTAAGTGCCTTTGGAGAGTTTTGTGGTG ACCAGACTTGCTCCCCAAGAGCTGGGCAGCGGGGAGCCTCACAGCTGTCCTTCACCCTCACCCATGCCTCTGGCTTGGAGTCTGGGTGGG GGGTTCTCACTCCCCACTCTCAGCACAGTACAGACTTCTGGATCTCTCTCAGGTCTTGCCCAGGGCGGTCACAATGTGAAGAAACTGCGG GCAAGTGGGAAGACTATGAGATTTCTGGGTTCCCTTCTCAGACTTGGAGTTAGTAGATGATTCCTGCATTGCCCCTGCTTGCCCTCTGAG ACCAGCTGGGCCCCACCTTGCTCTTTCCCCCTGCTACCAAGTGCCTTTGGGGTCTGACCAGGGGTACTGAGCACCGGCCCTAACACTTCC ATCTCCACCCACCCCATCTCCCTGGCGATGTGCTCCAGCCCAAGCAGCCTCCGTAGGCTTTAGATCCTGTGGTTGCTAGATCCAGTCCTT TCTAATACCCTGAGTCAACACATTACTCCTGCAGGTCTTAGGCTACAATGCAGGTCCCTTGAGGGCCACCAACATGGAGGTAGGCAGTTT CTAGGACTGTCCCCAGTACATCTCACCACCCACAGCCCTTTTTTTGCCTTGATTCGAGCCTCACCCTGGCCTTTTGGCTTCCCCTGCCTG AGAGAGACCTGAGGAGGGGACAGAGCCCAGCCCCTCTCCTGTGGCTGAGCAGGCCTCTGTGTCCATGACACCTGTCTTCCGGGCCTGGGG GCTGTGGGTGTATGTCCTCCCTACTGGCTTCCCCGGCCCCTGCTGCATGATGCTCTTGGAACTCTTCTCCAAGGAGTCAGTCCCCCAGGC CTATCAGGGGATCCTTTTGTATCTGCACTTTGGGTTTTAGTTTCAAAGCTCCATCAGGTACAGCTTGCATTTCAGGATGTGTGGAAAGCT CGGGTGAGGGCTGCCCTGGTTCATCATAGCTCCACCTTCCTCGGAAGGAGTGGGCTGTTGGAGACCCCCCATCCATGGCACACTAGCTCA GCACTGCATTTCCCGAGATGATTCCCAAGACAGCTGGTGCCTCCTGGCTTTCCTGTGCCAGGCCAAGGGGCACCACAGAGGACCCTGGAT CCTTTGCCTCTTCTTGGTTGAAGGATCTCTATGTATGTGTGTATATAAATATAGTTTTTTATCTATATATATAAAATAGAGATCTATTTT TTTTCTGGAATTCTGTTAGAAAAGTAAAGAAAAAGCAAATGCTGTTGGTTTATCTCAGGGTGCCCAAAGTGGTTATAGTCAATTTTTGGT ACTAGGAAAGGCACCCAATGCATTTCCTGACTTTTAAGCATTTCCTTGTTGGAAGCAGCAGAGGGCCAGGCCAAGTTGCTGACAGTGACT TTGCAGGTTGAATAAAGAAACCCTTGGAGGGGAAGCAGGCTTGTCTGAAGCAGCATGTATATTCACTGGGCATGTAGCTCCCACACCAGC CTTGAGCCAGGCCCTGGACAGGAGGGGCTGTTGCAGGATGAGGGAGGCCAGAGAAGGCATCGAAGCCAAGACCTGGGCCCACCTGGGGAG GGATGTGGGAAAGGAAGGATGGGAGGGAGGACCCTCTGGGAAAATGTGGATTTGAGCTGGTGAGAGTGTTGCTAAGGCTGGGCTAAAGCC TGGAGAGGGTAGGAGGAGGCAAGAGGGGTCCAGGCAGGGCTGATCCTGGCCTCTGACCTGTCCAGGGCGACCCCTGAAGCCCCTGCTGCC TCTGGGCATTGCTGGGAGAGGCCAAGGCAGGACTCACGTCTGAACAGAGATCCCCTCGGGCATTGCTGATGGGCCACCTTCAGCTGCAGG GAAGAAGCCTAGGAGAGGAGGCATGGGAGGGACCTGGGCCTTGTTCAGATTGGCCACCTCTGCTGAGAAGTCCATACCAGTACACCCCTA >In-frame_MSH2_ENST00000406134_chr2_47630541_+_TTC7A_ENST00000409245_chr2_47177502_+_2791nt AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG CAGATGACTTTGGGAAATTGCTGCTGGCTGAGGCCCTCCTGGAGCAGTGTTTGAAGGAGAACCATGCCAAAATAAAAGACTCCATGCCTT TGCTGGAGAAGAATGAGCCGAAGATGAGCGAAGCCAAAAATTATCTAAGCAGTATCCTTAACCATGGGAGGCTCTCGCCACAGTACATGT GTGAGGCCATGCTGATCCTGGGCAAACTGCATTACGTGGAGGGCTCATACCGAGATGCCATCAGCATGTACGCACGGGCCGGGATTGATG ACATGTCCATGGAGAACAAGCCCCTGTATCAGATGCGGCTGCTGTCGGAGGCTTTTGTCATCAAAGGCCTCTCTCTGGAACGCCTACCCA ACTCCATCGCCTCCCGCTTCCGCCTGACAGAGAGGGAGGAGGAAGTGATCACCTGTTTTGAGAGGGCCTCCTGGATCGCTCAGGTGTTCC TGCAGGAATTGGAGAAGACCACAAATAACAGCACGTCGAGGCATCTGAAAGGCTGTCACCCGCTTGACTATGAGCTCACCTACTTCCTGG AAGCTGCCCTCCAGAGCGCCTATGTGAAAAACCTGAAGAAGGGGAACATCGTGAAGGGCATGAGAGAGCTCCGGGAGGTGCTGCGGACTG TGGAGACCAAAGCAACTCAGAACTTCAAAGTGATGGCGGCCAAGCACCTGGCGGGGGTCCTGCTGCACTCCCTGAGTGAGGAGTGCTACT GGAGCCCCCTGTCCCACCCTCTGCCTGAGTTCATGGGCAAGGAGGAGAGTTCTTTCGCCACTCAGGCCCTGCGGAAACCTCACCTCTATG AAGGAGACAACCTCTACTGCCCCAAGGACAACATCGAGGAAGCCCTCCTGCTCCTCCTCATCAGCGAATCCATGGCAACTCGAGATGTGG TGCTGAGCCGGGTGCCGGAGCAGGAGGAGGACCGGACAGTGAGCTTGCAGAATGCCGCAGCCATCTATGACCTCCTGAGCATCACGTTGG GCAGAAGGGGACAGTACGTCATGCTCTCGGAGTGCCTGGAGCGAGCCATGAAGTTTGCGTTTGGAGAATTTCACCTTTGGTACCAGGTGG CCCTCTCCATGGTGGCTTGTGGGAAGTCAGCCTACGCTGTGTCCCTGCTGCGGGAGTGTGTGAAGTTGCGGCCCTCGGACCCCACCGTGC CCCTGATGGCCGCGAAGGTCTGCATCGGGTCCCTTCGCTGGCTAGAGGAAGCAGAGCACTTTGCCATGATGGTGATCAGCCTCGGAGAGG AAGCCGGGGAGTTCCTCCCCAAGGGCTACCTGGCTCTGGGTCTCACCTATAGCCTGCAGGCCACCGACGCCACCCTGAAGTCCAAGCAAG ATGAATTGCACCGGAAGGCACTGCAGACGCTGGAGAGGGCTCAGCAGCTGGCGCCCAGTGACCCCCAGGTCATCCTCTATGTCTCGCTGC AGCTGGCCCTCGTCCGACAGATCTCCAGTGCCATGGAGCAGCTGCAGGAGGCCCTGAAGGTACGCAAGGATGATGCCCACGCCCTCCACC TGCTGGCACTGCTCTTCTCTGCCCAGAAGCACCACCAGCATGCCCTGGATGTTGTCAACATGGCCATCACCGAGCACCCTGAGAACTTCA ACCTGATGTTCACCAAGGTGAAGCTGGAGCAGGTGCTGAAAGGCCCAGAGGAAGCCCTCGTGACCTGCAGACAAGTGCTGAGGCTGTGGC AGACCCTGTACAGCTTCTCCCAGCTGGGAGGCCTAGAAAAGGATGGCAGCTTCGGTGAGGGCCTCACCATGAAGAAGCAGAGTGGCATGC ACCTGACTTTGCCTGATGCCCATGATGCAGACTCTGGCTCCCGGCGGGCTTCGTCCATCGCCGCCTCCCGGCTGGAGGAGGCCATGTCAG AGCTGACTATGCCCTCTTCGGTCCTGAAGCAGGGCCCCATGCAGCTGTGGACCACGCTGGAACAGATCTGGCTGCAGGCTGCTGAGCTGT TCATGGAGCAGCAGCACCTCAAGGAAGCAGGTTTCTGCATCCAGGAGGCGGCGGGCCTCTTCCCCACTTCTCACTCAGTACTCTATATGC GGGGCCGGCTGGCTGAGGTGAAGGGCAACCTGGAGGAGGCCAAGCAGCTGTACAAGGAGGCGCTCACGGTGAACCCAGATGGCGTGCGCA TCATGCATAGCCTGGGTCTGATGCTGAGTCGGCTGGGCCACAAGAGCTTGGCCCAGAAGGTGCTTCGTGATGCCGTGGAGAGGCAGAGTA CGTGCCACGAGGCGTGGCAGGGCCTGGGCGAGGTGCTGCAGGCCCAGGGCCAGAACGAGGCTGCCGTTGACTGCTTCCTCACCGCCCTTG AGCTGGAGGCCAGCAGCCCTGTACTGCCCTTCTCCATCATCCCCAGAGAGCTCTGACGACGCTGCAGCCGCAGGGAGGGAGGGGCTGGCC AGAGGGAGAGGCAGCAGGGAACGTGGGTCAGGGTGGGGCAACAGTGGCATCAGGTGCGGGGCCTCAGGGAAATACATCTTTAGTGAACGC >In-frame_MSH2_ENST00000406134_chr2_47630541_+_TTC7A_ENST00000319190_chr2_47177502_+_4878nt AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG CAGATGACTTTGGGAAATTGCTGCTGGCTGAGGCCCTCCTGGAGCAGTGTTTGAAGGAGAACCATGCCAAAATAAAAGACTCCATGCCTT TGCTGGAGAAGAATGAGCCGAAGATGAGCGAAGCCAAAAATTATCTAAGCAGTATCCTTAACCATGGGAGGCTCTCGCCACAGTACATGT GTGAGGCCATGCTGATCCTGGGCAAACTGCATTACGTGGAGGGCTCATACCGAGATGCCATCAGCATGTACGCACGGGCCGGGATTGATG ACATGTCCATGGAGAACAAGCCCCTGTATCAGATGCGGCTGCTGTCGGAGGCTTTTGTCATCAAAGGCCTCTCTCTGGAACGCCTACCCA ACTCCATCGCCTCCCGCTTCCGCCTGACAGAGAGGGAGGAGGAAGTGATCACCTGTTTTGAGAGGGCCTCCTGGATCGCTCAGGTGTTCC TGCAGGAATTGGAGAAGACCACAAATAACAGCACGTCGAGGCATCTGAAAGGCTGTCACCCGCTTGACTATGAGCTCACCTACTTCCTGG AAGCTGCCCTCCAGAGCGCCTATGTGAAAAACCTGAAGAAGGGGAACATCGTGAAGGGCATGAGAGAGCTCCGGGAGGTGCTGCGGACTG TGGAGACCAAAGCAACTCAGAACTTCAAAGTGATGGCGGCCAAGCACCTGGCGGGGGTCCTGCTGCACTCCCTGAGTGAGGAGTGCTACT GGAGCCCCCTGTCCCACCCTCTGCCTGAGTTCATGGGCAAGGAGGAGAGTTCTTTCGCCACTCAGGCCCTGCGGAAACCTCACCTCTATG AAGGAGACAACCTCTACTGCCCCAAGGACAACATCGAGGAAGCCCTCCTGCTCCTCCTCATCAGCGAATCCATGGCAACTCGAGATGTGG