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Fusion gene ID: 22409 |
FusionGeneSummary for MPZL1_PDE4DIP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MPZL1_PDE4DIP | Fusion gene ID: 22409 | Hgene | Tgene | Gene symbol | MPZL1 | PDE4DIP | Gene ID | 9019 | 9659 |
| Gene name | myelin protein zero like 1 | phosphodiesterase 4D interacting protein | |
| Synonyms | MPZL1b|PZR|PZR1b|PZRa|PZRb | CMYA2|MMGL | |
| Cytomap | 1q24.2 | 1q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myelin protein zero-like protein 1immunoglobulin family transmembrane proteinprotein zero related | myomegalincardiomyopathy-associated protein 2myomegalin/phosphodiesterase 4D interacting protein variant 8 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O95297 | Q5VU43 | |
| Ensembl transtripts involved in fusion gene | ENST00000359523, ENST00000392121, ENST00000474859, ENST00000403379, | ENST00000313382, ENST00000369354, ENST00000369356, ENST00000530740, ENST00000369359, ENST00000369351, ENST00000369349, ENST00000369347, ENST00000369348, ENST00000524974, ENST00000313431, ENST00000529945, ENST00000479408, ENST00000493130, ENST00000478649, ENST00000369345, | |
| Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 5 X 4 X 3=60 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MPZL1 [Title/Abstract] AND PDE4DIP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PDE4DIP | GO:1903358 | regulation of Golgi organization | 27666745 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A1FW-01A | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000359523 | ENST00000313382 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000359523 | ENST00000369354 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000359523 | ENST00000369356 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000359523 | ENST00000530740 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000359523 | ENST00000369359 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000359523 | ENST00000369351 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000359523 | ENST00000369349 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000359523 | ENST00000369347 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000359523 | ENST00000369348 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000359523 | ENST00000524974 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000359523 | ENST00000313431 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000359523 | ENST00000529945 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000359523 | ENST00000479408 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000359523 | ENST00000493130 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000359523 | ENST00000478649 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000359523 | ENST00000369345 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000392121 | ENST00000313382 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000392121 | ENST00000369354 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000392121 | ENST00000369356 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000392121 | ENST00000530740 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000392121 | ENST00000369359 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000392121 | ENST00000369351 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000392121 | ENST00000369349 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000392121 | ENST00000369347 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000392121 | ENST00000369348 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000392121 | ENST00000524974 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000392121 | ENST00000313431 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000392121 | ENST00000529945 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000392121 | ENST00000479408 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000392121 | ENST00000493130 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000392121 | ENST00000478649 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000392121 | ENST00000369345 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000474859 | ENST00000313382 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000474859 | ENST00000369354 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000474859 | ENST00000369356 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000474859 | ENST00000530740 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000474859 | ENST00000369359 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000474859 | ENST00000369351 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| Frame-shift | ENST00000474859 | ENST00000369349 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000474859 | ENST00000369347 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000474859 | ENST00000369348 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000474859 | ENST00000524974 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000474859 | ENST00000313431 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000474859 | ENST00000529945 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000474859 | ENST00000479408 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000474859 | ENST00000493130 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000474859 | ENST00000478649 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| 5CDS-intron | ENST00000474859 | ENST00000369345 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| intron-3CDS | ENST00000403379 | ENST00000313382 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| intron-3CDS | ENST00000403379 | ENST00000369354 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| intron-3CDS | ENST00000403379 | ENST00000369356 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| intron-3CDS | ENST00000403379 | ENST00000530740 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| intron-3CDS | ENST00000403379 | ENST00000369359 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| intron-3CDS | ENST00000403379 | ENST00000369351 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| intron-3CDS | ENST00000403379 | ENST00000369349 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| intron-intron | ENST00000403379 | ENST00000369347 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| intron-intron | ENST00000403379 | ENST00000369348 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| intron-intron | ENST00000403379 | ENST00000524974 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| intron-intron | ENST00000403379 | ENST00000313431 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| intron-intron | ENST00000403379 | ENST00000529945 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| intron-intron | ENST00000403379 | ENST00000479408 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| intron-intron | ENST00000403379 | ENST00000493130 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| intron-intron | ENST00000403379 | ENST00000478649 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
| intron-intron | ENST00000403379 | ENST00000369345 | MPZL1 | chr1 | 167691479 | + | PDE4DIP | chr1 | 144946742 | - |
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FusionProtFeatures for MPZL1_PDE4DIP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MPZL1 | PDE4DIP |
| Cell surface receptor, which is involved in signaltransduction processes. Recruits PTPN11/SHP-2 to the cell membraneand is a putative substrate of PTPN11/SHP-2. Is a major receptorfor concanavalin-A (ConA) and is involved in cellular signalinginduced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role;it blocks tyrosine phosphorylation of MPZL1 induced by ConA.Isoform 1, but not isoform 2 and isoform 3, may be involved inregulation of integrin-mediated cell motility.{ECO:0000269|PubMed:11751924, ECO:0000269|PubMed:12410637}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MPZL1_PDE4DIP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MPZL1_PDE4DIP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MPZL1 | PTPN11, SRC, ELAVL1, EXOSC4, FHL3, CCDC8, LGALS3, HCCS, SPACA1, LGALS9, NOXRED1, SLC39A4, LIPF, STAT3, DOK7, TMEM17, CRKL, BAIAP2, MYO5C, PAPD5, KIF7, CDH1, CTDSPL, IFIH1, SIGLECL1, TMEM30B, FTO, IPPK, CPA2, TMEM65, TMEM206, CYP2S1, CPA5, FCGRT, MED21, TRPC4AP, VAC14, ACTBL2, GGT7, SFTPC, VIPR1, ALDH1A2, CBWD1, POLA2, TMPRSS11B, HSPA8 | PDE4DIP | PDE4D, CDC5L, TNIK, OSGEP, GADD45G, NEK2, SNCA, FES, TK1, FHL1, CDKN1A, LAMTOR3, KRAS, SMN1, IMMT, PFDN1, ITSN2, ELAVL1, TRAF4, PRNP, GFI1B, ZNF512B, USO1, KRT18, PIAS4, ADH1B, KDM1A, PRKACA, PRKACB, ANKRD11, ARNT2, BYSL, KRT31, NEFL, SDCBP, ZSCAN26, NAA10, LMO4, UTP14C, FCHSD2, MAPRE1, MTUS2, TFIP11, PRPF31, ZNF581, CHCHD3, C1orf109, C14orf105, C19orf66, VAC14, MIF4GD, CCDC146, SH2D4A, AEN, SCNM1, ZFYVE21, LENG1, ZNF408, FAM161A, KLC4, HAUS1, KLC3, PPP1R18, ZBTB38, RTP5, GOLGA8EP, FAM74A4, GOLGA8F, RNF2, MLF1, CEP170, PRKAR2B, SCCPDH, TEAD4, DYNLL1, PDE4DIP, PM20D1, A2ML1, AKAP9, FAM129B, CSNK1D, PRKACG, LCN2, CD207, CSNK1E, IVL, NDRG1, IGHG1, IGHG2, EVPL, ANXA8, C3, CRABP2, TYMP, DNAJC10, CCDC6, CDK5RAP2, ALDH1A3, ZNF785, RAB25, GATM, SERPINB4, S100A7, CALML3, MAPRE3, ACADVL, IGKC, PKP3, C1orf87, AKR1B10, PPL, S100A9, JUP, TGM1, LGALS7B, POF1B, SERPINB5, CST6, GM2A, ARF6, HMGCS2, GDPD3, NCCRP1, SERPINB3, CALML5, CYLD |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MPZL1_PDE4DIP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MPZL1_PDE4DIP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MPZL1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | MPZL1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | MPZL1 | C0036341 | Schizophrenia | 1 | PSYGENET |
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