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Fusion gene ID: 22606 |
FusionGeneSummary for MSH2_SLC3A1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MSH2_SLC3A1 | Fusion gene ID: 22606 | Hgene | Tgene | Gene symbol | MSH2 | SLC3A1 | Gene ID | 4436 | 6519 |
| Gene name | mutS homolog 2 | solute carrier family 3 member 1 | |
| Synonyms | COCA1|FCC1|HNPCC|HNPCC1|LCFS2 | ATR1|CSNU1|D2H|NBAT|RBAT | |
| Cytomap | 2p21-p16.3 | 2p21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA mismatch repair protein Msh2hMSH2mutS homolog 2, colon cancer, nonpolyposis type 1 | neutral and basic amino acid transport protein rBATB(0,+)-type amino acid transport proteinSLC3A1 variant BSLC3A1 variant CSLC3A1 variant DSLC3A1 variant ESLC3A1 variant FSLC3A1 variant Gamino acid transporter 1solute carrier family 3 (amino acid | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P43246 | Q07837 | |
| Ensembl transtripts involved in fusion gene | ENST00000233146, ENST00000543555, ENST00000406134, ENST00000461394, | ENST00000260649, ENST00000409387, ENST00000410056, ENST00000409741, ENST00000409229, ENST00000409380, ENST00000409294, ENST00000409740, | |
| Fusion gene scores | * DoF score | 8 X 6 X 8=384 | 2 X 2 X 2=8 |
| # samples | 10 | 2 | |
| ** MAII score | log2(10/384*10)=-1.94110631094643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: MSH2 [Title/Abstract] AND SLC3A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MSH2 | GO:0006281 | DNA repair | 8942985 |
| Hgene | MSH2 | GO:0006298 | mismatch repair | 7923193|11555625 |
| Hgene | MSH2 | GO:0006301 | postreplication repair | 7923193 |
| Hgene | MSH2 | GO:0045910 | negative regulation of DNA recombination | 17715146 |
| Hgene | MSH2 | GO:0051096 | positive regulation of helicase activity | 17715146 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A04U-01A | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000233146 | ENST00000260649 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| In-frame | ENST00000233146 | ENST00000409387 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000233146 | ENST00000410056 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000233146 | ENST00000409741 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000233146 | ENST00000409229 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000233146 | ENST00000409380 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000233146 | ENST00000409294 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000233146 | ENST00000409740 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| In-frame | ENST00000543555 | ENST00000260649 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| In-frame | ENST00000543555 | ENST00000409387 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000543555 | ENST00000410056 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000543555 | ENST00000409741 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000543555 | ENST00000409229 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000543555 | ENST00000409380 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000543555 | ENST00000409294 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000543555 | ENST00000409740 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| In-frame | ENST00000406134 | ENST00000260649 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| In-frame | ENST00000406134 | ENST00000409387 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000406134 | ENST00000410056 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000406134 | ENST00000409741 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000406134 | ENST00000409229 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000406134 | ENST00000409380 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000406134 | ENST00000409294 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| 5CDS-intron | ENST00000406134 | ENST00000409740 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| intron-3CDS | ENST00000461394 | ENST00000260649 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| intron-3CDS | ENST00000461394 | ENST00000409387 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| intron-intron | ENST00000461394 | ENST00000410056 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| intron-intron | ENST00000461394 | ENST00000409741 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| intron-intron | ENST00000461394 | ENST00000409229 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| intron-intron | ENST00000461394 | ENST00000409380 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| intron-intron | ENST00000461394 | ENST00000409294 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
| intron-intron | ENST00000461394 | ENST00000409740 | MSH2 | chr2 | 47637511 | + | SLC3A1 | chr2 | 44539725 | + |
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FusionProtFeatures for MSH2_SLC3A1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MSH2 | SLC3A1 |
| Component of the post-replicative DNA mismatch repairsystem (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) whichbinds to DNA mismatches thereby initiating DNA repair. When bound,heterodimers bend the DNA helix and shields approximately 20 basepairs. MutS alpha recognizes single base mismatches anddinucleotide insertion-deletion loops (IDL) in the DNA. MutS betarecognizes larger insertion-deletion loops up to 13 nucleotideslong. After mismatch binding, MutS alpha or beta forms a ternarycomplex with the MutL alpha heterodimer, which is thought to beresponsible for directing the downstream MMR events, includingstrand discrimination, excision, and resynthesis. ATP binding andhydrolysis play a pivotal role in mismatch repair functions. TheATPase activity associated with MutS alpha regulates bindingsimilar to a molecular switch: mismatched DNA provokes ADP-->ATPexchange, resulting in a discernible conformational transitionthat converts MutS alpha into a sliding clamp capable ofhydrolysis-independent diffusion along the DNA backbone. Thistransition is crucial for mismatch repair. MutS alpha may alsoplay a role in DNA homologous recombination repair. In melanocytesmay modulate both UV-B-induced cell cycle regulation andapoptosis. {ECO:0000269|PubMed:10078208,ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730,ECO:0000269|PubMed:17611581, ECO:0000269|PubMed:21120944,ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679,ECO:0000269|PubMed:9822680}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MSH2 | chr2:47637511 | chr2:44539725 | ENST00000233146 | + | 3 | 16 | 669_676 | 215 | 935 | Nucleotide binding | ATP |
| Hgene | >MSH2 | chr2:47637511 | chr2:44539725 | ENST00000543555 | + | 4 | 17 | 669_676 | 149 | 869 | Nucleotide binding | ATP |
| Tgene | SLC3A1 | chr2:47637511 | chr2:44539725 | ENST00000260649 | + | 6 | 10 | 109_685 | 444 | 686 | Topological domain | Extracellular |
| Tgene | SLC3A1 | chr2:47637511 | chr2:44539725 | ENST00000260649 | + | 6 | 10 | 1_87 | 444 | 686 | Topological domain | Cytoplasmic |
| Tgene | SLC3A1 | chr2:47637511 | chr2:44539725 | ENST00000260649 | + | 6 | 10 | 88_108 | 444 | 686 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for MSH2_SLC3A1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MSH2_ENST00000233146_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_457aa MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYD INTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGI DRIFIVVLNFGESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLN >In-frame_MSH2_ENST00000233146_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_336aa MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYD >In-frame_MSH2_ENST00000543555_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_391aa MGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVD GQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGT PITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLL NRGWFCHLRNDSHYVVYTRELDGIDRIFIVVLNFGESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNL >In-frame_MSH2_ENST00000543555_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_270aa MGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVD GQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGT PITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDSCSVTHARVQWRDLGTLQPLLPGFKX >In-frame_MSH2_ENST00000406134_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_457aa MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYD INTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGI DRIFIVVLNFGESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLN >In-frame_MSH2_ENST00000406134_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_336aa MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MSH2_ENST00000233146_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_1371nt ATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCG ACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACC CAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAA GATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCA TATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTT AAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGAT AATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATG GGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTT TTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGAT ATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACC AATTCAGATTACCACACTGTGAATGTTGATGTCCAAAAGACTCAGCCCAGATCGGCTTTGAAGTTATATCAAGATTTAAGTCTACTTCAT GCCAATGAGCTACTCCTCAACAGGGGCTGGTTTTGCCATTTGAGGAATGACAGCCACTATGTTGTGTACACAAGAGAGCTGGATGGCATC GACAGAATCTTTATCGTGGTTCTGAATTTTGGAGAATCAACACTGTTAAATCTACATAATATGATTTCGGGCCTTCCCGCTAAAATGAGA ATAAGGTTAAGTACCAATTCTGCCGACAAAGGCAGTAAAGTTGATACAAGTGGCATTTTTCTGGACAAGGGAGAGGGACTCATCTTTGAA CACAACACGAAGAATCTCCTTCATCGCCAAACAGCTTTCAGAGATAGATGCTTTGTTTCCAATCGAGCATGCTATTCCAGTGTACTGAAC >In-frame_MSH2_ENST00000233146_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_1008nt ATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCG ACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACC CAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAA GATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCA TATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTT AAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGAT AATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATG GGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTT TTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGAT ATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACC AATTCAGATTACCACACTGTGAATGTTGATTCTTGCTCCGTCACCCATGCTCGAGTGCAGTGGCGTGATCTCGGCACACTGCAGCCTCTG >In-frame_MSH2_ENST00000543555_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_1173nt ATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGT CAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGC AATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGAT GGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAAT CTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATT GGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACT CCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCA AAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACT GTGAATGTTGATGTCCAAAAGACTCAGCCCAGATCGGCTTTGAAGTTATATCAAGATTTAAGTCTACTTCATGCCAATGAGCTACTCCTC AACAGGGGCTGGTTTTGCCATTTGAGGAATGACAGCCACTATGTTGTGTACACAAGAGAGCTGGATGGCATCGACAGAATCTTTATCGTG GTTCTGAATTTTGGAGAATCAACACTGTTAAATCTACATAATATGATTTCGGGCCTTCCCGCTAAAATGAGAATAAGGTTAAGTACCAAT TCTGCCGACAAAGGCAGTAAAGTTGATACAAGTGGCATTTTTCTGGACAAGGGAGAGGGACTCATCTTTGAACACAACACGAAGAATCTC CTTCATCGCCAAACAGCTTTCAGAGATAGATGCTTTGTTTCCAATCGAGCATGCTATTCCAGTGTACTGAACATACTGTATACCTCGTGT >In-frame_MSH2_ENST00000543555_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_810nt ATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGT CAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGC AATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGAT GGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAAT CTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATT GGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACT CCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCA AAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACT GTGAATGTTGATTCTTGCTCCGTCACCCATGCTCGAGTGCAGTGGCGTGATCTCGGCACACTGCAGCCTCTGCTTCCTGGGTTCAAGTGA >In-frame_MSH2_ENST00000406134_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_1371nt ATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCG ACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACC CAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAA GATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCA TATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTT AAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGAT AATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATG GGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTT TTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGAT ATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACC AATTCAGATTACCACACTGTGAATGTTGATGTCCAAAAGACTCAGCCCAGATCGGCTTTGAAGTTATATCAAGATTTAAGTCTACTTCAT GCCAATGAGCTACTCCTCAACAGGGGCTGGTTTTGCCATTTGAGGAATGACAGCCACTATGTTGTGTACACAAGAGAGCTGGATGGCATC GACAGAATCTTTATCGTGGTTCTGAATTTTGGAGAATCAACACTGTTAAATCTACATAATATGATTTCGGGCCTTCCCGCTAAAATGAGA ATAAGGTTAAGTACCAATTCTGCCGACAAAGGCAGTAAAGTTGATACAAGTGGCATTTTTCTGGACAAGGGAGAGGGACTCATCTTTGAA CACAACACGAAGAATCTCCTTCATCGCCAAACAGCTTTCAGAGATAGATGCTTTGTTTCCAATCGAGCATGCTATTCCAGTGTACTGAAC >In-frame_MSH2_ENST00000406134_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_1008nt ATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCG ACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACC CAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAA GATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCA TATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTT AAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGAT AATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATG GGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTT TTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGAT ATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACC AATTCAGATTACCACACTGTGAATGTTGATTCTTGCTCCGTCACCCATGCTCGAGTGCAGTGGCGTGATCTCGGCACACTGCAGCCTCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MSH2_ENST00000233146_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_2449nt GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCA GAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAG AGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTT TGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGT GGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACC AAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTC GCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGG AATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTC AAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTGATGTCCAAAAGACTCAGCC CAGATCGGCTTTGAAGTTATATCAAGATTTAAGTCTACTTCATGCCAATGAGCTACTCCTCAACAGGGGCTGGTTTTGCCATTTGAGGAA TGACAGCCACTATGTTGTGTACACAAGAGAGCTGGATGGCATCGACAGAATCTTTATCGTGGTTCTGAATTTTGGAGAATCAACACTGTT AAATCTACATAATATGATTTCGGGCCTTCCCGCTAAAATGAGAATAAGGTTAAGTACCAATTCTGCCGACAAAGGCAGTAAAGTTGATAC AAGTGGCATTTTTCTGGACAAGGGAGAGGGACTCATCTTTGAACACAACACGAAGAATCTCCTTCATCGCCAAACAGCTTTCAGAGATAG ATGCTTTGTTTCCAATCGAGCATGCTATTCCAGTGTACTGAACATACTGTATACCTCGTGTTAGGCACCTTTATGAAGAGATGAAGACAC TGGCATTTCAGTGGGATTGTAAGCATTTGTAATAGCTTCATGTACAGCATGCTGCTTGGTGAACAATCATTAATTCTTCGATATTTCTGT AGCTTGAATGTAACTGCTTTAAGAAAGGTTCTCAAATGTTTTGAAAAAAATAAAATGTTTAAAAGTAAATTATGGCTTATAGGAGCTTAT AACTTTATTCAGATAGCATCAATCAGGGATGACCAGAACACATTAGGACCCCAGATTATTCAAAAACTTTAACGAATTTTAAGGGGAAGA ATTTTATCTTTTCCCTTAAAATGCAGTCATAGAAATTAGAGGATGACTCACTGCCACAGTGTCTAAAAGCATTTGCTAGCAAAGAGGCAG GACACTAATTTGTAAACTGCTCAACTGTTCTGACTGGAAGGGAGGCCTGGAGCTCTGCTATCACCAATCCTTCCCTTCCCTCTACTCCAC ATCCTTCTAAGGAGCATGATTTGAAAATTACTTTCCTAGGTTAATGGGCATGTGCATCAATGGAGAGAATAGTATAAGCAAGTGAGATGT AGACTAAGCAAAATTTAGATGGAGAAGCACATTTTAAAAAATTAATAACTTAAAAGTCTCAAGTTATTAATTTTTTTTTTGCTAACTCAA TTGGAAGTAAGACTATGAAATATTTCAGTGTGTTTCCAATTCCCAGTTGAATGCAGTGTTTCAGAATTTCAGGTATTTCTTAAGATCCTC GAAAACACTGGTGCTGTCAAGTCCAAGTTCCTCGTACAGGAATTTAATTTGGGCTGTAATCTAAAAGAAACACATTAAAAAAATTAAATA >In-frame_MSH2_ENST00000233146_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_1791nt GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCA GAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAG AGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTT TGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGT GGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACC AAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTC GCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGG AATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTC AAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTGATTCTTGCTCCGTCACCCA TGCTCGAGTGCAGTGGCGTGATCTCGGCACACTGCAGCCTCTGCTTCCTGGGTTCAAGTGATTCTCCTGCTGCAGCCTCCCAAGTAGCTG GGATTACAGGTGCACGTCATTATGCCCGGGTAATTTCTGTATTTTTTAGTAGAGATGGTGTTTCACCATGTTGGCCAGGCTGGTCTTGAA CTCCTGACCTCTGGTGATCTGTCTGCCTTGCCTCCCAAAGTGCTAGGATTACGGGCCTGAGCCACCTTGCCTGGCCTGCAAAATTTGTTT TTAATAGAAGACACAAGAAATGATTTAAATATTTTATCAACAGAAAACCAGTTCTATCAACTATGGGCCCAGTATGCAGCTTTTAAAAAT GACAGTTCTATATACATTGATATGAGACCATTTCAAACAGGTATTCAATAAAGTATAGAATGGTAACATATCACCAACTGTGTAAAGAAA AATATATAAACATATGAAATGATACATTCTGTGCCTATGCAAACATATGATACATTAAAAACAAAAGAACATATAGTGCCTGTCTCTGAG >In-frame_MSH2_ENST00000543555_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_2167nt AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCT TAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAA GGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGA TATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACA GAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGT TTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAA TCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATAT TGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTT TTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTGATGTCCAAAAGACTCAGCCCAGATCGGCTTT GAAGTTATATCAAGATTTAAGTCTACTTCATGCCAATGAGCTACTCCTCAACAGGGGCTGGTTTTGCCATTTGAGGAATGACAGCCACTA TGTTGTGTACACAAGAGAGCTGGATGGCATCGACAGAATCTTTATCGTGGTTCTGAATTTTGGAGAATCAACACTGTTAAATCTACATAA TATGATTTCGGGCCTTCCCGCTAAAATGAGAATAAGGTTAAGTACCAATTCTGCCGACAAAGGCAGTAAAGTTGATACAAGTGGCATTTT TCTGGACAAGGGAGAGGGACTCATCTTTGAACACAACACGAAGAATCTCCTTCATCGCCAAACAGCTTTCAGAGATAGATGCTTTGTTTC CAATCGAGCATGCTATTCCAGTGTACTGAACATACTGTATACCTCGTGTTAGGCACCTTTATGAAGAGATGAAGACACTGGCATTTCAGT GGGATTGTAAGCATTTGTAATAGCTTCATGTACAGCATGCTGCTTGGTGAACAATCATTAATTCTTCGATATTTCTGTAGCTTGAATGTA ACTGCTTTAAGAAAGGTTCTCAAATGTTTTGAAAAAAATAAAATGTTTAAAAGTAAATTATGGCTTATAGGAGCTTATAACTTTATTCAG ATAGCATCAATCAGGGATGACCAGAACACATTAGGACCCCAGATTATTCAAAAACTTTAACGAATTTTAAGGGGAAGAATTTTATCTTTT CCCTTAAAATGCAGTCATAGAAATTAGAGGATGACTCACTGCCACAGTGTCTAAAAGCATTTGCTAGCAAAGAGGCAGGACACTAATTTG TAAACTGCTCAACTGTTCTGACTGGAAGGGAGGCCTGGAGCTCTGCTATCACCAATCCTTCCCTTCCCTCTACTCCACATCCTTCTAAGG AGCATGATTTGAAAATTACTTTCCTAGGTTAATGGGCATGTGCATCAATGGAGAGAATAGTATAAGCAAGTGAGATGTAGACTAAGCAAA ATTTAGATGGAGAAGCACATTTTAAAAAATTAATAACTTAAAAGTCTCAAGTTATTAATTTTTTTTTTGCTAACTCAATTGGAAGTAAGA CTATGAAATATTTCAGTGTGTTTCCAATTCCCAGTTGAATGCAGTGTTTCAGAATTTCAGGTATTTCTTAAGATCCTCGAAAACACTGGT GCTGTCAAGTCCAAGTTCCTCGTACAGGAATTTAATTTGGGCTGTAATCTAAAAGAAACACATTAAAAAAATTAAATAGAAGGCCTTTGT >In-frame_MSH2_ENST00000543555_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_1509nt AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCT TAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAA GGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGA TATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACA GAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGT TTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAA TCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATAT TGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTT TTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTGATTCTTGCTCCGTCACCCATGCTCGAGTGCA GTGGCGTGATCTCGGCACACTGCAGCCTCTGCTTCCTGGGTTCAAGTGATTCTCCTGCTGCAGCCTCCCAAGTAGCTGGGATTACAGGTG CACGTCATTATGCCCGGGTAATTTCTGTATTTTTTAGTAGAGATGGTGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCT GGTGATCTGTCTGCCTTGCCTCCCAAAGTGCTAGGATTACGGGCCTGAGCCACCTTGCCTGGCCTGCAAAATTTGTTTTTAATAGAAGAC ACAAGAAATGATTTAAATATTTTATCAACAGAAAACCAGTTCTATCAACTATGGGCCCAGTATGCAGCTTTTAAAAATGACAGTTCTATA TACATTGATATGAGACCATTTCAAACAGGTATTCAATAAAGTATAGAATGGTAACATATCACCAACTGTGTAAAGAAAAATATATAAACA TATGAAATGATACATTCTGTGCCTATGCAAACATATGATACATTAAAAACAAAAGAACATATAGTGCCTGTCTCTGAGGGGAACTGTGAA >In-frame_MSH2_ENST00000406134_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_2288nt AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG CAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAG TTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTC AGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGAC AGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTC TCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAG ACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTT ACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAA TGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTG ATGTCCAAAAGACTCAGCCCAGATCGGCTTTGAAGTTATATCAAGATTTAAGTCTACTTCATGCCAATGAGCTACTCCTCAACAGGGGCT GGTTTTGCCATTTGAGGAATGACAGCCACTATGTTGTGTACACAAGAGAGCTGGATGGCATCGACAGAATCTTTATCGTGGTTCTGAATT TTGGAGAATCAACACTGTTAAATCTACATAATATGATTTCGGGCCTTCCCGCTAAAATGAGAATAAGGTTAAGTACCAATTCTGCCGACA AAGGCAGTAAAGTTGATACAAGTGGCATTTTTCTGGACAAGGGAGAGGGACTCATCTTTGAACACAACACGAAGAATCTCCTTCATCGCC AAACAGCTTTCAGAGATAGATGCTTTGTTTCCAATCGAGCATGCTATTCCAGTGTACTGAACATACTGTATACCTCGTGTTAGGCACCTT TATGAAGAGATGAAGACACTGGCATTTCAGTGGGATTGTAAGCATTTGTAATAGCTTCATGTACAGCATGCTGCTTGGTGAACAATCATT AATTCTTCGATATTTCTGTAGCTTGAATGTAACTGCTTTAAGAAAGGTTCTCAAATGTTTTGAAAAAAATAAAATGTTTAAAAGTAAATT ATGGCTTATAGGAGCTTATAACTTTATTCAGATAGCATCAATCAGGGATGACCAGAACACATTAGGACCCCAGATTATTCAAAAACTTTA ACGAATTTTAAGGGGAAGAATTTTATCTTTTCCCTTAAAATGCAGTCATAGAAATTAGAGGATGACTCACTGCCACAGTGTCTAAAAGCA TTTGCTAGCAAAGAGGCAGGACACTAATTTGTAAACTGCTCAACTGTTCTGACTGGAAGGGAGGCCTGGAGCTCTGCTATCACCAATCCT TCCCTTCCCTCTACTCCACATCCTTCTAAGGAGCATGATTTGAAAATTACTTTCCTAGGTTAATGGGCATGTGCATCAATGGAGAGAATA GTATAAGCAAGTGAGATGTAGACTAAGCAAAATTTAGATGGAGAAGCACATTTTAAAAAATTAATAACTTAAAAGTCTCAAGTTATTAAT TTTTTTTTTGCTAACTCAATTGGAAGTAAGACTATGAAATATTTCAGTGTGTTTCCAATTCCCAGTTGAATGCAGTGTTTCAGAATTTCA GGTATTTCTTAAGATCCTCGAAAACACTGGTGCTGTCAAGTCCAAGTTCCTCGTACAGGAATTTAATTTGGGCTGTAATCTAAAAGAAAC >In-frame_MSH2_ENST00000406134_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_1630nt AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG CAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAG TTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTC AGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGAC AGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTC TCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAG ACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTT ACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAA TGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTG ATTCTTGCTCCGTCACCCATGCTCGAGTGCAGTGGCGTGATCTCGGCACACTGCAGCCTCTGCTTCCTGGGTTCAAGTGATTCTCCTGCT GCAGCCTCCCAAGTAGCTGGGATTACAGGTGCACGTCATTATGCCCGGGTAATTTCTGTATTTTTTAGTAGAGATGGTGTTTCACCATGT TGGCCAGGCTGGTCTTGAACTCCTGACCTCTGGTGATCTGTCTGCCTTGCCTCCCAAAGTGCTAGGATTACGGGCCTGAGCCACCTTGCC TGGCCTGCAAAATTTGTTTTTAATAGAAGACACAAGAAATGATTTAAATATTTTATCAACAGAAAACCAGTTCTATCAACTATGGGCCCA GTATGCAGCTTTTAAAAATGACAGTTCTATATACATTGATATGAGACCATTTCAAACAGGTATTCAATAAAGTATAGAATGGTAACATAT CACCAACTGTGTAAAGAAAAATATATAAACATATGAAATGATACATTCTGTGCCTATGCAAACATATGATACATTAAAAACAAAAGAACA TATAGTGCCTGTCTCTGAGGGGAACTGTGAAGCTATGGAAAGGTGTTGAAGAAAACCTTTTTATAGTATGTATTCTTGTAATTGAATAAA |
Top |
FusionGenePPI for MSH2_SLC3A1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MSH2 | BRCA1, PTP4A3, BARD1, BLM, CHEK1, CHEK2, ATM, MLH1, MRE11A, NBN, RAD50, MSH6, RFC1, MSH3, ATR, MAX, MYC, ATRIP, PCNA, MSH2, EXO1, OTUB1, SLX4, PMS2, AIRE, PRKCZ, XPA, RPA4, MGMT, TP53, ESR1, ESR2, SNW1, CREBBP, FANCA, GRB7, RPP14, TK1, CDKN1A, SMN1, ANXA7, DTL, SMARCAD1, CDK9, NELFB, PMS1, RAD51, XRCC6, SIRT7, FANCD2, CDK2, HUS1, RAD1, RAD9A, MUTYH, SRSF5, SART1, SRSF11, SRSF7, IK, RBM25, SMARCA5, SRSF10, RPS24, TOP2B, SEPT9, RAD21, HNRNPD, SUPT16H, ERCC1, ERCC4, HDAC6, ATP6V1B2, CUL2, JUP, DPYSL3, XRCC5, NRD1, PDE3A, SEC23A, ST13, STAT3, SUPT5H, RPA3, RPA2, RPA1, POLK, REV1, CCDC8, SUMO2, SIRT6, ANXA6, DNAJC9, EIF3B, FEN1, AARS, CIAPIN1, DHX15, PFDN4, RECQL, RPLP0, RPS5, TRIP13, ZW10, NMD3, SNX27, TIPRL, TPP2, TPT1, NTRK1, CEP19, E2F3, CDC5L, RNF126, UBXN8, FAF2, USP10, ZNF746, CDC14B, RAF1, RPGRIP1L, BRIP1, TOP1, TOP2A, TOP3A, TRIM25, TES, MCM9, MCM8 | SLC3A1 | SLC7A8, EGFR |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MSH2 | chr2:47637511 | chr2:44539725 | ENST00000233146 | + | 3 | 16 | 601_671 | 215 | 935 | EXO1 |
| Hgene | MSH2 | chr2:47637511 | chr2:44539725 | ENST00000543555 | + | 4 | 17 | 601_671 | 149 | 869 | EXO1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MSH2_SLC3A1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MSH2_SLC3A1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MSH2 | C2936783 | Colorectal cancer, hereditary nonpolyposis, type 1 | 48 | UNIPROT |
| Hgene | MSH2 | C0009405 | Hereditary Nonpolyposis Colorectal Neoplasms | 4 | CTD_human |
| Hgene | MSH2 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | MSH2 | C0919267 | ovarian neoplasm | 1 | CTD_human |
| Hgene | MSH2 | C2931459 | Lynch syndrome I (site-specific colonic cancer) | 1 | CTD_human |
| Tgene | SLC3A1 | C0010691 | Cystinuria | 10 | CTD_human;HPO;ORPHANET;UNIPROT |
| Tgene | SLC3A1 | C1848030 | Hypotonia-Cystinuria Syndrome | 1 | CTD_human;ORPHANET |
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