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Fusion gene ID: 22396 |
FusionGeneSummary for MPRIP_MED9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MPRIP_MED9 | Fusion gene ID: 22396 | Hgene | Tgene | Gene symbol | MPRIP | MED9 | Gene ID | 23164 | 55090 |
| Gene name | myosin phosphatase Rho interacting protein | mediator complex subunit 9 | |
| Synonyms | M-RIP|MRIP|RHOIP3|RIP3|p116Rip | MED25 | |
| Cytomap | 17p11.2 | 17p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myosin phosphatase Rho-interacting proteinRho interacting protein 3 | mediator of RNA polymerase II transcription subunit 9mediator of RNA polymerase II transcription, subunit 9 homologmediator subunit 25 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q6WCQ1 | Q9NWA0 | |
| Ensembl transtripts involved in fusion gene | ENST00000395811, ENST00000444976, ENST00000395804, ENST00000341712, ENST00000395806, ENST00000395807, | ENST00000268711, ENST00000580462, ENST00000585041, | |
| Fusion gene scores | * DoF score | 12 X 5 X 7=420 | 3 X 1 X 2=6 |
| # samples | 12 | 2 | |
| ** MAII score | log2(12/420*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/6*10)=1.73696559416621 | |
| Context | PubMed: MPRIP [Title/Abstract] AND MED9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-K4-A5RH-01A | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000395811 | ENST00000268711 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| 5CDS-intron | ENST00000395811 | ENST00000580462 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| 5CDS-intron | ENST00000395811 | ENST00000585041 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| In-frame | ENST00000444976 | ENST00000268711 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| 5CDS-intron | ENST00000444976 | ENST00000580462 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| 5CDS-intron | ENST00000444976 | ENST00000585041 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| In-frame | ENST00000395804 | ENST00000268711 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| 5CDS-intron | ENST00000395804 | ENST00000580462 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| 5CDS-intron | ENST00000395804 | ENST00000585041 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| In-frame | ENST00000341712 | ENST00000268711 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| 5CDS-intron | ENST00000341712 | ENST00000580462 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| 5CDS-intron | ENST00000341712 | ENST00000585041 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| In-frame | ENST00000395806 | ENST00000268711 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| 5CDS-intron | ENST00000395806 | ENST00000580462 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| 5CDS-intron | ENST00000395806 | ENST00000585041 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| 3UTR-3CDS | ENST00000395807 | ENST00000268711 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| 3UTR-intron | ENST00000395807 | ENST00000580462 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
| 3UTR-intron | ENST00000395807 | ENST00000585041 | MPRIP | chr17 | 16946285 | + | MED9 | chr17 | 17394593 | + |
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FusionProtFeatures for MPRIP_MED9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MPRIP | MED9 |
| Targets myosin phosphatase to the actin cytoskeleton.Required for the regulation of the actin cytoskeleton by RhoA andROCK1. Depletion leads to an increased number of stress fibers insmooth muscle cells through stabilization of actin fibers byphosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers inneuronal cells. {ECO:0000250|UniProtKB:P97434,ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. | Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >MED9 | chr17:16946285 | chr17:17394593 | ENST00000268711 | + | 0 | 2 | 112_139 | 74 | 147 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MPRIP | chr17:16946285 | chr17:17394593 | ENST00000341712 | + | 1 | 24 | 673_977 | 41 | 1231 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >MPRIP | chr17:16946285 | chr17:17394593 | ENST00000395804 | + | 1 | 23 | 673_977 | 41 | 1026 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >MPRIP | chr17:16946285 | chr17:17394593 | ENST00000395811 | + | 1 | 23 | 673_977 | 41 | 1039 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >MPRIP | chr17:16946285 | chr17:17394593 | ENST00000444976 | + | 1 | 22 | 673_977 | 41 | 1001 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >MPRIP | chr17:16946285 | chr17:17394593 | ENST00000341712 | + | 1 | 24 | 179_252 | 41 | 1231 | Compositional bias | Note=Ser-rich |
| Hgene | >MPRIP | chr17:16946285 | chr17:17394593 | ENST00000395804 | + | 1 | 23 | 179_252 | 41 | 1026 | Compositional bias | Note=Ser-rich |
| Hgene | >MPRIP | chr17:16946285 | chr17:17394593 | ENST00000395811 | + | 1 | 23 | 179_252 | 41 | 1039 | Compositional bias | Note=Ser-rich |
| Hgene | >MPRIP | chr17:16946285 | chr17:17394593 | ENST00000444976 | + | 1 | 22 | 179_252 | 41 | 1001 | Compositional bias | Note=Ser-rich |
| Hgene | >MPRIP | chr17:16946285 | chr17:17394593 | ENST00000341712 | + | 1 | 24 | 387_483 | 41 | 1231 | Domain | PH 2 |
| Hgene | >MPRIP | chr17:16946285 | chr17:17394593 | ENST00000341712 | + | 1 | 24 | 43_150 | 41 | 1231 | Domain | PH 1 |
| Hgene | >MPRIP | chr17:16946285 | chr17:17394593 | ENST00000395804 | + | 1 | 23 | 387_483 | 41 | 1026 | Domain | PH 2 |
| Hgene | >MPRIP | chr17:16946285 | chr17:17394593 | ENST00000395804 | + | 1 | 23 | 43_150 | 41 | 1026 | Domain | PH 1 |
| Hgene | >MPRIP | chr17:16946285 | chr17:17394593 | ENST00000395811 | + | 1 | 23 | 387_483 | 41 | 1039 | Domain | PH 2 |
| Hgene | >MPRIP | chr17:16946285 | chr17:17394593 | ENST00000395811 | + | 1 | 23 | 43_150 | 41 | 1039 | Domain | PH 1 |
| Hgene | >MPRIP | chr17:16946285 | chr17:17394593 | ENST00000444976 | + | 1 | 22 | 387_483 | 41 | 1001 | Domain | PH 2 |
| Hgene | >MPRIP | chr17:16946285 | chr17:17394593 | ENST00000444976 | + | 1 | 22 | 43_150 | 41 | 1001 | Domain | PH 1 |
| Tgene | MED9 | chr17:16946285 | chr17:17394593 | ENST00000268711 | + | 0 | 2 | 17_54 | 74 | 147 | Compositional bias | Note=Pro-rich |
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FusionGeneSequence for MPRIP_MED9 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MPRIP_ENST00000395811_chr17_16946285_+_MED9_ENST00000268711_chr17_17394593_+_113aa MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQHGQGQPGGPPGPERPQKQVPGDAQAHQHHARHPPEPRTAAAAAAEPPGA >In-frame_MPRIP_ENST00000444976_chr17_16946285_+_MED9_ENST00000268711_chr17_17394593_+_113aa MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQHGQGQPGGPPGPERPQKQVPGDAQAHQHHARHPPEPRTAAAAAAEPPGA >In-frame_MPRIP_ENST00000395804_chr17_16946285_+_MED9_ENST00000268711_chr17_17394593_+_113aa MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQHGQGQPGGPPGPERPQKQVPGDAQAHQHHARHPPEPRTAAAAAAEPPGA >In-frame_MPRIP_ENST00000341712_chr17_16946285_+_MED9_ENST00000268711_chr17_17394593_+_113aa MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQHGQGQPGGPPGPERPQKQVPGDAQAHQHHARHPPEPRTAAAAAAEPPGA >In-frame_MPRIP_ENST00000395806_chr17_16946285_+_MED9_ENST00000268711_chr17_17394593_+_113aa MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQHGQGQPGGPPGPERPQKQVPGDAQAHQHHARHPPEPRTAAAAAAEPPGA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MPRIP_ENST00000395811_chr17_16946285_+_MED9_ENST00000268711_chr17_17394593_+_340nt ATGTCGGCAGCCAAGGAGAACCCGTGCAGGAAATTCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAG TCGCATCTGCTCAACGACGAGGACCTGACGCAGCATGGACAAGGACAGCCCGGAGGTCCACCAGGACCTGAACGCCCTCAAAAGCAAGTT CCAGGAGATGCGCAAGCTCATCAGCACCATGCCCGGCATCCACCTGAGCCCCGAACAGCAGCAGCAGCAGCTGCAGAGCCTCCGGGAGCA >In-frame_MPRIP_ENST00000444976_chr17_16946285_+_MED9_ENST00000268711_chr17_17394593_+_340nt ATGTCGGCAGCCAAGGAGAACCCGTGCAGGAAATTCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAG TCGCATCTGCTCAACGACGAGGACCTGACGCAGCATGGACAAGGACAGCCCGGAGGTCCACCAGGACCTGAACGCCCTCAAAAGCAAGTT CCAGGAGATGCGCAAGCTCATCAGCACCATGCCCGGCATCCACCTGAGCCCCGAACAGCAGCAGCAGCAGCTGCAGAGCCTCCGGGAGCA >In-frame_MPRIP_ENST00000395804_chr17_16946285_+_MED9_ENST00000268711_chr17_17394593_+_340nt ATGTCGGCAGCCAAGGAGAACCCGTGCAGGAAATTCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAG TCGCATCTGCTCAACGACGAGGACCTGACGCAGCATGGACAAGGACAGCCCGGAGGTCCACCAGGACCTGAACGCCCTCAAAAGCAAGTT CCAGGAGATGCGCAAGCTCATCAGCACCATGCCCGGCATCCACCTGAGCCCCGAACAGCAGCAGCAGCAGCTGCAGAGCCTCCGGGAGCA >In-frame_MPRIP_ENST00000341712_chr17_16946285_+_MED9_ENST00000268711_chr17_17394593_+_340nt ATGTCGGCAGCCAAGGAGAACCCGTGCAGGAAATTCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAG TCGCATCTGCTCAACGACGAGGACCTGACGCAGCATGGACAAGGACAGCCCGGAGGTCCACCAGGACCTGAACGCCCTCAAAAGCAAGTT CCAGGAGATGCGCAAGCTCATCAGCACCATGCCCGGCATCCACCTGAGCCCCGAACAGCAGCAGCAGCAGCTGCAGAGCCTCCGGGAGCA >In-frame_MPRIP_ENST00000395806_chr17_16946285_+_MED9_ENST00000268711_chr17_17394593_+_340nt ATGTCGGCAGCCAAGGAGAACCCGTGCAGGAAATTCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAG TCGCATCTGCTCAACGACGAGGACCTGACGCAGCATGGACAAGGACAGCCCGGAGGTCCACCAGGACCTGAACGCCCTCAAAAGCAAGTT CCAGGAGATGCGCAAGCTCATCAGCACCATGCCCGGCATCCACCTGAGCCCCGAACAGCAGCAGCAGCAGCTGCAGAGCCTCCGGGAGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MPRIP_ENST00000395811_chr17_16946285_+_MED9_ENST00000268711_chr17_17394593_+_2160nt GCGGCCGCGCTGAGCCCCTAGCCCGCCGGGAGCGCCAGGCCGGCCAGGCCTGCGCCGCCGCCGCCGCCGCCGTCGCCGCCGCGCCGACCA TGTCGGCAGCCAAGGAGAACCCGTGCAGGAAATTCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAGT CGCATCTGCTCAACGACGAGGACCTGACGCAGCATGGACAAGGACAGCCCGGAGGTCCACCAGGACCTGAACGCCCTCAAAAGCAAGTTC CAGGAGATGCGCAAGCTCATCAGCACCATGCCCGGCATCCACCTGAGCCCCGAACAGCAGCAGCAGCAGCTGCAGAGCCTCCGGGAGCAA GTCAGGACCAAGAATGAGCTTCTGCAAAAGTACAAGAGCCTCTGCATGTTCGAAATCCCCAAGGAGTAGAGTGAGGCTGACTTCCTTAGA AAGAGGGGGAAGCCAATGGCCTGTCTCCCCACTACCATCCCCAAACGCTCCTTGGGGCGTGGTTCCTGTGGACCCCAGCTCAGCTCGTCA AGCTGCAGGGGCGGGGCTCCTGTGCTGCTGCGCGCGCTTCGCCTGTGCGGGAGCCAGCGCAGAGCTTGGCTGCGCCGGGGGTTCCTCGTG TAGATCCATATGTCTAGATGCATAATAACTGGAGTGCCTGCTGGTGGAAGTCAGAATGCTCCTGGAGGCTGCAGAGGGGGTGGAGGACTC TCCCCTGCCTCTGGGGAGGGGGCCATCTGCTGCGCCCGGCCCCACTGACAGATCTGAAGAGCACAGTAGGAAGGGAGGCGGCTCCTCTTT GCTTCCTTCCCTCTCTCTCCTCCCACCCCCATAGGATCAGTGTGTACCAGGTACACATTGTTCCTGTTAACAGCAGCTTCTTGAAACATT TGCATAGAATTCACTGGACGAATTAAGCCTGCACTCATATGGCATAGAATTGTGAGAGAATGTTTTGAAAGGCCAGAGGGTGGCCTTTTT CCCCAAACAGTTTGGTTCCTTTTATGTTTGAGCCAGTGAAGGGAACTACGCTTTGGGGGCTTCAGCCTAGAGCCCTGCCAGGCAGCCCCT GGCTCCAGGTTCCCTGCCTCCTAGCGCTCTCCTCGCCTTCAGCTCTTGCTCCCTTCCTCGTTCATCACCCTCAGTCAGTGCCCAAGAGTG GCCAAACCGCTTCACATCTGCAGTGCTTCCCCAGGGTTGACAAGGGGCCGTCCTTTCCACACAGGCCAGAAGAGGTCTTCAGGCGAACCG ACCTTCCCCCTTCTGGCATTTCAGATTCCCCTTGCTCTGGTTAAAAGGTCTTTCCCTCGTGGCCTTTGCACTTGCGGCAGCAACGTGTAC TACACTGCAGAAGGGTTCAGTATGCACCTTGTGTTGAGAGAGAGGCAACCCTGGGGGCCAGTTCAGGTGGTCCCCAACCATAAGCTAGGT CTGAAAGTTACACAGCCAAGTTTGAGCTCTTAAAAGTTGATGAACAGCCTCATTTCCCCAGCTTCCCTGATTTCTTCCAGATGGGACGTT TTATTTGTGTGCTCTCCCTTGACTGTCAGATTGAAGTAAGAGCAGTTCTCTCCGTTGCCTCTCGAGGAGGAGGTGCGAAGTCCTGGAGTA TTGTTTGGGTCTCGGAATGGGCGCATAACCTGCGCTGACCAGTTTAGGGGCTTAGCAGATGCCTGCCAGCTGACCTCGTTGGCAGGAGGG TTGGGTGGAGATGTTTTTAGCAGAGCTTCCATTAGTGTAGACCTGTAGCCACCTGTCAGAAGGTGGGTGGCATATTGGGGACCTGGGAAT GTGTGAAGGAGGAGATCAAATTTCAGTGGCTTTGGACAGAAAAGAAGGCTCTGGATTTAAGCGGGTGGTCACCTGTGAGACCAGGTCTAC CTTGGGACTGTTATTTAACTGAATCAGTTATTTCCTTGAAATTTCACAGTAGTGGGTGGGCCTGTTTTAAGGCTCTGACAGATACCACGA AACATGAAGCACGTGGAACTACAAGACCCCCGGGGTCTTTCTGAGTGCAAGGCTGAAATGGACAAGGGCTCCTCACGGGGGTGGAGGGAG CCGGAGCCTGCCTTGTGTTCCTTTTTTGACTTGTGACATTTTTCAAACACATAATTAAAAGGACTTATGCTCTGCTGTCTCAGGACATAA >In-frame_MPRIP_ENST00000444976_chr17_16946285_+_MED9_ENST00000268711_chr17_17394593_+_2151nt CTGAGCCCCTAGCCCGCCGGGAGCGCCAGGCCGGCCAGGCCTGCGCCGCCGCCGCCGCCGCCGTCGCCGCCGCGCCGACCATGTCGGCAG CCAAGGAGAACCCGTGCAGGAAATTCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAGTCGCATCTGC TCAACGACGAGGACCTGACGCAGCATGGACAAGGACAGCCCGGAGGTCCACCAGGACCTGAACGCCCTCAAAAGCAAGTTCCAGGAGATG CGCAAGCTCATCAGCACCATGCCCGGCATCCACCTGAGCCCCGAACAGCAGCAGCAGCAGCTGCAGAGCCTCCGGGAGCAAGTCAGGACC AAGAATGAGCTTCTGCAAAAGTACAAGAGCCTCTGCATGTTCGAAATCCCCAAGGAGTAGAGTGAGGCTGACTTCCTTAGAAAGAGGGGG AAGCCAATGGCCTGTCTCCCCACTACCATCCCCAAACGCTCCTTGGGGCGTGGTTCCTGTGGACCCCAGCTCAGCTCGTCAAGCTGCAGG GGCGGGGCTCCTGTGCTGCTGCGCGCGCTTCGCCTGTGCGGGAGCCAGCGCAGAGCTTGGCTGCGCCGGGGGTTCCTCGTGTAGATCCAT ATGTCTAGATGCATAATAACTGGAGTGCCTGCTGGTGGAAGTCAGAATGCTCCTGGAGGCTGCAGAGGGGGTGGAGGACTCTCCCCTGCC TCTGGGGAGGGGGCCATCTGCTGCGCCCGGCCCCACTGACAGATCTGAAGAGCACAGTAGGAAGGGAGGCGGCTCCTCTTTGCTTCCTTC CCTCTCTCTCCTCCCACCCCCATAGGATCAGTGTGTACCAGGTACACATTGTTCCTGTTAACAGCAGCTTCTTGAAACATTTGCATAGAA TTCACTGGACGAATTAAGCCTGCACTCATATGGCATAGAATTGTGAGAGAATGTTTTGAAAGGCCAGAGGGTGGCCTTTTTCCCCAAACA GTTTGGTTCCTTTTATGTTTGAGCCAGTGAAGGGAACTACGCTTTGGGGGCTTCAGCCTAGAGCCCTGCCAGGCAGCCCCTGGCTCCAGG TTCCCTGCCTCCTAGCGCTCTCCTCGCCTTCAGCTCTTGCTCCCTTCCTCGTTCATCACCCTCAGTCAGTGCCCAAGAGTGGCCAAACCG CTTCACATCTGCAGTGCTTCCCCAGGGTTGACAAGGGGCCGTCCTTTCCACACAGGCCAGAAGAGGTCTTCAGGCGAACCGACCTTCCCC CTTCTGGCATTTCAGATTCCCCTTGCTCTGGTTAAAAGGTCTTTCCCTCGTGGCCTTTGCACTTGCGGCAGCAACGTGTACTACACTGCA GAAGGGTTCAGTATGCACCTTGTGTTGAGAGAGAGGCAACCCTGGGGGCCAGTTCAGGTGGTCCCCAACCATAAGCTAGGTCTGAAAGTT ACACAGCCAAGTTTGAGCTCTTAAAAGTTGATGAACAGCCTCATTTCCCCAGCTTCCCTGATTTCTTCCAGATGGGACGTTTTATTTGTG TGCTCTCCCTTGACTGTCAGATTGAAGTAAGAGCAGTTCTCTCCGTTGCCTCTCGAGGAGGAGGTGCGAAGTCCTGGAGTATTGTTTGGG TCTCGGAATGGGCGCATAACCTGCGCTGACCAGTTTAGGGGCTTAGCAGATGCCTGCCAGCTGACCTCGTTGGCAGGAGGGTTGGGTGGA GATGTTTTTAGCAGAGCTTCCATTAGTGTAGACCTGTAGCCACCTGTCAGAAGGTGGGTGGCATATTGGGGACCTGGGAATGTGTGAAGG AGGAGATCAAATTTCAGTGGCTTTGGACAGAAAAGAAGGCTCTGGATTTAAGCGGGTGGTCACCTGTGAGACCAGGTCTACCTTGGGACT GTTATTTAACTGAATCAGTTATTTCCTTGAAATTTCACAGTAGTGGGTGGGCCTGTTTTAAGGCTCTGACAGATACCACGAAACATGAAG CACGTGGAACTACAAGACCCCCGGGGTCTTTCTGAGTGCAAGGCTGAAATGGACAAGGGCTCCTCACGGGGGTGGAGGGAGCCGGAGCCT >In-frame_MPRIP_ENST00000395804_chr17_16946285_+_MED9_ENST00000268711_chr17_17394593_+_2127nt GCCAGGCCGGCCAGGCCTGCGCCGCCGCCGCCGCCGCCGTCGCCGCCGCGCCGACCATGTCGGCAGCCAAGGAGAACCCGTGCAGGAAAT TCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAGTCGCATCTGCTCAACGACGAGGACCTGACGCAGC ATGGACAAGGACAGCCCGGAGGTCCACCAGGACCTGAACGCCCTCAAAAGCAAGTTCCAGGAGATGCGCAAGCTCATCAGCACCATGCCC GGCATCCACCTGAGCCCCGAACAGCAGCAGCAGCAGCTGCAGAGCCTCCGGGAGCAAGTCAGGACCAAGAATGAGCTTCTGCAAAAGTAC AAGAGCCTCTGCATGTTCGAAATCCCCAAGGAGTAGAGTGAGGCTGACTTCCTTAGAAAGAGGGGGAAGCCAATGGCCTGTCTCCCCACT ACCATCCCCAAACGCTCCTTGGGGCGTGGTTCCTGTGGACCCCAGCTCAGCTCGTCAAGCTGCAGGGGCGGGGCTCCTGTGCTGCTGCGC GCGCTTCGCCTGTGCGGGAGCCAGCGCAGAGCTTGGCTGCGCCGGGGGTTCCTCGTGTAGATCCATATGTCTAGATGCATAATAACTGGA GTGCCTGCTGGTGGAAGTCAGAATGCTCCTGGAGGCTGCAGAGGGGGTGGAGGACTCTCCCCTGCCTCTGGGGAGGGGGCCATCTGCTGC GCCCGGCCCCACTGACAGATCTGAAGAGCACAGTAGGAAGGGAGGCGGCTCCTCTTTGCTTCCTTCCCTCTCTCTCCTCCCACCCCCATA GGATCAGTGTGTACCAGGTACACATTGTTCCTGTTAACAGCAGCTTCTTGAAACATTTGCATAGAATTCACTGGACGAATTAAGCCTGCA CTCATATGGCATAGAATTGTGAGAGAATGTTTTGAAAGGCCAGAGGGTGGCCTTTTTCCCCAAACAGTTTGGTTCCTTTTATGTTTGAGC CAGTGAAGGGAACTACGCTTTGGGGGCTTCAGCCTAGAGCCCTGCCAGGCAGCCCCTGGCTCCAGGTTCCCTGCCTCCTAGCGCTCTCCT CGCCTTCAGCTCTTGCTCCCTTCCTCGTTCATCACCCTCAGTCAGTGCCCAAGAGTGGCCAAACCGCTTCACATCTGCAGTGCTTCCCCA GGGTTGACAAGGGGCCGTCCTTTCCACACAGGCCAGAAGAGGTCTTCAGGCGAACCGACCTTCCCCCTTCTGGCATTTCAGATTCCCCTT GCTCTGGTTAAAAGGTCTTTCCCTCGTGGCCTTTGCACTTGCGGCAGCAACGTGTACTACACTGCAGAAGGGTTCAGTATGCACCTTGTG TTGAGAGAGAGGCAACCCTGGGGGCCAGTTCAGGTGGTCCCCAACCATAAGCTAGGTCTGAAAGTTACACAGCCAAGTTTGAGCTCTTAA AAGTTGATGAACAGCCTCATTTCCCCAGCTTCCCTGATTTCTTCCAGATGGGACGTTTTATTTGTGTGCTCTCCCTTGACTGTCAGATTG AAGTAAGAGCAGTTCTCTCCGTTGCCTCTCGAGGAGGAGGTGCGAAGTCCTGGAGTATTGTTTGGGTCTCGGAATGGGCGCATAACCTGC GCTGACCAGTTTAGGGGCTTAGCAGATGCCTGCCAGCTGACCTCGTTGGCAGGAGGGTTGGGTGGAGATGTTTTTAGCAGAGCTTCCATT AGTGTAGACCTGTAGCCACCTGTCAGAAGGTGGGTGGCATATTGGGGACCTGGGAATGTGTGAAGGAGGAGATCAAATTTCAGTGGCTTT GGACAGAAAAGAAGGCTCTGGATTTAAGCGGGTGGTCACCTGTGAGACCAGGTCTACCTTGGGACTGTTATTTAACTGAATCAGTTATTT CCTTGAAATTTCACAGTAGTGGGTGGGCCTGTTTTAAGGCTCTGACAGATACCACGAAACATGAAGCACGTGGAACTACAAGACCCCCGG GGTCTTTCTGAGTGCAAGGCTGAAATGGACAAGGGCTCCTCACGGGGGTGGAGGGAGCCGGAGCCTGCCTTGTGTTCCTTTTTTGACTTG >In-frame_MPRIP_ENST00000341712_chr17_16946285_+_MED9_ENST00000268711_chr17_17394593_+_2071nt ATGTCGGCAGCCAAGGAGAACCCGTGCAGGAAATTCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAG TCGCATCTGCTCAACGACGAGGACCTGACGCAGCATGGACAAGGACAGCCCGGAGGTCCACCAGGACCTGAACGCCCTCAAAAGCAAGTT CCAGGAGATGCGCAAGCTCATCAGCACCATGCCCGGCATCCACCTGAGCCCCGAACAGCAGCAGCAGCAGCTGCAGAGCCTCCGGGAGCA AGTCAGGACCAAGAATGAGCTTCTGCAAAAGTACAAGAGCCTCTGCATGTTCGAAATCCCCAAGGAGTAGAGTGAGGCTGACTTCCTTAG AAAGAGGGGGAAGCCAATGGCCTGTCTCCCCACTACCATCCCCAAACGCTCCTTGGGGCGTGGTTCCTGTGGACCCCAGCTCAGCTCGTC AAGCTGCAGGGGCGGGGCTCCTGTGCTGCTGCGCGCGCTTCGCCTGTGCGGGAGCCAGCGCAGAGCTTGGCTGCGCCGGGGGTTCCTCGT GTAGATCCATATGTCTAGATGCATAATAACTGGAGTGCCTGCTGGTGGAAGTCAGAATGCTCCTGGAGGCTGCAGAGGGGGTGGAGGACT CTCCCCTGCCTCTGGGGAGGGGGCCATCTGCTGCGCCCGGCCCCACTGACAGATCTGAAGAGCACAGTAGGAAGGGAGGCGGCTCCTCTT TGCTTCCTTCCCTCTCTCTCCTCCCACCCCCATAGGATCAGTGTGTACCAGGTACACATTGTTCCTGTTAACAGCAGCTTCTTGAAACAT TTGCATAGAATTCACTGGACGAATTAAGCCTGCACTCATATGGCATAGAATTGTGAGAGAATGTTTTGAAAGGCCAGAGGGTGGCCTTTT TCCCCAAACAGTTTGGTTCCTTTTATGTTTGAGCCAGTGAAGGGAACTACGCTTTGGGGGCTTCAGCCTAGAGCCCTGCCAGGCAGCCCC TGGCTCCAGGTTCCCTGCCTCCTAGCGCTCTCCTCGCCTTCAGCTCTTGCTCCCTTCCTCGTTCATCACCCTCAGTCAGTGCCCAAGAGT GGCCAAACCGCTTCACATCTGCAGTGCTTCCCCAGGGTTGACAAGGGGCCGTCCTTTCCACACAGGCCAGAAGAGGTCTTCAGGCGAACC GACCTTCCCCCTTCTGGCATTTCAGATTCCCCTTGCTCTGGTTAAAAGGTCTTTCCCTCGTGGCCTTTGCACTTGCGGCAGCAACGTGTA CTACACTGCAGAAGGGTTCAGTATGCACCTTGTGTTGAGAGAGAGGCAACCCTGGGGGCCAGTTCAGGTGGTCCCCAACCATAAGCTAGG TCTGAAAGTTACACAGCCAAGTTTGAGCTCTTAAAAGTTGATGAACAGCCTCATTTCCCCAGCTTCCCTGATTTCTTCCAGATGGGACGT TTTATTTGTGTGCTCTCCCTTGACTGTCAGATTGAAGTAAGAGCAGTTCTCTCCGTTGCCTCTCGAGGAGGAGGTGCGAAGTCCTGGAGT ATTGTTTGGGTCTCGGAATGGGCGCATAACCTGCGCTGACCAGTTTAGGGGCTTAGCAGATGCCTGCCAGCTGACCTCGTTGGCAGGAGG GTTGGGTGGAGATGTTTTTAGCAGAGCTTCCATTAGTGTAGACCTGTAGCCACCTGTCAGAAGGTGGGTGGCATATTGGGGACCTGGGAA TGTGTGAAGGAGGAGATCAAATTTCAGTGGCTTTGGACAGAAAAGAAGGCTCTGGATTTAAGCGGGTGGTCACCTGTGAGACCAGGTCTA CCTTGGGACTGTTATTTAACTGAATCAGTTATTTCCTTGAAATTTCACAGTAGTGGGTGGGCCTGTTTTAAGGCTCTGACAGATACCACG AAACATGAAGCACGTGGAACTACAAGACCCCCGGGGTCTTTCTGAGTGCAAGGCTGAAATGGACAAGGGCTCCTCACGGGGGTGGAGGGA GCCGGAGCCTGCCTTGTGTTCCTTTTTTGACTTGTGACATTTTTCAAACACATAATTAAAAGGACTTATGCTCTGCTGTCTCAGGACATA >In-frame_MPRIP_ENST00000395806_chr17_16946285_+_MED9_ENST00000268711_chr17_17394593_+_2160nt GCGGCCGCGCTGAGCCCCTAGCCCGCCGGGAGCGCCAGGCCGGCCAGGCCTGCGCCGCCGCCGCCGCCGCCGTCGCCGCCGCGCCGACCA TGTCGGCAGCCAAGGAGAACCCGTGCAGGAAATTCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAGT CGCATCTGCTCAACGACGAGGACCTGACGCAGCATGGACAAGGACAGCCCGGAGGTCCACCAGGACCTGAACGCCCTCAAAAGCAAGTTC CAGGAGATGCGCAAGCTCATCAGCACCATGCCCGGCATCCACCTGAGCCCCGAACAGCAGCAGCAGCAGCTGCAGAGCCTCCGGGAGCAA GTCAGGACCAAGAATGAGCTTCTGCAAAAGTACAAGAGCCTCTGCATGTTCGAAATCCCCAAGGAGTAGAGTGAGGCTGACTTCCTTAGA AAGAGGGGGAAGCCAATGGCCTGTCTCCCCACTACCATCCCCAAACGCTCCTTGGGGCGTGGTTCCTGTGGACCCCAGCTCAGCTCGTCA AGCTGCAGGGGCGGGGCTCCTGTGCTGCTGCGCGCGCTTCGCCTGTGCGGGAGCCAGCGCAGAGCTTGGCTGCGCCGGGGGTTCCTCGTG TAGATCCATATGTCTAGATGCATAATAACTGGAGTGCCTGCTGGTGGAAGTCAGAATGCTCCTGGAGGCTGCAGAGGGGGTGGAGGACTC TCCCCTGCCTCTGGGGAGGGGGCCATCTGCTGCGCCCGGCCCCACTGACAGATCTGAAGAGCACAGTAGGAAGGGAGGCGGCTCCTCTTT GCTTCCTTCCCTCTCTCTCCTCCCACCCCCATAGGATCAGTGTGTACCAGGTACACATTGTTCCTGTTAACAGCAGCTTCTTGAAACATT TGCATAGAATTCACTGGACGAATTAAGCCTGCACTCATATGGCATAGAATTGTGAGAGAATGTTTTGAAAGGCCAGAGGGTGGCCTTTTT CCCCAAACAGTTTGGTTCCTTTTATGTTTGAGCCAGTGAAGGGAACTACGCTTTGGGGGCTTCAGCCTAGAGCCCTGCCAGGCAGCCCCT GGCTCCAGGTTCCCTGCCTCCTAGCGCTCTCCTCGCCTTCAGCTCTTGCTCCCTTCCTCGTTCATCACCCTCAGTCAGTGCCCAAGAGTG GCCAAACCGCTTCACATCTGCAGTGCTTCCCCAGGGTTGACAAGGGGCCGTCCTTTCCACACAGGCCAGAAGAGGTCTTCAGGCGAACCG ACCTTCCCCCTTCTGGCATTTCAGATTCCCCTTGCTCTGGTTAAAAGGTCTTTCCCTCGTGGCCTTTGCACTTGCGGCAGCAACGTGTAC TACACTGCAGAAGGGTTCAGTATGCACCTTGTGTTGAGAGAGAGGCAACCCTGGGGGCCAGTTCAGGTGGTCCCCAACCATAAGCTAGGT CTGAAAGTTACACAGCCAAGTTTGAGCTCTTAAAAGTTGATGAACAGCCTCATTTCCCCAGCTTCCCTGATTTCTTCCAGATGGGACGTT TTATTTGTGTGCTCTCCCTTGACTGTCAGATTGAAGTAAGAGCAGTTCTCTCCGTTGCCTCTCGAGGAGGAGGTGCGAAGTCCTGGAGTA TTGTTTGGGTCTCGGAATGGGCGCATAACCTGCGCTGACCAGTTTAGGGGCTTAGCAGATGCCTGCCAGCTGACCTCGTTGGCAGGAGGG TTGGGTGGAGATGTTTTTAGCAGAGCTTCCATTAGTGTAGACCTGTAGCCACCTGTCAGAAGGTGGGTGGCATATTGGGGACCTGGGAAT GTGTGAAGGAGGAGATCAAATTTCAGTGGCTTTGGACAGAAAAGAAGGCTCTGGATTTAAGCGGGTGGTCACCTGTGAGACCAGGTCTAC CTTGGGACTGTTATTTAACTGAATCAGTTATTTCCTTGAAATTTCACAGTAGTGGGTGGGCCTGTTTTAAGGCTCTGACAGATACCACGA AACATGAAGCACGTGGAACTACAAGACCCCCGGGGTCTTTCTGAGTGCAAGGCTGAAATGGACAAGGGCTCCTCACGGGGGTGGAGGGAG CCGGAGCCTGCCTTGTGTTCCTTTTTTGACTTGTGACATTTTTCAAACACATAATTAAAAGGACTTATGCTCTGCTGTCTCAGGACATAA |
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FusionGenePPI for MPRIP_MED9 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MPRIP | PPP1R12C, YWHAB, YWHAG, YWHAQ, SFN, RHOA, ATXN7, ARRB1, FBXO25, LRRK2, NOS3, AGAP2, PAN2, IKBKG, RACGAP1, PIAS4, LSM8, YTHDC1, RPA3, RPA2, RPA1, CCDC101, WDR83, PSAT1, TCP10L2, PSMC3, FNDC4, PACSIN2, ZFP41, PTEN, PCM1, RPGRIP1L, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, PDLIM7, SYNPO, LIMA1, ANLN, MYO19, MYO18A, ESR1, ARMC7, CDH1, VAPB, BTRC, JPH4, VAPA, PACSIN1, PLK1, VTN, NECAB1, CTAGE5, TRIM25 | MED9 | MED10, MED13L, MED13, MED12, MED14, MED23, MED15, MED24, MED16, MED25, MED17, MED26, CDK8, CDK19, MED27, MED4, MED19, MED6, MED7, MED8, MED18, MED20, MED29, MED30, MED28, MED21, MED22, MED11, MED31, MED1, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2J, ZC3H13, OBFC1, APP, FBXW7, ESR1, CCNC, NRGN, TCL1B, SPAG9, CARM1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MPRIP | chr17:16946285 | chr17:17394593 | ENST00000341712 | + | 1 | 24 | 2_383 | 41 | 1231 | F-actin |
| Hgene | MPRIP | chr17:16946285 | chr17:17394593 | ENST00000395804 | + | 1 | 23 | 2_383 | 41 | 1026 | F-actin |
| Hgene | MPRIP | chr17:16946285 | chr17:17394593 | ENST00000395811 | + | 1 | 23 | 2_383 | 41 | 1039 | F-actin |
| Hgene | MPRIP | chr17:16946285 | chr17:17394593 | ENST00000444976 | + | 1 | 22 | 2_383 | 41 | 1001 | F-actin |
| Hgene | MPRIP | chr17:16946285 | chr17:17394593 | ENST00000341712 | + | 1 | 24 | 824_879 | 41 | 1231 | PPP1R12A |
| Hgene | MPRIP | chr17:16946285 | chr17:17394593 | ENST00000395804 | + | 1 | 23 | 824_879 | 41 | 1026 | PPP1R12A |
| Hgene | MPRIP | chr17:16946285 | chr17:17394593 | ENST00000395811 | + | 1 | 23 | 824_879 | 41 | 1039 | PPP1R12A |
| Hgene | MPRIP | chr17:16946285 | chr17:17394593 | ENST00000444976 | + | 1 | 22 | 824_879 | 41 | 1001 | PPP1R12A |
| Hgene | MPRIP | chr17:16946285 | chr17:17394593 | ENST00000341712 | + | 1 | 24 | 546_824 | 41 | 1231 | RHOA |
| Hgene | MPRIP | chr17:16946285 | chr17:17394593 | ENST00000395804 | + | 1 | 23 | 546_824 | 41 | 1026 | RHOA |
| Hgene | MPRIP | chr17:16946285 | chr17:17394593 | ENST00000395811 | + | 1 | 23 | 546_824 | 41 | 1039 | RHOA |
| Hgene | MPRIP | chr17:16946285 | chr17:17394593 | ENST00000444976 | + | 1 | 22 | 546_824 | 41 | 1001 | RHOA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MPRIP_MED9 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MPRIP_MED9 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MPRIP | C0043094 | Weight Gain | 1 | CTD_human |
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