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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22436

FusionGeneSummary for MRFAP1_TACC2

check button Fusion gene summary
Fusion gene informationFusion gene name: MRFAP1_TACC2
Fusion gene ID: 22436
HgeneTgene
Gene symbol

MRFAP1

TACC2

Gene ID

93621

10579

Gene nameMorf4 family associated protein 1transforming acidic coiled-coil containing protein 2
SynonymsPAM14|PGR1AZU-1|ECTACC
Cytomap

4p16.1

10q26.13

Type of geneprotein-codingprotein-coding
DescriptionMORF4 family-associated protein 1Mof4 family associated protein 1T-cell activation proteinprotein associated with MRG of 14 kDatransforming acidic coiled-coil-containing protein 2anti zuai-1
Modification date2018052220180523
UniProtAcc

Q9Y605

O95359

Ensembl transtripts involved in fusion geneENST00000320912, ENST00000507420, 
ENST00000382581, 		ENST00000369005, 
ENST00000513429, ENST00000515273, 
ENST00000515603, ENST00000453444, 
ENST00000358010, ENST00000334433, 
ENST00000369001, ENST00000369000, 
ENST00000360561, ENST00000368999, 
ENST00000369004, ENST00000260733, 
ENST00000493951, 
Fusion gene scores* DoF score4 X 4 X 1=167 X 8 X 3=168
# samples 59
** MAII scorelog2(5/16*10)=1.64385618977472
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MRFAP1 [Title/Abstract] AND TACC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA232766MRFAP1chr4

6644139

+TACC2chr10

124013892

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000320912ENST00000369005MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000320912ENST00000513429MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-intronENST00000320912ENST00000515273MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-intronENST00000320912ENST00000515603MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-intronENST00000320912ENST00000453444MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000320912ENST00000358010MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000320912ENST00000334433MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000320912ENST00000369001MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000320912ENST00000369000MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000320912ENST00000360561MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000320912ENST00000368999MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000320912ENST00000369004MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000320912ENST00000260733MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-intronENST00000320912ENST00000493951MRFAP1chr4

6644139

+TACC2chr10

124013892

+
intron-3UTRENST00000507420ENST00000369005MRFAP1chr4

6644139

+TACC2chr10

124013892

+
intron-3UTRENST00000507420ENST00000513429MRFAP1chr4

6644139

+TACC2chr10

124013892

+
intron-intronENST00000507420ENST00000515273MRFAP1chr4

6644139

+TACC2chr10

124013892

+
intron-intronENST00000507420ENST00000515603MRFAP1chr4

6644139

+TACC2chr10

124013892

+
intron-intronENST00000507420ENST00000453444MRFAP1chr4

6644139

+TACC2chr10

124013892

+
intron-3UTRENST00000507420ENST00000358010MRFAP1chr4

6644139

+TACC2chr10

124013892

+
intron-3UTRENST00000507420ENST00000334433MRFAP1chr4

6644139

+TACC2chr10

124013892

+
intron-3UTRENST00000507420ENST00000369001MRFAP1chr4

6644139

+TACC2chr10

124013892

+
intron-3UTRENST00000507420ENST00000369000MRFAP1chr4

6644139

+TACC2chr10

124013892

+
intron-3UTRENST00000507420ENST00000360561MRFAP1chr4

6644139

+TACC2chr10

124013892

+
intron-3UTRENST00000507420ENST00000368999MRFAP1chr4

6644139

+TACC2chr10

124013892

+
intron-3UTRENST00000507420ENST00000369004MRFAP1chr4

6644139

+TACC2chr10

124013892

+
intron-3UTRENST00000507420ENST00000260733MRFAP1chr4

6644139

+TACC2chr10

124013892

+
intron-intronENST00000507420ENST00000493951MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000382581ENST00000369005MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000382581ENST00000513429MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-intronENST00000382581ENST00000515273MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-intronENST00000382581ENST00000515603MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-intronENST00000382581ENST00000453444MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000382581ENST00000358010MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000382581ENST00000334433MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000382581ENST00000369001MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000382581ENST00000369000MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000382581ENST00000360561MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000382581ENST00000368999MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000382581ENST00000369004MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-3UTRENST00000382581ENST00000260733MRFAP1chr4

6644139

+TACC2chr10

124013892

+
3UTR-intronENST00000382581ENST00000493951MRFAP1chr4

6644139

+TACC2chr10

124013892

+

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FusionProtFeatures for MRFAP1_TACC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MRFAP1

Q9Y605

TACC2

O95359


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MRFAP1_TACC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MRFAP1_TACC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MRFAP1_TACC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MRFAP1_TACC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource