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Fusion gene ID: 22390 |
FusionGeneSummary for MPPED1_SCFD2 |
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Fusion gene information | Fusion gene name: MPPED1_SCFD2 | Fusion gene ID: 22390 | Hgene | Tgene | Gene symbol | MPPED1 | SCFD2 | Gene ID | 758 | 152579 |
Gene name | metallophosphoesterase domain containing 1 | sec1 family domain containing 2 | |
Synonyms | 239AB|C22orf1|FAM1A | STXBP1L1 | |
Cytomap | 22q13.2 | 4q12 | |
Type of gene | protein-coding | protein-coding | |
Description | metallophosphoesterase domain-containing protein 1adult brain protein 239 | sec1 family domain-containing protein 2syntaxin binding protein 1-like 1 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O15442 | Q8WU76 | |
Ensembl transtripts involved in fusion gene | ENST00000417669, ENST00000414469, ENST00000439548, ENST00000443721, ENST00000465861, ENST00000542779, ENST00000538182, | ENST00000401642, ENST00000388940, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 10 X 8 X 10=800 |
# samples | 1 | 11 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(11/800*10)=-2.86249647625006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MPPED1 [Title/Abstract] AND SCFD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCS | TCGA-NA-A4QY-01A | MPPED1 | chr22 | 43870841 | + | SCFD2 | chr4 | 53740228 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000417669 | ENST00000401642 | MPPED1 | chr22 | 43870841 | + | SCFD2 | chr4 | 53740228 | - |
Frame-shift | ENST00000417669 | ENST00000388940 | MPPED1 | chr22 | 43870841 | + | SCFD2 | chr4 | 53740228 | - |
Frame-shift | ENST00000414469 | ENST00000401642 | MPPED1 | chr22 | 43870841 | + | SCFD2 | chr4 | 53740228 | - |
Frame-shift | ENST00000414469 | ENST00000388940 | MPPED1 | chr22 | 43870841 | + | SCFD2 | chr4 | 53740228 | - |
Frame-shift | ENST00000439548 | ENST00000401642 | MPPED1 | chr22 | 43870841 | + | SCFD2 | chr4 | 53740228 | - |
Frame-shift | ENST00000439548 | ENST00000388940 | MPPED1 | chr22 | 43870841 | + | SCFD2 | chr4 | 53740228 | - |
Frame-shift | ENST00000443721 | ENST00000401642 | MPPED1 | chr22 | 43870841 | + | SCFD2 | chr4 | 53740228 | - |
Frame-shift | ENST00000443721 | ENST00000388940 | MPPED1 | chr22 | 43870841 | + | SCFD2 | chr4 | 53740228 | - |
intron-3CDS | ENST00000465861 | ENST00000401642 | MPPED1 | chr22 | 43870841 | + | SCFD2 | chr4 | 53740228 | - |
intron-3CDS | ENST00000465861 | ENST00000388940 | MPPED1 | chr22 | 43870841 | + | SCFD2 | chr4 | 53740228 | - |
Frame-shift | ENST00000542779 | ENST00000401642 | MPPED1 | chr22 | 43870841 | + | SCFD2 | chr4 | 53740228 | - |
Frame-shift | ENST00000542779 | ENST00000388940 | MPPED1 | chr22 | 43870841 | + | SCFD2 | chr4 | 53740228 | - |
Frame-shift | ENST00000538182 | ENST00000401642 | MPPED1 | chr22 | 43870841 | + | SCFD2 | chr4 | 53740228 | - |
Frame-shift | ENST00000538182 | ENST00000388940 | MPPED1 | chr22 | 43870841 | + | SCFD2 | chr4 | 53740228 | - |
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FusionProtFeatures for MPPED1_SCFD2 |
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Hgene | Tgene |
MPPED1 | SCFD2 |
May have metallophosphoesterase activity (in vitro).{ECO:0000250}. | May be involved in protein transport. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MPPED1_SCFD2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MPPED1_SCFD2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MPPED1 | DISC1, TK1, ANXA7, SPP1, CUL4B, CIAO1, CCT7, PHKA1, PHKA2, CCT6B, MMS19, NR2F6, NR2F1, NR2F2, CLUH, PHKB, UCKL1, NARF, TXNDC9, MPPED2, UCK1, DNPEP, PHKG2, USP33, UPRT, ZNF232, FBXW7 | SCFD2 | USE1, STX12, NAPG, SIRT2, RINT1, NBAS, SEC22B, BNIP1, ZW10, C19orf25, VAMP4, STX18 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MPPED1_SCFD2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MPPED1_SCFD2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |