|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 22448 |
FusionGeneSummary for MROH2B_MRPS30 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MROH2B_MRPS30 | Fusion gene ID: 22448 | Hgene | Tgene | Gene symbol | MROH2B | MRPS30 | Gene ID | 133558 | 10884 |
| Gene name | maestro heat like repeat family member 2B | mitochondrial ribosomal protein S30 | |
| Synonyms | HEATR7B2|SPIF | MRP-S30|PAP|PDCD9|S30mt | |
| Cytomap | 5p13.1 | 5p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | maestro heat-like repeat-containing protein family member 2BHEAT repeat family member 7B2HEAT repeat family member B2HEAT repeat-containing protein 7B2sperm PKA-interacting factor | 39S ribosomal protein S30, mitochondrial28S ribosomal protein S30, mitochondrialmitochondrial large ribosomal subunit protein mL65mitochondrial large ribosomal subunit protein mS30programmed cell death 9 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q7Z745 | Q9NP92 | |
| Ensembl transtripts involved in fusion gene | ENST00000506092, ENST00000399564, | ENST00000507110, ENST00000230914, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 3=27 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MROH2B [Title/Abstract] AND MRPS30 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-55-1596-01A | MROH2B | chr5 | 41017952 | - | MRPS30 | chr5 | 44813208 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000506092 | ENST00000507110 | MROH2B | chr5 | 41017952 | - | MRPS30 | chr5 | 44813208 | + |
| 5CDS-intron | ENST00000506092 | ENST00000230914 | MROH2B | chr5 | 41017952 | - | MRPS30 | chr5 | 44813208 | + |
| In-frame | ENST00000399564 | ENST00000507110 | MROH2B | chr5 | 41017952 | - | MRPS30 | chr5 | 44813208 | + |
| 5CDS-intron | ENST00000399564 | ENST00000230914 | MROH2B | chr5 | 41017952 | - | MRPS30 | chr5 | 44813208 | + |
Top |
FusionProtFeatures for MROH2B_MRPS30 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MROH2B | MRPS30 |
| May play a role in the process of sperm capacitation.{ECO:0000250|UniProtKB:Q7M6Y6}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MROH2B | chr5:41017952 | chr5:44813208 | ENST00000399564 | - | 28 | 42 | 228_263 | 961 | 1586 | Repeat | Note=HEAT 2 |
| Hgene | MROH2B | chr5:41017952 | chr5:44813208 | ENST00000399564 | - | 28 | 42 | 272_309 | 961 | 1586 | Repeat | Note=HEAT 3 |
| Hgene | MROH2B | chr5:41017952 | chr5:44813208 | ENST00000399564 | - | 28 | 42 | 28_65 | 961 | 1586 | Repeat | Note=HEAT 1 |
