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Fusion gene ID: 22495 |
FusionGeneSummary for MRPL37_MASP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MRPL37_MASP2 | Fusion gene ID: 22495 | Hgene | Tgene | Gene symbol | MRPL37 | MASP2 | Gene ID | 51253 | 10747 |
| Gene name | mitochondrial ribosomal protein L37 | mannan binding lectin serine peptidase 2 | |
| Synonyms | L2mt|L37mt|MRP-L2|MRP-L37|MRPL2|RPML2 | MAP19|MASP-2|MASP1P1|sMAP | |
| Cytomap | 1p32.3 | 1p36.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 39S ribosomal protein L37, mitochondrial39S ribosomal protein L2, mitochondrialmitochondrial large ribosomal subunit protein mL37ribosomal protein, mitochondrial, L2 | mannan-binding lectin serine protease 2MBL-associated plasma protein of 19 kDMBL-associated serine protease 2mannan-binding lectin serine peptidase 1 pseudogene 1mannan-binding lectin serine protease 1 pseudogene 1mannose-binding protein-associated s | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9BZE1 | O00187 | |
| Ensembl transtripts involved in fusion gene | ENST00000487096, ENST00000360840, ENST00000605337, ENST00000336230, | ENST00000400897, ENST00000400898, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 3 X 2 X 2=12 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MRPL37 [Title/Abstract] AND MASP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MASP2 | GO:0001867 | complement activation, lectin pathway | 9087411|17182967 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-BR-4357-01A | MRPL37 | chr1 | 54666262 | + | MASP2 | chr1 | 11090939 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000487096 | ENST00000400897 | MRPL37 | chr1 | 54666262 | + | MASP2 | chr1 | 11090939 | - |
| intron-intron | ENST00000487096 | ENST00000400898 | MRPL37 | chr1 | 54666262 | + | MASP2 | chr1 | 11090939 | - |
| In-frame | ENST00000360840 | ENST00000400897 | MRPL37 | chr1 | 54666262 | + | MASP2 | chr1 | 11090939 | - |
| 5CDS-intron | ENST00000360840 | ENST00000400898 | MRPL37 | chr1 | 54666262 | + | MASP2 | chr1 | 11090939 | - |
| In-frame | ENST00000605337 | ENST00000400897 | MRPL37 | chr1 | 54666262 | + | MASP2 | chr1 | 11090939 | - |
| 5CDS-intron | ENST00000605337 | ENST00000400898 | MRPL37 | chr1 | 54666262 | + | MASP2 | chr1 | 11090939 | - |
| Frame-shift | ENST00000336230 | ENST00000400897 | MRPL37 | chr1 | 54666262 | + | MASP2 | chr1 | 11090939 | - |
| 5CDS-intron | ENST00000336230 | ENST00000400898 | MRPL37 | chr1 | 54666262 | + | MASP2 | chr1 | 11090939 | - |
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FusionProtFeatures for MRPL37_MASP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MRPL37 | MASP2 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MRPL37_MASP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MRPL37_ENST00000360840_chr1_54666262_+_MASP2_ENST00000400897_chr1_11090939_-_440aa MALASGPARRALAGSGQLGLGGFGAPRRGAYEWGVRSTRKSEPPPLDRVYEIPGLEPITFAGKMHFVPWLARPIFPPWDRGYKDPRFYRS PPLHEHPLYKDQACYIFHHRCRLLEVVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSL PVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAV FIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPY >In-frame_MRPL37_ENST00000605337_chr1_54666262_+_MASP2_ENST00000400897_chr1_11090939_-_440aa MALASGPARRALAGSGQLGLGGFGAPRRGAYEWGVRSTRKSEPPPLDRVYEIPGLEPITFAGKMHFVPWLARPIFPPWDRGYKDPRFYRS PPLHEHPLYKDQACYIFHHRCRLLEVVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSL PVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAV FIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MRPL37_ENST00000360840_chr1_54666262_+_MASP2_ENST00000400897_chr1_11090939_-_1320nt ATGGCATTGGCGTCCGGGCCCGCAAGGCGGGCGCTAGCTGGCTCCGGGCAGCTCGGCCTTGGGGGCTTCGGGGCCCCGAGACGCGGGGCG TATGAGTGGGGCGTGCGCTCCACGCGGAAGTCGGAGCCTCCTCCCCTGGATAGGGTGTACGAGATCCCTGGACTGGAGCCCATCACCTTT GCGGGGAAGATGCACTTCGTGCCCTGGCTGGCGCGGCCGATCTTTCCGCCCTGGGACCGCGGCTACAAGGACCCAAGGTTCTACCGCTCG CCCCCTCTTCACGAGCATCCGCTGTACAAAGACCAGGCCTGCTATATCTTTCACCACCGTTGCCGCCTTCTCGAGGTTGTTGACTGTGGC CCTCCTGATGATCTACCCAGTGGCCGAGTGGAGTACATCACAGGTCCTGGAGTGACCACCTACAAAGCTGTGATTCAGTACAGCTGTGAA GAGACCTTCTACACAATGAAAGTGAATGATGGTAAATATGTGTGTGAGGCTGATGGATTCTGGACGAGCTCCAAAGGAGAAAAATCACTC CCAGTCTGTGAGCCTGTTTGTGGACTATCAGCCCGCACAACAGGAGGGCGTATATATGGAGGGCAAAAGGCAAAACCTGGTGATTTTCCT TGGCAAGTCCTGATATTAGGTGGAACCACAGCAGCAGGTGCACTTTTATATGACAACTGGGTCCTAACAGCTGCTCATGCCGTCTATGAG CAAAAACATGATGCATCCGCCCTGGACATTCGAATGGGCACCCTGAAAAGACTATCACCTCATTATACACAAGCCTGGTCTGAAGCTGTT TTTATACATGAAGGTTATACTCATGATGCTGGCTTTGACAATGACATAGCACTGATTAAATTGAATAACAAAGTTGTAATCAATAGCAAC