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Fusion gene ID: 22471 |
FusionGeneSummary for MRPL21_LRP5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MRPL21_LRP5 | Fusion gene ID: 22471 | Hgene | Tgene | Gene symbol | MRPL21 | LRP5 | Gene ID | 219927 | 4041 |
| Gene name | mitochondrial ribosomal protein L21 | LDL receptor related protein 5 | |
| Synonyms | L21mt|MRP-L21 | BMND1|EVR1|EVR4|HBM|LR3|LRP-5|LRP7|OPPG|OPS|OPTA1|PCLD4|VBCH2 | |
| Cytomap | 11q13.3 | 11q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 39S ribosomal protein L21, mitochondrialmitochondrial large ribosomal subunit protein bL21m | low-density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 7 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q7Z2W9 | O75197 | |
| Ensembl transtripts involved in fusion gene | ENST00000450904, ENST00000362034, ENST00000567045, | ENST00000294304, ENST00000529481, | |
| Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 10 X 9 X 7=630 |
| # samples | 8 | 12 | |
| ** MAII score | log2(8/252*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/630*10)=-2.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MRPL21 [Title/Abstract] AND LRP5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | LRP5 | GO:0008284 | positive regulation of cell proliferation | 9790987 |
| Tgene | LRP5 | GO:0016055 | Wnt signaling pathway | 17955262 |
| Tgene | LRP5 | GO:0044332 | Wnt signaling pathway involved in dorsal/ventral axis specification | 11029007 |
| Tgene | LRP5 | GO:0045840 | positive regulation of mitotic nuclear division | 9790987 |
| Tgene | LRP5 | GO:0045893 | positive regulation of transcription, DNA-templated | 15035989|17955262 |
| Tgene | LRP5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12857724 |
| Tgene | LRP5 | GO:0060070 | canonical Wnt signaling pathway | 12121999|12857724|15035989 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-91-6831-01A | MRPL21 | chr11 | 68663983 | - | LRP5 | chr11 | 68115315 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000450904 | ENST00000294304 | MRPL21 | chr11 | 68663983 | - | LRP5 | chr11 | 68115315 | + |
| 5CDS-intron | ENST00000450904 | ENST00000529481 | MRPL21 | chr11 | 68663983 | - | LRP5 | chr11 | 68115315 | + |
| Frame-shit | ENST00000362034 | ENST00000294304 | MRPL21 | chr11 | 68663983 | - | LRP5 | chr11 | 68115315 | + |
| 5CDS-intron | ENST00000362034 | ENST00000529481 | MRPL21 | chr11 | 68663983 | - | LRP5 | chr11 | 68115315 | + |
| In-frame | ENST00000567045 | ENST00000294304 | MRPL21 | chr11 | 68663983 | - | LRP5 | chr11 | 68115315 | + |
| 5CDS-intron | ENST00000567045 | ENST00000529481 | MRPL21 | chr11 | 68663983 | - | LRP5 | chr11 | 68115315 | + |
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FusionProtFeatures for MRPL21_LRP5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MRPL21 | LRP5 |
| Component of the Wnt-Fzd-LRP5-LRP6 complex that triggersbeta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surfacecoreceptor of Wnt/beta-catenin signaling, which plays a pivotalrole in bone formation. Plays a role in norrin (NDP) signaltransduction (PubMed:27228167). The Wnt-induced Fzd/LRP6coreceptor complex recruits DVL1 polymers to the plasma membranewhich, in turn, recruits the AXIN1/GSK3B-complex to the cellsurface promoting the formation of signalsomes and inhibitingAXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascularregression in the eye (By similarity). Required for posteriorpatterning of the epiblast during gastrulation (By similarity).{ECO:0000250|UniProtKB:Q91VN0, ECO:0000269|PubMed:11336703,ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:14727154,ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15778503,ECO:0000269|PubMed:27228167}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 1495_1610 | 30 | 1616 | Compositional bias | Note=Pro-rich |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 1213_1254 | 30 | 1616 | Domain | Note=EGF-like 4 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 1258_1296 | 30 | 1616 | Domain | LDL-receptor class A 1 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 1297_1333 | 30 | 1616 | Domain | LDL-receptor class A 2 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 1335_1371 | 30 | 1616 | Domain | LDL-receptor class A 3 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 295_337 | 30 | 1616 | Domain | Note=EGF-like 1 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 601_641 | 30 | 1616 | Domain | Note=EGF-like 2 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 902_942 | 30 | 1616 | Domain | Note=EGF-like 3 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 1500_1506 | 30 | 1616 | Motif | Note=PPPSP motif A |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 1538_1545 | 30 | 1616 | Motif | Note=PPPSP motif B |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 1574_1581 | 30 | 1616 | Motif | Note=PPPSP motif C |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 1591_1596 | 30 | 1616 | Motif | Note=PPPSP motif D |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 1605_1612 | 30 | 1616 | Motif | Note=PPPSP motif E |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 32_288 | 30 | 1616 | Region | Note=Beta-propeller 1 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 341_602 | 30 | 1616 | Region | Note=Beta-propeller 2 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 644_903 | 30 | 1616 | Region | Note=Beta-propeller 3 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 945_1212 | 30 | 1616 | Region | Note=Beta-propeller 4 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 1036_1078 | 30 | 1616 | Repeat | Note=LDL-receptor class B 17 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 1079_1123 | 30 | 1616 | Repeat | Note=LDL-receptor class B 18 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 1124_1164 | 30 | 1616 | Repeat | Note=LDL-receptor class B 19 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 1165_1207 | 30 | 1616 | Repeat | Note=LDL-receptor class B 20 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 120_162 | 30 | 1616 | Repeat | Note=LDL-receptor class B 2 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 123_126 | 30 | 1616 | Repeat | Note=YWTD 2 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 163_206 | 30 | 1616 | Repeat | Note=LDL-receptor class B 3 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 166_169 | 30 | 1616 | Repeat | Note=YWTD 3 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 207_247 | 30 | 1616 | Repeat | Note=LDL-receptor class B 4 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 248_290 | 30 | 1616 | Repeat | Note=LDL-receptor class B 5 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 251_254 | 30 | 1616 | Repeat | Note=YWTD 4 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 385_427 | 30 | 1616 | Repeat | Note=LDL-receptor class B 6 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 388_391 | 30 | 1616 | Repeat | Note=YWTD 5 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 428_470 | 30 | 1616 | Repeat | Note=LDL-receptor class B 7 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 431_434 | 30 | 1616 | Repeat | Note=YWTD 6 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 471_514 | 30 | 1616 | Repeat | Note=LDL-receptor class B 8 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 474_477 | 30 | 1616 | Repeat | Note=YWTD 7 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 515_557 | 30 | 1616 | Repeat | Note=LDL-receptor class B 9 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 558_600 | 30 | 1616 | Repeat | Note=LDL-receptor class B 10 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 559_562 | 30 | 1616 | Repeat | Note=YWTD 8 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 687_729 | 30 | 1616 | Repeat | Note=LDL-receptor class B 11 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 690_693 | 30 | 1616 | Repeat | Note=YWTD 9 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 730_772 | 30 | 1616 | Repeat | Note=LDL-receptor class B 12 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 75_119 | 30 | 1616 | Repeat | Note=LDL-receptor class B 1 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 773_815 | 30 | 1616 | Repeat | Note=LDL-receptor class B 13 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 78_81 | 30 | 1616 | Repeat | Note=YWTD 1 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 816_855 | 30 | 1616 | Repeat | Note=LDL-receptor class B 14 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 819_822 | 30 | 1616 | Repeat | Note=YWTD 10 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 856_898 | 30 | 1616 | Repeat | Note=LDL-receptor class B 15 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 859_862 | 30 | 1616 | Repeat | Note=YWTD 11 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 989_1035 | 30 | 1616 | Repeat | Note=LDL-receptor class B 16 |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 1408_1615 | 30 | 1616 | Topological domain | Cytoplasmic |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 32_1384 | 30 | 1616 | Topological domain | Extracellular |
| Tgene | >LRP5 | chr11:68663983 | chr11:68115315 | ENST00000294304 | + | 0 | 23 | 1385_1407 | 30 | 1616 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MRPL21_LRP5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MRPL21_ENST00000450904_chr11_68663983_-_LRP5_ENST00000294304_chr11_68115315_+_1632aa MIVTGQTGRLFAVVHFASRQWKVTSEDLILIGNELDLACGERIRLEKPRRSCTLPTAGTYGWWTPAESSWSPPSWSAAWRMRPQWTSSFP REPCTGQT_ARRPSSRPT_TRRGPPCRTWSSPAWSLPTASPATGWARSCTGRTQRPTASRWPTSMAHPGRCSSGRTLTSRGPSPWTPLTG TCTGQTGVRRPGLSGQGWMAAPGRSLWTRTFTGPMD_PSTWRSRSSTGLTPSSASSTVPTWTARSGRRWWRAA_RTPSP_RSPGTLCTGQ TGRPAPSMPATSALGGRGRRS_VPSTHPWTSRC_ARSGSLSSTLAVRRTMAAAPTCACCPQASLSTHAPAPRVCSCRTTAGRVRQEPRRC CCWPGGRTYGGSRWTRRTSPTSCCRWTTSGTPLPSTTTR_RAMSTGQMTRCGPSAGRTWTGLGRRRWSTPRSTTPMASRSTGWPETSTGP TRARTASR_RASTAPPARSWCRRTWTSPEPSHCTP_WASCTGQTGERTLKSSVPTWMGRSGVCWSMPPSGGPTAWPWTCRRGSSTGETPR QTRSR_SMLMGRRGGPSWRTSSRTFLGSRCWGTSSTGLTGSAAASSGCTRSRPAGTSSLTSCPT_WGSKL_MWPRSSEPTRVRTGTGGAA TCASSHPTQPGVAAPSAWSC_VT_RPASCLRPSWSSPAEPPSTGSPSRPITTTWPSRSRASRRPQPWTLMCPTTTSTGQTSA_RPSAAPS _TGARWSTWWSLALTTPRAWPLTGWARTSTGPTLGPTESKWRGWTGSSGKSSCGGTWTTRGRWPWIPPRATSTGPSGAASRGSCGPSWTG PTA_RWWTRWAGPTTSPLTTLTSASTGPTWTPT_SSRPTCWVRSGS_LPTISRTRSV_RSTAIISTGQTGICTALSGPTRLAAGTAPSSR ATWTS_WTSWCSTPPARMASMTVCTTTGSVGSCALPSPAATAAAAPHTTPWTPAAATAARPPPSCCSARNLPSVG_SRTTSTARISSCPC MD_GTSKPSTMTHWTSSSTGWMGARTSSEPRTTGPSPLF_PL_AKAKTQTGSPTTSASTSTAGHCSGRARPPIPSTSTG_AGKPWGWCCV GTATSPGPSSSTRSEGTCTSPTCRTGQPRSNAQPWTAPSARSSSPPASSALWPWWWTTHWASCSGWTRT_SALRAVTCQGPTA_PWRTPT SCSLWA_PSLASISTGSTASSR_SSVWRRPPGTSGLASRAVSPTSLASMQWRKSAWRSSQPTHVPVTMVAAPTSVLPRVMGHHGAHAQST SCSCRTC_PVESRPPAPRTSLHVPQGRSTVSPGPGAVTAFPSAMTRATRRAAPCAPPPSSPARGVSVWTCACAATARQTVRTAQTRRTVT PSACPTSSGVRAASVSSSNSSATPSPTVSTAPTSSCVKSPSRPQTTARPTAVPSGPSLASSSLSSSWVVSILCASAWCASAMRGPTGPSR TSMSAGPRTCPSIS_PRAVPSMAPSQASHAESP__AP_A_WGAGAGCPSTTGTTSQGPRPAARPARRPRCTRRS_TRRPPRPRTPPCTTW TCSTLQTFRPLRDRTGPTSFEEWRPRRRPAAPTCVTATTAPAAGRPASTTWI_TRTQTPIHPHPRPTASTCRRRTAARPRPPPRGATSIS >In-frame_MRPL21_ENST00000567045_chr11_68663983_-_LRP5_ENST00000294304_chr11_68115315_+_1632aa MIVTGQTGRLFAVVHFASRQWKVTSEDLILIGNELDLACGERIRLEKPRRSCTLPTAGTYGWWTPAESSWSPPSWSAAWRMRPQWTSSFP REPCTGQT_ARRPSSRPT_TRRGPPCRTWSSPAWSLPTASPATGWARSCTGRTQRPTASRWPTSMAHPGRCSSGRTLTSRGPSPWTPLTG TCTGQTGVRRPGLSGQGWMAAPGRSLWTRTFTGPMD_PSTWRSRSSTGLTPSSASSTVPTWTARSGRRWWRAA_RTPSP_RSPGTLCTGQ TGRPAPSMPATSALGGRGRRS_VPSTHPWTSRC_ARSGSLSSTLAVRRTMAAAPTCACCPQASLSTHAPAPRVCSCRTTAGRVRQEPRRC CCWPGGRTYGGSRWTRRTSPTSCCRWTTSGTPLPSTTTR_RAMSTGQMTRCGPSAGRTWTGLGRRRWSTPRSTTPMASRSTGWPETSTGP TRARTASR_RASTAPPARSWCRRTWTSPEPSHCTP_WASCTGQTGERTLKSSVPTWMGRSGVCWSMPPSGGPTAWPWTCRRGSSTGETPR QTRSR_SMLMGRRGGPSWRTSSRTFLGSRCWGTSSTGLTGSAAASSGCTRSRPAGTSSLTSCPT_WGSKL_MWPRSSEPTRVRTGTGGAA TCASSHPTQPGVAAPSAWSC_VT_RPASCLRPSWSSPAEPPSTGSPSRPITTTWPSRSRASRRPQPWTLMCPTTTSTGQTSA_RPSAAPS _TGARWSTWWSLALTTPRAWPLTGWARTSTGPTLGPTESKWRGWTGSSGKSSCGGTWTTRGRWPWIPPRATSTGPSGAASRGSCGPSWTG PTA_RWWTRWAGPTTSPLTTLTSASTGPTWTPT_SSRPTCWVRSGS_LPTISRTRSV_RSTAIISTGQTGICTALSGPTRLAAGTAPSSR ATWTS_WTSWCSTPPARMASMTVCTTTGSVGSCALPSPAATAAAAPHTTPWTPAAATAARPPPSCCSARNLPSVG_SRTTSTARISSCPC MD_GTSKPSTMTHWTSSSTGWMGARTSSEPRTTGPSPLF_PL_AKAKTQTGSPTTSASTSTAGHCSGRARPPIPSTSTG_AGKPWGWCCV GTATSPGPSSSTRSEGTCTSPTCRTGQPRSNAQPWTAPSARSSSPPASSALWPWWWTTHWASCSGWTRT_SALRAVTCQGPTA_PWRTPT SCSLWA_PSLASISTGSTASSR_SSVWRRPPGTSGLASRAVSPTSLASMQWRKSAWRSSQPTHVPVTMVAAPTSVLPRVMGHHGAHAQST SCSCRTC_PVESRPPAPRTSLHVPQGRSTVSPGPGAVTAFPSAMTRATRRAAPCAPPPSSPARGVSVWTCACAATARQTVRTAQTRRTVT PSACPTSSGVRAASVSSSNSSATPSPTVSTAPTSSCVKSPSRPQTTARPTAVPSGPSLASSSLSSSWVVSILCASAWCASAMRGPTGPSR TSMSAGPRTCPSIS_PRAVPSMAPSQASHAESP__AP_A_WGAGAGCPSTTGTTSQGPRPAARPARRPRCTRRS_TRRPPRPRTPPCTTW TCSTLQTFRPLRDRTGPTSFEEWRPRRRPAAPTCVTATTAPAAGRPASTTWI_TRTQTPIHPHPRPTASTCRRRTAARPRPPPRGATSIS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MRPL21_ENST00000450904_chr11_68663983_-_LRP5_ENST00000294304_chr11_68115315_+_4898nt ATGATCGTCACGGGGCAGTATGGCAGGCTCTTTGCCGTGGTGCACTTTGCCAGCCGCCAGTGGAAGGTGACCTCTGAAGACCTGATCTTA ATTGGAAATGAACTAGACCTTGCGTGTGGAGAGAGAATTCGACTGGAGAAGCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTAC GGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTCCACCATCGTGGTCAGCGGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCA AGGGAGCCGTGTACTGGACAGACGTGAGCGAGGAGGCCATCAAGCAGACCTACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCA TCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTGCGACTGGGTGGGCAAGAAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGG TGGCCAACCTCAATGGCACATCCCGGAAGGTGCTCTTCTGGCAGGACCTTGACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGT ACATGTACTGGACAGACTGGGGTGAGACGCCCCGGATTGAGCGGGCAGGGATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACA TTTACTGGCCCAATGGACTGACCATCGACCTGGAGGAGCAGAAGCTCTACTGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACC TGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGGCAGCCTGACGCACCCCTTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAG ACTGGCAGACCCGCTCCATCCATGCCTGCAACAAGCGCACTGGGGGGAAGAGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACA TCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTTCCACACTCGCTGTGAGGAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCC CAAGCGAGCCTTTCTACACATGCGCCTGCCCCACGGGTGTGCAGCTGCAGGACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGC TGCTGCTGGCCCGGCGGACGGACCTACGGAGGATCTCGCTGGACACGCCGGACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGC ACGCCATTGCCATCGACTACGACCCGCTAGAGGGCTATGTCTACTGGACAGATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACG GGTCTGGGGCGCAGACGCTGGTCAACACCGAGATCAACGACCCCGATGGCATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCG ACACGGGCACGGACCGCATCGAGGTGACGCGCCTCAACGGCACCTCCCGCAAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCA TCGCACTGCACCCCGTGATGGGCCTCATGTACTGGACAGACTGGGGAGAGAACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGC GGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCCCAACGGCCTGGCCCTGGACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGA CAGACAAGATCGAGGTGATCAATGTTGATGGGACGAAGAGGCGGACCCTCCTGGAGGACAAGCTCCCGCACATTTTTGGGTTCACGCTGC TGGGGGACTTCATCTACTGGACTGACTGGCAGCGCCGCAGCATCGAGCGGGTGCACAAGGTCAAGGCCAGCCGGGACGTCATCATTGACC AGCTGCCCGACCTGATGGGGCTCAAAGCTGTGAATGTGGCCAAGGTCGTCGGAACCAACCCGTGTGCGGACAGGAACGGGGGGTGCAGCC ACCTGTGCTTCTTCACACCCCACGCAACCCGGTGTGGCTGCCCCATCGGCCTGGAGCTGCTGAGTGACATGAAGACCTGCATCGTGCCTG AGGCCTTCTTGGTCTTCACCAGCAGAGCCGCCATCCACAGGATCTCCCTCGAGACCAATAACAACGACGTGGCCATCCCGCTCACGGGCG TCAAGGAGGCCTCAGCCCTGGACTTTGATGTGTCCAACAACCACATCTACTGGACAGACGTCAGCCTGAAGACCATCAGCCGCGCCTTCA TGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTTTGGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGATGGGCAAGAACCTCTACT GGGCCGACACTGGGACCAACAGAATCGAAGTGGCGCGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAGGGACTTGGACAACCCGA GGTCGCTGGCCCTGGATCCCACCAAGGGCTACATCTACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCGGGCCTTCATGGACGGGA CCAACTGCATGACGCTGGTGGACAAGGTGGGCCGGGCCAACGACCTCACCATTGACTACGCTGACCAGCGCCTCTACTGGACCGACCTGG ACACCAACATGATCGAGTCGTCCAACATGCTGGGTCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGTCTGACGCAGT ACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACCCTCATCCAGG GCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAACGGGCAGTGTG GGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAACTGCAGCCCGC CCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTCATCCTGCCCCTGC ATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAACATCAAGCGAGCCA AGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTCAGCATCGACATCT ACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGGGTGGTGCTGCGTG GGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGGGCAGCCAAGATCG AACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTGGACAACACACTGG GCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTGGAGGACGCCAACA TCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGTGTGGAGAAGACCA CCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTGGAGGAGTTCTCAG CCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCATGCCCAGTCCACC TCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGGGAGATCGACTGTA TCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCCGCCGCCCAGTTCC CCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAGGCGGACTGTGACG CCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCCGACTGTATCGACG GCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCCGTCATTGGCATCA TCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAACGGGCCCTTCCCGC ACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACAGGCATCGCATGCG GAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACAGGGGCCTCGTCCA GCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACCCCTCCCTGTACAACATGG ACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTACATCATTCGAGGAATGGCGCCCCCGACGACGCCCTGCA GCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACTCGGACTCAGACCCCTATC CACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGAGGAGCTACTTCCATCTCT >In-frame_MRPL21_ENST00000567045_chr11_68663983_-_LRP5_ENST00000294304_chr11_68115315_+_4898nt ATGATCGTCACGGGGCAGTATGGCAGGCTCTTTGCCGTGGTGCACTTTGCCAGCCGCCAGTGGAAGGTGACCTCTGAAGACCTGATCTTA ATTGGAAATGAACTAGACCTTGCGTGTGGAGAGAGAATTCGACTGGAGAAGCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTAC GGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTCCACCATCGTGGTCAGCGGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCA AGGGAGCCGTGTACTGGACAGACGTGAGCGAGGAGGCCATCAAGCAGACCTACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCA TCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTGCGACTGGGTGGGCAAGAAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGG TGGCCAACCTCAATGGCACATCCCGGAAGGTGCTCTTCTGGCAGGACCTTGACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGT ACATGTACTGGACAGACTGGGGTGAGACGCCCCGGATTGAGCGGGCAGGGATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACA TTTACTGGCCCAATGGACTGACCATCGACCTGGAGGAGCAGAAGCTCTACTGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACC TGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGGCAGCCTGACGCACCCCTTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAG ACTGGCAGACCCGCTCCATCCATGCCTGCAACAAGCGCACTGGGGGGAAGAGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACA TCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTTCCACACTCGCTGTGAGGAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCC CAAGCGAGCCTTTCTACACATGCGCCTGCCCCACGGGTGTGCAGCTGCAGGACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGC TGCTGCTGGCCCGGCGGACGGACCTACGGAGGATCTCGCTGGACACGCCGGACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGC ACGCCATTGCCATCGACTACGACCCGCTAGAGGGCTATGTCTACTGGACAGATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACG GGTCTGGGGCGCAGACGCTGGTCAACACCGAGATCAACGACCCCGATGGCATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCG ACACGGGCACGGACCGCATCGAGGTGACGCGCCTCAACGGCACCTCCCGCAAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCA TCGCACTGCACCCCGTGATGGGCCTCATGTACTGGACAGACTGGGGAGAGAACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGC GGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCCCAACGGCCTGGCCCTGGACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGA CAGACAAGATCGAGGTGATCAATGTTGATGGGACGAAGAGGCGGACCCTCCTGGAGGACAAGCTCCCGCACATTTTTGGGTTCACGCTGC TGGGGGACTTCATCTACTGGACTGACTGGCAGCGCCGCAGCATCGAGCGGGTGCACAAGGTCAAGGCCAGCCGGGACGTCATCATTGACC AGCTGCCCGACCTGATGGGGCTCAAAGCTGTGAATGTGGCCAAGGTCGTCGGAACCAACCCGTGTGCGGACAGGAACGGGGGGTGCAGCC ACCTGTGCTTCTTCACACCCCACGCAACCCGGTGTGGCTGCCCCATCGGCCTGGAGCTGCTGAGTGACATGAAGACCTGCATCGTGCCTG AGGCCTTCTTGGTCTTCACCAGCAGAGCCGCCATCCACAGGATCTCCCTCGAGACCAATAACAACGACGTGGCCATCCCGCTCACGGGCG TCAAGGAGGCCTCAGCCCTGGACTTTGATGTGTCCAACAACCACATCTACTGGACAGACGTCAGCCTGAAGACCATCAGCCGCGCCTTCA TGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTTTGGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGATGGGCAAGAACCTCTACT GGGCCGACACTGGGACCAACAGAATCGAAGTGGCGCGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAGGGACTTGGACAACCCGA GGTCGCTGGCCCTGGATCCCACCAAGGGCTACATCTACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCGGGCCTTCATGGACGGGA CCAACTGCATGACGCTGGTGGACAAGGTGGGCCGGGCCAACGACCTCACCATTGACTACGCTGACCAGCGCCTCTACTGGACCGACCTGG ACACCAACATGATCGAGTCGTCCAACATGCTGGGTCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGTCTGACGCAGT ACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACCCTCATCCAGG GCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAACGGGCAGTGTG GGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAACTGCAGCCCGC CCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTCATCCTGCCCCTGC ATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAACATCAAGCGAGCCA AGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTCAGCATCGACATCT ACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGGGTGGTGCTGCGTG GGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGGGCAGCCAAGATCG AACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTGGACAACACACTGG GCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTGGAGGACGCCAACA TCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGTGTGGAGAAGACCA CCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTGGAGGAGTTCTCAG CCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCATGCCCAGTCCACC TCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGGGAGATCGACTGTA TCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCCGCCGCCCAGTTCC CCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAGGCGGACTGTGACG CCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCCGACTGTATCGACG GCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCCGTCATTGGCATCA TCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAACGGGCCCTTCCCGC ACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACAGGCATCGCATGCG GAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACAGGGGCCTCGTCCA GCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACCCCTCCCTGTACAACATGG ACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTACATCATTCGAGGAATGGCGCCCCCGACGACGCCCTGCA GCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACTCGGACTCAGACCCCTATC CACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGAGGAGCTACTTCCATCTCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MRPL21_ENST00000450904_chr11_68663983_-_LRP5_ENST00000294304_chr11_68115315_+_5347nt ACCTTAGGGCGGCTGGCGTCCGCGTGCAGCCACAGCATCCTGAGACCTTCGGGGCCCGGAGCAGCCTCCCTTTGGTCTGCTTCTCGAAGG TTCAATTCACAGAGCACTTCATATCTACCAGGGTAATATCAAAATATATGTTCCTAAAACATCCCTGAGTTCACCACCTTGGCCAGAAGT TGTTCTGCCAGACCCAGTTGAGGAGACCAGACACCATGCAGAGGTCGTGAAGAAGGTGAATGAGATGATCGTCACGGGGCAGTATGGCAG GCTCTTTGCCGTGGTGCACTTTGCCAGCCGCCAGTGGAAGGTGACCTCTGAAGACCTGATCTTAATTGGAAATGAACTAGACCTTGCGTG TGGAGAGAGAATTCGACTGGAGAAGCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAG CTGGAGTCCACCATCGTGGTCAGCGGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTG AGCGAGGAGGCCATCAAGCAGACCTACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGC CTCGCCTGCGACTGGGTGGGCAAGAAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGG AAGGTGCTCTTCTGGCAGGACCTTGACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAG ACGCCCCGGATTGAGCGGGCAGGGATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATC GACCTGGAGGAGCAGAAGCTCTACTGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTG GTGGAGGGCAGCCTGACGCACCCCTTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCC TGCAACAAGCGCACTGGGGGGAAGAGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAG CCTTTCTTCCACACTCGCTGTGAGGAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCC TGCCCCACGGGTGTGCAGCTGCAGGACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTA CGGAGGATCTCGCTGGACACGCCGGACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCG CTAGAGGGCTATGTCTACTGGACAGATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAAC ACCGAGATCAACGACCCCGATGGCATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTG ACGCGCCTCAACGGCACCTCCCGCAAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTC ATGTACTGGACAGACTGGGGAGAGAACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTC GGGTGGCCCAACGGCCTGGCCCTGGACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTGATCAATGTT GATGGGACGAAGAGGCGGACCCTCCTGGAGGACAAGCTCCCGCACATTTTTGGGTTCACGCTGCTGGGGGACTTCATCTACTGGACTGAC TGGCAGCGCCGCAGCATCGAGCGGGTGCACAAGGTCAAGGCCAGCCGGGACGTCATCATTGACCAGCTGCCCGACCTGATGGGGCTCAAA GCTGTGAATGTGGCCAAGGTCGTCGGAACCAACCCGTGTGCGGACAGGAACGGGGGGTGCAGCCACCTGTGCTTCTTCACACCCCACGCA ACCCGGTGTGGCTGCCCCATCGGCCTGGAGCTGCTGAGTGACATGAAGACCTGCATCGTGCCTGAGGCCTTCTTGGTCTTCACCAGCAGA GCCGCCATCCACAGGATCTCCCTCGAGACCAATAACAACGACGTGGCCATCCCGCTCACGGGCGTCAAGGAGGCCTCAGCCCTGGACTTT GATGTGTCCAACAACCACATCTACTGGACAGACGTCAGCCTGAAGACCATCAGCCGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTG GTGGAGTTTGGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGATGGGCAAGAACCTCTACTGGGCCGACACTGGGACCAACAGAATC GAAGTGGCGCGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAGGGACTTGGACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAG GGCTACATCTACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCGGGCCTTCATGGACGGGACCAACTGCATGACGCTGGTGGACAAG GTGGGCCGGGCCAACGACCTCACCATTGACTACGCTGACCAGCGCCTCTACTGGACCGACCTGGACACCAACATGATCGAGTCGTCCAAC ATGCTGGGTCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGAC TGGAATCTGCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATC CTGGTGTTCCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGC GGCCACCGCTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAACTGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAG AAATCTGCCATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTCATCCTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATC GACTATGACCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAACATCAAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTT TTGACCTCTCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTCAGCATCGACATCTACAGCCGGACACTGTTCTGGACGTGC GAGGCCACCAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGGGTGGTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATC GTCGTCAACGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGGGCAGCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAG CGCGAGGTCCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTGGACAACACACTGGGCAAGCTGTTCTGGGTGGACGCGGAC CTGAAGCGCATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTGGAGGACGCCAACATCGTGCAGCCTCTGGGCCTGACCATC CTTGGCAAGCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGTGTGGAGAAGACCACCGGGGACAAGCGGACTCGCATCCAG GGCCGTGTCGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTGGAGGAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGT GGCTGCTCCCACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCATGCCCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACC TGTGGAGAGCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGGGAGATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGC TTTCCCGAGTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCCGCCGCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGAC CTGCGCCTGCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAGGCGGACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGG TGTGCGAGCGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCCGACTGTATCGACGGCTCCGACGAGCTCATGTGTGAAATC ACCAAGCCGCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCCGTCATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGT GTCTATTTTGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAACGGGCCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCAC GTGCCCCTCAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACAGGCATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGC CTGATGGGGGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACAGGGGCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACG CTGTACCCGCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACCCCTCCCTGTACAACATGGACATGTTCTACTCTTCAAACATTCCG GCCACTGCGAGACCGTACAGGCCCTACATCATTCGAGGAATGGCGCCCCCGACGACGCCCTGCAGCACCGACGTGTGTGACAGCGACTAC AGCGCCAGCCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACTCGGACTCAGACCCCTATCCACCCCCACCCACGCCCCACAGCCAG TACCTGTCGGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGAGGAGCTACTTCCATCTCTTCCCGCCCCCTCCGTCCCCCTGCACG GACTCATCCTGACCTCGGCCGGGCCACTCTGGCTTCTCTGTGCCCCTGTAAATAGTTTTAAATATGAACAAAGAAAAAAATATATTTTAT GATTTAAAAAATAAATATAATTGGGATTTTAAAAACATGAGAAATGTGAACTGTGATGGGGTGGGCAGGGCTGGGAGAACTTTGTACAGT >In-frame_MRPL21_ENST00000567045_chr11_68663983_-_LRP5_ENST00000294304_chr11_68115315_+_5339nt GCGGCTGGCGTCCGCGTGCAGCCACAGCATCCTGAGACCTTCGGGGCCCGGAGCAGCCTCCCTTTGGTCTGCTTCTCGAAGGTTCAATTC ACAGAGCACTTCATATCTACCAGGGTAATATCAAAATATATGTTCCTAAAACATCCCTGAGTTCACCACCTTGGCCAGAAGTTGTTCTGC CAGACCCAGTTGAGGAGACCAGACACCATGCAGAGGTCGTGAAGAAGGTGAATGAGATGATCGTCACGGGGCAGTATGGCAGGCTCTTTG CCGTGGTGCACTTTGCCAGCCGCCAGTGGAAGGTGACCTCTGAAGACCTGATCTTAATTGGAAATGAACTAGACCTTGCGTGTGGAGAGA GAATTCGACTGGAGAAGCCTCGCCGCTCCTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTCAAGCTGGAGTC CACCATCGTGGTCAGCGGCCTGGAGGATGCGGCCGCAGTGGACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGA GGCCATCAAGCAGACCTACCTGAACCAGACGGGGGCCGCCGTGCAGAACGTGGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTG CGACTGGGTGGGCAAGAAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAACCTCAATGGCACATCCCGGAAGGTGCT CTTCTGGCAGGACCTTGACCAGCCGAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTGGGGTGAGACGCCCCG GATTGAGCGGGCAGGGATGGATGGCAGCACCCGGAAGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACCTGGA GGAGCAGAAGCTCTACTGGGCTGACGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGG CAGCCTGACGCACCCCTTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACTGGCAGACCCGCTCCATCCATGCCTGCAACAA GCGCACTGGGGGGAAGAGGAAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGCCAGGAGCGGCAGCCTTTCTT CCACACTCGCTGTGAGGAGGACAATGGCGGCTGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCTGCCCCAC GGGTGTGCAGCTGCAGGACAACGGCAGGACGTGTAAGGCAGGAGCCGAGGAGGTGCTGCTGCTGGCCCGGCGGACGGACCTACGGAGGAT CTCGCTGGACACGCCGGACTTCACCGACATCGTGCTGCAGGTGGACGACATCCGGCACGCCATTGCCATCGACTACGACCCGCTAGAGGG CTATGTCTACTGGACAGATGACGAGGTGCGGGCCATCCGCAGGGCGTACCTGGACGGGTCTGGGGCGCAGACGCTGGTCAACACCGAGAT CAACGACCCCGATGGCATCGCGGTCGACTGGGTGGCCCGAAACCTCTACTGGACCGACACGGGCACGGACCGCATCGAGGTGACGCGCCT CAACGGCACCTCCCGCAAGATCCTGGTGTCGGAGGACCTGGACGAGCCCCGAGCCATCGCACTGCACCCCGTGATGGGCCTCATGTACTG GACAGACTGGGGAGAGAACCCTAAAATCGAGTGTGCCAACTTGGATGGGCAGGAGCGGCGTGTGCTGGTCAATGCCTCCCTCGGGTGGCC CAACGGCCTGGCCCTGGACCTGCAGGAGGGGAAGCTCTACTGGGGAGACGCCAAGACAGACAAGATCGAGGTGATCAATGTTGATGGGAC GAAGAGGCGGACCCTCCTGGAGGACAAGCTCCCGCACATTTTTGGGTTCACGCTGCTGGGGGACTTCATCTACTGGACTGACTGGCAGCG CCGCAGCATCGAGCGGGTGCACAAGGTCAAGGCCAGCCGGGACGTCATCATTGACCAGCTGCCCGACCTGATGGGGCTCAAAGCTGTGAA TGTGGCCAAGGTCGTCGGAACCAACCCGTGTGCGGACAGGAACGGGGGGTGCAGCCACCTGTGCTTCTTCACACCCCACGCAACCCGGTG TGGCTGCCCCATCGGCCTGGAGCTGCTGAGTGACATGAAGACCTGCATCGTGCCTGAGGCCTTCTTGGTCTTCACCAGCAGAGCCGCCAT CCACAGGATCTCCCTCGAGACCAATAACAACGACGTGGCCATCCCGCTCACGGGCGTCAAGGAGGCCTCAGCCCTGGACTTTGATGTGTC CAACAACCACATCTACTGGACAGACGTCAGCCTGAAGACCATCAGCCGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTT TGGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGATGGGCAAGAACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGC GCGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAGGGACTTGGACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACAT CTACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCGGGCCTTCATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCG GGCCAACGACCTCACCATTGACTACGCTGACCAGCGCCTCTACTGGACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGG TCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCT GCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTT CCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCG CTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAACTGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGC CATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTCATCCTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGA CCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAACATCAAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTC TCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTCAGCATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCAC CAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGGGTGGTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAA CGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGGGCAGCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGT CCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTGGACAACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCG CATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTGGAGGACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAA GCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGTGTGGAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGT CGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTGGAGGAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTC CCACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCATGCCCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGA GCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGGGAGATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGA GTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCCGCCGCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCT GCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAGGCGGACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAG CGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCCGACTGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCC GCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCCGTCATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTT TGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAACGGGCCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCT CAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACAGGCATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGG GGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACAGGGGCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCC GCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACCCCTCCCTGTACAACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGC GAGACCGTACAGGCCCTACATCATTCGAGGAATGGCGCCCCCGACGACGCCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAG CCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACTCGGACTCAGACCCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTC GGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGAGGAGCTACTTCCATCTCTTCCCGCCCCCTCCGTCCCCCTGCACGGACTCATC CTGACCTCGGCCGGGCCACTCTGGCTTCTCTGTGCCCCTGTAAATAGTTTTAAATATGAACAAAGAAAAAAATATATTTTATGATTTAAA AAATAAATATAATTGGGATTTTAAAAACATGAGAAATGTGAACTGTGATGGGGTGGGCAGGGCTGGGAGAACTTTGTACAGTGGAGAAAT |
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FusionGenePPI for MRPL21_LRP5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MRPL21 | CUL3, MRPL40, MRPL51, MRPL32, MRPS9, MRPL19, MRPL24, MRPL38, ILF2, FAF2, C1QBP, GRSF1, BTRC, ZC3H3, RPS8, MRPL4, HNRNPA1, MRPL39, CASQ2, MRPS30, MRPL47, MRPL50, MRPL9, MRPL1, FOXL2, C6orf203, DUSP11, NBEA, MRPL42, MTIF2, GTPBP8, AUH, MRPL20, HARS2, NDUFAF7, MRPL10, FDXR, LARS2, ELAC2, TOP3A, NDUFAF5, IARS2, CYLD | LRP5 | AXIN1, SMAD9, CAPRIN2, SOST, DKK1, FZD8, TAZ, RASD2, SUSD4, PARP16, POMK, B3GALT2, ETV6, CHST9, LIPH, PRSS37, CSNK1A1, TGIF2LY, DKKL1, SERPINA12, ST8SIA4, SCGB1D1, DKK4, MGAT4C, F9, FAM3B, C4orf26, FCGRT, PODN, ADAM33, BRINP3, LRRC4C, CLPSL1, NXPH2, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MRPL21_LRP5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MRPL21_LRP5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | LRP5 | C0432252 | Osteoporosis with pseudoglioma | 8 | CTD_human;ORPHANET;UNIPROT |
| Tgene | LRP5 | C1866176 | EXUDATIVE VITREORETINOPATHY 4 (disorder) | 8 | CTD_human;UNIPROT |
| Tgene | LRP5 | C1866079 | BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 1 | 5 | UNIPROT |
| Tgene | LRP5 | C0242852 | Proliferative vitreoretinopathy | 1 | CTD_human |
| Tgene | LRP5 | C0432273 | Worth disease | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | LRP5 | C1843330 | OSTEOPETROSIS, AUTOSOMAL DOMINANT 1 | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | LRP5 | C1851402 | Exudative vitreoretinopathy 1 | 1 | ORPHANET;UNIPROT |
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