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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 225

FusionGeneSummary for ABHD3_ANKRD29

check button Fusion gene summary
Fusion gene informationFusion gene name: ABHD3_ANKRD29
Fusion gene ID: 225
HgeneTgene
Gene symbol

ABHD3

ANKRD29

Gene ID

171586

147463

Gene nameabhydrolase domain containing 3ankyrin repeat domain 29
SynonymsLABH3-
Cytomap

18q11.2

18q11.2

Type of geneprotein-codingprotein-coding
Descriptionphospholipase ABHD3abhydrolase domain-containing protein 3alpha/beta hydrolase domain containing protein 3lung alpha/beta hydrolase 3ankyrin repeat domain-containing protein 29
Modification date2018052320180519
UniProtAcc

Q8WU67

Q8N6D5

Ensembl transtripts involved in fusion geneENST00000289119, ENST00000580981, 
ENST00000578270, ENST00000579875, 
ENST00000592179, ENST00000322980, 
ENST00000585908, ENST00000284207, 
ENST00000586511, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 4 X 6=144
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABHD3 [Title/Abstract] AND ANKRD29 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-L5-A893-01AABHD3chr18

19244079

-ANKRD29chr18

21214113

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000289119ENST00000592179ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
Frame-shitENST00000289119ENST00000322980ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
5CDS-intronENST00000289119ENST00000585908ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
5CDS-intronENST00000289119ENST00000284207ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
5CDS-intronENST00000289119ENST00000586511ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-3CDSENST00000580981ENST00000592179ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-3CDSENST00000580981ENST00000322980ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000580981ENST00000585908ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000580981ENST00000284207ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000580981ENST00000586511ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-3CDSENST00000578270ENST00000592179ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-3CDSENST00000578270ENST00000322980ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000578270ENST00000585908ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000578270ENST00000284207ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000578270ENST00000586511ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-3CDSENST00000579875ENST00000592179ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-3CDSENST00000579875ENST00000322980ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000579875ENST00000585908ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000579875ENST00000284207ABHD3chr18

19244079

-ANKRD29chr18

21214113

-
intron-intronENST00000579875ENST00000586511ABHD3chr18

19244079

-ANKRD29chr18

21214113

-

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FusionProtFeatures for ABHD3_ANKRD29


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABHD3

Q8WU67

ANKRD29

Q8N6D5

Phospholipase that may play a role in phospholipidsremodeling. May selectively cleave myristate (C14)-containingphosphatidylcholines through its predominant phospholipase 1activity, cleaving preferentially acyl groups in sn1 position. Inparallel, may have a minor phospholipase 2 activity acting on acylgroups in position sn2. In addition to (C14)-containingphosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.{ECO:0000269|PubMed:21926997}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ABHD3_ANKRD29


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ABHD3_ANKRD29


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ABHD3KLK15, ATP1B3, HTR3C, MAS1, HTR3A, IL17RCANKRD29YTHDF1, ADD2, ADD1, FAM122B, UBP1, TFCP2, ADD3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ABHD3_ANKRD29


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ABHD3_ANKRD29


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource