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Fusion gene ID: 22477 |
FusionGeneSummary for MRPL24_CCT3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MRPL24_CCT3 | Fusion gene ID: 22477 | Hgene | Tgene | Gene symbol | MRPL24 | CCT3 | Gene ID | 79590 | 7203 |
| Gene name | mitochondrial ribosomal protein L24 | chaperonin containing TCP1 subunit 3 | |
| Synonyms | L24mt|MRP-L18|MRP-L24 | CCT-gamma|CCTG|PIG48|TCP-1-gamma|TRIC5 | |
| Cytomap | 1q23.1 | 1q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 39S ribosomal protein L24, mitochondrialmitochondrial large ribosomal subunit protein uL24m | T-complex protein 1 subunit gammaT-complex protein 1, gamma subunitTCP1 (t-complex-1) ring complex, polypeptide 5chaperonin containing TCP1, subunit 3 (gamma)hTRiC5 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96A35 | P49368 | |
| Ensembl transtripts involved in fusion gene | ENST00000478899, ENST00000361531, ENST00000368211, | ENST00000295688, ENST00000368259, ENST00000368261, ENST00000472765, ENST00000368256, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 12 X 8 X 9=864 |
| # samples | 1 | 12 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(12/864*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MRPL24 [Title/Abstract] AND CCT3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LGG | TCGA-TM-A84J-01A | MRPL24 | chr1 | 156707438 | - | CCT3 | chr1 | 156294880 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000478899 | ENST00000295688 | MRPL24 | chr1 | 156707438 | - | CCT3 | chr1 | 156294880 | - |
| 5UTR-3CDS | ENST00000478899 | ENST00000368259 | MRPL24 | chr1 | 156707438 | - | CCT3 | chr1 | 156294880 | - |
| 5UTR-3CDS | ENST00000478899 | ENST00000368261 | MRPL24 | chr1 | 156707438 | - | CCT3 | chr1 | 156294880 | - |
| 5UTR-3CDS | ENST00000478899 | ENST00000472765 | MRPL24 | chr1 | 156707438 | - | CCT3 | chr1 | 156294880 | - |
| 5UTR-intron | ENST00000478899 | ENST00000368256 | MRPL24 | chr1 | 156707438 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000361531 | ENST00000295688 | MRPL24 | chr1 | 156707438 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000361531 | ENST00000368259 | MRPL24 | chr1 | 156707438 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000361531 | ENST00000368261 | MRPL24 | chr1 | 156707438 | - | CCT3 | chr1 | 156294880 | - |
| In-frame | ENST00000361531 | ENST00000472765 | MRPL24 | chr1 | 156707438 | - | CCT3 | chr1 | 156294880 | - |
| 5CDS-intron | ENST00000361531 | ENST00000368256 | MRPL24 | chr1 | 156707438 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000368211 | ENST00000295688 | MRPL24 | chr1 | 156707438 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000368211 | ENST00000368259 | MRPL24 | chr1 | 156707438 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000368211 | ENST00000368261 | MRPL24 | chr1 | 156707438 | - | CCT3 | chr1 | 156294880 | - |
| Frame-shift | ENST00000368211 | ENST00000472765 | MRPL24 | chr1 | 156707438 | - | CCT3 | chr1 | 156294880 | - |
| 5CDS-intron | ENST00000368211 | ENST00000368256 | MRPL24 | chr1 | 156707438 | - | CCT3 | chr1 | 156294880 | - |
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FusionProtFeatures for MRPL24_CCT3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MRPL24 | CCT3 |
| Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MRPL24_CCT3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MRPL24_ENST00000361531_chr1_156707438_-_CCT3_ENST00000295688_chr1_156294880_-_444aa QGKCCLXLSTSWSSRCTQQWXSVLTARHWMIXSAPXRKXVSQSTSVTVIXCXTSSTALLLPKPSVGGHLWLATLPWMLSRWYSLRRMVGK RLTXKNMQEWKRYLEASLKTPVSCVESXLTRMXPIHVCGAISRTLALCCWILLWNTRKEKARLTLRLHERRTSPEFSRWRKSTSSSSVRT LSNXSPMWSSLKRASQIXLSTTLCGPISQPSAESGRQTIIALLEPVGPGXSADQRNXEKMMLEQEQACWKSRKLEMNTLLSSLTAKTPRP APFSSGGLAKRFSRKXNATSRMPCKCVAMFSWTLSWCQGVGPPRWLWPMPXQKNPRPXLVWNNGHTGLLPRPXRSFLVPXSRTVGPAPSV >In-frame_MRPL24_ENST00000361531_chr1_156707438_-_CCT3_ENST00000368259_chr1_156294880_-_444aa QGKCCLXLSTSWSSRCTQQWXSVLTARHWMIXSAPXRKXVSQSTSVTVIXCXTSSTALLLPKPSVGGHLWLATLPWMLSRWYSLRRMVGK RLTXKNMQEWKRYLEASLKTPVSCVESXLTRMXPIHVCGAISRTLALCCWILLWNTRKEKARLTLRLHERRTSPEFSRWRKSTSSSSVRT LSNXSPMWSSLKRASQIXLSTTLCGPISQPSAESGRQTIIALLEPVGPGXSADQRNXEKMMLEQEQACWKSRKLEMNTLLSSLTAKTPRP APFSSGGLAKRFSRKXNATSRMPCKCVAMFSWTLSWCQGVGPPRWLWPMPXQKNPRPXLVWNNGHTGLLPRPXRSFLVPXSRTVGPAPSV >In-frame_MRPL24_ENST00000361531_chr1_156707438_-_CCT3_ENST00000368261_chr1_156294880_-_444aa QGKCCLXLSTSWSSRCTQQWXSVLTARHWMIXSAPXRKXVSQSTSVTVIXCXTSSTALLLPKPSVGGHLWLATLPWMLSRWYSLRRMVGK RLTXKNMQEWKRYLEASLKTPVSCVESXLTRMXPIHVCGAISRTLALCCWILLWNTRKEKARLTLRLHERRTSPEFSRWRKSTSSSSVRT LSNXSPMWSSLKRASQIXLSTTLCGPISQPSAESGRQTIIALLEPVGPGXSADQRNXEKMMLEQEQACWKSRKLEMNTLLSSLTAKTPRP APFSSGGLAKRFSRKXNATSRMPCKCVAMFSWTLSWCQGVGPPRWLWPMPXQKNPRPXLVWNNGHTGLLPRPXRSFLVPXSRTVGPAPSV >In-frame_MRPL24_ENST00000361531_chr1_156707438_-_CCT3_ENST00000472765_chr1_156294880_-_444aa QGKCCLXLSTSWSSRCTQQWXSVLTARHWMIXSAPXRKXVSQSTSVTVIXCXTSSTALLLPKPSVGGHLWLATLPWMLSRWYSLRRMVGK RLTXKNMQEWKRYLEASLKTPVSCVESXLTRMXPIHVCGAISRTLALCCWILLWNTRKEKARLTLRLHERRTSPEFSRWRKSTSSSSVRT LSNXSPMWSSLKRASQIXLSTTLCGPISQPSAESGRQTIIALLEPVGPGXSADQRNXEKMMLEQEQACWKSRKLEMNTLLSSLTAKTPRP APFSSGGLAKRFSRKXNATSRMPCKCVAMFSWTLSWCQGVGPPRWLWPMPXQKNPRPXLVWNNGHTGLLPRPXRSFLVPXSRTVGPAPSV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MRPL24_ENST00000361531_chr1_156707438_-_CCT3_ENST00000295688_chr1_156294880_-_1334nt CAGGGGAAATGCTGTCTGTAGCTGAGCACTTCCTGGAGCAGCAGATGCACCCAACAGTGGTGATCAGTGCTTACCGCAAGGCATTGGATG ATATGATCAGCACCCTAAAGAAAATAAGTATCCCAGTCGACATCAGTGACAGTGATATGATGCTGAACATCATCAACAGCTCTATTACTA CCAAAGCCATCAGTCGGTGGTCATCTTTGGCTTGCAACATTGCCCTGGATGCTGTCAAGATGGTACAGTTTGAGGAGAATGGTCGGAAAG