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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22563

FusionGeneSummary for MRPS27_MRPS27

check button Fusion gene summary
Fusion gene informationFusion gene name: MRPS27_MRPS27
Fusion gene ID: 22563
HgeneTgene
Gene symbol

MRPS27

MRPS27

Gene ID

23107

23107

Gene namemitochondrial ribosomal protein S27mitochondrial ribosomal protein S27
SynonymsMRP-S27|S27mtMRP-S27|S27mt
Cytomap

5q13.2

5q13.2

Type of geneprotein-codingprotein-coding
Description28S ribosomal protein S27, mitochondrialmitochondrial 28S ribosomal protein S27mitochondrial small ribosomal subunit protein mS2728S ribosomal protein S27, mitochondrialmitochondrial 28S ribosomal protein S27mitochondrial small ribosomal subunit protein mS27
Modification date2018051920180519
UniProtAcc

Q92552

Q92552

Ensembl transtripts involved in fusion geneENST00000261413, ENST00000457646, 
ENST00000513900, ENST00000515404, 
ENST00000522562, ENST00000522095, 
ENST00000261413, ENST00000457646, 
ENST00000513900, ENST00000515404, 
ENST00000522562, ENST00000522095, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 2=18
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MRPS27 [Title/Abstract] AND MRPS27 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI763814MRPS27chr5

71528331

+MRPS27chr5

71528292

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000261413ENST00000261413MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000261413ENST00000457646MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000261413ENST00000513900MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000261413ENST00000515404MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-5UTRENST00000261413ENST00000522562MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-intronENST00000261413ENST00000522095MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000457646ENST00000261413MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000457646ENST00000457646MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000457646ENST00000513900MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000457646ENST00000515404MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-5UTRENST00000457646ENST00000522562MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-intronENST00000457646ENST00000522095MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000513900ENST00000261413MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000513900ENST00000457646MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000513900ENST00000513900MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000513900ENST00000515404MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-5UTRENST00000513900ENST00000522562MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-intronENST00000513900ENST00000522095MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000515404ENST00000261413MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000515404ENST00000457646MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000515404ENST00000513900MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000515404ENST00000515404MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-5UTRENST00000515404ENST00000522562MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-intronENST00000515404ENST00000522095MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000522562ENST00000261413MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000522562ENST00000457646MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000522562ENST00000513900MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000522562ENST00000515404MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-5UTRENST00000522562ENST00000522562MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-intronENST00000522562ENST00000522095MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000522095ENST00000261413MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000522095ENST00000457646MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000522095ENST00000513900MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-3CDSENST00000522095ENST00000515404MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-5UTRENST00000522095ENST00000522562MRPS27chr5

71528331

+MRPS27chr5

71528292

-
intron-intronENST00000522095ENST00000522095MRPS27chr5

71528331

+MRPS27chr5

71528292

-

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FusionProtFeatures for MRPS27_MRPS27


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRPS27

Q92552

MRPS27

Q92552

RNA-binding component of the mitochondrial smallribosomal subunit (mt-SSU) that plays a role in mitochondrialprotein synthesis (PubMed:22841715). Stimulates mitochondrial mRNAtranslation of subunit components of the mitochondrial electrontransport chain (PubMed:22841715). Binds to the mitochondrial 12SrRNA (12S mt-rRNA) and tRNA(Glu) (PubMed:22841715). Involved alsoin positive regulation of cell proliferation and tumor cell growth(PubMed:28714366). {ECO:0000269|PubMed:22841715,ECO:0000269|PubMed:28714366}. RNA-binding component of the mitochondrial smallribosomal subunit (mt-SSU) that plays a role in mitochondrialprotein synthesis (PubMed:22841715). Stimulates mitochondrial mRNAtranslation of subunit components of the mitochondrial electrontransport chain (PubMed:22841715). Binds to the mitochondrial 12SrRNA (12S mt-rRNA) and tRNA(Glu) (PubMed:22841715). Involved alsoin positive regulation of cell proliferation and tumor cell growth(PubMed:28714366). {ECO:0000269|PubMed:22841715,ECO:0000269|PubMed:28714366}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MRPS27_MRPS27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MRPS27_MRPS27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MRPS27_MRPS27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MRPS27_MRPS27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource