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Fusion gene ID: 22513 |
FusionGeneSummary for MRPL48_LRP5 |
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Fusion gene information | Fusion gene name: MRPL48_LRP5 | Fusion gene ID: 22513 | Hgene | Tgene | Gene symbol | MRPL48 | LRP5 | Gene ID | 51642 | 4041 |
Gene name | mitochondrial ribosomal protein L48 | LDL receptor related protein 5 | |
Synonyms | CGI-118|HSPC290|L48MT|MRP-L48 | BMND1|EVR1|EVR4|HBM|LR3|LRP-5|LRP7|OPPG|OPS|OPTA1|PCLD4|VBCH2 | |
Cytomap | 11q13.4 | 11q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | 39S ribosomal protein L48, mitochondrialmitochondrial large ribosomal subunit protein mL48 | low-density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 7 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96GC5 | O75197 | |
Ensembl transtripts involved in fusion gene | ENST00000310614, ENST00000535529, ENST00000411840, ENST00000398483, ENST00000542303, ENST00000314282, | ENST00000294304, ENST00000529481, | |
Fusion gene scores | * DoF score | 11 X 4 X 8=352 | 10 X 9 X 7=630 |
# samples | 17 | 12 | |
** MAII score | log2(17/352*10)=-1.0500406824996 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/630*10)=-2.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MRPL48 [Title/Abstract] AND LRP5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | LRP5 | GO:0008284 | positive regulation of cell proliferation | 9790987 |
Tgene | LRP5 | GO:0016055 | Wnt signaling pathway | 17955262 |
Tgene | LRP5 | GO:0044332 | Wnt signaling pathway involved in dorsal/ventral axis specification | 11029007 |
Tgene | LRP5 | GO:0045840 | positive regulation of mitotic nuclear division | 9790987 |
Tgene | LRP5 | GO:0045893 | positive regulation of transcription, DNA-templated | 15035989|17955262 |
Tgene | LRP5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12857724 |
Tgene | LRP5 | GO:0060070 | canonical Wnt signaling pathway | 12121999|12857724|15035989 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LIHC | TCGA-DD-AADY-01A | MRPL48 | chr11 | 73536841 | + | LRP5 | chr11 | 68115315 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000310614 | ENST00000294304 | MRPL48 | chr11 | 73536841 | + | LRP5 | chr11 | 68115315 | + |
5CDS-intron | ENST00000310614 | ENST00000529481 | MRPL48 | chr11 | 73536841 | + | LRP5 | chr11 | 68115315 | + |
Frame-shift | ENST00000535529 | ENST00000294304 | MRPL48 | chr11 | 73536841 | + | LRP5 | chr11 | 68115315 | + |
5CDS-intron | ENST00000535529 | ENST00000529481 | MRPL48 | chr11 | 73536841 | + | LRP5 | chr11 | 68115315 | + |
5UTR-3CDS | ENST00000411840 | ENST00000294304 | MRPL48 | chr11 | 73536841 | + | LRP5 | chr11 | 68115315 | + |
5UTR-intron | ENST00000411840 | ENST00000529481 | MRPL48 | chr11 | 73536841 | + | LRP5 | chr11 | 68115315 | + |
5UTR-3CDS | ENST00000398483 | ENST00000294304 | MRPL48 | chr11 | 73536841 | + | LRP5 | chr11 | 68115315 | + |
5UTR-intron | ENST00000398483 | ENST00000529481 | MRPL48 | chr11 | 73536841 | + | LRP5 | chr11 | 68115315 | + |
Frame-shift | ENST00000542303 | ENST00000294304 | MRPL48 | chr11 | 73536841 | + | LRP5 | chr11 | 68115315 | + |
5CDS-intron | ENST00000542303 | ENST00000529481 | MRPL48 | chr11 | 73536841 | + | LRP5 | chr11 | 68115315 | + |
intron-3CDS | ENST00000314282 | ENST00000294304 | MRPL48 | chr11 | 73536841 | + | LRP5 | chr11 | 68115315 | + |
intron-intron | ENST00000314282 | ENST00000529481 | MRPL48 | chr11 | 73536841 | + | LRP5 | chr11 | 68115315 | + |
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FusionProtFeatures for MRPL48_LRP5 |
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Hgene | Tgene |
MRPL48 | LRP5 |
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggersbeta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surfacecoreceptor of Wnt/beta-catenin signaling, which plays a pivotalrole in bone formation. Plays a role in norrin (NDP) signaltransduction (PubMed:27228167). The Wnt-induced Fzd/LRP6coreceptor complex recruits DVL1 polymers to the plasma membranewhich, in turn, recruits the AXIN1/GSK3B-complex to the cellsurface promoting the formation of signalsomes and inhibitingAXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascularregression in the eye (By similarity). Required for posteriorpatterning of the epiblast during gastrulation (By similarity).{ECO:0000250|UniProtKB:Q91VN0, ECO:0000269|PubMed:11336703,ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:14727154,ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15778503,ECO:0000269|PubMed:27228167}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MRPL48_LRP5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MRPL48_LRP5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MRPL48 | OXA1L, ICT1, APP, HNRNPU, EXOSC2, LSM8, TARDBP, GRSF1, RNF2, BTRC, RPL13, NIFK, MRPL46, MRPL4, MRPL39, MRPS30, MRPL47, HNRNPA1, MRPL9, MRPL55, SDHB, CRK, RPL10, AP4M1, EXOSC4, MRPL50, CDC14B, MRPL10, MRPL41, RPL18, MRPL12, MRPL42, MRPL35 | LRP5 | AXIN1, SMAD9, CAPRIN2, SOST, DKK1, FZD8, TAZ, RASD2, SUSD4, PARP16, POMK, B3GALT2, ETV6, CHST9, LIPH, PRSS37, CSNK1A1, TGIF2LY, DKKL1, SERPINA12, ST8SIA4, SCGB1D1, DKK4, MGAT4C, F9, FAM3B, C4orf26, FCGRT, PODN, ADAM33, BRINP3, LRRC4C, CLPSL1, NXPH2, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MRPL48_LRP5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MRPL48_LRP5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | LRP5 | C0432252 | Osteoporosis with pseudoglioma | 8 | CTD_human;ORPHANET;UNIPROT |
Tgene | LRP5 | C1866176 | EXUDATIVE VITREORETINOPATHY 4 (disorder) | 8 | CTD_human;UNIPROT |
Tgene | LRP5 | C1866079 | BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 1 | 5 | UNIPROT |
Tgene | LRP5 | C0242852 | Proliferative vitreoretinopathy | 1 | CTD_human |
Tgene | LRP5 | C0432273 | Worth disease | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | LRP5 | C1843330 | OSTEOPETROSIS, AUTOSOMAL DOMINANT 1 | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | LRP5 | C1851402 | Exudative vitreoretinopathy 1 | 1 | ORPHANET;UNIPROT |