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Fusion gene ID: 22474 |
FusionGeneSummary for MRPL21_SSH3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MRPL21_SSH3 | Fusion gene ID: 22474 | Hgene | Tgene | Gene symbol | MRPL21 | SSH3 | Gene ID | 219927 | 54961 |
| Gene name | mitochondrial ribosomal protein L21 | slingshot protein phosphatase 3 | |
| Synonyms | L21mt|MRP-L21 | SSH3L | |
| Cytomap | 11q13.3 | 11q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 39S ribosomal protein L21, mitochondrialmitochondrial large ribosomal subunit protein bL21m | protein phosphatase Slingshot homolog 3SSH-3LSSH-like protein 3hSSH-3Lslingshot 3slingshot homolog 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q7Z2W9 | Q8TE77 | |
| Ensembl transtripts involved in fusion gene | ENST00000450904, ENST00000362034, ENST00000567045, | ENST00000308127, ENST00000308298, ENST00000376757, ENST00000532181, | |
| Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 4 X 3 X 3=36 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/252*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MRPL21 [Title/Abstract] AND SSH3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E2-A15O-01A | MRPL21 | chr11 | 68663983 | - | SSH3 | chr11 | 67074309 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000450904 | ENST00000308127 | MRPL21 | chr11 | 68663983 | - | SSH3 | chr11 | 67074309 | + |
| Frame-shift | ENST00000450904 | ENST00000308298 | MRPL21 | chr11 | 68663983 | - | SSH3 | chr11 | 67074309 | + |
| Frame-shift | ENST00000450904 | ENST00000376757 | MRPL21 | chr11 | 68663983 | - | SSH3 | chr11 | 67074309 | + |
| 5CDS-3UTR | ENST00000450904 | ENST00000532181 | MRPL21 | chr11 | 68663983 | - | SSH3 | chr11 | 67074309 | + |
| In-frame | ENST00000362034 | ENST00000308127 | MRPL21 | chr11 | 68663983 | - | SSH3 | chr11 | 67074309 | + |
| In-frame | ENST00000362034 | ENST00000308298 | MRPL21 | chr11 | 68663983 | - | SSH3 | chr11 | 67074309 | + |
| In-frame | ENST00000362034 | ENST00000376757 | MRPL21 | chr11 | 68663983 | - | SSH3 | chr11 | 67074309 | + |
| 5CDS-3UTR | ENST00000362034 | ENST00000532181 | MRPL21 | chr11 | 68663983 | - | SSH3 | chr11 | 67074309 | + |
| Frame-shift | ENST00000567045 | ENST00000308127 | MRPL21 | chr11 | 68663983 | - | SSH3 | chr11 | 67074309 | + |
| Frame-shift | ENST00000567045 | ENST00000308298 | MRPL21 | chr11 | 68663983 | - | SSH3 | chr11 | 67074309 | + |
| Frame-shift | ENST00000567045 | ENST00000376757 | MRPL21 | chr11 | 68663983 | - | SSH3 | chr11 | 67074309 | + |
| 5CDS-3UTR | ENST00000567045 | ENST00000532181 | MRPL21 | chr11 | 68663983 | - | SSH3 | chr11 | 67074309 | + |
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FusionProtFeatures for MRPL21_SSH3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MRPL21 | SSH3 |
| Protein phosphatase which may play a role in theregulation of actin filament dynamics. Can dephosphorylate andactivate the actin binding/depolymerizing factor cofilin, whichsubsequently binds to actin filaments and stimulates theirdisassembly (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MRPL21_SSH3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MRPL21_ENST00000362034_chr11_68663983_-_SSH3_ENST00000308127_chr11_67074309_+_679aa MAASSLTVTLGRLASACSHSILRPSGPGAASLWSASRRFNSQSTSYLPGYVPKTSLSSPPWPEVVLPDPVEETRHHAEVVKKVNEMIVTG QYGRLFAVVHFASRQWKVTSEDLILIGNELDLACGERIRLEKAAQLEAPRPPRLRYLLVVSTREGEGLSQDETVLLGVDFPDSSSPSCTL GLVLPLWSDTQVYLDGDGGFSVTSGGQSRIFKPISIQTMWATLQVLHQACEAALGSGLVPGGSALTWASHYQERLNSEQSCLNEWTAMAD LESLRPPSAEPGGSSEQEQMEQAIRAELWKVLDVSDLESVTSKEIRQALELRLGLPLQQYRDFIDNQMLLLVAQRDRASRIFPHLYLGSE WNAANLEELQRNRVTHILNMAREIDNFYPERFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAYAMKQ YECSLEQALRHVQELRPIARPNPGFLRQLQIYQGILTASRQSHVWEQKVGGVSPEEHPAPEVSTPFPPLPPEPEGGGEEKVVGMEESQAA PKEEPGPRPRINLRGVMRSISLLEPSLELESTSETSDMPEVFSSHESSHEEPLQPFPQLARTKGGQQVDRGPQPALKSRQSVVTLQGSAV >In-frame_MRPL21_ENST00000362034_chr11_68663983_-_SSH3_ENST00000308298_chr11_67074309_+_414aa MAASSLTVTLGRLASACSHSILRPSGPGAASLWSASRRFNSQSTSYLPGYVPKTSLSSPPWPEVVLPDPVEETRHHAEVVKKVNEMIVTG QYGRLFAVVHFASRQWKVTSEDLILIGNELDLACGERIRLEKAAQLEAPRPPRLRYLLVVSTREGEGLSQDETVLLGVDFPDSSSPSCTL GLVLPLWSDTQVYLDGDGGFSVTSGGQSRIFKPISIQTMWATLQVLHQACEAALGSGLVPGGSALTWASHYQERLNSEQSCLNEWTAMAD LESLRPPSAEPGGSSEQEQMEQAIRAELWKVLDLESTSETSDMPEVFSSHESSHEEPLQPFPQLARTKGGQQVDRGPQPALKSRQSVVTL >In-frame_MRPL21_ENST00000362034_chr11_68663983_-_SSH3_ENST00000376757_chr11_67074309_+_491aa MAASSLTVTLGRLASACSHSILRPSGPGAASLWSASRRFNSQSTSYLPGYVPKTSLSSPPWPEVVLPDPVEETRHHAEVVKKVNEMIVTG QYGRLFAVVHFASRQWKVTSEDLILIGNELDLACGERIRLEKAAQLEAPRPPRLRYLLVVSTREGEGLSQDETVLLGVDFPDSSSPSCTL GLVLPLWSDTQVYLDGDGGFSVTSGGQSRIFKPISIQTMWATLQVLHQACEAALGSGLVPGGSALTWASHYQERLNSEQSCLNEWTAMAD LESLRPPSAEPGGSSEQEQMEQAIRAELWKVLDVSDLESVTSKEIRQALELRLGLPLQQYRDFIDNQMLLLVAQRDRASRIFPHLYLGSE WNAANLEELQRNRVTHILNMAREIDNFYPERFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAYAMKQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MRPL21_ENST00000362034_chr11_68663983_-_SSH3_ENST00000308127_chr11_67074309_+_2037nt ATGGCAGCATCTTCCCTGACGGTCACCTTAGGGCGGCTGGCGTCCGCGTGCAGCCACAGCATCCTGAGACCTTCGGGGCCCGGAGCAGCC TCCCTTTGGTCTGCTTCTCGAAGGTTCAATTCACAGAGCACTTCATATCTACCAGGATATGTTCCTAAAACATCCCTGAGTTCACCACCT TGGCCAGAAGTTGTTCTGCCAGACCCAGTTGAGGAGACCAGACACCATGCAGAGGTCGTGAAGAAGGTGAATGAGATGATCGTCACGGGG CAGTATGGCAGGCTCTTTGCCGTGGTGCACTTTGCCAGCCGCCAGTGGAAGGTGACCTCTGAAGACCTGATCTTAATTGGAAATGAACTA GACCTTGCGTGTGGAGAGAGAATTCGACTGGAGAAGGCAGCCCAGCTGGAGGCACCCCGGCCTCCCCGGCTCCGCTACCTGCTGGTAGTT TCTACACGAGAAGGAGAAGGTCTGAGCCAGGATGAGACGGTCCTCCTGGGCGTGGATTTCCCTGACAGCAGCTCCCCCAGCTGCACCCTG GGCCTGGTCTTGCCCCTCTGGAGTGACACCCAGGTGTACTTAGATGGAGACGGGGGCTTCAGCGTGACGTCTGGTGGGCAAAGCCGGATC TTCAAGCCCATCTCCATCCAGACCATGTGGGCCACACTCCAGGTATTGCACCAAGCATGTGAGGCAGCTCTAGGCAGCGGCCTTGTACCG GGTGGCAGTGCCCTCACCTGGGCCAGCCACTACCAGGAGAGACTGAACTCCGAACAGAGCTGCCTCAATGAGTGGACGGCTATGGCCGAC CTGGAGTCTCTGCGGCCTCCCAGCGCCGAGCCTGGCGGGTCCTCAGAACAGGAGCAGATGGAGCAGGCGATCCGTGCTGAGCTGTGGAAA GTGTTGGATGTCAGTGACCTGGAGAGTGTCACTTCCAAAGAGATCCGCCAGGCTCTGGAGCTGCGCCTGGGGCTCCCCCTCCAGCAGTAC CGTGACTTCATCGACAACCAGATGCTGCTGCTGGTGGCACAGCGGGACCGAGCCTCCCGCATCTTCCCCCACCTCTACCTGGGCTCAGAG TGGAACGCAGCAAACCTGGAGGAGCTGCAGAGGAACAGGGTCACCCACATCTTGAACATGGCCCGGGAGATTGACAACTTCTACCCTGAG CGCTTCACCTACCACAATGTGCGCCTCTGGGATGAGGAGTCGGCCCAGCTGCTGCCGCACTGGAAGGAGACGCACCGCTTCATTGAGGCT GCAAGAGCACAGGGCACCCACGTGCTGGTCCACTGCAAGATGGGCGTCAGCCGCTCAGCGGCCACAGTGCTGGCCTATGCCATGAAGCAG TACGAATGCAGCCTGGAGCAGGCCCTGCGCCACGTGCAGGAGCTCCGGCCCATCGCCCGCCCCAACCCTGGCTTCCTGCGCCAGCTGCAG ATCTACCAGGGCATCCTGACGGCCAGCCGCCAGAGCCATGTCTGGGAGCAGAAAGTGGGTGGGGTCTCCCCAGAGGAGCACCCAGCCCCT GAAGTCTCTACACCATTCCCACCTCTTCCGCCAGAACCTGAGGGTGGTGGGGAGGAGAAGGTTGTAGGCATGGAAGAGAGCCAGGCAGCC CCGAAAGAAGAGCCTGGGCCACGGCCACGTATAAACCTCCGAGGGGTCATGAGGTCCATCAGTCTTCTGGAGCCCTCCTTGGAGCTGGAG AGCACCTCAGAGACCAGTGACATGCCAGAGGTCTTCTCTTCCCACGAGTCTTCACATGAAGAGCCTCTGCAGCCCTTCCCACAGCTTGCA AGGACCAAGGGAGGCCAGCAGGTGGACAGGGGGCCTCAGCCTGCCCTGAAGTCCCGCCAGTCAGTGGTTACCCTCCAGGGCAGTGCCGTG