TGCTGAGCCGGGTGCCGGAGCAGGAGGAGGACCGGACAGTGAGCTTGCAGAATGCCGCAGCCATCTATGACCTCCTGAGCATCACGTTGG GCAGAAGGGGACAGTACGTCATGCTCTCGGAGTGCCTGGAGCGAGCCATGAAGTTTGCGTTTGGAGAATTTCACCTTTGGTACCAGGTGG CCCTCTCCATGGTGGCTTGTGGGAAGTCAGCCTACGCTGTGTCCCTGCTGCGGGAGTGTGTGAAGTTGCGGCCCTCGGACCCCACCGTGC CCCTGATGGCCGCGAAGGTCTGCATCGGGTCCCTTCGCTGGCTAGAGGAAGCAGAGCACTTTGCCATGATGGTGATCAGCCTCGGAGAGG AAGCCGGGGAGTTCCTCCCCAAGGGCTACCTGGCTCTGGGTCTCACCTATAGCCTGCAGGCCACCGACGCCACCCTGAAGTCCAAGCAAG ATGAATTGCACCGGAAGGCACTGCAGACGCTGGAGAGGGCTCAGCAGCTGGCGCCCAGTGACCCCCAGGTCATCCTCTATGTCTCGCTGC AGCTGGCCCTCGTCCGACAGATCTCCAGTGCCATGGAGCAGCTGCAGGAGGCCCTGAAGGTACGCAAGGATGATGCCCACGCCCTCCACC TGCTGGCACTGCTCTTCTCTGCCCAGAAGCACCACCAGCATGCCCTGGATGTTGTCAACATGGCCATCACCGAGCACCCTGAGAACTTCA ACCTGATGTTCACCAAGGTGAAGCTGGAGCAGGTGCTGAAAGGCCCAGAGGAAGCCCTCGTGACCTGCAGACAAGTGCTGAGGCTGTGGC AGACCCTGTACAGCTTCTCCCAGCTGGGAGGCCTAGAAAAGGATGGCAGCTTCGGTGAGGGCCTCACCATGAAGAAGCAGAGTGGCATGC ACCTGACTTTGCCTGATGCCCATGATGCAGACTCTGGCTCCCGGCGGGCTTCGTCCATCGCCGCCTCCCGGCTGGAGGAGGCCATGTCAG AGCTGACTATGCCCTCTTCGGTCCTGAAGCAGGGCCCCATGCAGCTGTGGACCACGCTGGAACAGATCTGGCTGCAGGCTGCTGAGCTGT TCATGGAGCAGCAGCACCTCAAGGAAGCAGGTTTCTGCATCCAGGAGGCGGCGGGCCTCTTCCCCACTTCTCACTCAGTACTCTATATGC GGGGCCGGCTGGCTGAGGTGAAGGGCAACCTGGAGGAGGCCAAGCAGCTGTACAAGGAGGCGCTCACGGTGAACCCAGATGGCGTGCGCA TCATGCATAGCCTGGGTCTGATGCTGAGTCGGCTGGGCCACAAGAGCTTGGCCCAGAAGGTGCTTCGTGATGCCGTGGAGAGGCAGAGTA CGTGCCACGAGGCGTGGCAGGGCCTGGGCGAGGTGCTGCAGGCCCAGGGCCAGAACGAGGCTGCCGTTGACTGCTTCCTCACCGCCCTTG AGCTGGAGGCCAGCAGCCCTGTACTGCCCTTCTCCATCATCCCCAGAGAGCTCTGACGACGCTGCAGCCGCAGGGAGGGAGGGGCTGGCC AGAGGGAGAGGCAGCAGGGAACGTGGGTCAGGGTGGGGCAACAGTGGCATCAGGTGCGGGGCCTCAGGGAAATACATCTTTAGTGAACGC CTCTGCAGCTGCAGCCCTCGTTCTCTTGGCTGGGCCAAGAGGGCCTTCCTGGATTTCTTTGTTGGTGCCTTGGGAAACAGTCTGACTTGA ACCCTAAGTGCCTTTGGAGAGTTTTGTGGTGACCAGACTTGCTCCCCAAGAGCTGGGCAGCGGGGAGCCTCACAGCTGTCCTTCACCCTC ACCCATGCCTCTGGCTTGGAGTCTGGGTGGGGGGTTCTCACTCCCCACTCTCAGCACAGTACAGACTTCTGGATCTCTCTCAGGTCTTGC CCAGGGCGGTCACAATGTGAAGAAACTGCGGGCAAGTGGGAAGACTATGAGATTTCTGGGTTCCCTTCTCAGACTTGGAGTTAGTAGATG ATTCCTGCATTGCCCCTGCTTGCCCTCTGAGACCAGCTGGGCCCCACCTTGCTCTTTCCCCCTGCTACCAAGTGCCTTTGGGGTCTGACC AGGGGTACTGAGCACCGGCCCTAACACTTCCATCTCCACCCACCCCATCTCCCTGGCGATGTGCTCCAGCCCAAGCAGCCTCCGTAGGCT TTAGATCCTGTGGTTGCTAGATCCAGTCCTTTCTAATACCCTGAGTCAACACATTACTCCTGCAGGTCTTAGGCTACAATGCAGGTCCCT TGAGGGCCACCAACATGGAGGTAGGCAGTTTCTAGGACTGTCCCCAGTACATCTCACCACCCACAGCCCTTTTTTTGCCTTGATTCGAGC CTCACCCTGGCCTTTTGGCTTCCCCTGCCTGAGAGAGACCTGAGGAGGGGACAGAGCCCAGCCCCTCTCCTGTGGCTGAGCAGGCCTCTG TGTCCATGACACCTGTCTTCCGGGCCTGGGGGCTGTGGGTGTATGTCCTCCCTACTGGCTTCCCCGGCCCCTGCTGCATGATGCTCTTGG AACTCTTCTCCAAGGAGTCAGTCCCCCAGGCCTATCAGGGGATCCTTTTGTATCTGCACTTTGGGTTTTAGTTTCAAAGCTCCATCAGGT ACAGCTTGCATTTCAGGATGTGTGGAAAGCTCGGGTGAGGGCTGCCCTGGTTCATCATAGCTCCACCTTCCTCGGAAGGAGTGGGCTGTT GGAGACCCCCCATCCATGGCACACTAGCTCAGCACTGCATTTCCCGAGATGATTCCCAAGACAGCTGGTGCCTCCTGGCTTTCCTGTGCC AGGCCAAGGGGCACCACAGAGGACCCTGGATCCTTTGCCTCTTCTTGGTTGAAGGATCTCTATGTATGTGTGTATATAAATATAGTTTTT TATCTATATATATAAAATAGAGATCTATTTTTTTTCTGGAATTCTGTTAGAAAAGTAAAGAAAAAGCAAATGCTGTTGGTTTATCTCAGG GTGCCCAAAGTGGTTATAGTCAATTTTTGGTACTAGGAAAGGCACCCAATGCATTTCCTGACTTTTAAGCATTTCCTTGTTGGAAGCAGC AGAGGGCCAGGCCAAGTTGCTGACAGTGACTTTGCAGGTTGAATAAAGAAACCCTTGGAGGGGAAGCAGGCTTGTCTGAAGCAGCATGTA TATTCACTGGGCATGTAGCTCCCACACCAGCCTTGAGCCAGGCCCTGGACAGGAGGGGCTGTTGCAGGATGAGGGAGGCCAGAGAAGGCA TCGAAGCCAAGACCTGGGCCCACCTGGGGAGGGATGTGGGAAAGGAAGGATGGGAGGGAGGACCCTCTGGGAAAATGTGGATTTGAGCTG GTGAGAGTGTTGCTAAGGCTGGGCTAAAGCCTGGAGAGGGTAGGAGGAGGCAAGAGGGGTCCAGGCAGGGCTGATCCTGGCCTCTGACCT GTCCAGGGCGACCCCTGAAGCCCCTGCTGCCTCTGGGCATTGCTGGGAGAGGCCAAGGCAGGACTCACGTCTGAACAGAGATCCCCTCGG GCATTGCTGATGGGCCACCTTCAGCTGCAGGGAAGAAGCCTAGGAGAGGAGGCATGGGAGGGACCTGGGCCTTGTTCAGATTGGCCACCT CTGCTGAGAAGTCCATACCAGTACACCCCTAATAAGTTATGCCACATACCAACGTACTGTGGATATTATAACCTGCATTAAAACAACTCT |
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FusionGenePPI for MSH2_TTC7A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MSH2 | BRCA1, PTP4A3, BARD1, BLM, CHEK1, CHEK2, ATM, MLH1, MRE11A, NBN, RAD50, MSH6, RFC1, MSH3, ATR, MAX, MYC, ATRIP, PCNA, MSH2, EXO1, OTUB1, SLX4, PMS2, AIRE, PRKCZ, XPA, RPA4, MGMT, TP53, ESR1, ESR2, SNW1, CREBBP, FANCA, GRB7, RPP14, TK1, CDKN1A, SMN1, ANXA7, DTL, SMARCAD1, CDK9, NELFB, PMS1, RAD51, XRCC6, SIRT7, FANCD2, CDK2, HUS1, RAD1, RAD9A, MUTYH, SRSF5, SART1, SRSF11, SRSF7, IK, RBM25, SMARCA5, SRSF10, RPS24, TOP2B, SEPT9, RAD21, HNRNPD, SUPT16H, ERCC1, ERCC4, HDAC6, ATP6V1B2, CUL2, JUP, DPYSL3, XRCC5, NRD1, PDE3A, SEC23A, ST13, STAT3, SUPT5H, RPA3, RPA2, RPA1, POLK, REV1, CCDC8, SUMO2, SIRT6, ANXA6, DNAJC9, EIF3B, FEN1, AARS, CIAPIN1, DHX15, PFDN4, RECQL, RPLP0, RPS5, TRIP13, ZW10, NMD3, SNX27, TIPRL, TPP2, TPT1, NTRK1, CEP19, E2F3, CDC5L, RNF126, UBXN8, FAF2, USP10, ZNF746, CDC14B, RAF1, RPGRIP1L, BRIP1, TOP1, TOP2A, TOP3A, TRIM25, TES, MCM9, MCM8 | TTC7A | CHMP4B, CDH1, CAMKV, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MSH2 | chr2:47630541 | chr2:47177502 | ENST00000233146 | + | 1 | 16 | 601_671 | 70 | 935 | EXO1 |
| Hgene | MSH2 | chr2:47630541 | chr2:47177502 | ENST00000543555 | + | 2 | 17 | 601_671 | 4 | 869 | EXO1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MSH2_TTC7A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MSH2_TTC7A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MSH2 | C2936783 | Colorectal cancer, hereditary nonpolyposis, type 1 | 48 | UNIPROT |
| Hgene | MSH2 | C0009405 | Hereditary Nonpolyposis Colorectal Neoplasms | 4 | CTD_human |
| Hgene | MSH2 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | MSH2 | C0919267 | ovarian neoplasm | 1 | CTD_human |
| Hgene | MSH2 | C2931459 | Lynch syndrome I (site-specific colonic cancer) | 1 | CTD_human |
| Tgene | TTC7A | C0220744 | Multiple gastrointestinal atresias (disorder) | 6 | ORPHANET;UNIPROT |
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