![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 22434 |
FusionGeneSummary for MRFAP1_DAGLB |
![]() |
Fusion gene information | Fusion gene name: MRFAP1_DAGLB | Fusion gene ID: 22434 | Hgene | Tgene | Gene symbol | MRFAP1 | DAGLB | Gene ID | 93621 | 221955 |
Gene name | Morf4 family associated protein 1 | diacylglycerol lipase beta | |
Synonyms | PAM14|PGR1 | DAGLBETA|KCCR13L | |
Cytomap | 4p16.1 | 7p22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | MORF4 family-associated protein 1Mof4 family associated protein 1T-cell activation proteinprotein associated with MRG of 14 kDa | sn1-specific diacylglycerol lipase betaDGL-beta | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q9Y605 | Q8NCG7 | |
Ensembl transtripts involved in fusion gene | ENST00000320912, ENST00000507420, ENST00000382581, | ENST00000297056, ENST00000425398, ENST00000436575, ENST00000428902, ENST00000421761, ENST00000479922, | |
Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 5 X 5 X 1=25 |
# samples | 5 | 7 | |
** MAII score | log2(5/16*10)=1.64385618977472 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/25*10)=1.48542682717024 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MRFAP1 [Title/Abstract] AND DAGLB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | DAGLB | GO:0019369 | arachidonic acid metabolic process | 14610053 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BC014568 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - | ||
ChiTaRS3.1 | BF184327 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000320912 | ENST00000297056 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
5CDS-intron | ENST00000320912 | ENST00000425398 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
5CDS-5UTR | ENST00000320912 | ENST00000436575 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
5CDS-intron | ENST00000320912 | ENST00000428902 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
5CDS-intron | ENST00000320912 | ENST00000421761 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
5CDS-intron | ENST00000320912 | ENST00000479922 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
5CDS-intron | ENST00000507420 | ENST00000297056 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
5CDS-intron | ENST00000507420 | ENST00000425398 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
5CDS-5UTR | ENST00000507420 | ENST00000436575 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
5CDS-intron | ENST00000507420 | ENST00000428902 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
5CDS-intron | ENST00000507420 | ENST00000421761 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
5CDS-intron | ENST00000507420 | ENST00000479922 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
5CDS-intron | ENST00000382581 | ENST00000297056 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
5CDS-intron | ENST00000382581 | ENST00000425398 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
5CDS-5UTR | ENST00000382581 | ENST00000436575 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
5CDS-intron | ENST00000382581 | ENST00000428902 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
5CDS-intron | ENST00000382581 | ENST00000421761 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
5CDS-intron | ENST00000382581 | ENST00000479922 | MRFAP1 | chr4 | 6642847 | + | DAGLB | chr7 | 6523728 | - |
Top |
FusionProtFeatures for MRFAP1_DAGLB |
![]() |
Hgene | Tgene |
MRFAP1 | DAGLB |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MRFAP1_DAGLB |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for MRFAP1_DAGLB |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MRFAP1_DAGLB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MRFAP1_DAGLB |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |