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Fusion gene ID: 22424 |
FusionGeneSummary for MRC2_SECISBP2 |
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Fusion gene information | Fusion gene name: MRC2_SECISBP2 | Fusion gene ID: 22424 | Hgene | Tgene | Gene symbol | MRC2 | SECISBP2 | Gene ID | 9902 | 79048 |
Gene name | mannose receptor C type 2 | SECIS binding protein 2 | |
Synonyms | CD280|CLEC13E|ENDO180|UPARAP | SBP2 | |
Cytomap | 17q23.2 | 9q22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | C-type mannose receptor 2C-type lectin domain family 13 member EUPAR-associated proteinendocytic receptor (macrophage mannose receptor family)endocytic receptor 180macrophage mannose receptor 2urokinase-type plasminogen activator receptor-associated | selenocysteine insertion sequence-binding protein 2Sec insertion sequence-binding protein 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UBG0 | Q96T21 | |
Ensembl transtripts involved in fusion gene | ENST00000303375, ENST00000446119, ENST00000580916, | ENST00000375807, ENST00000339901, ENST00000534113, ENST00000470305, | |
Fusion gene scores | * DoF score | 9 X 7 X 5=315 | 4 X 4 X 2=32 |
# samples | 10 | 6 | |
** MAII score | log2(10/315*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/32*10)=0.906890595608518 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MRC2 [Title/Abstract] AND SECISBP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MRC2 | GO:0030574 | collagen catabolic process | 12972549 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA837640 | MRC2 | chr17 | 60770843 | - | SECISBP2 | chr9 | 91940369 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000303375 | ENST00000375807 | MRC2 | chr17 | 60770843 | - | SECISBP2 | chr9 | 91940369 | - |
3UTR-intron | ENST00000303375 | ENST00000339901 | MRC2 | chr17 | 60770843 | - | SECISBP2 | chr9 | 91940369 | - |
3UTR-intron | ENST00000303375 | ENST00000534113 | MRC2 | chr17 | 60770843 | - | SECISBP2 | chr9 | 91940369 | - |
3UTR-3UTR | ENST00000303375 | ENST00000470305 | MRC2 | chr17 | 60770843 | - | SECISBP2 | chr9 | 91940369 | - |
3UTR-3CDS | ENST00000446119 | ENST00000375807 | MRC2 | chr17 | 60770843 | - | SECISBP2 | chr9 | 91940369 | - |
3UTR-intron | ENST00000446119 | ENST00000339901 | MRC2 | chr17 | 60770843 | - | SECISBP2 | chr9 | 91940369 | - |
3UTR-intron | ENST00000446119 | ENST00000534113 | MRC2 | chr17 | 60770843 | - | SECISBP2 | chr9 | 91940369 | - |
3UTR-3UTR | ENST00000446119 | ENST00000470305 | MRC2 | chr17 | 60770843 | - | SECISBP2 | chr9 | 91940369 | - |
intron-3CDS | ENST00000580916 | ENST00000375807 | MRC2 | chr17 | 60770843 | - | SECISBP2 | chr9 | 91940369 | - |
intron-intron | ENST00000580916 | ENST00000339901 | MRC2 | chr17 | 60770843 | - | SECISBP2 | chr9 | 91940369 | - |
intron-intron | ENST00000580916 | ENST00000534113 | MRC2 | chr17 | 60770843 | - | SECISBP2 | chr9 | 91940369 | - |
intron-3UTR | ENST00000580916 | ENST00000470305 | MRC2 | chr17 | 60770843 | - | SECISBP2 | chr9 | 91940369 | - |
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FusionProtFeatures for MRC2_SECISBP2 |
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Hgene | Tgene |
MRC2 | SECISBP2 |
May play a role as endocytotic lectin receptordisplaying calcium-dependent lectin activity. Internalizesglycosylated ligands from the extracellular space for release inan endosomal compartment via clathrin-mediated endocytosis. May beinvolved in plasminogen activation system controlling theextracellular level of PLAUR/PLAU, and thus may regulate proteaseactivity at the cell surface. May contribute to cellular uptake,remodeling and degradation of extracellular collagen matrices. Mayplay a role during cancer progression as well as in other chronictissue destructive diseases acting on collagen turnover. Mayparticipate in remodeling of extracellular matrix cooperating withthe matrix metalloproteinases (MMPs).{ECO:0000269|PubMed:10683150, ECO:0000269|PubMed:12972549}. | Binds to the SECIS element in the 3'-UTR of some mRNAsencoding selenoproteins. Binding is stimulated by SELB. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MRC2_SECISBP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MRC2_SECISBP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MRC2_SECISBP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MRC2_SECISBP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MRC2 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | MRC2 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | SECISBP2 | C0002514 | Amino Acid Metabolism, Inborn Errors | 1 | CTD_human |
Tgene | SECISBP2 | C0018273 | Growth Disorders | 1 | CTD_human |
Tgene | SECISBP2 | C1864761 | Thyroid Hormone Metabolism, Abnormal | 1 | CTD_human;ORPHANET;UNIPROT |