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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22390

FusionGeneSummary for MPPED1_SCFD2

check button Fusion gene summary
Fusion gene informationFusion gene name: MPPED1_SCFD2
Fusion gene ID: 22390
HgeneTgene
Gene symbol

MPPED1

SCFD2

Gene ID

758

152579

Gene namemetallophosphoesterase domain containing 1sec1 family domain containing 2
Synonyms239AB|C22orf1|FAM1ASTXBP1L1
Cytomap

22q13.2

4q12

Type of geneprotein-codingprotein-coding
Descriptionmetallophosphoesterase domain-containing protein 1adult brain protein 239sec1 family domain-containing protein 2syntaxin binding protein 1-like 1
Modification date2018051920180519
UniProtAcc

O15442

Q8WU76

Ensembl transtripts involved in fusion geneENST00000417669, ENST00000414469, 
ENST00000439548, ENST00000443721, 
ENST00000465861, ENST00000542779, 
ENST00000538182, 
ENST00000401642, 
ENST00000388940, 
Fusion gene scores* DoF score1 X 1 X 1=110 X 8 X 10=800
# samples 111
** MAII scorelog2(1/1*10)=3.32192809488736log2(11/800*10)=-2.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MPPED1 [Title/Abstract] AND SCFD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-NA-A4QY-01AMPPED1chr22

43870841

+SCFD2chr4

53740228

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000417669ENST00000401642MPPED1chr22

43870841

+SCFD2chr4

53740228

-
Frame-shiftENST00000417669ENST00000388940MPPED1chr22

43870841

+SCFD2chr4

53740228

-
Frame-shiftENST00000414469ENST00000401642MPPED1chr22

43870841

+SCFD2chr4

53740228

-
Frame-shiftENST00000414469ENST00000388940MPPED1chr22

43870841

+SCFD2chr4

53740228

-
Frame-shiftENST00000439548ENST00000401642MPPED1chr22

43870841

+SCFD2chr4

53740228

-
Frame-shiftENST00000439548ENST00000388940MPPED1chr22

43870841

+SCFD2chr4

53740228

-
Frame-shiftENST00000443721ENST00000401642MPPED1chr22

43870841

+SCFD2chr4

53740228

-
Frame-shiftENST00000443721ENST00000388940MPPED1chr22

43870841

+SCFD2chr4

53740228

-
intron-3CDSENST00000465861ENST00000401642MPPED1chr22

43870841

+SCFD2chr4

53740228

-
intron-3CDSENST00000465861ENST00000388940MPPED1chr22

43870841

+SCFD2chr4

53740228

-
Frame-shiftENST00000542779ENST00000401642MPPED1chr22

43870841

+SCFD2chr4

53740228

-
Frame-shiftENST00000542779ENST00000388940MPPED1chr22

43870841

+SCFD2chr4

53740228

-
Frame-shiftENST00000538182ENST00000401642MPPED1chr22

43870841

+SCFD2chr4

53740228

-
Frame-shiftENST00000538182ENST00000388940MPPED1chr22

43870841

+SCFD2chr4

53740228

-

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FusionProtFeatures for MPPED1_SCFD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPPED1

O15442

SCFD2

Q8WU76

May have metallophosphoesterase activity (in vitro).{ECO:0000250}. May be involved in protein transport.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MPPED1_SCFD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MPPED1_SCFD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MPPED1DISC1, TK1, ANXA7, SPP1, CUL4B, CIAO1, CCT7, PHKA1, PHKA2, CCT6B, MMS19, NR2F6, NR2F1, NR2F2, CLUH, PHKB, UCKL1, NARF, TXNDC9, MPPED2, UCK1, DNPEP, PHKG2, USP33, UPRT, ZNF232, FBXW7SCFD2USE1, STX12, NAPG, SIRT2, RINT1, NBAS, SEC22B, BNIP1, ZW10, C19orf25, VAMP4, STX18


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MPPED1_SCFD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MPPED1_SCFD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource