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Fusion gene ID: 22437 |
FusionGeneSummary for MRFAP1_TOP1 |
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Fusion gene information | Fusion gene name: MRFAP1_TOP1 | Fusion gene ID: 22437 | Hgene | Tgene | Gene symbol | MRFAP1 | TOP1 | Gene ID | 93621 | 7150 |
Gene name | Morf4 family associated protein 1 | DNA topoisomerase I | |
Synonyms | PAM14|PGR1 | TOPI | |
Cytomap | 4p16.1 | 20q12 | |
Type of gene | protein-coding | protein-coding | |
Description | MORF4 family-associated protein 1Mof4 family associated protein 1T-cell activation proteinprotein associated with MRG of 14 kDa | DNA topoisomerase 1topoisomerase (DNA) Itype I DNA topoisomerase | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q9Y605 | P11387 | |
Ensembl transtripts involved in fusion gene | ENST00000320912, ENST00000507420, ENST00000382581, | ENST00000361337, | |
Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 6 X 5 X 3=90 |
# samples | 5 | 6 | |
** MAII score | log2(5/16*10)=1.64385618977472 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MRFAP1 [Title/Abstract] AND TOP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TOP1 | GO:0006265 | DNA topological change | 14594810 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ366641 | MRFAP1 | chr4 | 6643771 | - | TOP1 | chr20 | 39741875 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000320912 | ENST00000361337 | MRFAP1 | chr4 | 6643771 | - | TOP1 | chr20 | 39741875 | - |
intron-intron | ENST00000507420 | ENST00000361337 | MRFAP1 | chr4 | 6643771 | - | TOP1 | chr20 | 39741875 | - |
3UTR-intron | ENST00000382581 | ENST00000361337 | MRFAP1 | chr4 | 6643771 | - | TOP1 | chr20 | 39741875 | - |
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FusionProtFeatures for MRFAP1_TOP1 |
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Hgene | Tgene |
MRFAP1 | TOP1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MRFAP1_TOP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MRFAP1_TOP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MRFAP1_TOP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | TOP1 | P11387 | DB00762 | Irinotecan | DNA topoisomerase 1 | small molecule | approved|investigational |
Tgene | TOP1 | P11387 | DB01030 | Topotecan | DNA topoisomerase 1 | small molecule | approved|investigational |
Tgene | TOP1 | P11387 | DB05630 | Sodium stibogluconate | DNA topoisomerase 1 | small molecule | approved|investigational |
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RelatedDiseases for MRFAP1_TOP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TOP1 | C0041755 | Adverse reaction to drug | 1 | CTD_human |