| Hgene | MROH2B | chr5:41017952 | chr5:44813208 | ENST00000399564 | - | 28 | 42 | 310_346 | 961 | 1586 | Repeat | Note=HEAT 4 |
| Hgene | MROH2B | chr5:41017952 | chr5:44813208 | ENST00000399564 | - | 28 | 42 | 405_445 | 961 | 1586 | Repeat | Note=HEAT 5 |
| Hgene | MROH2B | chr5:41017952 | chr5:44813208 | ENST00000399564 | - | 28 | 42 | 531_569 | 961 | 1586 | Repeat | Note=HEAT 6 |
| Hgene | MROH2B | chr5:41017952 | chr5:44813208 | ENST00000399564 | - | 28 | 42 | 572_611 | 961 | 1586 | Repeat | Note=HEAT 7 |
| Hgene | MROH2B | chr5:41017952 | chr5:44813208 | ENST00000399564 | - | 28 | 42 | 662_699 | 961 | 1586 | Repeat | Note=HEAT 8 |
| Hgene | MROH2B | chr5:41017952 | chr5:44813208 | ENST00000399564 | - | 28 | 42 | 777_819 | 961 | 1586 | Repeat | Note=HEAT 9 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MROH2B | chr5:41017952 | chr5:44813208 | ENST00000399564 | - | 28 | 42 | 1021_1059 | 961 | 1586 | Repeat | Note=HEAT 11 |
| Hgene | >MROH2B | chr5:41017952 | chr5:44813208 | ENST00000399564 | - | 28 | 42 | 1112_1151 | 961 | 1586 | Repeat | Note=HEAT 12 |
| Hgene | >MROH2B | chr5:41017952 | chr5:44813208 | ENST00000399564 | - | 28 | 42 | 1157_1195 | 961 | 1586 | Repeat | Note=HEAT 13 |
| Hgene | >MROH2B | chr5:41017952 | chr5:44813208 | ENST00000399564 | - | 28 | 42 | 1258_1295 | 961 | 1586 | Repeat | Note=HEAT 14 |
| Hgene | >MROH2B | chr5:41017952 | chr5:44813208 | ENST00000399564 | - | 28 | 42 | 1363_1402 | 961 | 1586 | Repeat | Note=HEAT 15 |
| Hgene | >MROH2B | chr5:41017952 | chr5:44813208 | ENST00000399564 | - | 28 | 42 | 964_1001 | 961 | 1586 | Repeat | Note=HEAT 10 |
Top |
FusionGeneSequence for MROH2B_MRPS30 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MROH2B_ENST00000506092_chr5_41017952_-_MRPS30_ENST00000507110_chr5_44813208_+_672aa MPQVLWPRILTFVVPAEYTEALEPLFSIIRILIMAEEKKQHSAKESTALVVSTGAVKLPSPQQLLARLLVISMPASLGELRGAGAIGLLK ILPEIIHPKLVDLWKTRLPELLQPLEGKNISTVLWETMLLQLLKESLWKISDVAWTIQLTQDFKQQMGSYSNNSTEKKFLWKALGTTLAC CQDSDFVNSQIKEFLTAPNQLGDQRQGITSILGYCAENHLDIVLKVLKTFQNQEKFFMNRCKSLFSGKKSLTKTDVMVIYGAVALHAPKK QLLSRLNQDIISQVLSLHGQCSQVLGMSVMNKDMDLQMSFTRSITEIGIAVQDAEDQGFQFSYKEMLIGYMLDFIRDEPLDSLASPIRWK ALIAIRYLSKLKPQLSLQDHLNILEENIRRLLPLPPLENLKSEGQTDKDKEHIQFLYERSMDALGKLLKTMMWDNVNAEDCQEMFNLLQM WLVSQKEWERERAFQITAKVLTNDIEAPENFKIGSLLGLLAPHSCDTLPTIRQAAASSTIGLFYIKGSKTADPCCYGHTQFHLLPDKLRR ERLLRQNCADQIEVVFRANAIASLFAWTGAQAMYQGFWSEADVTRPFVSQAVITDGKYFSFFCYQLNTLALTTQADQNNPRKNICWGTQS >In-frame_MROH2B_ENST00000399564_chr5_41017952_-_MRPS30_ENST00000507110_chr5_44813208_+_1117aa MTLSTEESIEMFGDINLTLGMLNKEDIVNKEDIYSHLTSVIQNTDILDDAIVQRLIYYASKDMRDNNMLREIRMLAGEVLVSLAAHDFNS VMYEVQSNFRILELPDEFVVLALAELATSYVSQSIPFMMMTLLTMQTMLRLAEDERMKGTFCIALEKFSKAIYKYVNHWRDFPYPRLDAN RLSDKIFMLFWYIMEKWAPLASPMQTLSIVKAHGPTVSLLLHREDFRGYALGQVPWLLNQYKDKEIDFHVTQSLKQILTAAVLYDIGLPR SLRRSIFINLLQQICRAPEPPVKENEMKASSCFLILAHSNPGELMEFFDEQVRSNNEAIRVGILTLLRLAVNADEPRLRDHIISIERTVK IVMGDLSTKVRNSVLLLIQTMCEKSYIEAREGWPLIDYVFSQFATLNRNLEKPVKTNFHENEKEEESVRETSLEVLKTLDPLVIGMPQVL WPRILTFVVPAEYTEALEPLFSIIRILIMAEEKKQHSAKESTALVVSTGAVKLPSPQQLLARLLVISMPASLGELRGAGAIGLLKILPEI IHPKLVDLWKTRLPELLQPLEGKNISTVLWETMLLQLLKESLWKISDVAWTIQLTQDFKQQMGSYSNNSTEKKFLWKALGTTLACCQDSD FVNSQIKEFLTAPNQLGDQRQGITSILGYCAENHLDIVLKVLKTFQNQEKFFMNRCKSLFSGKKSLTKTDVMVIYGAVALHAPKKQLLSR LNQDIISQVLSLHGQCSQVLGMSVMNKDMDLQMSFTRSITEIGIAVQDAEDQGFQFSYKEMLIGYMLDFIRDEPLDSLASPIRWKALIAI RYLSKLKPQLSLQDHLNILEENIRRLLPLPPLENLKSEGQTDKDKEHIQFLYERSMDALGKLLKTMMWDNVNAEDCQEMFNLLQMWLVSQ KEWERERAFQITAKVLTNDIEAPENFKIGSLLGLLAPHSCDTLPTIRQAAASSTIGLFYIKGSKTADPCCYGHTQFHLLPDKLRRERLLR QNCADQIEVVFRANAIASLFAWTGAQAMYQGFWSEADVTRPFVSQAVITDGKYFSFFCYQLNTLALTTQADQNNPRKNICWGTQSKPLYE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MROH2B_ENST00000506092_chr5_41017952_-_MRPS30_ENST00000507110_chr5_44813208_+_2016nt ATGCCTCAGGTGCTATGGCCAAGGATCCTGACTTTTGTGGTACCTGCAGAATACACAGAAGCTCTGGAGCCCCTGTTTAGTATCATCAGA ATTCTGATTATGGCAGAGGAGAAGAAGCAGCACAGTGCCAAGGAGTCGACAGCACTTGTCGTCTCTACAGGAGCTGTGAAACTTCCTTCA CCACAGCAGCTACTGGCCAGACTTCTGGTAATATCTATGCCTGCCAGTTTAGGGGAGTTACGTGGGGCTGGTGCAATAGGGCTTTTGAAG ATACTGCCTGAGATAATTCACCCAAAATTGGTAGACCTATGGAAAACACGTTTACCTGAGCTTCTGCAGCCTCTGGAAGGAAAGAACATC AGTACCGTTCTATGGGAAACCATGCTGCTTCAGTTGCTCAAAGAATCCTTATGGAAGATCAGTGATGTGGCCTGGACCATTCAGCTGACT CAGGATTTCAAACAGCAAATGGGCAGTTACAGCAATAACTCCACTGAGAAGAAATTCCTTTGGAAAGCCTTGGGAACCACCTTAGCATGC TGCCAAGATTCAGACTTTGTAAACTCACAGATTAAGGAGTTTCTGACTGCTCCCAACCAACTGGGGGATCAAAGACAGGGAATAACATCT ATTTTAGGATACTGTGCCGAGAACCATTTGGATATTGTTTTAAAAGTTCTTAAAACATTCCAAAATCAGGAAAAGTTTTTCATGAATCGA TGTAAGAGCCTTTTTTCTGGGAAAAAGAGCCTGACCAAGACAGATGTCATGGTCATCTATGGAGCAGTGGCCCTCCATGCTCCCAAGAAG CAACTTCTCTCCAGACTTAATCAAGATATCATATCCCAAGTCCTGTCTCTTCATGGCCAGTGCTCTCAGGTTCTGGGCATGTCTGTGATG AACAAGGACATGGATCTGCAAATGAGTTTCACAAGAAGCATCACTGAGATTGGCATTGCTGTCCAAGATGCTGAGGATCAGGGGTTCCAG TTTTCCTACAAGGAGATGCTGATTGGTTACATGCTGGACTTCATTAGAGACGAGCCCCTGGATTCCTTAGCTAGCCCTATTCGGTGGAAA GCCTTAATCGCCATTAGGTATCTCAGTAAACTGAAACCTCAGCTCTCACTACAAGACCACCTTAACATTCTTGAGGAGAATATTCGGAGG CTGCTGCCCCTTCCACCTCTGGAAAATCTGAAAAGTGAAGGCCAGACAGACAAGGACAAGGAGCACATTCAATTTCTCTATGAACGATCC ATGGACGCCCTAGGAAAACTTCTGAAGACCATGATGTGGGATAATGTGAATGCAGAGGACTGTCAAGAAATGTTTAATCTTCTCCAAATG TGGCTTGTTTCACAAAAAGAGTGGGAAAGAGAAAGAGCCTTCCAGATCACTGCGAAAGTGCTGACAAATGATATTGAGGCACCAGAGAAC TTTAAAATTGGTTCACTGCTTGGACTTCTGGCTCCTCACTCCTGTGATACCCTGCCCACCATCCGTCAGGCGGCTGCTAGCTCAACTATT GGTCTGTTCTATATAAAAGGCTCAAAAACTGCAGATCCTTGCTGTTACGGTCACACCCAGTTTCATCTGTTACCTGACAAATTAAGAAGG GAAAGGCTTTTGAGACAAAACTGTGCTGATCAGATAGAAGTTGTTTTTAGAGCTAATGCTATTGCAAGCCTTTTTGCTTGGACTGGAGCA CAAGCTATGTATCAAGGATTCTGGAGTGAAGCAGATGTTACTCGACCTTTTGTCTCCCAGGCTGTGATCACAGATGGAAAATACTTTTCC TTTTTCTGCTACCAGCTAAATACTTTGGCACTGACTACACAAGCTGATCAAAATAACCCTCGTAAAAATATATGTTGGGGTACACAAAGT AAGCCTCTTTATGAAACAATTGAGGATAATGATGTGAAAGGTTTTAATGATGATGTTCTACTTCAGATAGTTCACTTTCTACTGAATAGA >In-frame_MROH2B_ENST00000399564_chr5_41017952_-_MRPS30_ENST00000507110_chr5_44813208_+_3351nt ATGACACTTAGTACAGAGGAATCCATAGAGATGTTTGGGGATATTAACCTCACTCTTGGCATGCTGAACAAGGAAGATATTGTTAACAAG GAAGACATTTACAGTCATCTCACTTCTGTTATTCAGAATACTGACATCTTGGATGATGCAATTGTCCAACGATTGATTTATTATGCTTCT AAGGATATGAGAGACAACAATATGCTCAGAGAAATCAGAATGCTAGCTGGTGAGGTTTTGGTGTCTCTTGCTGCACATGATTTCAACTCT GTGATGTATGAAGTACAAAGTAACTTCAGGATCTTAGAGCTACCAGATGAATTCGTTGTGCTTGCCCTGGCTGAATTGGCAACCAGCTAT GTGTCCCAGAGTATTCCTTTCATGATGATGACCCTGCTCACCATGCAAACCATGCTCAGGCTGGCCGAGGATGAAAGGATGAAGGGGACT TTCTGTATTGCCCTTGAGAAATTCAGCAAAGCCATTTACAAATATGTCAACCACTGGAGAGATTTTCCCTACCCCAGACTGGATGCCAAC CGACTGTCTGACAAGATCTTCATGCTGTTCTGGTATATAATGGAGAAGTGGGCCCCTTTGGCCTCACCCATGCAGACTTTGAGCATCGTT AAGGCCCACGGGCCCACGGTGAGCTTGCTGCTGCATCGGGAAGACTTCCGTGGATACGCCCTGGGCCAGGTGCCCTGGCTCCTGAACCAG TATAAAGACAAAGAGATTGATTTCCATGTCACTCAGAGCCTAAAACAAATACTGACTGCAGCAGTTCTTTATGACATTGGCCTTCCAAGG AGCTTGAGAAGATCCATCTTTATCAATTTACTCCAGCAGATCTGCAGAGCTCCAGAGCCTCCAGTAAAGGAAAATGAAATGAAAGCTTCA AGCTGTTTTCTCATTCTAGCCCATTCCAATCCTGGAGAGCTGATGGAATTTTTTGATGAACAAGTAAGAAGTAATAATGAAGCCATTCGA GTGGGAATCTTGACTTTGTTAAGATTGGCTGTCAATGCTGATGAGCCCAGGTTGAGGGATCACATCATTTCAATAGAAAGAACAGTCAAA ATCGTCATGGGTGATCTCAGTACAAAAGTAAGAAATTCTGTTCTTCTCCTCATCCAAACCATGTGTGAAAAGTCCTATATTGAAGCTCGG GAAGGATGGCCATTGATTGATTATGTCTTCTCCCAGTTTGCAACGTTGAACAGGAATCTGGAGAAACCAGTGAAAACTAACTTTCATGAG AATGAAAAGGAAGAGGAATCTGTCCGAGAAACAAGCCTTGAGGTCTTAAAAACCCTGGACCCACTGGTCATTGGAATGCCTCAGGTGCTA TGGCCAAGGATCCTGACTTTTGTGGTACCTGCAGAATACACAGAAGCTCTGGAGCCCCTGTTTAGTATCATCAGAATTCTGATTATGGCA GAGGAGAAGAAGCAGCACAGTGCCAAGGAGTCGACAGCACTTGTCGTCTCTACAGGAGCTGTGAAACTTCCTTCACCACAGCAGCTACTG GCCAGACTTCTGGTAATATCTATGCCTGCCAGTTTAGGGGAGTTACGTGGGGCTGGTGCAATAGGGCTTTTGAAGATACTGCCTGAGATA ATTCACCCAAAATTGGTAGACCTATGGAAAACACGTTTACCTGAGCTTCTGCAGCCTCTGGAAGGAAAGAACATCAGTACCGTTCTATGG GAAACCATGCTGCTTCAGTTGCTCAAAGAATCCTTATGGAAGATCAGTGATGTGGCCTGGACCATTCAGCTGACTCAGGATTTCAAACAG CAAATGGGCAGTTACAGCAATAACTCCACTGAGAAGAAATTCCTTTGGAAAGCCTTGGGAACCACCTTAGCATGCTGCCAAGATTCAGAC TTTGTAAACTCACAGATTAAGGAGTTTCTGACTGCTCCCAACCAACTGGGGGATCAAAGACAGGGAATAACATCTATTTTAGGATACTGT GCCGAGAACCATTTGGATATTGTTTTAAAAGTTCTTAAAACATTCCAAAATCAGGAAAAGTTTTTCATGAATCGATGTAAGAGCCTTTTT TCTGGGAAAAAGAGCCTGACCAAGACAGATGTCATGGTCATCTATGGAGCAGTGGCCCTCCATGCTCCCAAGAAGCAACTTCTCTCCAGA CTTAATCAAGATATCATATCCCAAGTCCTGTCTCTTCATGGCCAGTGCTCTCAGGTTCTGGGCATGTCTGTGATGAACAAGGACATGGAT CTGCAAATGAGTTTCACAAGAAGCATCACTGAGATTGGCATTGCTGTCCAAGATGCTGAGGATCAGGGGTTCCAGTTTTCCTACAAGGAG ATGCTGATTGGTTACATGCTGGACTTCATTAGAGACGAGCCCCTGGATTCCTTAGCTAGCCCTATTCGGTGGAAAGCCTTAATCGCCATT AGGTATCTCAGTAAACTGAAACCTCAGCTCTCACTACAAGACCACCTTAACATTCTTGAGGAGAATATTCGGAGGCTGCTGCCCCTTCCA CCTCTGGAAAATCTGAAAAGTGAAGGCCAGACAGACAAGGACAAGGAGCACATTCAATTTCTCTATGAACGATCCATGGACGCCCTAGGA AAACTTCTGAAGACCATGATGTGGGATAATGTGAATGCAGAGGACTGTCAAGAAATGTTTAATCTTCTCCAAATGTGGCTTGTTTCACAA AAAGAGTGGGAAAGAGAAAGAGCCTTCCAGATCACTGCGAAAGTGCTGACAAATGATATTGAGGCACCAGAGAACTTTAAAATTGGTTCA CTGCTTGGACTTCTGGCTCCTCACTCCTGTGATACCCTGCCCACCATCCGTCAGGCGGCTGCTAGCTCAACTATTGGTCTGTTCTATATA AAAGGCTCAAAAACTGCAGATCCTTGCTGTTACGGTCACACCCAGTTTCATCTGTTACCTGACAAATTAAGAAGGGAAAGGCTTTTGAGA CAAAACTGTGCTGATCAGATAGAAGTTGTTTTTAGAGCTAATGCTATTGCAAGCCTTTTTGCTTGGACTGGAGCACAAGCTATGTATCAA GGATTCTGGAGTGAAGCAGATGTTACTCGACCTTTTGTCTCCCAGGCTGTGATCACAGATGGAAAATACTTTTCCTTTTTCTGCTACCAG CTAAATACTTTGGCACTGACTACACAAGCTGATCAAAATAACCCTCGTAAAAATATATGTTGGGGTACACAAAGTAAGCCTCTTTATGAA ACAATTGAGGATAATGATGTGAAAGGTTTTAATGATGATGTTCTACTTCAGATAGTTCACTTTCTACTGAATAGACCAAAAGAAGAAAAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MROH2B_ENST00000506092_chr5_41017952_-_MRPS30_ENST00000507110_chr5_44813208_+_2627nt ATTTGTTTGCTGCCTGTACAGACTTTGAGCATCGTTAAGGCCCACGGGCCCACGGTGAGCTTGCTGCTGCATCGGGAAGACTTCCGTGGA TACGCCCTGGGCCAGGTGCCCTGGCTCCTGAACCAGTATAAAGACAAAGAGATTGATTTCCATGTCACTCAGTTTGCAACGTTGAACAGG AATCTGGAGAAACCAGTGAAAACTAACTTTCATGAGAATGAAAAGGAAGAGGAATCTGTCCGAGAAACAAGCCTTGAGGTCTTAAAAACC CTGGACCCACTGGTCATTGGAATGCCTCAGGTGCTATGGCCAAGGATCCTGACTTTTGTGGTACCTGCAGAATACACAGAAGCTCTGGAG CCCCTGTTTAGTATCATCAGAATTCTGATTATGGCAGAGGAGAAGAAGCAGCACAGTGCCAAGGAGTCGACAGCACTTGTCGTCTCTACA GGAGCTGTGAAACTTCCTTCACCACAGCAGCTACTGGCCAGACTTCTGGTAATATCTATGCCTGCCAGTTTAGGGGAGTTACGTGGGGCT GGTGCAATAGGGCTTTTGAAGATACTGCCTGAGATAATTCACCCAAAATTGGTAGACCTATGGAAAACACGTTTACCTGAGCTTCTGCAG CCTCTGGAAGGAAAGAACATCAGTACCGTTCTATGGGAAACCATGCTGCTTCAGTTGCTCAAAGAATCCTTATGGAAGATCAGTGATGTG GCCTGGACCATTCAGCTGACTCAGGATTTCAAACAGCAAATGGGCAGTTACAGCAATAACTCCACTGAGAAGAAATTCCTTTGGAAAGCC TTGGGAACCACCTTAGCATGCTGCCAAGATTCAGACTTTGTAAACTCACAGATTAAGGAGTTTCTGACTGCTCCCAACCAACTGGGGGAT CAAAGACAGGGAATAACATCTATTTTAGGATACTGTGCCGAGAACCATTTGGATATTGTTTTAAAAGTTCTTAAAACATTCCAAAATCAG GAAAAGTTTTTCATGAATCGATGTAAGAGCCTTTTTTCTGGGAAAAAGAGCCTGACCAAGACAGATGTCATGGTCATCTATGGAGCAGTG GCCCTCCATGCTCCCAAGAAGCAACTTCTCTCCAGACTTAATCAAGATATCATATCCCAAGTCCTGTCTCTTCATGGCCAGTGCTCTCAG GTTCTGGGCATGTCTGTGATGAACAAGGACATGGATCTGCAAATGAGTTTCACAAGAAGCATCACTGAGATTGGCATTGCTGTCCAAGAT GCTGAGGATCAGGGGTTCCAGTTTTCCTACAAGGAGATGCTGATTGGTTACATGCTGGACTTCATTAGAGACGAGCCCCTGGATTCCTTA GCTAGCCCTATTCGGTGGAAAGCCTTAATCGCCATTAGGTATCTCAGTAAACTGAAACCTCAGCTCTCACTACAAGACCACCTTAACATT CTTGAGGAGAATATTCGGAGGCTGCTGCCCCTTCCACCTCTGGAAAATCTGAAAAGTGAAGGCCAGACAGACAAGGACAAGGAGCACATT CAATTTCTCTATGAACGATCCATGGACGCCCTAGGAAAACTTCTGAAGACCATGATGTGGGATAATGTGAATGCAGAGGACTGTCAAGAA ATGTTTAATCTTCTCCAAATGTGGCTTGTTTCACAAAAAGAGTGGGAAAGAGAAAGAGCCTTCCAGATCACTGCGAAAGTGCTGACAAAT GATATTGAGGCACCAGAGAACTTTAAAATTGGTTCACTGCTTGGACTTCTGGCTCCTCACTCCTGTGATACCCTGCCCACCATCCGTCAG GCGGCTGCTAGCTCAACTATTGGTCTGTTCTATATAAAAGGCTCAAAAACTGCAGATCCTTGCTGTTACGGTCACACCCAGTTTCATCTG TTACCTGACAAATTAAGAAGGGAAAGGCTTTTGAGACAAAACTGTGCTGATCAGATAGAAGTTGTTTTTAGAGCTAATGCTATTGCAAGC CTTTTTGCTTGGACTGGAGCACAAGCTATGTATCAAGGATTCTGGAGTGAAGCAGATGTTACTCGACCTTTTGTCTCCCAGGCTGTGATC ACAGATGGAAAATACTTTTCCTTTTTCTGCTACCAGCTAAATACTTTGGCACTGACTACACAAGCTGATCAAAATAACCCTCGTAAAAAT ATATGTTGGGGTACACAAAGTAAGCCTCTTTATGAAACAATTGAGGATAATGATGTGAAAGGTTTTAATGATGATGTTCTACTTCAGATA GTTCACTTTCTACTGAATAGACCAAAAGAAGAAAAATCACAGCTGTTGGAAAACTGAAAAAGCATATTTGATTGAGAACTGTGGGAATAT TTAAATTTTACTGAAGGAACAATAATGATGAGATTTGTAACTGTCAACTATTAAATACATTGATTTTTGAGACAAATATTTCTTATGTCA ACCTGTTATTAGATCTCTTACTCTGCTCAAATTCATCACTGAAAGATTTAATTTTAGTTACCTTTTGTTGATTTAAAAATAATTGCATTT GTATATTGCTAACTGATAAGACAAATTGAGTTATTGAGCTATTAAATGCACATTTTAATATAAATGCAGAAATCCCAAATAAAATGCTAA >In-frame_MROH2B_ENST00000399564_chr5_41017952_-_MRPS30_ENST00000507110_chr5_44813208_+_4122nt GAGTTCACCATAAAGCCTTTCCCAACATCAGGACAGTAAAGCAACTACTGAAAACCATTCCTGAATTTGTGATCAATGGACTCAAGTTTA GGGAGAGGAGCACCTTTGGTCTGCAACAATGGTTTGAATCCCAGTCTCTAATTACTTCTTTCCCAAATACTCTGGTCACCAAAGGGACAA TATTTGGTGAGATGCAGCCATTTTGTTGGTTAGCAGGAGTTCAGACGCAAGACAATGTCATAGTGGTAGAATACAGTATCAACTTCAACA GCAAGCCCATCTCTGGAAGCTCCCAGACCATTGTGCCAATCAAGTGGAGGAGGCACTTTCATTTAGAGAGGCTTATGTGAACCTTATATG AGAAACTTGCCAACCTGCCTCTTTGATTTTTTAGCCTTACTATTTCTAATACTTAGGTGCTATCTTTTAGAGACCCTGAAACAGCCAAGA CATGACACTTAGTACAGAGGAATCCATAGAGATGTTTGGGGATATTAACCTCACTCTTGGCATGCTGAACAAGGAAGATATTGTTAACAA GGAAGACATTTACAGTCATCTCACTTCTGTTATTCAGAATACTGACATCTTGGATGATGCAATTGTCCAACGATTGATTTATTATGCTTC TAAGGATATGAGAGACAACAATATGCTCAGAGAAATCAGAATGCTAGCTGGTGAGGTTTTGGTGTCTCTTGCTGCACATGATTTCAACTC TGTGATGTATGAAGTACAAAGTAACTTCAGGATCTTAGAGCTACCAGATGAATTCGTTGTGCTTGCCCTGGCTGAATTGGCAACCAGCTA TGTGTCCCAGAGTATTCCTTTCATGATGATGACCCTGCTCACCATGCAAACCATGCTCAGGCTGGCCGAGGATGAAAGGATGAAGGGGAC TTTCTGTATTGCCCTTGAGAAATTCAGCAAAGCCATTTACAAATATGTCAACCACTGGAGAGATTTTCCCTACCCCAGACTGGATGCCAA CCGACTGTCTGACAAGATCTTCATGCTGTTCTGGTATATAATGGAGAAGTGGGCCCCTTTGGCCTCACCCATGCAGACTTTGAGCATCGT TAAGGCCCACGGGCCCACGGTGAGCTTGCTGCTGCATCGGGAAGACTTCCGTGGATACGCCCTGGGCCAGGTGCCCTGGCTCCTGAACCA GTATAAAGACAAAGAGATTGATTTCCATGTCACTCAGAGCCTAAAACAAATACTGACTGCAGCAGTTCTTTATGACATTGGCCTTCCAAG GAGCTTGAGAAGATCCATCTTTATCAATTTACTCCAGCAGATCTGCAGAGCTCCAGAGCCTCCAGTAAAGGAAAATGAAATGAAAGCTTC AAGCTGTTTTCTCATTCTAGCCCATTCCAATCCTGGAGAGCTGATGGAATTTTTTGATGAACAAGTAAGAAGTAATAATGAAGCCATTCG AGTGGGAATCTTGACTTTGTTAAGATTGGCTGTCAATGCTGATGAGCCCAGGTTGAGGGATCACATCATTTCAATAGAAAGAACAGTCAA AATCGTCATGGGTGATCTCAGTACAAAAGTAAGAAATTCTGTTCTTCTCCTCATCCAAACCATGTGTGAAAAGTCCTATATTGAAGCTCG GGAAGGATGGCCATTGATTGATTATGTCTTCTCCCAGTTTGCAACGTTGAACAGGAATCTGGAGAAACCAGTGAAAACTAACTTTCATGA GAATGAAAAGGAAGAGGAATCTGTCCGAGAAACAAGCCTTGAGGTCTTAAAAACCCTGGACCCACTGGTCATTGGAATGCCTCAGGTGCT ATGGCCAAGGATCCTGACTTTTGTGGTACCTGCAGAATACACAGAAGCTCTGGAGCCCCTGTTTAGTATCATCAGAATTCTGATTATGGC AGAGGAGAAGAAGCAGCACAGTGCCAAGGAGTCGACAGCACTTGTCGTCTCTACAGGAGCTGTGAAACTTCCTTCACCACAGCAGCTACT GGCCAGACTTCTGGTAATATCTATGCCTGCCAGTTTAGGGGAGTTACGTGGGGCTGGTGCAATAGGGCTTTTGAAGATACTGCCTGAGAT AATTCACCCAAAATTGGTAGACCTATGGAAAACACGTTTACCTGAGCTTCTGCAGCCTCTGGAAGGAAAGAACATCAGTACCGTTCTATG GGAAACCATGCTGCTTCAGTTGCTCAAAGAATCCTTATGGAAGATCAGTGATGTGGCCTGGACCATTCAGCTGACTCAGGATTTCAAACA GCAAATGGGCAGTTACAGCAATAACTCCACTGAGAAGAAATTCCTTTGGAAAGCCTTGGGAACCACCTTAGCATGCTGCCAAGATTCAGA CTTTGTAAACTCACAGATTAAGGAGTTTCTGACTGCTCCCAACCAACTGGGGGATCAAAGACAGGGAATAACATCTATTTTAGGATACTG TGCCGAGAACCATTTGGATATTGTTTTAAAAGTTCTTAAAACATTCCAAAATCAGGAAAAGTTTTTCATGAATCGATGTAAGAGCCTTTT TTCTGGGAAAAAGAGCCTGACCAAGACAGATGTCATGGTCATCTATGGAGCAGTGGCCCTCCATGCTCCCAAGAAGCAACTTCTCTCCAG ACTTAATCAAGATATCATATCCCAAGTCCTGTCTCTTCATGGCCAGTGCTCTCAGGTTCTGGGCATGTCTGTGATGAACAAGGACATGGA TCTGCAAATGAGTTTCACAAGAAGCATCACTGAGATTGGCATTGCTGTCCAAGATGCTGAGGATCAGGGGTTCCAGTTTTCCTACAAGGA GATGCTGATTGGTTACATGCTGGACTTCATTAGAGACGAGCCCCTGGATTCCTTAGCTAGCCCTATTCGGTGGAAAGCCTTAATCGCCAT TAGGTATCTCAGTAAACTGAAACCTCAGCTCTCACTACAAGACCACCTTAACATTCTTGAGGAGAATATTCGGAGGCTGCTGCCCCTTCC ACCTCTGGAAAATCTGAAAAGTGAAGGCCAGACAGACAAGGACAAGGAGCACATTCAATTTCTCTATGAACGATCCATGGACGCCCTAGG AAAACTTCTGAAGACCATGATGTGGGATAATGTGAATGCAGAGGACTGTCAAGAAATGTTTAATCTTCTCCAAATGTGGCTTGTTTCACA AAAAGAGTGGGAAAGAGAAAGAGCCTTCCAGATCACTGCGAAAGTGCTGACAAATGATATTGAGGCACCAGAGAACTTTAAAATTGGTTC ACTGCTTGGACTTCTGGCTCCTCACTCCTGTGATACCCTGCCCACCATCCGTCAGGCGGCTGCTAGCTCAACTATTGGTCTGTTCTATAT AAAAGGCTCAAAAACTGCAGATCCTTGCTGTTACGGTCACACCCAGTTTCATCTGTTACCTGACAAATTAAGAAGGGAAAGGCTTTTGAG ACAAAACTGTGCTGATCAGATAGAAGTTGTTTTTAGAGCTAATGCTATTGCAAGCCTTTTTGCTTGGACTGGAGCACAAGCTATGTATCA AGGATTCTGGAGTGAAGCAGATGTTACTCGACCTTTTGTCTCCCAGGCTGTGATCACAGATGGAAAATACTTTTCCTTTTTCTGCTACCA GCTAAATACTTTGGCACTGACTACACAAGCTGATCAAAATAACCCTCGTAAAAATATATGTTGGGGTACACAAAGTAAGCCTCTTTATGA AACAATTGAGGATAATGATGTGAAAGGTTTTAATGATGATGTTCTACTTCAGATAGTTCACTTTCTACTGAATAGACCAAAAGAAGAAAA ATCACAGCTGTTGGAAAACTGAAAAAGCATATTTGATTGAGAACTGTGGGAATATTTAAATTTTACTGAAGGAACAATAATGATGAGATT TGTAACTGTCAACTATTAAATACATTGATTTTTGAGACAAATATTTCTTATGTCAACCTGTTATTAGATCTCTTACTCTGCTCAAATTCA TCACTGAAAGATTTAATTTTAGTTACCTTTTGTTGATTTAAAAATAATTGCATTTGTATATTGCTAACTGATAAGACAAATTGAGTTATT |
Top |
FusionGenePPI for MROH2B_MRPS30 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MROH2B | UGP2 | MRPS30 | ICT1, RNMTL1, SLC25A3, C1QBP, NPM1, MRPL43, RPL13, MRPL28, RPL6, MRPS18A, RPS8, MRPL4, MRPL39, MRPL37, MRPL57, MRPL12, ELAC2, MRPL46, MRPL45, MRPL9, RPL26L1, MRPL32, MRPL11, MRPL48, MRPL40, MRPL3, MRPL1, MRPL23, MRPL41, MRPL22, ARMC8, MRPL17, RPL36AL, MRPL10, MRPL24, MRPL49, MRPL44, PMPCA, MRPL50, MRPL38, MRPL20, CLPP, MRPL27, MRPL55, MALSU1, MRPL47, MRPL16, DDX28, MRPL19, ZMYND19, MRPL15, MRPL2, MRPL21, MRPL13, GTPBP10, MRPL33, GADD45GIP1, MRPL35, MRPL30, RBFOX3, MRPL14, TRUB2, MRPL42, MRPL18, MRPL51, MRPL53, MRPL34, MRPL52, HNRNPA1, VPS26B, FOXB1, FOXL1, MEX3C, HSPD1, FGF8, CYLD |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MROH2B_MRPS30 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MROH2B_MRPS30 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|