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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 22606

FusionGeneSummary for MSH2_SLC3A1

check button Fusion gene summary
Fusion gene informationFusion gene name: MSH2_SLC3A1
Fusion gene ID: 22606
HgeneTgene
Gene symbol

MSH2

SLC3A1

Gene ID

4436

6519

Gene namemutS homolog 2solute carrier family 3 member 1
SynonymsCOCA1|FCC1|HNPCC|HNPCC1|LCFS2ATR1|CSNU1|D2H|NBAT|RBAT
Cytomap

2p21-p16.3

2p21

Type of geneprotein-codingprotein-coding
DescriptionDNA mismatch repair protein Msh2hMSH2mutS homolog 2, colon cancer, nonpolyposis type 1neutral and basic amino acid transport protein rBATB(0,+)-type amino acid transport proteinSLC3A1 variant BSLC3A1 variant CSLC3A1 variant DSLC3A1 variant ESLC3A1 variant FSLC3A1 variant Gamino acid transporter 1solute carrier family 3 (amino acid
Modification date2018052320180523
UniProtAcc

P43246

Q07837

Ensembl transtripts involved in fusion geneENST00000233146, ENST00000543555, 
ENST00000406134, ENST00000461394, 
ENST00000260649, ENST00000409387, 
ENST00000410056, ENST00000409741, 
ENST00000409229, ENST00000409380, 
ENST00000409294, ENST00000409740, 
Fusion gene scores* DoF score8 X 6 X 8=3842 X 2 X 2=8
# samples 102
** MAII scorelog2(10/384*10)=-1.94110631094643
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: MSH2 [Title/Abstract] AND SLC3A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMSH2

GO:0006281

DNA repair

8942985

HgeneMSH2

GO:0006298

mismatch repair

7923193|11555625

HgeneMSH2

GO:0006301

postreplication repair

7923193

HgeneMSH2

GO:0045910

negative regulation of DNA recombination

17715146

HgeneMSH2

GO:0051096

positive regulation of helicase activity

17715146


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A2-A04U-01AMSH2chr2

47637511

+SLC3A1chr2

44539725

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000233146ENST00000260649MSH2chr2

47637511

+SLC3A1chr2

44539725

+
In-frameENST00000233146ENST00000409387MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000233146ENST00000410056MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000233146ENST00000409741MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000233146ENST00000409229MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000233146ENST00000409380MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000233146ENST00000409294MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000233146ENST00000409740MSH2chr2

47637511

+SLC3A1chr2

44539725

+
In-frameENST00000543555ENST00000260649MSH2chr2

47637511

+SLC3A1chr2

44539725

+
In-frameENST00000543555ENST00000409387MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000543555ENST00000410056MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000543555ENST00000409741MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000543555ENST00000409229MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000543555ENST00000409380MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000543555ENST00000409294MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000543555ENST00000409740MSH2chr2

47637511

+SLC3A1chr2

44539725

+
In-frameENST00000406134ENST00000260649MSH2chr2

47637511

+SLC3A1chr2

44539725

+
In-frameENST00000406134ENST00000409387MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000406134ENST00000410056MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000406134ENST00000409741MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000406134ENST00000409229MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000406134ENST00000409380MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000406134ENST00000409294MSH2chr2

47637511

+SLC3A1chr2

44539725

+
5CDS-intronENST00000406134ENST00000409740MSH2chr2

47637511

+SLC3A1chr2

44539725

+
intron-3CDSENST00000461394ENST00000260649MSH2chr2

47637511

+SLC3A1chr2

44539725

+
intron-3CDSENST00000461394ENST00000409387MSH2chr2

47637511

+SLC3A1chr2

44539725

+
intron-intronENST00000461394ENST00000410056MSH2chr2

47637511

+SLC3A1chr2

44539725

+
intron-intronENST00000461394ENST00000409741MSH2chr2

47637511

+SLC3A1chr2

44539725

+
intron-intronENST00000461394ENST00000409229MSH2chr2

47637511

+SLC3A1chr2

44539725

+
intron-intronENST00000461394ENST00000409380MSH2chr2

47637511

+SLC3A1chr2

44539725

+
intron-intronENST00000461394ENST00000409294MSH2chr2

47637511

+SLC3A1chr2

44539725

+
intron-intronENST00000461394ENST00000409740MSH2chr2

47637511

+SLC3A1chr2

44539725

+

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FusionProtFeatures for MSH2_SLC3A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MSH2

P43246

SLC3A1

Q07837

Component of the post-replicative DNA mismatch repairsystem (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) whichbinds to DNA mismatches thereby initiating DNA repair. When bound,heterodimers bend the DNA helix and shields approximately 20 basepairs. MutS alpha recognizes single base mismatches anddinucleotide insertion-deletion loops (IDL) in the DNA. MutS betarecognizes larger insertion-deletion loops up to 13 nucleotideslong. After mismatch binding, MutS alpha or beta forms a ternarycomplex with the MutL alpha heterodimer, which is thought to beresponsible for directing the downstream MMR events, includingstrand discrimination, excision, and resynthesis. ATP binding andhydrolysis play a pivotal role in mismatch repair functions. TheATPase activity associated with MutS alpha regulates bindingsimilar to a molecular switch: mismatched DNA provokes ADP-->ATPexchange, resulting in a discernible conformational transitionthat converts MutS alpha into a sliding clamp capable ofhydrolysis-independent diffusion along the DNA backbone. Thistransition is crucial for mismatch repair. MutS alpha may alsoplay a role in DNA homologous recombination repair. In melanocytesmay modulate both UV-B-induced cell cycle regulation andapoptosis. {ECO:0000269|PubMed:10078208,ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730,ECO:0000269|PubMed:17611581, ECO:0000269|PubMed:21120944,ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679,ECO:0000269|PubMed:9822680}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMSH2chr2:47637511chr2:44539725ENST00000233146+316669_676215935Nucleotide bindingATP
HgeneMSH2chr2:47637511chr2:44539725ENST00000543555+417669_676149869Nucleotide bindingATP
TgeneSLC3A1chr2:47637511chr2:44539725ENST00000260649+610109_685444686Topological domainExtracellular
TgeneSLC3A1chr2:47637511chr2:44539725ENST00000260649+6101_87444686Topological domainCytoplasmic
TgeneSLC3A1chr2:47637511chr2:44539725ENST00000260649+61088_108444686TransmembraneHelical%3B Signal-anchor for type II membrane protein


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FusionGeneSequence for MSH2_SLC3A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MSH2_ENST00000233146_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_457aa
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYD
INTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGI
DRIFIVVLNFGESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLN

>In-frame_MSH2_ENST00000233146_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_336aa
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYD

>In-frame_MSH2_ENST00000543555_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_391aa
MGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVD
GQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGT
PITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLL
NRGWFCHLRNDSHYVVYTRELDGIDRIFIVVLNFGESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNL

>In-frame_MSH2_ENST00000543555_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_270aa
MGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVD
GQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGT
PITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDSCSVTHARVQWRDLGTLQPLLPGFKX

>In-frame_MSH2_ENST00000406134_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_457aa
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYD
INTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGI
DRIFIVVLNFGESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLN

>In-frame_MSH2_ENST00000406134_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_336aa
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVK
DLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD
NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MSH2_ENST00000233146_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_1371nt
ATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCG
ACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACC
CAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAA
GATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCA
TATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTT
AAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGAT
AATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATG
GGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTT
TTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGAT
ATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACC
AATTCAGATTACCACACTGTGAATGTTGATGTCCAAAAGACTCAGCCCAGATCGGCTTTGAAGTTATATCAAGATTTAAGTCTACTTCAT
GCCAATGAGCTACTCCTCAACAGGGGCTGGTTTTGCCATTTGAGGAATGACAGCCACTATGTTGTGTACACAAGAGAGCTGGATGGCATC
GACAGAATCTTTATCGTGGTTCTGAATTTTGGAGAATCAACACTGTTAAATCTACATAATATGATTTCGGGCCTTCCCGCTAAAATGAGA
ATAAGGTTAAGTACCAATTCTGCCGACAAAGGCAGTAAAGTTGATACAAGTGGCATTTTTCTGGACAAGGGAGAGGGACTCATCTTTGAA
CACAACACGAAGAATCTCCTTCATCGCCAAACAGCTTTCAGAGATAGATGCTTTGTTTCCAATCGAGCATGCTATTCCAGTGTACTGAAC

>In-frame_MSH2_ENST00000233146_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_1008nt
ATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCG
ACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACC
CAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAA
GATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCA
TATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTT
AAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGAT
AATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATG
GGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTT
TTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGAT
ATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACC
AATTCAGATTACCACACTGTGAATGTTGATTCTTGCTCCGTCACCCATGCTCGAGTGCAGTGGCGTGATCTCGGCACACTGCAGCCTCTG

>In-frame_MSH2_ENST00000543555_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_1173nt
ATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGT
CAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGC
AATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGAT
GGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAAT
CTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATT
GGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACT
CCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCA
AAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACT
GTGAATGTTGATGTCCAAAAGACTCAGCCCAGATCGGCTTTGAAGTTATATCAAGATTTAAGTCTACTTCATGCCAATGAGCTACTCCTC
AACAGGGGCTGGTTTTGCCATTTGAGGAATGACAGCCACTATGTTGTGTACACAAGAGAGCTGGATGGCATCGACAGAATCTTTATCGTG
GTTCTGAATTTTGGAGAATCAACACTGTTAAATCTACATAATATGATTTCGGGCCTTCCCGCTAAAATGAGAATAAGGTTAAGTACCAAT
TCTGCCGACAAAGGCAGTAAAGTTGATACAAGTGGCATTTTTCTGGACAAGGGAGAGGGACTCATCTTTGAACACAACACGAAGAATCTC
CTTCATCGCCAAACAGCTTTCAGAGATAGATGCTTTGTTTCCAATCGAGCATGCTATTCCAGTGTACTGAACATACTGTATACCTCGTGT

>In-frame_MSH2_ENST00000543555_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_810nt
ATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGT
CAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGC
AATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGAT
GGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAAT
CTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATT
GGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACT
CCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCA
AAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACT
GTGAATGTTGATTCTTGCTCCGTCACCCATGCTCGAGTGCAGTGGCGTGATCTCGGCACACTGCAGCCTCTGCTTCCTGGGTTCAAGTGA

>In-frame_MSH2_ENST00000406134_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_1371nt
ATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCG
ACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACC
CAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAA
GATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCA
TATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTT
AAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGAT
AATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATG
GGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTT
TTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGAT
ATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACC
AATTCAGATTACCACACTGTGAATGTTGATGTCCAAAAGACTCAGCCCAGATCGGCTTTGAAGTTATATCAAGATTTAAGTCTACTTCAT
GCCAATGAGCTACTCCTCAACAGGGGCTGGTTTTGCCATTTGAGGAATGACAGCCACTATGTTGTGTACACAAGAGAGCTGGATGGCATC
GACAGAATCTTTATCGTGGTTCTGAATTTTGGAGAATCAACACTGTTAAATCTACATAATATGATTTCGGGCCTTCCCGCTAAAATGAGA
ATAAGGTTAAGTACCAATTCTGCCGACAAAGGCAGTAAAGTTGATACAAGTGGCATTTTTCTGGACAAGGGAGAGGGACTCATCTTTGAA
CACAACACGAAGAATCTCCTTCATCGCCAAACAGCTTTCAGAGATAGATGCTTTGTTTCCAATCGAGCATGCTATTCCAGTGTACTGAAC

>In-frame_MSH2_ENST00000406134_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_1008nt
ATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCG
ACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACC
CAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAA
GATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCA
TATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTT
AAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGAT
AATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATG
GGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTT
TTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGAT
ATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACC
AATTCAGATTACCACACTGTGAATGTTGATTCTTGCTCCGTCACCCATGCTCGAGTGCAGTGGCGTGATCTCGGCACACTGCAGCCTCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_MSH2_ENST00000233146_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_2449nt
GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC
AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG
GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA
GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA
CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCA
GAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAG
AGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTT
TGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGT
GGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACC
AAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTC
GCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGG
AATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTC
AAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTGATGTCCAAAAGACTCAGCC
CAGATCGGCTTTGAAGTTATATCAAGATTTAAGTCTACTTCATGCCAATGAGCTACTCCTCAACAGGGGCTGGTTTTGCCATTTGAGGAA
TGACAGCCACTATGTTGTGTACACAAGAGAGCTGGATGGCATCGACAGAATCTTTATCGTGGTTCTGAATTTTGGAGAATCAACACTGTT
AAATCTACATAATATGATTTCGGGCCTTCCCGCTAAAATGAGAATAAGGTTAAGTACCAATTCTGCCGACAAAGGCAGTAAAGTTGATAC
AAGTGGCATTTTTCTGGACAAGGGAGAGGGACTCATCTTTGAACACAACACGAAGAATCTCCTTCATCGCCAAACAGCTTTCAGAGATAG
ATGCTTTGTTTCCAATCGAGCATGCTATTCCAGTGTACTGAACATACTGTATACCTCGTGTTAGGCACCTTTATGAAGAGATGAAGACAC
TGGCATTTCAGTGGGATTGTAAGCATTTGTAATAGCTTCATGTACAGCATGCTGCTTGGTGAACAATCATTAATTCTTCGATATTTCTGT
AGCTTGAATGTAACTGCTTTAAGAAAGGTTCTCAAATGTTTTGAAAAAAATAAAATGTTTAAAAGTAAATTATGGCTTATAGGAGCTTAT
AACTTTATTCAGATAGCATCAATCAGGGATGACCAGAACACATTAGGACCCCAGATTATTCAAAAACTTTAACGAATTTTAAGGGGAAGA
ATTTTATCTTTTCCCTTAAAATGCAGTCATAGAAATTAGAGGATGACTCACTGCCACAGTGTCTAAAAGCATTTGCTAGCAAAGAGGCAG
GACACTAATTTGTAAACTGCTCAACTGTTCTGACTGGAAGGGAGGCCTGGAGCTCTGCTATCACCAATCCTTCCCTTCCCTCTACTCCAC
ATCCTTCTAAGGAGCATGATTTGAAAATTACTTTCCTAGGTTAATGGGCATGTGCATCAATGGAGAGAATAGTATAAGCAAGTGAGATGT
AGACTAAGCAAAATTTAGATGGAGAAGCACATTTTAAAAAATTAATAACTTAAAAGTCTCAAGTTATTAATTTTTTTTTTGCTAACTCAA
TTGGAAGTAAGACTATGAAATATTTCAGTGTGTTTCCAATTCCCAGTTGAATGCAGTGTTTCAGAATTTCAGGTATTTCTTAAGATCCTC
GAAAACACTGGTGCTGTCAAGTCCAAGTTCCTCGTACAGGAATTTAATTTGGGCTGTAATCTAAAAGAAACACATTAAAAAAATTAAATA

>In-frame_MSH2_ENST00000233146_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_1791nt
GCAGTAGCTAAAGTCACCAGCGTGCGCGGGAAGCTGGGCCGCGTCTGCTTATGATTGGTTGCCGCGGCAGACTCCCACCCACCGAAACGC
AGCCCTGGAAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTG
GGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGA
GGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCGCA
CGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCA
GAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAG
AGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTT
TGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGT
GGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACC
AAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTC
GCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGG
AATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTC
AAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTGATTCTTGCTCCGTCACCCA
TGCTCGAGTGCAGTGGCGTGATCTCGGCACACTGCAGCCTCTGCTTCCTGGGTTCAAGTGATTCTCCTGCTGCAGCCTCCCAAGTAGCTG
GGATTACAGGTGCACGTCATTATGCCCGGGTAATTTCTGTATTTTTTAGTAGAGATGGTGTTTCACCATGTTGGCCAGGCTGGTCTTGAA
CTCCTGACCTCTGGTGATCTGTCTGCCTTGCCTCCCAAAGTGCTAGGATTACGGGCCTGAGCCACCTTGCCTGGCCTGCAAAATTTGTTT
TTAATAGAAGACACAAGAAATGATTTAAATATTTTATCAACAGAAAACCAGTTCTATCAACTATGGGCCCAGTATGCAGCTTTTAAAAAT
GACAGTTCTATATACATTGATATGAGACCATTTCAAACAGGTATTCAATAAAGTATAGAATGGTAACATATCACCAACTGTGTAAAGAAA
AATATATAAACATATGAAATGATACATTCTGTGCCTATGCAAACATATGATACATTAAAAACAAAAGAACATATAGTGCCTGTCTCTGAG

>In-frame_MSH2_ENST00000543555_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_2167nt
AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG
CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCT
TAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAA
GGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGA
TATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACA
GAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGT
TTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAA
TCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATAT
TGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTT
TTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTGATGTCCAAAAGACTCAGCCCAGATCGGCTTT
GAAGTTATATCAAGATTTAAGTCTACTTCATGCCAATGAGCTACTCCTCAACAGGGGCTGGTTTTGCCATTTGAGGAATGACAGCCACTA
TGTTGTGTACACAAGAGAGCTGGATGGCATCGACAGAATCTTTATCGTGGTTCTGAATTTTGGAGAATCAACACTGTTAAATCTACATAA
TATGATTTCGGGCCTTCCCGCTAAAATGAGAATAAGGTTAAGTACCAATTCTGCCGACAAAGGCAGTAAAGTTGATACAAGTGGCATTTT
TCTGGACAAGGGAGAGGGACTCATCTTTGAACACAACACGAAGAATCTCCTTCATCGCCAAACAGCTTTCAGAGATAGATGCTTTGTTTC
CAATCGAGCATGCTATTCCAGTGTACTGAACATACTGTATACCTCGTGTTAGGCACCTTTATGAAGAGATGAAGACACTGGCATTTCAGT
GGGATTGTAAGCATTTGTAATAGCTTCATGTACAGCATGCTGCTTGGTGAACAATCATTAATTCTTCGATATTTCTGTAGCTTGAATGTA
ACTGCTTTAAGAAAGGTTCTCAAATGTTTTGAAAAAAATAAAATGTTTAAAAGTAAATTATGGCTTATAGGAGCTTATAACTTTATTCAG
ATAGCATCAATCAGGGATGACCAGAACACATTAGGACCCCAGATTATTCAAAAACTTTAACGAATTTTAAGGGGAAGAATTTTATCTTTT
CCCTTAAAATGCAGTCATAGAAATTAGAGGATGACTCACTGCCACAGTGTCTAAAAGCATTTGCTAGCAAAGAGGCAGGACACTAATTTG
TAAACTGCTCAACTGTTCTGACTGGAAGGGAGGCCTGGAGCTCTGCTATCACCAATCCTTCCCTTCCCTCTACTCCACATCCTTCTAAGG
AGCATGATTTGAAAATTACTTTCCTAGGTTAATGGGCATGTGCATCAATGGAGAGAATAGTATAAGCAAGTGAGATGTAGACTAAGCAAA
ATTTAGATGGAGAAGCACATTTTAAAAAATTAATAACTTAAAAGTCTCAAGTTATTAATTTTTTTTTTGCTAACTCAATTGGAAGTAAGA
CTATGAAATATTTCAGTGTGTTTCCAATTCCCAGTTGAATGCAGTGTTTCAGAATTTCAGGTATTTCTTAAGATCCTCGAAAACACTGGT
GCTGTCAAGTCCAAGTTCCTCGTACAGGAATTTAATTTGGGCTGTAATCTAAAAGAAACACATTAAAAAAATTAAATAGAAGGCCTTTGT

>In-frame_MSH2_ENST00000543555_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_1509nt
AAGCTGATTGGGTGTGGTCGCCGTGGCCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCG
CATTTTCTTCAACCAGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTGCT
TAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAA
GGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTTGGTAACAATGA
TATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACA
GAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCAAAGGAATGTGT
TTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAGACAGTTCACGGCTGACTTCGCGTTTGGGGAA
TCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTTACTATGGAGAAGAAATTGGAATGGGAAATAT
TGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAATGCAGTGGGACAATAGTTCAAATGCTGGTTT
TTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTGATTCTTGCTCCGTCACCCATGCTCGAGTGCA
GTGGCGTGATCTCGGCACACTGCAGCCTCTGCTTCCTGGGTTCAAGTGATTCTCCTGCTGCAGCCTCCCAAGTAGCTGGGATTACAGGTG
CACGTCATTATGCCCGGGTAATTTCTGTATTTTTTAGTAGAGATGGTGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCT
GGTGATCTGTCTGCCTTGCCTCCCAAAGTGCTAGGATTACGGGCCTGAGCCACCTTGCCTGGCCTGCAAAATTTGTTTTTAATAGAAGAC
ACAAGAAATGATTTAAATATTTTATCAACAGAAAACCAGTTCTATCAACTATGGGCCCAGTATGCAGCTTTTAAAAATGACAGTTCTATA
TACATTGATATGAGACCATTTCAAACAGGTATTCAATAAAGTATAGAATGGTAACATATCACCAACTGTGTAAAGAAAAATATATAAACA
TATGAAATGATACATTCTGTGCCTATGCAAACATATGATACATTAAAAACAAAAGAACATATAGTGCCTGTCTCTGAGGGGAACTGTGAA

>In-frame_MSH2_ENST00000406134_chr2_47637511_+_SLC3A1_ENST00000260649_chr2_44539725_+_2288nt
AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC
AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG
GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG
CAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAG
TTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTC
AGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGAC
AGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTC
TCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAG
ACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTT
ACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAA
TGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTG
ATGTCCAAAAGACTCAGCCCAGATCGGCTTTGAAGTTATATCAAGATTTAAGTCTACTTCATGCCAATGAGCTACTCCTCAACAGGGGCT
GGTTTTGCCATTTGAGGAATGACAGCCACTATGTTGTGTACACAAGAGAGCTGGATGGCATCGACAGAATCTTTATCGTGGTTCTGAATT
TTGGAGAATCAACACTGTTAAATCTACATAATATGATTTCGGGCCTTCCCGCTAAAATGAGAATAAGGTTAAGTACCAATTCTGCCGACA
AAGGCAGTAAAGTTGATACAAGTGGCATTTTTCTGGACAAGGGAGAGGGACTCATCTTTGAACACAACACGAAGAATCTCCTTCATCGCC
AAACAGCTTTCAGAGATAGATGCTTTGTTTCCAATCGAGCATGCTATTCCAGTGTACTGAACATACTGTATACCTCGTGTTAGGCACCTT
TATGAAGAGATGAAGACACTGGCATTTCAGTGGGATTGTAAGCATTTGTAATAGCTTCATGTACAGCATGCTGCTTGGTGAACAATCATT
AATTCTTCGATATTTCTGTAGCTTGAATGTAACTGCTTTAAGAAAGGTTCTCAAATGTTTTGAAAAAAATAAAATGTTTAAAAGTAAATT
ATGGCTTATAGGAGCTTATAACTTTATTCAGATAGCATCAATCAGGGATGACCAGAACACATTAGGACCCCAGATTATTCAAAAACTTTA
ACGAATTTTAAGGGGAAGAATTTTATCTTTTCCCTTAAAATGCAGTCATAGAAATTAGAGGATGACTCACTGCCACAGTGTCTAAAAGCA
TTTGCTAGCAAAGAGGCAGGACACTAATTTGTAAACTGCTCAACTGTTCTGACTGGAAGGGAGGCCTGGAGCTCTGCTATCACCAATCCT
TCCCTTCCCTCTACTCCACATCCTTCTAAGGAGCATGATTTGAAAATTACTTTCCTAGGTTAATGGGCATGTGCATCAATGGAGAGAATA
GTATAAGCAAGTGAGATGTAGACTAAGCAAAATTTAGATGGAGAAGCACATTTTAAAAAATTAATAACTTAAAAGTCTCAAGTTATTAAT
TTTTTTTTTGCTAACTCAATTGGAAGTAAGACTATGAAATATTTCAGTGTGTTTCCAATTCCCAGTTGAATGCAGTGTTTCAGAATTTCA
GGTATTTCTTAAGATCCTCGAAAACACTGGTGCTGTCAAGTCCAAGTTCCTCGTACAGGAATTTAATTTGGGCTGTAATCTAAAAGAAAC

>In-frame_MSH2_ENST00000406134_chr2_47637511_+_SLC3A1_ENST00000409387_chr2_44539725_+_1630nt
AAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGAGGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGC
AGTTGGAGAGCGCGGCCGAGGTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTTTTCGACCGGG
GCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGG
CAGGAGCAAAGAATCTGCAGAGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAG
TTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTC
AGTTTGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGATGGCCAGAGAC
AGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTC
TCCTCATCCAGATTGGACCAAAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATTGGTGGACCAG
ACAGTTCACGGCTGACTTCGCGTTTGGGGAATCAGTATGTCAACGTGATGAACATGCTTCTTTTCACACTCCCTGGAACTCCTATAACTT
ACTATGGAGAAGAAATTGGAATGGGAAATATTGTAGCCGCAAATCTCAATGAAAGCTATGATATTAATACCCTTCGCTCAAAGTCACCAA
TGCAGTGGGACAATAGTTCAAATGCTGGTTTTTCTGAAGCTAGTAACACCTGGTTACCTACCAATTCAGATTACCACACTGTGAATGTTG
ATTCTTGCTCCGTCACCCATGCTCGAGTGCAGTGGCGTGATCTCGGCACACTGCAGCCTCTGCTTCCTGGGTTCAAGTGATTCTCCTGCT
GCAGCCTCCCAAGTAGCTGGGATTACAGGTGCACGTCATTATGCCCGGGTAATTTCTGTATTTTTTAGTAGAGATGGTGTTTCACCATGT
TGGCCAGGCTGGTCTTGAACTCCTGACCTCTGGTGATCTGTCTGCCTTGCCTCCCAAAGTGCTAGGATTACGGGCCTGAGCCACCTTGCC
TGGCCTGCAAAATTTGTTTTTAATAGAAGACACAAGAAATGATTTAAATATTTTATCAACAGAAAACCAGTTCTATCAACTATGGGCCCA
GTATGCAGCTTTTAAAAATGACAGTTCTATATACATTGATATGAGACCATTTCAAACAGGTATTCAATAAAGTATAGAATGGTAACATAT
CACCAACTGTGTAAAGAAAAATATATAAACATATGAAATGATACATTCTGTGCCTATGCAAACATATGATACATTAAAAACAAAAGAACA
TATAGTGCCTGTCTCTGAGGGGAACTGTGAAGCTATGGAAAGGTGTTGAAGAAAACCTTTTTATAGTATGTATTCTTGTAATTGAATAAA


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FusionGenePPI for MSH2_SLC3A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MSH2BRCA1, PTP4A3, BARD1, BLM, CHEK1, CHEK2, ATM, MLH1, MRE11A, NBN, RAD50, MSH6, RFC1, MSH3, ATR, MAX, MYC, ATRIP, PCNA, MSH2, EXO1, OTUB1, SLX4, PMS2, AIRE, PRKCZ, XPA, RPA4, MGMT, TP53, ESR1, ESR2, SNW1, CREBBP, FANCA, GRB7, RPP14, TK1, CDKN1A, SMN1, ANXA7, DTL, SMARCAD1, CDK9, NELFB, PMS1, RAD51, XRCC6, SIRT7, FANCD2, CDK2, HUS1, RAD1, RAD9A, MUTYH, SRSF5, SART1, SRSF11, SRSF7, IK, RBM25, SMARCA5, SRSF10, RPS24, TOP2B, SEPT9, RAD21, HNRNPD, SUPT16H, ERCC1, ERCC4, HDAC6, ATP6V1B2, CUL2, JUP, DPYSL3, XRCC5, NRD1, PDE3A, SEC23A, ST13, STAT3, SUPT5H, RPA3, RPA2, RPA1, POLK, REV1, CCDC8, SUMO2, SIRT6, ANXA6, DNAJC9, EIF3B, FEN1, AARS, CIAPIN1, DHX15, PFDN4, RECQL, RPLP0, RPS5, TRIP13, ZW10, NMD3, SNX27, TIPRL, TPP2, TPT1, NTRK1, CEP19, E2F3, CDC5L, RNF126, UBXN8, FAF2, USP10, ZNF746, CDC14B, RAF1, RPGRIP1L, BRIP1, TOP1, TOP2A, TOP3A, TRIM25, TES, MCM9, MCM8SLC3A1SLC7A8, EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMSH2chr2:47637511chr2:44539725ENST00000233146+316601_671215935EXO1
HgeneMSH2chr2:47637511chr2:44539725ENST00000543555+417601_671149869EXO1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MSH2_SLC3A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MSH2_SLC3A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMSH2C2936783Colorectal cancer, hereditary nonpolyposis, type 148UNIPROT
HgeneMSH2C0009405Hereditary Nonpolyposis Colorectal Neoplasms4CTD_human
HgeneMSH2C0009404Colorectal Neoplasms1CTD_human
HgeneMSH2C0919267ovarian neoplasm1CTD_human
HgeneMSH2C2931459Lynch syndrome I (site-specific colonic cancer)1CTD_human
TgeneSLC3A1C0010691Cystinuria10CTD_human;HPO;ORPHANET;UNIPROT
TgeneSLC3A1C1848030Hypotonia-Cystinuria Syndrome1CTD_human;ORPHANET