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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22546

FusionGeneSummary for MRPS18C_SIGLEC10

check button Fusion gene summary
Fusion gene informationFusion gene name: MRPS18C_SIGLEC10
Fusion gene ID: 22546
HgeneTgene
Gene symbol

MRPS18C

SIGLEC10

Gene ID

51023

89790

Gene namemitochondrial ribosomal protein S18Csialic acid binding Ig like lectin 10
SynonymsCGI-134|MRP-S18-1|MRP-S18-c|MRPS18-1|S18mt-c|mrps18-cPRO940|SIGLEC-10|SLG2
Cytomap

4q21.23

19q13.41

Type of geneprotein-codingprotein-coding
Description28S ribosomal protein S18c, mitochondrial28S ribosomal protein S18-1, mitochondrialmitochondrial ribosomal protein S18-1mitochondrial small ribosomal subunit protein bS18cmitochondrial small ribosomal subunit protein bS18mmitochondrial small ribosomasialic acid-binding Ig-like lectin 10sialic acid binding Ig-like lectin 10 Ig-like lectin 7siglec-like gene 2siglec-like protein 2
Modification date2018052320180519
UniProtAcc

Q9Y3D5

Q96LC7

Ensembl transtripts involved in fusion geneENST00000295491, ENST00000507019, 
ENST00000507349, ENST00000509571, 
ENST00000441969, ENST00000353836, 
ENST00000442846, ENST00000356298, 
ENST00000432469, ENST00000525998, 
ENST00000436984, ENST00000439889, 
ENST00000339313, 
Fusion gene scores* DoF score3 X 3 X 2=181 X 1 X 1=1
# samples 42
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/1*10)=4.32192809488736
Context

PubMed: MRPS18C [Title/Abstract] AND SIGLEC10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX363877MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
ChiTaRS3.1BX328907MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000295491ENST00000441969MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-3UTRENST00000295491ENST00000353836MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-3UTRENST00000295491ENST00000442846MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-intronENST00000295491ENST00000356298MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-3UTRENST00000295491ENST00000432469MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-intronENST00000295491ENST00000525998MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-intronENST00000295491ENST00000436984MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-intronENST00000295491ENST00000439889MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-intronENST00000295491ENST00000339313MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-3UTRENST00000507019ENST00000441969MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-3UTRENST00000507019ENST00000353836MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-3UTRENST00000507019ENST00000442846MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-intronENST00000507019ENST00000356298MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-3UTRENST00000507019ENST00000432469MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-intronENST00000507019ENST00000525998MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-intronENST00000507019ENST00000436984MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-intronENST00000507019ENST00000439889MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-intronENST00000507019ENST00000339313MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
5CDS-3UTRENST00000507349ENST00000441969MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
5CDS-3UTRENST00000507349ENST00000353836MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
5CDS-3UTRENST00000507349ENST00000442846MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
5CDS-intronENST00000507349ENST00000356298MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
5CDS-3UTRENST00000507349ENST00000432469MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
5CDS-intronENST00000507349ENST00000525998MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
5CDS-intronENST00000507349ENST00000436984MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
5CDS-intronENST00000507349ENST00000439889MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
5CDS-intronENST00000507349ENST00000339313MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-3UTRENST00000509571ENST00000441969MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-3UTRENST00000509571ENST00000353836MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-3UTRENST00000509571ENST00000442846MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-intronENST00000509571ENST00000356298MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-3UTRENST00000509571ENST00000432469MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-intronENST00000509571ENST00000525998MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-intronENST00000509571ENST00000436984MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-intronENST00000509571ENST00000439889MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-
3UTR-intronENST00000509571ENST00000339313MRPS18Cchr4

84382386

+SIGLEC10chr19

51913817

-

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FusionProtFeatures for MRPS18C_SIGLEC10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRPS18C

Q9Y3D5

SIGLEC10

Q96LC7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MRPS18C_SIGLEC10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MRPS18C_SIGLEC10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MRPS18C_SIGLEC10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MRPS18C_SIGLEC10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource