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Fusion gene ID: 22538 |
FusionGeneSummary for MRPS17_PSPH |
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Fusion gene information | Fusion gene name: MRPS17_PSPH | Fusion gene ID: 22538 | Hgene | Tgene | Gene symbol | MRPS17 | PSPH | Gene ID | 51373 | 5723 |
Gene name | mitochondrial ribosomal protein S17 | phosphoserine phosphatase | |
Synonyms | HSPC011|MRP-S17|RPMS17|S17mt | PSP|PSPHD | |
Cytomap | 7p11.2 | 7p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | 28S ribosomal protein S17, mitochondrialmitochondrial small ribosomal subunit protein uS17m | phosphoserine phosphataseL-3-phosphoserine phosphataseO-phosphoserine phosphohydrolasePSPase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9Y2R5 | P78330 | |
Ensembl transtripts involved in fusion gene | ENST00000426595, ENST00000285298, | ENST00000275605, ENST00000395471, ENST00000459834, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 12 X 13 X 4=624 |
# samples | 1 | 14 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(14/624*10)=-2.15611920191728 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MRPS17 [Title/Abstract] AND PSPH [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PSPH | GO:0006563 | L-serine metabolic process | 15291819 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-21-A5DI-01A | MRPS17 | chr7 | 56019623 | + | PSPH | chr7 | 56082864 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000426595 | ENST00000275605 | MRPS17 | chr7 | 56019623 | + | PSPH | chr7 | 56082864 | - |
intron-3CDS | ENST00000426595 | ENST00000395471 | MRPS17 | chr7 | 56019623 | + | PSPH | chr7 | 56082864 | - |
intron-5UTR | ENST00000426595 | ENST00000459834 | MRPS17 | chr7 | 56019623 | + | PSPH | chr7 | 56082864 | - |
5UTR-3CDS | ENST00000285298 | ENST00000275605 | MRPS17 | chr7 | 56019623 | + | PSPH | chr7 | 56082864 | - |
5UTR-3CDS | ENST00000285298 | ENST00000395471 | MRPS17 | chr7 | 56019623 | + | PSPH | chr7 | 56082864 | - |
5UTR-5UTR | ENST00000285298 | ENST00000459834 | MRPS17 | chr7 | 56019623 | + | PSPH | chr7 | 56082864 | - |
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FusionProtFeatures for MRPS17_PSPH |
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Hgene | Tgene |
MRPS17 | PSPH |
Catalyzes the last step in the biosynthesis of serinefrom carbohydrates. The reaction mechanism proceeds via theformation of a phosphoryl-enzyme intermediates.{ECO:0000269|PubMed:12777757}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MRPS17_PSPH |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MRPS17_PSPH |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MRPS17 | ICT1, RNF2, MED4, ECSIT, THOC1, VPS16, ERBB3, ZNF746, KIFAP3, DLST | PSPH | PRPSAP1, STYXL1, ASF1B, PSPH, ATXN1, FLAD1, OGT, PHGDH, SHC1, TIMM8B, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MRPS17_PSPH |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PSPH | P78330 | DB01593 | Zinc | Phosphoserine phosphatase | small molecule | approved|investigational |
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RelatedDiseases for MRPS17_PSPH |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PSPH | C0002514 | Amino Acid Metabolism, Inborn Errors | 1 | CTD_human |
Tgene | PSPH | C1291463 | Deficiency of phosphoserine phosphatase | 1 | ORPHANET;UNIPROT |