GTGGCCAACCGGACCCAGGCCTTCCAGGAGCAGGAGCAGGGGCAGGGGCAGGGGCAGGGAGAGCCCTGCATTTCCTCTACGCCCAGGTTC >In-frame_MRPL21_ENST00000362034_chr11_68663983_-_SSH3_ENST00000308298_chr11_67074309_+_1242nt ATGGCAGCATCTTCCCTGACGGTCACCTTAGGGCGGCTGGCGTCCGCGTGCAGCCACAGCATCCTGAGACCTTCGGGGCCCGGAGCAGCC TCCCTTTGGTCTGCTTCTCGAAGGTTCAATTCACAGAGCACTTCATATCTACCAGGATATGTTCCTAAAACATCCCTGAGTTCACCACCT TGGCCAGAAGTTGTTCTGCCAGACCCAGTTGAGGAGACCAGACACCATGCAGAGGTCGTGAAGAAGGTGAATGAGATGATCGTCACGGGG CAGTATGGCAGGCTCTTTGCCGTGGTGCACTTTGCCAGCCGCCAGTGGAAGGTGACCTCTGAAGACCTGATCTTAATTGGAAATGAACTA GACCTTGCGTGTGGAGAGAGAATTCGACTGGAGAAGGCAGCCCAGCTGGAGGCACCCCGGCCTCCCCGGCTCCGCTACCTGCTGGTAGTT TCTACACGAGAAGGAGAAGGTCTGAGCCAGGATGAGACGGTCCTCCTGGGCGTGGATTTCCCTGACAGCAGCTCCCCCAGCTGCACCCTG GGCCTGGTCTTGCCCCTCTGGAGTGACACCCAGGTGTACTTAGATGGAGACGGGGGCTTCAGCGTGACGTCTGGTGGGCAAAGCCGGATC TTCAAGCCCATCTCCATCCAGACCATGTGGGCCACACTCCAGGTATTGCACCAAGCATGTGAGGCAGCTCTAGGCAGCGGCCTTGTACCG GGTGGCAGTGCCCTCACCTGGGCCAGCCACTACCAGGAGAGACTGAACTCCGAACAGAGCTGCCTCAATGAGTGGACGGCTATGGCCGAC CTGGAGTCTCTGCGGCCTCCCAGCGCCGAGCCTGGCGGGTCCTCAGAACAGGAGCAGATGGAGCAGGCGATCCGTGCTGAGCTGTGGAAA GTGTTGGATCTGGAGAGCACCTCAGAGACCAGTGACATGCCAGAGGTCTTCTCTTCCCACGAGTCTTCACATGAAGAGCCTCTGCAGCCC TTCCCACAGCTTGCAAGGACCAAGGGAGGCCAGCAGGTGGACAGGGGGCCTCAGCCTGCCCTGAAGTCCCGCCAGTCAGTGGTTACCCTC CAGGGCAGTGCCGTGGTGGCCAACCGGACCCAGGCCTTCCAGGAGCAGGAGCAGGGGCAGGGGCAGGGGCAGGGAGAGCCCTGCATTTCC >In-frame_MRPL21_ENST00000362034_chr11_68663983_-_SSH3_ENST00000376757_chr11_67074309_+_1473nt ATGGCAGCATCTTCCCTGACGGTCACCTTAGGGCGGCTGGCGTCCGCGTGCAGCCACAGCATCCTGAGACCTTCGGGGCCCGGAGCAGCC TCCCTTTGGTCTGCTTCTCGAAGGTTCAATTCACAGAGCACTTCATATCTACCAGGATATGTTCCTAAAACATCCCTGAGTTCACCACCT TGGCCAGAAGTTGTTCTGCCAGACCCAGTTGAGGAGACCAGACACCATGCAGAGGTCGTGAAGAAGGTGAATGAGATGATCGTCACGGGG CAGTATGGCAGGCTCTTTGCCGTGGTGCACTTTGCCAGCCGCCAGTGGAAGGTGACCTCTGAAGACCTGATCTTAATTGGAAATGAACTA GACCTTGCGTGTGGAGAGAGAATTCGACTGGAGAAGGCAGCCCAGCTGGAGGCACCCCGGCCTCCCCGGCTCCGCTACCTGCTGGTAGTT TCTACACGAGAAGGAGAAGGTCTGAGCCAGGATGAGACGGTCCTCCTGGGCGTGGATTTCCCTGACAGCAGCTCCCCCAGCTGCACCCTG GGCCTGGTCTTGCCCCTCTGGAGTGACACCCAGGTGTACTTAGATGGAGACGGGGGCTTCAGCGTGACGTCTGGTGGGCAAAGCCGGATC TTCAAGCCCATCTCCATCCAGACCATGTGGGCCACACTCCAGGTATTGCACCAAGCATGTGAGGCAGCTCTAGGCAGCGGCCTTGTACCG GGTGGCAGTGCCCTCACCTGGGCCAGCCACTACCAGGAGAGACTGAACTCCGAACAGAGCTGCCTCAATGAGTGGACGGCTATGGCCGAC