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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22455

FusionGeneSummary for MRPL11_MRFAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: MRPL11_MRFAP1
Fusion gene ID: 22455
HgeneTgene
Gene symbol

MRPL11

MRFAP1

Gene ID

65003

93621

Gene namemitochondrial ribosomal protein L11Morf4 family associated protein 1
SynonymsCGI-113|L11MT|MRP-L11PAM14|PGR1
Cytomap

11q13.2

4p16.1

Type of geneprotein-codingprotein-coding
Description39S ribosomal protein L11, mitochondrialmitochondrial large ribosomal subunit protein uL11mMORF4 family-associated protein 1Mof4 family associated protein 1T-cell activation proteinprotein associated with MRG of 14 kDa
Modification date2018052320180522
UniProtAcc

Q9Y3B7

Q9Y605

Ensembl transtripts involved in fusion geneENST00000310999, ENST00000430466, 
ENST00000524576, ENST00000329819, 
ENST00000320912, ENST00000507420, 
ENST00000382581, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 5 X 4=120
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRPL11 [Title/Abstract] AND MRFAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF090922MRPL11chr11

66206312

+MRFAP1chr4

6643927

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000310999ENST00000320912MRPL11chr11

66206312

+MRFAP1chr4

6643927

+
intron-intronENST00000310999ENST00000507420MRPL11chr11

66206312

+MRFAP1chr4

6643927

+
intron-3UTRENST00000310999ENST00000382581MRPL11chr11

66206312

+MRFAP1chr4

6643927

+
intron-3UTRENST00000430466ENST00000320912MRPL11chr11

66206312

+MRFAP1chr4

6643927

+
intron-intronENST00000430466ENST00000507420MRPL11chr11

66206312

+MRFAP1chr4

6643927

+
intron-3UTRENST00000430466ENST00000382581MRPL11chr11

66206312

+MRFAP1chr4

6643927

+
intron-3UTRENST00000524576ENST00000320912MRPL11chr11

66206312

+MRFAP1chr4

6643927

+
intron-intronENST00000524576ENST00000507420MRPL11chr11

66206312

+MRFAP1chr4

6643927

+
intron-3UTRENST00000524576ENST00000382581MRPL11chr11

66206312

+MRFAP1chr4

6643927

+
intron-3UTRENST00000329819ENST00000320912MRPL11chr11

66206312

+MRFAP1chr4

6643927

+
intron-intronENST00000329819ENST00000507420MRPL11chr11

66206312

+MRFAP1chr4

6643927

+
intron-3UTRENST00000329819ENST00000382581MRPL11chr11

66206312

+MRFAP1chr4

6643927

+

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FusionProtFeatures for MRPL11_MRFAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRPL11

Q9Y3B7

MRFAP1

Q9Y605


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MRPL11_MRFAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MRPL11_MRFAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MRPL11_MRFAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MRPL11_MRFAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource