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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22467

FusionGeneSummary for MRPL19_PTBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: MRPL19_PTBP2
Fusion gene ID: 22467
HgeneTgene
Gene symbol

MRPL19

PTBP2

Gene ID

9801

58155

Gene namemitochondrial ribosomal protein L19polypyrimidine tract binding protein 2
SynonymsL19mt|MRP-L15|MRP-L19|MRPL15|RLX1|RPML15PTBLP|brPTB|nPTB
Cytomap

2p12

1p21.3

Type of geneprotein-codingprotein-coding
Description39S ribosomal protein L19, mitochondrial39S ribosomal protein L15, mitochondrialL15mtmitochondrial large ribosomal subunit protein bL19mpolypyrimidine tract-binding protein 2PTB-like proteinneural polypyrimidine tract binding proteinneurally-enriched homolog of PTB
Modification date2018052320180519
UniProtAcc

P49406

Q9UKA9

Ensembl transtripts involved in fusion geneENST00000358788, ENST00000409374, 
ENST00000393909, 
ENST00000482253, 
ENST00000609116, ENST00000370197, 
ENST00000370198, ENST00000426398, 
ENST00000394184, ENST00000541987, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 1=9
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MRPL19 [Title/Abstract] AND PTBP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTBP2

GO:0033119

negative regulation of RNA splicing

18335065


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG708259MRPL19chr2

75881911

+PTBP2chr1

97279392

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000358788ENST00000482253MRPL19chr2

75881911

+PTBP2chr1

97279392

+
intron-3UTRENST00000358788ENST00000609116MRPL19chr2

75881911

+PTBP2chr1

97279392

+
intron-3UTRENST00000358788ENST00000370197MRPL19chr2

75881911

+PTBP2chr1

97279392

+
intron-3UTRENST00000358788ENST00000370198MRPL19chr2

75881911

+PTBP2chr1

97279392

+
intron-3UTRENST00000358788ENST00000426398MRPL19chr2

75881911

+PTBP2chr1

97279392

+
intron-intronENST00000358788ENST00000394184MRPL19chr2

75881911

+PTBP2chr1

97279392

+
intron-intronENST00000358788ENST00000541987MRPL19chr2

75881911

+PTBP2chr1

97279392

+
5CDS-intronENST00000409374ENST00000482253MRPL19chr2

75881911

+PTBP2chr1

97279392

+
5CDS-3UTRENST00000409374ENST00000609116MRPL19chr2

75881911

+PTBP2chr1

97279392

+
5CDS-3UTRENST00000409374ENST00000370197MRPL19chr2

75881911

+PTBP2chr1

97279392

+
5CDS-3UTRENST00000409374ENST00000370198MRPL19chr2

75881911

+PTBP2chr1

97279392

+
5CDS-3UTRENST00000409374ENST00000426398MRPL19chr2

75881911

+PTBP2chr1

97279392

+
5CDS-intronENST00000409374ENST00000394184MRPL19chr2

75881911

+PTBP2chr1

97279392

+
5CDS-intronENST00000409374ENST00000541987MRPL19chr2

75881911

+PTBP2chr1

97279392

+
5CDS-intronENST00000393909ENST00000482253MRPL19chr2

75881911

+PTBP2chr1

97279392

+
5CDS-3UTRENST00000393909ENST00000609116MRPL19chr2

75881911

+PTBP2chr1

97279392

+
5CDS-3UTRENST00000393909ENST00000370197MRPL19chr2

75881911

+PTBP2chr1

97279392

+
5CDS-3UTRENST00000393909ENST00000370198MRPL19chr2

75881911

+PTBP2chr1

97279392

+
5CDS-3UTRENST00000393909ENST00000426398MRPL19chr2

75881911

+PTBP2chr1

97279392

+
5CDS-intronENST00000393909ENST00000394184MRPL19chr2

75881911

+PTBP2chr1

97279392

+
5CDS-intronENST00000393909ENST00000541987MRPL19chr2

75881911

+PTBP2chr1

97279392

+

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FusionProtFeatures for MRPL19_PTBP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRPL19

P49406

PTBP2

Q9UKA9

RNA-binding protein which binds to intronicpolypyrimidine tracts and mediates negative regulation of exonssplicing. May antagonize in a tissue-specific manner the abilityof NOVA1 to activate exon selection. In addition to its functionin pre-mRNA splicing, plays also a role in the regulation oftranslation. Isoform 5 has a reduced affinity for RNA.{ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:12667457}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MRPL19_PTBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MRPL19_PTBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MRPL19_PTBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MRPL19_PTBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMRPL19C1458155Mammary Neoplasms1CTD_human