CTGGAGTCTCTGCGGCCTCCCAGCGCCGAGCCTGGCGGGTCCTCAGAACAGGAGCAGATGGAGCAGGCGATCCGTGCTGAGCTGTGGAAA GTGTTGGATGTCAGTGACCTGGAGAGTGTCACTTCCAAAGAGATCCGCCAGGCTCTGGAGCTGCGCCTGGGGCTCCCCCTCCAGCAGTAC CGTGACTTCATCGACAACCAGATGCTGCTGCTGGTGGCACAGCGGGACCGAGCCTCCCGCATCTTCCCCCACCTCTACCTGGGCTCAGAG TGGAACGCAGCAAACCTGGAGGAGCTGCAGAGGAACAGGGTCACCCACATCTTGAACATGGCCCGGGAGATTGACAACTTCTACCCTGAG CGCTTCACCTACCACAATGTGCGCCTCTGGGATGAGGAGTCGGCCCAGCTGCTGCCGCACTGGAAGGAGACGCACCGCTTCATTGAGGCT GCAAGAGCACAGGGCACCCACGTGCTGGTCCACTGCAAGATGGGCGTCAGCCGCTCAGCGGCCACAGTGCTGGCCTATGCCATGAAGCAG TACGAATGCAGCCTGGAGCAGGCCCTGCGCCACGTGCAGGAGCTCCGGCCCATCGCCCGCCCCAACCCTGGCTTCCTGCGCCAGCTGCAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MRPL21_ENST00000362034_chr11_68663983_-_SSH3_ENST00000308127_chr11_67074309_+_2760nt GGCTGCGGCCATGGCAGCATCTTCCCTGACGGTCACCTTAGGGCGGCTGGCGTCCGCGTGCAGCCACAGCATCCTGAGACCTTCGGGGCC CGGAGCAGCCTCCCTTTGGTCTGCTTCTCGAAGGTTCAATTCACAGAGCACTTCATATCTACCAGGATATGTTCCTAAAACATCCCTGAG TTCACCACCTTGGCCAGAAGTTGTTCTGCCAGACCCAGTTGAGGAGACCAGACACCATGCAGAGGTCGTGAAGAAGGTGAATGAGATGAT CGTCACGGGGCAGTATGGCAGGCTCTTTGCCGTGGTGCACTTTGCCAGCCGCCAGTGGAAGGTGACCTCTGAAGACCTGATCTTAATTGG AAATGAACTAGACCTTGCGTGTGGAGAGAGAATTCGACTGGAGAAGGCAGCCCAGCTGGAGGCACCCCGGCCTCCCCGGCTCCGCTACCT GCTGGTAGTTTCTACACGAGAAGGAGAAGGTCTGAGCCAGGATGAGACGGTCCTCCTGGGCGTGGATTTCCCTGACAGCAGCTCCCCCAG CTGCACCCTGGGCCTGGTCTTGCCCCTCTGGAGTGACACCCAGGTGTACTTAGATGGAGACGGGGGCTTCAGCGTGACGTCTGGTGGGCA AAGCCGGATCTTCAAGCCCATCTCCATCCAGACCATGTGGGCCACACTCCAGGTATTGCACCAAGCATGTGAGGCAGCTCTAGGCAGCGG CCTTGTACCGGGTGGCAGTGCCCTCACCTGGGCCAGCCACTACCAGGAGAGACTGAACTCCGAACAGAGCTGCCTCAATGAGTGGACGGC TATGGCCGACCTGGAGTCTCTGCGGCCTCCCAGCGCCGAGCCTGGCGGGTCCTCAGAACAGGAGCAGATGGAGCAGGCGATCCGTGCTGA GCTGTGGAAAGTGTTGGATGTCAGTGACCTGGAGAGTGTCACTTCCAAAGAGATCCGCCAGGCTCTGGAGCTGCGCCTGGGGCTCCCCCT CCAGCAGTACCGTGACTTCATCGACAACCAGATGCTGCTGCTGGTGGCACAGCGGGACCGAGCCTCCCGCATCTTCCCCCACCTCTACCT GGGCTCAGAGTGGAACGCAGCAAACCTGGAGGAGCTGCAGAGGAACAGGGTCACCCACATCTTGAACATGGCCCGGGAGATTGACAACTT CTACCCTGAGCGCTTCACCTACCACAATGTGCGCCTCTGGGATGAGGAGTCGGCCCAGCTGCTGCCGCACTGGAAGGAGACGCACCGCTT CATTGAGGCTGCAAGAGCACAGGGCACCCACGTGCTGGTCCACTGCAAGATGGGCGTCAGCCGCTCAGCGGCCACAGTGCTGGCCTATGC CATGAAGCAGTACGAATGCAGCCTGGAGCAGGCCCTGCGCCACGTGCAGGAGCTCCGGCCCATCGCCCGCCCCAACCCTGGCTTCCTGCG CCAGCTGCAGATCTACCAGGGCATCCTGACGGCCAGCCGCCAGAGCCATGTCTGGGAGCAGAAAGTGGGTGGGGTCTCCCCAGAGGAGCA CCCAGCCCCTGAAGTCTCTACACCATTCCCACCTCTTCCGCCAGAACCTGAGGGTGGTGGGGAGGAGAAGGTTGTAGGCATGGAAGAGAG CCAGGCAGCCCCGAAAGAAGAGCCTGGGCCACGGCCACGTATAAACCTCCGAGGGGTCATGAGGTCCATCAGTCTTCTGGAGCCCTCCTT GGAGCTGGAGAGCACCTCAGAGACCAGTGACATGCCAGAGGTCTTCTCTTCCCACGAGTCTTCACATGAAGAGCCTCTGCAGCCCTTCCC ACAGCTTGCAAGGACCAAGGGAGGCCAGCAGGTGGACAGGGGGCCTCAGCCTGCCCTGAAGTCCCGCCAGTCAGTGGTTACCCTCCAGGG CAGTGCCGTGGTGGCCAACCGGACCCAGGCCTTCCAGGAGCAGGAGCAGGGGCAGGGGCAGGGGCAGGGAGAGCCCTGCATTTCCTCTAC GCCCAGGTTCCGGAAGGTGGTGAGACAGGCCAGCGTGCATGACAGTGGAGAGGAGGGCGAGGCCTGAGCCCTCACACATGCCCACGCTCC CCTGACACTGAAGAGGATCCACAACTCCTTGGAGAAACACCCTCACGTCTGTTGCCGCACACATTCCTCTCAGCTCCGCCCCATACCCGT CACTACAGCCTCACCTCCCACCCCTGTCACTACGGCCTCACCTCCCACCCCTGTCACTACAGCCTCACCTCCTACAGCCTTAAGTCCCAG GCCCATGTCTGCCTGTCCAAGGGCTCAAGACTTTCTAACTGGGATGTGGTAGAGGGACTGAAGGTACCTTTGGGGGCAACAGCACCCTAG TTTCATTCTCAACTCTAGCCCTGCACACTCACCTGTGGCACGGAATGAAAACAGAGCTTCCCGTGCAAAAAGGGTCACGCCTCCCACCCC CGCCCCCTCCCTGCACCTCCTGTCCTCTCCCAGTTCATTCCTGGAACCAGCCAGGCCAGGCAACCAGTGGCCCCCAAAGGCAGGCAGGAT CCTCAGGCCCCAGCCGCGGGAGGCTGGAAGGGCTGGCAGATCGCTTCCCTCATCCACCTCCACCGGTCCAGGTCTTTGCTGCTGTCCCCA GACCTCCTGTGACACCACGCCAGATCACAGGGCACCAGGCCAGAGATAGTCTTCTTTTTGTCCTTTCTGGCCTCTGGCTAGTCAGTTTTT >In-frame_MRPL21_ENST00000362034_chr11_68663983_-_SSH3_ENST00000308298_chr11_67074309_+_1967nt GGCTGCGGCCATGGCAGCATCTTCCCTGACGGTCACCTTAGGGCGGCTGGCGTCCGCGTGCAGCCACAGCATCCTGAGACCTTCGGGGCC CGGAGCAGCCTCCCTTTGGTCTGCTTCTCGAAGGTTCAATTCACAGAGCACTTCATATCTACCAGGATATGTTCCTAAAACATCCCTGAG TTCACCACCTTGGCCAGAAGTTGTTCTGCCAGACCCAGTTGAGGAGACCAGACACCATGCAGAGGTCGTGAAGAAGGTGAATGAGATGAT CGTCACGGGGCAGTATGGCAGGCTCTTTGCCGTGGTGCACTTTGCCAGCCGCCAGTGGAAGGTGACCTCTGAAGACCTGATCTTAATTGG AAATGAACTAGACCTTGCGTGTGGAGAGAGAATTCGACTGGAGAAGGCAGCCCAGCTGGAGGCACCCCGGCCTCCCCGGCTCCGCTACCT GCTGGTAGTTTCTACACGAGAAGGAGAAGGTCTGAGCCAGGATGAGACGGTCCTCCTGGGCGTGGATTTCCCTGACAGCAGCTCCCCCAG CTGCACCCTGGGCCTGGTCTTGCCCCTCTGGAGTGACACCCAGGTGTACTTAGATGGAGACGGGGGCTTCAGCGTGACGTCTGGTGGGCA AAGCCGGATCTTCAAGCCCATCTCCATCCAGACCATGTGGGCCACACTCCAGGTATTGCACCAAGCATGTGAGGCAGCTCTAGGCAGCGG CCTTGTACCGGGTGGCAGTGCCCTCACCTGGGCCAGCCACTACCAGGAGAGACTGAACTCCGAACAGAGCTGCCTCAATGAGTGGACGGC TATGGCCGACCTGGAGTCTCTGCGGCCTCCCAGCGCCGAGCCTGGCGGGTCCTCAGAACAGGAGCAGATGGAGCAGGCGATCCGTGCTGA GCTGTGGAAAGTGTTGGATCTGGAGAGCACCTCAGAGACCAGTGACATGCCAGAGGTCTTCTCTTCCCACGAGTCTTCACATGAAGAGCC TCTGCAGCCCTTCCCACAGCTTGCAAGGACCAAGGGAGGCCAGCAGGTGGACAGGGGGCCTCAGCCTGCCCTGAAGTCCCGCCAGTCAGT GGTTACCCTCCAGGGCAGTGCCGTGGTGGCCAACCGGACCCAGGCCTTCCAGGAGCAGGAGCAGGGGCAGGGGCAGGGGCAGGGAGAGCC CTGCATTTCCTCTACGCCCAGGTTCCGGAAGGTGGTGAGACAGGCCAGCGTGCATGACAGTGGAGAGGAGGGCGAGGCCTGAGCCCTCAC ACATGCCCACGCTCCCCTGACACTGAAGAGGATCCACAACTCCTTGGAGAAACACCCTCACGTCTGTTGCCGCACACATTCCTCTCAGCT CCGCCCCATACCCGTCACTACAGCCTCACCTCCCACCCCTGTCACTACGGCCTCACCTCCCACCCCTGTCACTACAGCCTCACCTCCTAC AGCCTTAAGTCCCAGGCCCATGTCTGCCTGTCCAAGGGCTCAAGACTTTCTAACTGGGATGTGGTAGAGGGACTGAAGGTACCTTTGGGG GCAACAGCACCCTAGTTTCATTCTCAACTCTAGCCCTGCACACTCACCTGTGGCACGGAATGAAAACAGAGCTTCCCGTGCAAAAAGGGT CACGCCTCCCACCCCCGCCCCCTCCCTGCACCTCCTGTCCTCTCCCAGTTCATTCCTGGAACCAGCCAGGCCAGGCAACCAGTGGCCCCC AAAGGCAGGCAGGATCCTCAGGCCCCAGCCGCGGGAGGCTGGAAGGGCTGGCAGATCGCTTCCCTCATCCACCTCCACCGGTCCAGGTCT TTGCTGCTGTCCCCAGACCTCCTGTGACACCACGCCAGATCACAGGGCACCAGGCCAGAGATAGTCTTCTTTTTGTCCTTTCTGGCCTCT >In-frame_MRPL21_ENST00000362034_chr11_68663983_-_SSH3_ENST00000376757_chr11_67074309_+_2654nt GGCTGCGGCCATGGCAGCATCTTCCCTGACGGTCACCTTAGGGCGGCTGGCGTCCGCGTGCAGCCACAGCATCCTGAGACCTTCGGGGCC CGGAGCAGCCTCCCTTTGGTCTGCTTCTCGAAGGTTCAATTCACAGAGCACTTCATATCTACCAGGATATGTTCCTAAAACATCCCTGAG TTCACCACCTTGGCCAGAAGTTGTTCTGCCAGACCCAGTTGAGGAGACCAGACACCATGCAGAGGTCGTGAAGAAGGTGAATGAGATGAT CGTCACGGGGCAGTATGGCAGGCTCTTTGCCGTGGTGCACTTTGCCAGCCGCCAGTGGAAGGTGACCTCTGAAGACCTGATCTTAATTGG AAATGAACTAGACCTTGCGTGTGGAGAGAGAATTCGACTGGAGAAGGCAGCCCAGCTGGAGGCACCCCGGCCTCCCCGGCTCCGCTACCT GCTGGTAGTTTCTACACGAGAAGGAGAAGGTCTGAGCCAGGATGAGACGGTCCTCCTGGGCGTGGATTTCCCTGACAGCAGCTCCCCCAG CTGCACCCTGGGCCTGGTCTTGCCCCTCTGGAGTGACACCCAGGTGTACTTAGATGGAGACGGGGGCTTCAGCGTGACGTCTGGTGGGCA AAGCCGGATCTTCAAGCCCATCTCCATCCAGACCATGTGGGCCACACTCCAGGTATTGCACCAAGCATGTGAGGCAGCTCTAGGCAGCGG CCTTGTACCGGGTGGCAGTGCCCTCACCTGGGCCAGCCACTACCAGGAGAGACTGAACTCCGAACAGAGCTGCCTCAATGAGTGGACGGC TATGGCCGACCTGGAGTCTCTGCGGCCTCCCAGCGCCGAGCCTGGCGGGTCCTCAGAACAGGAGCAGATGGAGCAGGCGATCCGTGCTGA GCTGTGGAAAGTGTTGGATGTCAGTGACCTGGAGAGTGTCACTTCCAAAGAGATCCGCCAGGCTCTGGAGCTGCGCCTGGGGCTCCCCCT CCAGCAGTACCGTGACTTCATCGACAACCAGATGCTGCTGCTGGTGGCACAGCGGGACCGAGCCTCCCGCATCTTCCCCCACCTCTACCT GGGCTCAGAGTGGAACGCAGCAAACCTGGAGGAGCTGCAGAGGAACAGGGTCACCCACATCTTGAACATGGCCCGGGAGATTGACAACTT CTACCCTGAGCGCTTCACCTACCACAATGTGCGCCTCTGGGATGAGGAGTCGGCCCAGCTGCTGCCGCACTGGAAGGAGACGCACCGCTT CATTGAGGCTGCAAGAGCACAGGGCACCCACGTGCTGGTCCACTGCAAGATGGGCGTCAGCCGCTCAGCGGCCACAGTGCTGGCCTATGC CATGAAGCAGTACGAATGCAGCCTGGAGCAGGCCCTGCGCCACGTGCAGGAGCTCCGGCCCATCGCCCGCCCCAACCCTGGCTTCCTGCG CCAGCTGCAGATCTACCAGGGCATCCTGACGGCCAGAACCTGAGGGTGGTGGGGAGGAGAAGGTTGTAGGCATGGAAGAGAGCCAGGCAG CCCCGAAAGAAGAGCCTGGGCCACGGCCACGTATAAACCTCCGAGGGGTCATGAGGTCCATCAGTCTTCTGGAGCCCTCCTTGGAGCTGG AGAGCACCTCAGAGACCAGTGACATGCCAGAGGTCTTCTCTTCCCACGAGTCTTCACATGAAGAGCCTCTGCAGCCCTTCCCACAGCTTG CAAGGACCAAGGGAGGCCAGCAGGTGGACAGGGGGCCTCAGCCTGCCCTGAAGTCCCGCCAGTCAGTGGTTACCCTCCAGGGCAGTGCCG TGGTGGCCAACCGGACCCAGGCCTTCCAGGAGCAGGAGCAGGGGCAGGGGCAGGGGCAGGGAGAGCCCTGCATTTCCTCTACGCCCAGGT TCCGGAAGGTGGTGAGACAGGCCAGCGTGCATGACAGTGGAGAGGAGGGCGAGGCCTGAGCCCTCACACATGCCCACGCTCCCCTGACAC TGAAGAGGATCCACAACTCCTTGGAGAAACACCCTCACGTCTGTTGCCGCACACATTCCTCTCAGCTCCGCCCCATACCCGTCACTACAG CCTCACCTCCCACCCCTGTCACTACGGCCTCACCTCCCACCCCTGTCACTACAGCCTCACCTCCTACAGCCTTAAGTCCCAGGCCCATGT CTGCCTGTCCAAGGGCTCAAGACTTTCTAACTGGGATGTGGTAGAGGGACTGAAGGTACCTTTGGGGGCAACAGCACCCTAGTTTCATTC TCAACTCTAGCCCTGCACACTCACCTGTGGCACGGAATGAAAACAGAGCTTCCCGTGCAAAAAGGGTCACGCCTCCCACCCCCGCCCCCT CCCTGCACCTCCTGTCCTCTCCCAGTTCATTCCTGGAACCAGCCAGGCCAGGCAACCAGTGGCCCCCAAAGGCAGGCAGGATCCTCAGGC CCCAGCCGCGGGAGGCTGGAAGGGCTGGCAGATCGCTTCCCTCATCCACCTCCACCGGTCCAGGTCTTTGCTGCTGTCCCCAGACCTCCT GTGACACCACGCCAGATCACAGGGCACCAGGCCAGAGATAGTCTTCTTTTTGTCCTTTCTGGCCTCTGGCTAGTCAGTTTTTCATAGCCT |
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FusionGenePPI for MRPL21_SSH3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MRPL21 | CUL3, MRPL40, MRPL51, MRPL32, MRPS9, MRPL19, MRPL24, MRPL38, ILF2, FAF2, C1QBP, GRSF1, BTRC, ZC3H3, RPS8, MRPL4, HNRNPA1, MRPL39, CASQ2, MRPS30, MRPL47, MRPL50, MRPL9, MRPL1, FOXL2, C6orf203, DUSP11, NBEA, MRPL42, MTIF2, GTPBP8, AUH, MRPL20, HARS2, NDUFAF7, MRPL10, FDXR, LARS2, ELAC2, TOP3A, NDUFAF5, IARS2, CYLD | SSH3 | APP, SHMT2, SORT1, TMEM248, OTUB1, CDH1, SLC4A1AP, ZNF330, HERC1, RELA, CRYBG3, NBR1, CDK5RAP2, PFAS, BIRC6, KDM5C, C7orf55, KIAA0232, JMJD4, PSME3, MKS1, POLA2, YBEY, HSPA8, ANGEL1, SSH3, PCMT1, KEAP1, CALU, STIP1, SPATA5L1, CECR5, CCT8L1P, C2orf47 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MRPL21_SSH3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MRPL21_SSH3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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