AGATTGACATAAAAAAATATGCAAGAGTGGAAAAGATACCTGGAGGCATCATTGAAGACTCCTGTGTCTTGCGTGGAGTCATGATTAACA AGGATGTGACCCATCCACGTATGCGGCGCTATATCAAGAACCCTCGCATTGTGCTGCTGGATTCTTCTCTGGAATACAAGAAAGGAGAAA GCCAGACTGACATTGAGATTACACGAGAGGAGGACTTCACCCGAATTCTCCAGATGGAGGAAGAGTACATCCAGCAGCTCTGTGAGGACA TTATCCAACTGAAGCCCGATGTGGTCATCACTGAAAAGGGCATCTCAGATTTAGCTCAGCACTACCTTATGCGGGCCAATATCACAGCCA TCCGCAGAGTCCGGAAGACAGACAATAATCGCATTGCTAGAGCCTGTGGGGCCCGGATAGTCAGCCGACCAGAGGAACTGAGAGAAGATG ATGTTGGAACAGGAGCAGGCCTGTTGGAAATCAAGAAAATTGGAGATGAATACTTTACTTTCATCACTGACTGCAAAGACCCCAAGGCCT GCACCATTCTCCTCCGGGGGGCTAGCAAAGAGATTCTCTCGGAAGTAGAACGCAACCTCCAGGATGCCATGCAAGTGTGTCGCAATGTTC TCCTGGACCCTCAGCTGGTGCCAGGGGGTGGGGCCTCCGAGATGGCTGTGGCCCATGCCTTGACAGAAAAATCCAAGGCCATGACTGGTG TGGAACAATGGCCATACAGGGCTGTTGCCCAGGCCCTAGAGGTCATTCCTCGTACCCTGATCCAGAACTGTGGGGCCAGCACCATCCGTC TACTTACCTCCCTTCGGGCCAAGCACACCCAGGAGAACTGTGAGACCTGGGGTGTAAATGGTGAGACGGGTACTTTGGTGGACATGAAGG AACTGGGCATATGGGAGCCATTGGCTGTGAAGCTGCAGACTTATAAGACAGCAGTGGAGACGGCAGTTCTGCTACTGCGAATTGATGACA >In-frame_MRPL24_ENST00000361531_chr1_156707438_-_CCT3_ENST00000368259_chr1_156294880_-_1334nt CAGGGGAAATGCTGTCTGTAGCTGAGCACTTCCTGGAGCAGCAGATGCACCCAACAGTGGTGATCAGTGCTTACCGCAAGGCATTGGATG ATATGATCAGCACCCTAAAGAAAATAAGTATCCCAGTCGACATCAGTGACAGTGATATGATGCTGAACATCATCAACAGCTCTATTACTA CCAAAGCCATCAGTCGGTGGTCATCTTTGGCTTGCAACATTGCCCTGGATGCTGTCAAGATGGTACAGTTTGAGGAGAATGGTCGGAAAG AGATTGACATAAAAAAATATGCAAGAGTGGAAAAGATACCTGGAGGCATCATTGAAGACTCCTGTGTCTTGCGTGGAGTCATGATTAACA AGGATGTGACCCATCCACGTATGCGGCGCTATATCAAGAACCCTCGCATTGTGCTGCTGGATTCTTCTCTGGAATACAAGAAAGGAGAAA GCCAGACTGACATTGAGATTACACGAGAGGAGGACTTCACCCGAATTCTCCAGATGGAGGAAGAGTACATCCAGCAGCTCTGTGAGGACA TTATCCAACTGAAGCCCGATGTGGTCATCACTGAAAAGGGCATCTCAGATTTAGCTCAGCACTACCTTATGCGGGCCAATATCACAGCCA TCCGCAGAGTCCGGAAGACAGACAATAATCGCATTGCTAGAGCCTGTGGGGCCCGGATAGTCAGCCGACCAGAGGAACTGAGAGAAGATG ATGTTGGAACAGGAGCAGGCCTGTTGGAAATCAAGAAAATTGGAGATGAATACTTTACTTTCATCACTGACTGCAAAGACCCCAAGGCCT GCACCATTCTCCTCCGGGGGGCTAGCAAAGAGATTCTCTCGGAAGTAGAACGCAACCTCCAGGATGCCATGCAAGTGTGTCGCAATGTTC TCCTGGACCCTCAGCTGGTGCCAGGGGGTGGGGCCTCCGAGATGGCTGTGGCCCATGCCTTGACAGAAAAATCCAAGGCCATGACTGGTG TGGAACAATGGCCATACAGGGCTGTTGCCCAGGCCCTAGAGGTCATTCCTCGTACCCTGATCCAGAACTGTGGGGCCAGCACCATCCGTC TACTTACCTCCCTTCGGGCCAAGCACACCCAGGAGAACTGTGAGACCTGGGGTGTAAATGGTGAGACGGGTACTTTGGTGGACATGAAGG AACTGGGCATATGGGAGCCATTGGCTGTGAAGCTGCAGACTTATAAGACAGCAGTGGAGACGGCAGTTCTGCTACTGCGAATTGATGACA >In-frame_MRPL24_ENST00000361531_chr1_156707438_-_CCT3_ENST00000368261_chr1_156294880_-_1334nt CAGGGGAAATGCTGTCTGTAGCTGAGCACTTCCTGGAGCAGCAGATGCACCCAACAGTGGTGATCAGTGCTTACCGCAAGGCATTGGATG ATATGATCAGCACCCTAAAGAAAATAAGTATCCCAGTCGACATCAGTGACAGTGATATGATGCTGAACATCATCAACAGCTCTATTACTA CCAAAGCCATCAGTCGGTGGTCATCTTTGGCTTGCAACATTGCCCTGGATGCTGTCAAGATGGTACAGTTTGAGGAGAATGGTCGGAAAG AGATTGACATAAAAAAATATGCAAGAGTGGAAAAGATACCTGGAGGCATCATTGAAGACTCCTGTGTCTTGCGTGGAGTCATGATTAACA AGGATGTGACCCATCCACGTATGCGGCGCTATATCAAGAACCCTCGCATTGTGCTGCTGGATTCTTCTCTGGAATACAAGAAAGGAGAAA GCCAGACTGACATTGAGATTACACGAGAGGAGGACTTCACCCGAATTCTCCAGATGGAGGAAGAGTACATCCAGCAGCTCTGTGAGGACA TTATCCAACTGAAGCCCGATGTGGTCATCACTGAAAAGGGCATCTCAGATTTAGCTCAGCACTACCTTATGCGGGCCAATATCACAGCCA TCCGCAGAGTCCGGAAGACAGACAATAATCGCATTGCTAGAGCCTGTGGGGCCCGGATAGTCAGCCGACCAGAGGAACTGAGAGAAGATG ATGTTGGAACAGGAGCAGGCCTGTTGGAAATCAAGAAAATTGGAGATGAATACTTTACTTTCATCACTGACTGCAAAGACCCCAAGGCCT GCACCATTCTCCTCCGGGGGGCTAGCAAAGAGATTCTCTCGGAAGTAGAACGCAACCTCCAGGATGCCATGCAAGTGTGTCGCAATGTTC TCCTGGACCCTCAGCTGGTGCCAGGGGGTGGGGCCTCCGAGATGGCTGTGGCCCATGCCTTGACAGAAAAATCCAAGGCCATGACTGGTG TGGAACAATGGCCATACAGGGCTGTTGCCCAGGCCCTAGAGGTCATTCCTCGTACCCTGATCCAGAACTGTGGGGCCAGCACCATCCGTC TACTTACCTCCCTTCGGGCCAAGCACACCCAGGAGAACTGTGAGACCTGGGGTGTAAATGGTGAGACGGGTACTTTGGTGGACATGAAGG AACTGGGCATATGGGAGCCATTGGCTGTGAAGCTGCAGACTTATAAGACAGCAGTGGAGACGGCAGTTCTGCTACTGCGAATTGATGACA >In-frame_MRPL24_ENST00000361531_chr1_156707438_-_CCT3_ENST00000472765_chr1_156294880_-_1334nt CAGGGGAAATGCTGTCTGTAGCTGAGCACTTCCTGGAGCAGCAGATGCACCCAACAGTGGTGATCAGTGCTTACCGCAAGGCATTGGATG ATATGATCAGCACCCTAAAGAAAATAAGTATCCCAGTCGACATCAGTGACAGTGATATGATGCTGAACATCATCAACAGCTCTATTACTA CCAAAGCCATCAGTCGGTGGTCATCTTTGGCTTGCAACATTGCCCTGGATGCTGTCAAGATGGTACAGTTTGAGGAGAATGGTCGGAAAG AGATTGACATAAAAAAATATGCAAGAGTGGAAAAGATACCTGGAGGCATCATTGAAGACTCCTGTGTCTTGCGTGGAGTCATGATTAACA AGGATGTGACCCATCCACGTATGCGGCGCTATATCAAGAACCCTCGCATTGTGCTGCTGGATTCTTCTCTGGAATACAAGAAAGGAGAAA GCCAGACTGACATTGAGATTACACGAGAGGAGGACTTCACCCGAATTCTCCAGATGGAGGAAGAGTACATCCAGCAGCTCTGTGAGGACA TTATCCAACTGAAGCCCGATGTGGTCATCACTGAAAAGGGCATCTCAGATTTAGCTCAGCACTACCTTATGCGGGCCAATATCACAGCCA TCCGCAGAGTCCGGAAGACAGACAATAATCGCATTGCTAGAGCCTGTGGGGCCCGGATAGTCAGCCGACCAGAGGAACTGAGAGAAGATG ATGTTGGAACAGGAGCAGGCCTGTTGGAAATCAAGAAAATTGGAGATGAATACTTTACTTTCATCACTGACTGCAAAGACCCCAAGGCCT GCACCATTCTCCTCCGGGGGGCTAGCAAAGAGATTCTCTCGGAAGTAGAACGCAACCTCCAGGATGCCATGCAAGTGTGTCGCAATGTTC TCCTGGACCCTCAGCTGGTGCCAGGGGGTGGGGCCTCCGAGATGGCTGTGGCCCATGCCTTGACAGAAAAATCCAAGGCCATGACTGGTG TGGAACAATGGCCATACAGGGCTGTTGCCCAGGCCCTAGAGGTCATTCCTCGTACCCTGATCCAGAACTGTGGGGCCAGCACCATCCGTC TACTTACCTCCCTTCGGGCCAAGCACACCCAGGAGAACTGTGAGACCTGGGGTGTAAATGGTGAGACGGGTACTTTGGTGGACATGAAGG AACTGGGCATATGGGAGCCATTGGCTGTGAAGCTGCAGACTTATAAGACAGCAGTGGAGACGGCAGTTCTGCTACTGCGAATTGATGACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MRPL24_ENST00000361531_chr1_156707438_-_CCT3_ENST00000295688_chr1_156294880_-_2216nt ATGTGCTGAAAATCCGAAGTGCCGCGGAAAGTGGAGGTGAGGGCCGCCCGCCCTAGAGGTGCCCGTCCGAGAGGCAGAGCTGACAAGGAA GGTTTCGAGCGTTTTGCTGGCAAAGGGATTTCTTACAACCTCCAGGCATGCGTCTTTCTGCCCTGCTGGCCTTGGCATCCAAGGTCACTC TGCCCCCCCATTACCGCTATGGGATGAGCCCCCCAGGCTCTGTTGCAGACAAGAGGAAGAACCCCCCATGGATCAGGCGGCGCCCAGTGG TTGTGGAACCCATCTCTGATGAAGACTGGTATCTGTTCTGTGGGGACACGGTGGAGATCCTAGAAGGCAAGGATGCCGGGAAGCAGGGCA AAGTGGTTCAAGTTATCCGGCAGCGAAACTGGGTGGTCGTGGGAGGGCTGAACACACATTACCGCTACATTGGCAAGACCATGGATTACC GGGGAACCATGATCCCTAGTGAAGCCCCCTTGCTCCACCGCCAGGTCAAACTTGTGGATCCTATGGACAGGAAACCCACTGAGATCGAGT GGAGATTTACTGAAGCAGGAGAGCGGGTACGAGTCTCCACACGATCAGGGAGAATTATCCCTAAACCCGAATTTCCCAGAGCTGATGGCA TCGTCCCTGAAACGTGGATTGCAGGGGAAATGCTGTCTGTAGCTGAGCACTTCCTGGAGCAGCAGATGCACCCAACAGTGGTGATCAGTG CTTACCGCAAGGCATTGGATGATATGATCAGCACCCTAAAGAAAATAAGTATCCCAGTCGACATCAGTGACAGTGATATGATGCTGAACA TCATCAACAGCTCTATTACTACCAAAGCCATCAGTCGGTGGTCATCTTTGGCTTGCAACATTGCCCTGGATGCTGTCAAGATGGTACAGT TTGAGGAGAATGGTCGGAAAGAGATTGACATAAAAAAATATGCAAGAGTGGAAAAGATACCTGGAGGCATCATTGAAGACTCCTGTGTCT TGCGTGGAGTCATGATTAACAAGGATGTGACCCATCCACGTATGCGGCGCTATATCAAGAACCCTCGCATTGTGCTGCTGGATTCTTCTC TGGAATACAAGAAAGGAGAAAGCCAGACTGACATTGAGATTACACGAGAGGAGGACTTCACCCGAATTCTCCAGATGGAGGAAGAGTACA TCCAGCAGCTCTGTGAGGACATTATCCAACTGAAGCCCGATGTGGTCATCACTGAAAAGGGCATCTCAGATTTAGCTCAGCACTACCTTA TGCGGGCCAATATCACAGCCATCCGCAGAGTCCGGAAGACAGACAATAATCGCATTGCTAGAGCCTGTGGGGCCCGGATAGTCAGCCGAC CAGAGGAACTGAGAGAAGATGATGTTGGAACAGGAGCAGGCCTGTTGGAAATCAAGAAAATTGGAGATGAATACTTTACTTTCATCACTG ACTGCAAAGACCCCAAGGCCTGCACCATTCTCCTCCGGGGGGCTAGCAAAGAGATTCTCTCGGAAGTAGAACGCAACCTCCAGGATGCCA TGCAAGTGTGTCGCAATGTTCTCCTGGACCCTCAGCTGGTGCCAGGGGGTGGGGCCTCCGAGATGGCTGTGGCCCATGCCTTGACAGAAA AATCCAAGGCCATGACTGGTGTGGAACAATGGCCATACAGGGCTGTTGCCCAGGCCCTAGAGGTCATTCCTCGTACCCTGATCCAGAACT GTGGGGCCAGCACCATCCGTCTACTTACCTCCCTTCGGGCCAAGCACACCCAGGAGAACTGTGAGACCTGGGGTGTAAATGGTGAGACGG GTACTTTGGTGGACATGAAGGAACTGGGCATATGGGAGCCATTGGCTGTGAAGCTGCAGACTTATAAGACAGCAGTGGAGACGGCAGTTC TGCTACTGCGAATTGATGACATCGTTTCAGGCCACAAAAAGAAAGGCGATGACCAGAGCCGGCAAGGCGGGGCTCCTGATGCTGGCCAGG AGTGAGTGCTAGGCAAGGCTACTTCAATGCACAGAACCAGCAGAGTCTCCCCTTTTCCTGAGCCAGAGTGCCAGGAACACTGTGGACGTC TTTGTTCAGAAGGGATCAGGTTGGGGGGCAGCCCCCAGTCCCTTTCTGTCCCAGCTCAGTTTTCCAAAAGACACTGACATGTAATTCTTC >In-frame_MRPL24_ENST00000361531_chr1_156707438_-_CCT3_ENST00000368259_chr1_156294880_-_2215nt ATGTGCTGAAAATCCGAAGTGCCGCGGAAAGTGGAGGTGAGGGCCGCCCGCCCTAGAGGTGCCCGTCCGAGAGGCAGAGCTGACAAGGAA GGTTTCGAGCGTTTTGCTGGCAAAGGGATTTCTTACAACCTCCAGGCATGCGTCTTTCTGCCCTGCTGGCCTTGGCATCCAAGGTCACTC TGCCCCCCCATTACCGCTATGGGATGAGCCCCCCAGGCTCTGTTGCAGACAAGAGGAAGAACCCCCCATGGATCAGGCGGCGCCCAGTGG TTGTGGAACCCATCTCTGATGAAGACTGGTATCTGTTCTGTGGGGACACGGTGGAGATCCTAGAAGGCAAGGATGCCGGGAAGCAGGGCA AAGTGGTTCAAGTTATCCGGCAGCGAAACTGGGTGGTCGTGGGAGGGCTGAACACACATTACCGCTACATTGGCAAGACCATGGATTACC GGGGAACCATGATCCCTAGTGAAGCCCCCTTGCTCCACCGCCAGGTCAAACTTGTGGATCCTATGGACAGGAAACCCACTGAGATCGAGT GGAGATTTACTGAAGCAGGAGAGCGGGTACGAGTCTCCACACGATCAGGGAGAATTATCCCTAAACCCGAATTTCCCAGAGCTGATGGCA TCGTCCCTGAAACGTGGATTGCAGGGGAAATGCTGTCTGTAGCTGAGCACTTCCTGGAGCAGCAGATGCACCCAACAGTGGTGATCAGTG CTTACCGCAAGGCATTGGATGATATGATCAGCACCCTAAAGAAAATAAGTATCCCAGTCGACATCAGTGACAGTGATATGATGCTGAACA TCATCAACAGCTCTATTACTACCAAAGCCATCAGTCGGTGGTCATCTTTGGCTTGCAACATTGCCCTGGATGCTGTCAAGATGGTACAGT TTGAGGAGAATGGTCGGAAAGAGATTGACATAAAAAAATATGCAAGAGTGGAAAAGATACCTGGAGGCATCATTGAAGACTCCTGTGTCT TGCGTGGAGTCATGATTAACAAGGATGTGACCCATCCACGTATGCGGCGCTATATCAAGAACCCTCGCATTGTGCTGCTGGATTCTTCTC TGGAATACAAGAAAGGAGAAAGCCAGACTGACATTGAGATTACACGAGAGGAGGACTTCACCCGAATTCTCCAGATGGAGGAAGAGTACA TCCAGCAGCTCTGTGAGGACATTATCCAACTGAAGCCCGATGTGGTCATCACTGAAAAGGGCATCTCAGATTTAGCTCAGCACTACCTTA TGCGGGCCAATATCACAGCCATCCGCAGAGTCCGGAAGACAGACAATAATCGCATTGCTAGAGCCTGTGGGGCCCGGATAGTCAGCCGAC CAGAGGAACTGAGAGAAGATGATGTTGGAACAGGAGCAGGCCTGTTGGAAATCAAGAAAATTGGAGATGAATACTTTACTTTCATCACTG ACTGCAAAGACCCCAAGGCCTGCACCATTCTCCTCCGGGGGGCTAGCAAAGAGATTCTCTCGGAAGTAGAACGCAACCTCCAGGATGCCA TGCAAGTGTGTCGCAATGTTCTCCTGGACCCTCAGCTGGTGCCAGGGGGTGGGGCCTCCGAGATGGCTGTGGCCCATGCCTTGACAGAAA AATCCAAGGCCATGACTGGTGTGGAACAATGGCCATACAGGGCTGTTGCCCAGGCCCTAGAGGTCATTCCTCGTACCCTGATCCAGAACT GTGGGGCCAGCACCATCCGTCTACTTACCTCCCTTCGGGCCAAGCACACCCAGGAGAACTGTGAGACCTGGGGTGTAAATGGTGAGACGG GTACTTTGGTGGACATGAAGGAACTGGGCATATGGGAGCCATTGGCTGTGAAGCTGCAGACTTATAAGACAGCAGTGGAGACGGCAGTTC TGCTACTGCGAATTGATGACATCGTTTCAGGCCACAAAAAGAAAGGCGATGACCAGAGCCGGCAAGGCGGGGCTCCTGATGCTGGCCAGG AGTGAGTGCTAGGCAAGGCTACTTCAATGCACAGAACCAGCAGAGTCTCCCCTTTTCCTGAGCCAGAGTGCCAGGAACACTGTGGACGTC TTTGTTCAGAAGGGATCAGGTTGGGGGGCAGCCCCCAGTCCCTTTCTGTCCCAGCTCAGTTTTCCAAAAGACACTGACATGTAATTCTTC >In-frame_MRPL24_ENST00000361531_chr1_156707438_-_CCT3_ENST00000368261_chr1_156294880_-_2170nt ATGTGCTGAAAATCCGAAGTGCCGCGGAAAGTGGAGGTGAGGGCCGCCCGCCCTAGAGGTGCCCGTCCGAGAGGCAGAGCTGACAAGGAA GGTTTCGAGCGTTTTGCTGGCAAAGGGATTTCTTACAACCTCCAGGCATGCGTCTTTCTGCCCTGCTGGCCTTGGCATCCAAGGTCACTC TGCCCCCCCATTACCGCTATGGGATGAGCCCCCCAGGCTCTGTTGCAGACAAGAGGAAGAACCCCCCATGGATCAGGCGGCGCCCAGTGG TTGTGGAACCCATCTCTGATGAAGACTGGTATCTGTTCTGTGGGGACACGGTGGAGATCCTAGAAGGCAAGGATGCCGGGAAGCAGGGCA AAGTGGTTCAAGTTATCCGGCAGCGAAACTGGGTGGTCGTGGGAGGGCTGAACACACATTACCGCTACATTGGCAAGACCATGGATTACC GGGGAACCATGATCCCTAGTGAAGCCCCCTTGCTCCACCGCCAGGTCAAACTTGTGGATCCTATGGACAGGAAACCCACTGAGATCGAGT GGAGATTTACTGAAGCAGGAGAGCGGGTACGAGTCTCCACACGATCAGGGAGAATTATCCCTAAACCCGAATTTCCCAGAGCTGATGGCA TCGTCCCTGAAACGTGGATTGCAGGGGAAATGCTGTCTGTAGCTGAGCACTTCCTGGAGCAGCAGATGCACCCAACAGTGGTGATCAGTG CTTACCGCAAGGCATTGGATGATATGATCAGCACCCTAAAGAAAATAAGTATCCCAGTCGACATCAGTGACAGTGATATGATGCTGAACA TCATCAACAGCTCTATTACTACCAAAGCCATCAGTCGGTGGTCATCTTTGGCTTGCAACATTGCCCTGGATGCTGTCAAGATGGTACAGT TTGAGGAGAATGGTCGGAAAGAGATTGACATAAAAAAATATGCAAGAGTGGAAAAGATACCTGGAGGCATCATTGAAGACTCCTGTGTCT TGCGTGGAGTCATGATTAACAAGGATGTGACCCATCCACGTATGCGGCGCTATATCAAGAACCCTCGCATTGTGCTGCTGGATTCTTCTC TGGAATACAAGAAAGGAGAAAGCCAGACTGACATTGAGATTACACGAGAGGAGGACTTCACCCGAATTCTCCAGATGGAGGAAGAGTACA TCCAGCAGCTCTGTGAGGACATTATCCAACTGAAGCCCGATGTGGTCATCACTGAAAAGGGCATCTCAGATTTAGCTCAGCACTACCTTA TGCGGGCCAATATCACAGCCATCCGCAGAGTCCGGAAGACAGACAATAATCGCATTGCTAGAGCCTGTGGGGCCCGGATAGTCAGCCGAC CAGAGGAACTGAGAGAAGATGATGTTGGAACAGGAGCAGGCCTGTTGGAAATCAAGAAAATTGGAGATGAATACTTTACTTTCATCACTG ACTGCAAAGACCCCAAGGCCTGCACCATTCTCCTCCGGGGGGCTAGCAAAGAGATTCTCTCGGAAGTAGAACGCAACCTCCAGGATGCCA TGCAAGTGTGTCGCAATGTTCTCCTGGACCCTCAGCTGGTGCCAGGGGGTGGGGCCTCCGAGATGGCTGTGGCCCATGCCTTGACAGAAA AATCCAAGGCCATGACTGGTGTGGAACAATGGCCATACAGGGCTGTTGCCCAGGCCCTAGAGGTCATTCCTCGTACCCTGATCCAGAACT GTGGGGCCAGCACCATCCGTCTACTTACCTCCCTTCGGGCCAAGCACACCCAGGAGAACTGTGAGACCTGGGGTGTAAATGGTGAGACGG GTACTTTGGTGGACATGAAGGAACTGGGCATATGGGAGCCATTGGCTGTGAAGCTGCAGACTTATAAGACAGCAGTGGAGACGGCAGTTC TGCTACTGCGAATTGATGACATCGTTTCAGGCCACAAAAAGAAAGGCGATGACCAGAGCCGGCAAGGCGGGGCTCCTGATGCTGGCCAGG AGTGAGTGCTAGGCAAGGCTACTTCAATGCACAGAACCAGCAGAGTCTCCCCTTTTCCTGAGCCAGAGTGCCAGGAACACTGTGGACGTC TTTGTTCAGAAGGGATCAGGTTGGGGGGCAGCCCCCAGTCCCTTTCTGTCCCAGCTCAGTTTTCCAAAAGACACTGACATGTAATTCTTC >In-frame_MRPL24_ENST00000361531_chr1_156707438_-_CCT3_ENST00000472765_chr1_156294880_-_2019nt ATGTGCTGAAAATCCGAAGTGCCGCGGAAAGTGGAGGTGAGGGCCGCCCGCCCTAGAGGTGCCCGTCCGAGAGGCAGAGCTGACAAGGAA GGTTTCGAGCGTTTTGCTGGCAAAGGGATTTCTTACAACCTCCAGGCATGCGTCTTTCTGCCCTGCTGGCCTTGGCATCCAAGGTCACTC TGCCCCCCCATTACCGCTATGGGATGAGCCCCCCAGGCTCTGTTGCAGACAAGAGGAAGAACCCCCCATGGATCAGGCGGCGCCCAGTGG TTGTGGAACCCATCTCTGATGAAGACTGGTATCTGTTCTGTGGGGACACGGTGGAGATCCTAGAAGGCAAGGATGCCGGGAAGCAGGGCA AAGTGGTTCAAGTTATCCGGCAGCGAAACTGGGTGGTCGTGGGAGGGCTGAACACACATTACCGCTACATTGGCAAGACCATGGATTACC GGGGAACCATGATCCCTAGTGAAGCCCCCTTGCTCCACCGCCAGGTCAAACTTGTGGATCCTATGGACAGGAAACCCACTGAGATCGAGT GGAGATTTACTGAAGCAGGAGAGCGGGTACGAGTCTCCACACGATCAGGGAGAATTATCCCTAAACCCGAATTTCCCAGAGCTGATGGCA TCGTCCCTGAAACGTGGATTGCAGGGGAAATGCTGTCTGTAGCTGAGCACTTCCTGGAGCAGCAGATGCACCCAACAGTGGTGATCAGTG CTTACCGCAAGGCATTGGATGATATGATCAGCACCCTAAAGAAAATAAGTATCCCAGTCGACATCAGTGACAGTGATATGATGCTGAACA TCATCAACAGCTCTATTACTACCAAAGCCATCAGTCGGTGGTCATCTTTGGCTTGCAACATTGCCCTGGATGCTGTCAAGATGGTACAGT TTGAGGAGAATGGTCGGAAAGAGATTGACATAAAAAAATATGCAAGAGTGGAAAAGATACCTGGAGGCATCATTGAAGACTCCTGTGTCT TGCGTGGAGTCATGATTAACAAGGATGTGACCCATCCACGTATGCGGCGCTATATCAAGAACCCTCGCATTGTGCTGCTGGATTCTTCTC TGGAATACAAGAAAGGAGAAAGCCAGACTGACATTGAGATTACACGAGAGGAGGACTTCACCCGAATTCTCCAGATGGAGGAAGAGTACA TCCAGCAGCTCTGTGAGGACATTATCCAACTGAAGCCCGATGTGGTCATCACTGAAAAGGGCATCTCAGATTTAGCTCAGCACTACCTTA TGCGGGCCAATATCACAGCCATCCGCAGAGTCCGGAAGACAGACAATAATCGCATTGCTAGAGCCTGTGGGGCCCGGATAGTCAGCCGAC CAGAGGAACTGAGAGAAGATGATGTTGGAACAGGAGCAGGCCTGTTGGAAATCAAGAAAATTGGAGATGAATACTTTACTTTCATCACTG ACTGCAAAGACCCCAAGGCCTGCACCATTCTCCTCCGGGGGGCTAGCAAAGAGATTCTCTCGGAAGTAGAACGCAACCTCCAGGATGCCA TGCAAGTGTGTCGCAATGTTCTCCTGGACCCTCAGCTGGTGCCAGGGGGTGGGGCCTCCGAGATGGCTGTGGCCCATGCCTTGACAGAAA AATCCAAGGCCATGACTGGTGTGGAACAATGGCCATACAGGGCTGTTGCCCAGGCCCTAGAGGTCATTCCTCGTACCCTGATCCAGAACT GTGGGGCCAGCACCATCCGTCTACTTACCTCCCTTCGGGCCAAGCACACCCAGGAGAACTGTGAGACCTGGGGTGTAAATGGTGAGACGG GTACTTTGGTGGACATGAAGGAACTGGGCATATGGGAGCCATTGGCTGTGAAGCTGCAGACTTATAAGACAGCAGTGGAGACGGCAGTTC TGCTACTGCGAATTGATGACATCGTTTCAGGCCACAAAAAGAAAGGCGATGACCAGAGCCGGCAAGGCGGGGCTCCTGATGCTGGCCAGG |
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FusionGenePPI for MRPL24_CCT3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MRPL24 | ICT1, CUL3, APP, MRPL44, MRPL37, MRPL39, MRPL4, MRPL40, MRPL45, MRPL19, MRPL51, MRPL2, MRPL13, MRPL21, MRPS5, TMEM177, TSR1, TUFM, RPS15, ABCC2, ILF2, C19orf70, ERLEC1, NPM1, GRSF1, AURKA, TP53, NXF1, BTRC, MRPL28, RPL6, RPS8, MRPS30, MRPL47, HNRNPA1, NTRK1, MRPL18, MRPL22, POLR3A, RPL11, RPS11, RPS18, RPS5, MRPL38, MRPL46, MRPL9, MRPS10, RPL17, RPL8, CENPE, RBM4, SORT1, MRPL50, FOXB1, FOXL2, RC3H1, DUSP11, MRPL10, MRPL42, MRPL41, RPL18 | CCT3 | SSSCA1, FANCA, RAF1, EIF2B2, PAFAH1B2, PPP4C, CTTNBP2, MOB4, PPP2CA, STK24, STRN, STRN3, PPP2CB, PPP2R2C, IGBP1, TCP1, CDK9, RFWD2, ATG16L1, MAPK6, VHL, WDR82, UBC, MYC, PPP2R2A, PPP2R2B, PPP2R2D, PPP2R4, AGO3, HDAC5, PSMA3, FBXW8, RAD21, SH3BP4, VAV2, SIRT7, ISG15, PSMA2, CUL3, CDK2, XRCC6, INPPL1, UBASH3B, GRB2, EPS15, FBXO6, PACRG, CCT2, CCT5, CCT7, CCT8, CCT6A, CCT4, CCT6B, MARS, PSMA6, PSMA5, NOTCH1, VCP, FN1, VCAM1, ATF2, PEX14, NOS2, CAMKMT, FAM86B2, METTL18, METTL20, METTL21B, METTL21C, METTL23, ITGA4, CFTR, PAN2, CD81, IGSF8, ICAM1, HDAC3, HDAC11, HDAC6, FBXW4, PARK2, ACACA, COPA, EEF1G, LRRC47, PPP4R2, VARS, TRIM28, CDK5, ILK, CDC20, LGALS3BP, NEDD1, TP53, TUBG1, HUWE1, FUS, MIPOL1, CUL7, OBSL1, CCDC8, SUZ12, RNF2, BMI1, CDK13, IKBKE, IRAK1, JAK3, MAPK8, PRKY, PTK6, SGK2, TSSK6, TYK2, WDR76, POC1A, NXF5, TXNDC9, FYCO1, WDR37, WDR83, DCAF5, WDR92, PEX7, GNB5, TSSC1, DDB2, TUBB2B, ACTR1B, SEC31B, TUBAL3, ACTL6A, PNPLA1, TTLL3, TUBA3C, TUBA3E, C17orf102, RPS6KB2, LGALS3, DCAF7, AMBRA1, ARF1, CAD, CANX, CLTC, DNAJA1, DNAJA4, EHD2, ETFA, GTF2I, HSPE1, LDHA, LDHB, PDCL3, PSMC2, SLC25A3, SUCLG2, WARS, CYP27A1, HSP90B1, KPNA4, MCM7, PC, RPN1, STOM, UQCRC2, NTRK1, BTRC, B9D1, MKS1, CETN2, AHSA1, GBA, HDAC1, PDK3, DNAJC7, XRCC3, NSMAF, NIPSNAP1, PRPF4, ACTR2, WRAP53, RFWD3, KIF21A, SEH1L, TUBA1C, ARMC6, GAN, SKI, FBXW7, MCM2, SNW1, CDC5L, ERRFI1, TTC27, CDC73, ZNF746, PPM1J, TUBD1, DCAF12, DTL, WDR70, DCAF13, JMJD4, KLHL33, KDM4B, DCAF10, KLHDC8A, KLHL8, WDR77, WDR46, RAP2C, DCAF4, DNAI2, BUB3, WDR86, ODF1, KLHDC8B, DCAF11, WDTC1, TUBG2, GNB1L, METAP2, DCAF8, ACTR3B, TBL1Y, THOC3, PDCL, WDR34, UTP18, GNB2, GANAB, SMOX, HCFC2, WDR5B, C4orf26, C1orf127, ACTR3, NOL10, MLST8, POC1B, ACTBL2, MAPK15, P4HA2, C11orf70, KLHDC2, CDK11A, TTLL9, STRADB, RPE65, PNPLA5, TUBA1B, DCAF12L2, C11orf54, RBM3, CYLD, TRIM25, G3BP1, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MRPL24_CCT3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | CCT3 | P49368 | DB11638 | Artenimol | T-complex protein 1 subunit gamma | small molecule | approved|investigational |
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RelatedDiseases for MRPL24_CCT3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CCT3 | C0019693 | HIV Infections | 1 | CTD_human |
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