ATCACGCCTATTTGTCTGCCAAGAAAAGAAGCTGAATCCTTTATGAGGACAGATGACATTGGAACTGCATCTGGATGGGGATTAACCCAA AGGGGTTTTCTTGCTAGAAATCTAATGTATGTCGACATACCGATTGTTGACCATCAAAAATGTACTGCTGCATATGAAAAGCCACCCTAT CCAAGGGGAAGTGTAACTGCTAACATGCTTTGTGCTGGCTTAGAAAGTGGGGGCAAGGACAGCTGCAGAGGTGACAGCGGAGGGGCACTG GTGTTTCTAGATAGTGAAACAGAGAGGTGGTTTGTGGGAGGAATAGTGTCCTGGGGTTCCATGAATTGTGGGGAAGCAGGTCAGTATGGA >In-frame_MRPL37_ENST00000605337_chr1_54666262_+_MASP2_ENST00000400897_chr1_11090939_-_1320nt ATGGCATTGGCGTCCGGGCCCGCAAGGCGGGCGCTAGCTGGCTCCGGGCAGCTCGGCCTTGGGGGCTTCGGGGCCCCGAGACGCGGGGCG TATGAGTGGGGCGTGCGCTCCACGCGGAAGTCGGAGCCTCCTCCCCTGGATAGGGTGTACGAGATCCCTGGACTGGAGCCCATCACCTTT GCGGGGAAGATGCACTTCGTGCCCTGGCTGGCGCGGCCGATCTTTCCGCCCTGGGACCGCGGCTACAAGGACCCAAGGTTCTACCGCTCG CCCCCTCTTCACGAGCATCCGCTGTACAAAGACCAGGCCTGCTATATCTTTCACCACCGTTGCCGCCTTCTCGAGGTTGTTGACTGTGGC CCTCCTGATGATCTACCCAGTGGCCGAGTGGAGTACATCACAGGTCCTGGAGTGACCACCTACAAAGCTGTGATTCAGTACAGCTGTGAA GAGACCTTCTACACAATGAAAGTGAATGATGGTAAATATGTGTGTGAGGCTGATGGATTCTGGACGAGCTCCAAAGGAGAAAAATCACTC CCAGTCTGTGAGCCTGTTTGTGGACTATCAGCCCGCACAACAGGAGGGCGTATATATGGAGGGCAAAAGGCAAAACCTGGTGATTTTCCT TGGCAAGTCCTGATATTAGGTGGAACCACAGCAGCAGGTGCACTTTTATATGACAACTGGGTCCTAACAGCTGCTCATGCCGTCTATGAG CAAAAACATGATGCATCCGCCCTGGACATTCGAATGGGCACCCTGAAAAGACTATCACCTCATTATACACAAGCCTGGTCTGAAGCTGTT TTTATACATGAAGGTTATACTCATGATGCTGGCTTTGACAATGACATAGCACTGATTAAATTGAATAACAAAGTTGTAATCAATAGCAAC ATCACGCCTATTTGTCTGCCAAGAAAAGAAGCTGAATCCTTTATGAGGACAGATGACATTGGAACTGCATCTGGATGGGGATTAACCCAA AGGGGTTTTCTTGCTAGAAATCTAATGTATGTCGACATACCGATTGTTGACCATCAAAAATGTACTGCTGCATATGAAAAGCCACCCTAT CCAAGGGGAAGTGTAACTGCTAACATGCTTTGTGCTGGCTTAGAAAGTGGGGGCAAGGACAGCTGCAGAGGTGACAGCGGAGGGGCACTG GTGTTTCTAGATAGTGAAACAGAGAGGTGGTTTGTGGGAGGAATAGTGTCCTGGGGTTCCATGAATTGTGGGGAAGCAGGTCAGTATGGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MRPL37_ENST00000360840_chr1_54666262_+_MASP2_ENST00000400897_chr1_11090939_-_1759nt CTCATTCGTTCCCAGCAGGCCCTGCGCGCGGCAACATGGCGGGGTCCAGGTGGAGGTCTTGAGGCTATCAGATCGGTATGGCATTGGCGT CCGGGCCCGCAAGGCGGGCGCTAGCTGGCTCCGGGCAGCTCGGCCTTGGGGGCTTCGGGGCCCCGAGACGCGGGGCGTATGAGTGGGGCG TGCGCTCCACGCGGAAGTCGGAGCCTCCTCCCCTGGATAGGGTGTACGAGATCCCTGGACTGGAGCCCATCACCTTTGCGGGGAAGATGC ACTTCGTGCCCTGGCTGGCGCGGCCGATCTTTCCGCCCTGGGACCGCGGCTACAAGGACCCAAGGTTCTACCGCTCGCCCCCTCTTCACG AGCATCCGCTGTACAAAGACCAGGCCTGCTATATCTTTCACCACCGTTGCCGCCTTCTCGAGGTTGTTGACTGTGGCCCTCCTGATGATC TACCCAGTGGCCGAGTGGAGTACATCACAGGTCCTGGAGTGACCACCTACAAAGCTGTGATTCAGTACAGCTGTGAAGAGACCTTCTACA CAATGAAAGTGAATGATGGTAAATATGTGTGTGAGGCTGATGGATTCTGGACGAGCTCCAAAGGAGAAAAATCACTCCCAGTCTGTGAGC CTGTTTGTGGACTATCAGCCCGCACAACAGGAGGGCGTATATATGGAGGGCAAAAGGCAAAACCTGGTGATTTTCCTTGGCAAGTCCTGA TATTAGGTGGAACCACAGCAGCAGGTGCACTTTTATATGACAACTGGGTCCTAACAGCTGCTCATGCCGTCTATGAGCAAAAACATGATG CATCCGCCCTGGACATTCGAATGGGCACCCTGAAAAGACTATCACCTCATTATACACAAGCCTGGTCTGAAGCTGTTTTTATACATGAAG GTTATACTCATGATGCTGGCTTTGACAATGACATAGCACTGATTAAATTGAATAACAAAGTTGTAATCAATAGCAACATCACGCCTATTT GTCTGCCAAGAAAAGAAGCTGAATCCTTTATGAGGACAGATGACATTGGAACTGCATCTGGATGGGGATTAACCCAAAGGGGTTTTCTTG CTAGAAATCTAATGTATGTCGACATACCGATTGTTGACCATCAAAAATGTACTGCTGCATATGAAAAGCCACCCTATCCAAGGGGAAGTG TAACTGCTAACATGCTTTGTGCTGGCTTAGAAAGTGGGGGCAAGGACAGCTGCAGAGGTGACAGCGGAGGGGCACTGGTGTTTCTAGATA GTGAAACAGAGAGGTGGTTTGTGGGAGGAATAGTGTCCTGGGGTTCCATGAATTGTGGGGAAGCAGGTCAGTATGGAGTCTACACAAAAG TTATTAACTATATTCCCTGGATCGAGAACATAATTAGTGATTTTTAACTTGCGTGTCTGCAGTCAAGGATTCTTCATTTTTAGAAATGCC TGTGAAGACCTTGGCAGCGACGTGGCTCGAGAAGCATTCATCATTACTGTGGACATGGCAGTTGTTGCTCCACCCAAAAAAACAGACTCC AGGTGAGGCTGCTGTCATTTCTCCACTTGCCAGTTTAATTCCAGCCTTACCCATTGACTCAAGGGGACATAAACCACGAGAGTGACAGTC ATCTTTGCCCACCCAGTGTAATGTCACTGCTCAAATTACATTTCATTACCTTAAAAAGCCAGTCTCTTTTCATACTGGCTGTTGGCATTT >In-frame_MRPL37_ENST00000605337_chr1_54666262_+_MASP2_ENST00000400897_chr1_11090939_-_1730nt GGCAACATGGCGGGGTCCAGGTGGAGGTCTTGAGGCTATCAGATCGGTATGGCATTGGCGTCCGGGCCCGCAAGGCGGGCGCTAGCTGGC TCCGGGCAGCTCGGCCTTGGGGGCTTCGGGGCCCCGAGACGCGGGGCGTATGAGTGGGGCGTGCGCTCCACGCGGAAGTCGGAGCCTCCT CCCCTGGATAGGGTGTACGAGATCCCTGGACTGGAGCCCATCACCTTTGCGGGGAAGATGCACTTCGTGCCCTGGCTGGCGCGGCCGATC TTTCCGCCCTGGGACCGCGGCTACAAGGACCCAAGGTTCTACCGCTCGCCCCCTCTTCACGAGCATCCGCTGTACAAAGACCAGGCCTGC TATATCTTTCACCACCGTTGCCGCCTTCTCGAGGTTGTTGACTGTGGCCCTCCTGATGATCTACCCAGTGGCCGAGTGGAGTACATCACA GGTCCTGGAGTGACCACCTACAAAGCTGTGATTCAGTACAGCTGTGAAGAGACCTTCTACACAATGAAAGTGAATGATGGTAAATATGTG TGTGAGGCTGATGGATTCTGGACGAGCTCCAAAGGAGAAAAATCACTCCCAGTCTGTGAGCCTGTTTGTGGACTATCAGCCCGCACAACA GGAGGGCGTATATATGGAGGGCAAAAGGCAAAACCTGGTGATTTTCCTTGGCAAGTCCTGATATTAGGTGGAACCACAGCAGCAGGTGCA CTTTTATATGACAACTGGGTCCTAACAGCTGCTCATGCCGTCTATGAGCAAAAACATGATGCATCCGCCCTGGACATTCGAATGGGCACC CTGAAAAGACTATCACCTCATTATACACAAGCCTGGTCTGAAGCTGTTTTTATACATGAAGGTTATACTCATGATGCTGGCTTTGACAAT GACATAGCACTGATTAAATTGAATAACAAAGTTGTAATCAATAGCAACATCACGCCTATTTGTCTGCCAAGAAAAGAAGCTGAATCCTTT ATGAGGACAGATGACATTGGAACTGCATCTGGATGGGGATTAACCCAAAGGGGTTTTCTTGCTAGAAATCTAATGTATGTCGACATACCG ATTGTTGACCATCAAAAATGTACTGCTGCATATGAAAAGCCACCCTATCCAAGGGGAAGTGTAACTGCTAACATGCTTTGTGCTGGCTTA GAAAGTGGGGGCAAGGACAGCTGCAGAGGTGACAGCGGAGGGGCACTGGTGTTTCTAGATAGTGAAACAGAGAGGTGGTTTGTGGGAGGA ATAGTGTCCTGGGGTTCCATGAATTGTGGGGAAGCAGGTCAGTATGGAGTCTACACAAAAGTTATTAACTATATTCCCTGGATCGAGAAC ATAATTAGTGATTTTTAACTTGCGTGTCTGCAGTCAAGGATTCTTCATTTTTAGAAATGCCTGTGAAGACCTTGGCAGCGACGTGGCTCG AGAAGCATTCATCATTACTGTGGACATGGCAGTTGTTGCTCCACCCAAAAAAACAGACTCCAGGTGAGGCTGCTGTCATTTCTCCACTTG CCAGTTTAATTCCAGCCTTACCCATTGACTCAAGGGGACATAAACCACGAGAGTGACAGTCATCTTTGCCCACCCAGTGTAATGTCACTG CTCAAATTACATTTCATTACCTTAAAAAGCCAGTCTCTTTTCATACTGGCTGTTGGCATTTCTGTAAACTGCCTGTCCATGCTCTTTGTT |
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FusionGenePPI for MRPL37_MASP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MRPL37 | HNRNPA1, ICT1, TK1, SMN1, TCF3, CUL3, MRPL9, MRPL39, MRPL38, MRPL24, MRPL44, MRPL41, MRPL32, MRPL50, MRPL45, MRPL51, MRPL2, MRPL40, MRPL42, MRPL12, TSR1, HNRNPM, ABCC2, FAF2, DLD, UBC, NPM1, ENO1, SHMT2, MOV10, NXF1, BTRC, MRPL28, MRPL4, HSPD1, MRPL46, MRPL11, MRPL3, PDPR, MRPL49, PDP1, MRPL27, MRPL55, MALSU1, MRPL47, MRPL16, ACOT2, MRPL13, PM20D2, GADD45GIP1, MRPL15, MRPS30, MRPL30, DHRS4, MRPL14, AGPS, ATP5L, MRPL17, CYC1, MRPL18, MRPL22, MTCH2, PDCD6, STOML2, UQCRC2, NTRK1, MRPL1, NANOG, DNLZ, CYLD, TRIM25 | MASP2 | MBL2, MASP1, SERPING1, FCN2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MRPL37_MASP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MRPL37_MASP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MASP2 | C0009324 | Ulcerative Colitis | 1 | CTD_human |
| Tgene | MASP2 | C0014742 | Erythema Multiforme | 1 | CTD_human |
| Tgene | MASP2 | C0020951 | Immune Complex Diseases | 1 | CTD_human |
| Tgene | MASP2 | C0021368 | Inflammation | 1 | CTD_human |
| Tgene | MASP2 | C0155862 | Streptococcal pneumonia | 1 | CTD_human |
| Tgene | MASP2 | C3151085 | MASP2 Deficiency | 1 | CTD_human;ORPHANET;UNIPROT |
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