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Fusion gene ID: 22360 |
FusionGeneSummary for MPLKIP_TRA2A |
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Fusion gene information | Fusion gene name: MPLKIP_TRA2A | Fusion gene ID: 22360 | Hgene | Tgene | Gene symbol | MPLKIP | TRA2A | Gene ID | 136647 | 29896 |
Gene name | M-phase specific PLK1 interacting protein | transformer 2 alpha homolog | |
Synonyms | ABHS|C7orf11|ORF20|TTD4 | AWMS1|HSU53209 | |
Cytomap | 7p14.1 | 7p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | M-phase-specific PLK1-interacting proteinRussell-Silver syndrome regionTTD non-photosensitive 1 protein | transformer-2 protein homolog alphaTRA-2 alphaTRA2-alphaTra2alphahtra-2 alphaputative MAPK activating protein PM24transformer-2 alphatransformer-2 protein homolog A | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8TAP9 | Q13595 | |
Ensembl transtripts involved in fusion gene | ENST00000306984, | ENST00000297071, ENST00000392502, ENST00000538367, ENST00000474586, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 5 X 6 X 5=150 |
# samples | 2 | 7 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MPLKIP [Title/Abstract] AND TRA2A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TRA2A | GO:0000398 | mRNA splicing, via spliceosome | 9546399 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A2-A04P-01A | MPLKIP | chr7 | 40173828 | - | TRA2A | chr7 | 23556147 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000306984 | ENST00000297071 | MPLKIP | chr7 | 40173828 | - | TRA2A | chr7 | 23556147 | - |
5CDS-5UTR | ENST00000306984 | ENST00000392502 | MPLKIP | chr7 | 40173828 | - | TRA2A | chr7 | 23556147 | - |
5CDS-5UTR | ENST00000306984 | ENST00000538367 | MPLKIP | chr7 | 40173828 | - | TRA2A | chr7 | 23556147 | - |
5CDS-5UTR | ENST00000306984 | ENST00000474586 | MPLKIP | chr7 | 40173828 | - | TRA2A | chr7 | 23556147 | - |
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FusionProtFeatures for MPLKIP_TRA2A |
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Hgene | Tgene |
MPLKIP | TRA2A |
May play a role in maintenance of cell cycle integrityby regulating mitosis or cytokinesis.{ECO:0000269|PubMed:17310276}. | Sequence-specific RNA-binding protein which participatesin the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MPLKIP_TRA2A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MPLKIP_TRA2A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MPLKIP | SF3B4, CDV3, RBM27, NDUFA7, SF1, PPIF, SARNP, MRPL53, SERPINH1, SBDS, SUGP1, THY1, SCAMP3, SCP2, KCTD17, CDK7, XPO1, DBR1 | TRA2A | TADA2A, YWHAG, NUDT21, SELENBP1, CRABP1, TNNT1, CDK2AP2, C11orf58, ELAVL1, CUL3, CUL5, COPS5, SRSF10, RBM25, SRSF5, CDC5L, SEPT2, NFIA, NHP2L1, NCSTN, SF3A1, BUD31, SF3B3, PHGDH, S100A9, HNRNPC, HNRNPU, PRPF40A, SF3B6, HNRNPM, SAP18, PRPF6, IK, HP1BP3, SEPT7, SMARCB1, PLEC, BARD1, PAXIP1, MAGOH, EIF4A3, PPP1CC, DHX15, U2SURP, CDK6, LBP, NXF1, YTHDC1, CLK3, SRPK2, OBSL1, EZH2, SUZ12, EED, RNF2, BMI1, ZNF22, LARP7, SRRM1, MRPS9, MRPS26, THRAP3, LUC7L2, LUC7L, ZNF768, PTCD1, PTCD3, SRRM2, C17orf85, ZFR, PABPC4L, PABPC4, RBBP6, ELAVL2, RPL6, MRPS23, MRPS27, TRUB2, MRPS6, RPL26L1, MTERF3, PAIP1, MRPS18B, MRPL32, C10orf2, MRPS10, DAP3, MEPCE, UPF1, PPIG, LARP1, LARP1B, PHAX, MRPS31, MKRN1, MRPS18C, MRPS5, MRPS7, MRPS22, MRPS15, MRPS35, MRPS25, RRP9, NGRN, MRPS2, MOV10, MRPS33, SRRT, PRPF3, MRPS11, PNN, SRP14, GAR1, MRPS24, CASC3, WDR33, CSNK1E, CSNK1D, MRPS14, GAPDHS, ZCCHC3, MKRN2, ZC3H11A, NOA1, TRA2B, ISY1, SRSF8, CLK1, SRSF7, APOBEC3F, HIST1H2AG, SRSF12, CLK2, MRPL34, MRPS21, SNIP1, NTRK1, SRSF3, SRSF6, EWSR1, CNTRL, CDK2, FEN1, U2AF2, SNRNP70, ZC3H18, C11orf57, SNRPN, NCOA5, PABPC1, SYF2, APOBEC3D, NR3C1, FOXA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MPLKIP_TRA2A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MPLKIP_TRA2A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MPLKIP | C1313961 | Trichorrhexis nodosa syndrome | 1 | UNIPROT |
Tgene | TRA2A | C0037274 | Dermatologic disorders | 1 | CTD_human |
Tgene | TRA2A | C0311375 | Arsenic Poisoning | 1 | CTD_human |