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Fusion gene ID: 22544 |
FusionGeneSummary for MRPS18C_DDX21 |
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Fusion gene information | Fusion gene name: MRPS18C_DDX21 | Fusion gene ID: 22544 | Hgene | Tgene | Gene symbol | MRPS18C | DDX21 | Gene ID | 51023 | 54606 |
Gene name | mitochondrial ribosomal protein S18C | DEAD-box helicase 56 | |
Synonyms | CGI-134|MRP-S18-1|MRP-S18-c|MRPS18-1|S18mt-c|mrps18-c | DDX21|DDX26|NOH61 | |
Cytomap | 4q21.23 | 7p13 | |
Type of gene | protein-coding | protein-coding | |
Description | 28S ribosomal protein S18c, mitochondrial28S ribosomal protein S18-1, mitochondrialmitochondrial ribosomal protein S18-1mitochondrial small ribosomal subunit protein bS18cmitochondrial small ribosomal subunit protein bS18mmitochondrial small ribosoma | probable ATP-dependent RNA helicase DDX5661-kd nucleolar helicaseATP-dependent 61 kDa nucleolar RNA helicaseDEAD (Asp-Glu-Ala-Asp) box helicase 56DEAD (Asp-Glu-Ala-Asp) box polypeptide 56DEAD box protein 21DEAD box protein 56DEAD-box RNA helicasen | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q9Y3D5 | Q9NR30 | |
Ensembl transtripts involved in fusion gene | ENST00000295491, ENST00000507019, ENST00000507349, ENST00000509571, | ENST00000354185, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 33 X 8 X 14=3696 |
# samples | 4 | 37 | |
** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(37/3696*10)=-3.32036758089975 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MRPS18C [Title/Abstract] AND DDX21 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ776304 | MRPS18C | chr4 | 84382173 | - | DDX21 | chr10 | 70719718 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000295491 | ENST00000354185 | MRPS18C | chr4 | 84382173 | - | DDX21 | chr10 | 70719718 | + |
Frame-shift | ENST00000507019 | ENST00000354185 | MRPS18C | chr4 | 84382173 | - | DDX21 | chr10 | 70719718 | + |
In-frame | ENST00000507349 | ENST00000354185 | MRPS18C | chr4 | 84382173 | - | DDX21 | chr10 | 70719718 | + |
intron-3CDS | ENST00000509571 | ENST00000354185 | MRPS18C | chr4 | 84382173 | - | DDX21 | chr10 | 70719718 | + |
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FusionProtFeatures for MRPS18C_DDX21 |
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Hgene | Tgene |
MRPS18C | DDX21 |
RNA helicase that acts as a sensor of thetranscriptional status of both RNA polymerase (Pol) I and II:promotes ribosomal RNA (rRNA) processing and transcription frompolymerase II (Pol II) (PubMed:25470060). Binds various RNAs, suchas rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs(PubMed:25470060). In the nucleolus, localizes to rDNA locus,where it directly binds rRNAs and snoRNAs, and promotes rRNAtranscription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes(PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SKRNA and is recruited to the promoters of Pol II-transcribed genes:acts by facilitating the release of P-TEFb from inhibitory 7SKsnRNP in a manner that is dependent on its helicase activity,thereby promoting transcription of its target genes(PubMed:25470060). Functions as cofactor for JUN-activatedtranscription: required for phosphorylation of JUN at 'Ser-77'(PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA(helicase) and can fold or introduce a secondary structure to asingle-stranded RNA (foldase) (PubMed:9461305). Involved in rRNAprocessing (PubMed:14559904, PubMed:18180292). May bind tospecific miRNA hairpins (PubMed:28431233).{ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904,ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534,ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391,ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:9461305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MRPS18C_DDX21 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_MRPS18C_ENST00000507349_chr4_84382173_-_DDX21_ENST00000354185_chr10_70719718_+_0aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_MRPS18C_ENST00000507349_chr4_84382173_-_DDX21_ENST00000354185_chr10_70719718_+_0nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_MRPS18C_ENST00000507349_chr4_84382173_-_DDX21_ENST00000354185_chr10_70719718_+_0nt |
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FusionGenePPI for MRPS18C_DDX21 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MRPS18C_DDX21 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MRPS18C_DDX21 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |