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Fusion gene ID: 22467 |
FusionGeneSummary for MRPL19_PTBP2 |
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Fusion gene information | Fusion gene name: MRPL19_PTBP2 | Fusion gene ID: 22467 | Hgene | Tgene | Gene symbol | MRPL19 | PTBP2 | Gene ID | 9801 | 58155 |
Gene name | mitochondrial ribosomal protein L19 | polypyrimidine tract binding protein 2 | |
Synonyms | L19mt|MRP-L15|MRP-L19|MRPL15|RLX1|RPML15 | PTBLP|brPTB|nPTB | |
Cytomap | 2p12 | 1p21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | 39S ribosomal protein L19, mitochondrial39S ribosomal protein L15, mitochondrialL15mtmitochondrial large ribosomal subunit protein bL19m | polypyrimidine tract-binding protein 2PTB-like proteinneural polypyrimidine tract binding proteinneurally-enriched homolog of PTB | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P49406 | Q9UKA9 | |
Ensembl transtripts involved in fusion gene | ENST00000358788, ENST00000409374, ENST00000393909, | ENST00000482253, ENST00000609116, ENST00000370197, ENST00000370198, ENST00000426398, ENST00000394184, ENST00000541987, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 1=9 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MRPL19 [Title/Abstract] AND PTBP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PTBP2 | GO:0033119 | negative regulation of RNA splicing | 18335065 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG708259 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000358788 | ENST00000482253 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
intron-3UTR | ENST00000358788 | ENST00000609116 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
intron-3UTR | ENST00000358788 | ENST00000370197 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
intron-3UTR | ENST00000358788 | ENST00000370198 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
intron-3UTR | ENST00000358788 | ENST00000426398 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
intron-intron | ENST00000358788 | ENST00000394184 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
intron-intron | ENST00000358788 | ENST00000541987 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
5CDS-intron | ENST00000409374 | ENST00000482253 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
5CDS-3UTR | ENST00000409374 | ENST00000609116 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
5CDS-3UTR | ENST00000409374 | ENST00000370197 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
5CDS-3UTR | ENST00000409374 | ENST00000370198 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
5CDS-3UTR | ENST00000409374 | ENST00000426398 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
5CDS-intron | ENST00000409374 | ENST00000394184 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
5CDS-intron | ENST00000409374 | ENST00000541987 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
5CDS-intron | ENST00000393909 | ENST00000482253 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
5CDS-3UTR | ENST00000393909 | ENST00000609116 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
5CDS-3UTR | ENST00000393909 | ENST00000370197 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
5CDS-3UTR | ENST00000393909 | ENST00000370198 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
5CDS-3UTR | ENST00000393909 | ENST00000426398 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
5CDS-intron | ENST00000393909 | ENST00000394184 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
5CDS-intron | ENST00000393909 | ENST00000541987 | MRPL19 | chr2 | 75881911 | + | PTBP2 | chr1 | 97279392 | + |
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FusionProtFeatures for MRPL19_PTBP2 |
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Hgene | Tgene |
MRPL19 | PTBP2 |
RNA-binding protein which binds to intronicpolypyrimidine tracts and mediates negative regulation of exonssplicing. May antagonize in a tissue-specific manner the abilityof NOVA1 to activate exon selection. In addition to its functionin pre-mRNA splicing, plays also a role in the regulation oftranslation. Isoform 5 has a reduced affinity for RNA.{ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:12667457}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MRPL19_PTBP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MRPL19_PTBP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MRPL19_PTBP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MRPL19_PTBP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MRPL19 | C1458155 | Mammary Neoplasms | 1 | CTD_human |