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Fusion gene ID: 22339 |
FusionGeneSummary for MPDZ_ZPBP |
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Fusion gene information | Fusion gene name: MPDZ_ZPBP | Fusion gene ID: 22339 | Hgene | Tgene | Gene symbol | MPDZ | ZPBP | Gene ID | 84708 | 11055 |
Gene name | ligand of numb-protein X 1 | zona pellucida binding protein | |
Synonyms | LNX|MPDZ|PDZRN2 | ZPBP1 | |
Cytomap | 4q12 | 7p12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 ubiquitin-protein ligase LNXPDZ domain-containing ring finger protein 2RING-type E3 ubiquitin transferase LNXligand of numb-protein X 1, E3 ubiquitin protein ligasemulti-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNXnumb-binding pr | zona pellucida-binding protein 1inner acrosomal membrane IAM38 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | O75970 | Q9BS86 | |
Ensembl transtripts involved in fusion gene | ENST00000319217, ENST00000541718, ENST00000381022, ENST00000541093, ENST00000538841, ENST00000536827, ENST00000447879, ENST00000381015, ENST00000546205, ENST00000540202, | ENST00000491129, ENST00000046087, ENST00000419417, | |
Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 3 X 3 X 3=27 |
# samples | 6 | 3 | |
** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MPDZ [Title/Abstract] AND ZPBP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-22-4591-01A | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000319217 | ENST00000491129 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000319217 | ENST00000046087 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000319217 | ENST00000419417 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000541718 | ENST00000491129 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000541718 | ENST00000046087 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000541718 | ENST00000419417 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000381022 | ENST00000491129 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000381022 | ENST00000046087 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000381022 | ENST00000419417 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
intron-5UTR | ENST00000541093 | ENST00000491129 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
intron-5UTR | ENST00000541093 | ENST00000046087 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
intron-5UTR | ENST00000541093 | ENST00000419417 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000538841 | ENST00000491129 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000538841 | ENST00000046087 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000538841 | ENST00000419417 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000536827 | ENST00000491129 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000536827 | ENST00000046087 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000536827 | ENST00000419417 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000447879 | ENST00000491129 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000447879 | ENST00000046087 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000447879 | ENST00000419417 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000381015 | ENST00000491129 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000381015 | ENST00000046087 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000381015 | ENST00000419417 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000546205 | ENST00000491129 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000546205 | ENST00000046087 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
5CDS-5UTR | ENST00000546205 | ENST00000419417 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
intron-5UTR | ENST00000540202 | ENST00000491129 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
intron-5UTR | ENST00000540202 | ENST00000046087 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
intron-5UTR | ENST00000540202 | ENST00000419417 | MPDZ | chr9 | 13150510 | - | ZPBP | chr7 | 50023115 | - |
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FusionProtFeatures for MPDZ_ZPBP |
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Hgene | Tgene |
MPDZ | ZPBP |
Plays a role in acrosome compaction and spermmorphogenesis (PubMed:21911476). Is implicated in sperm-oocyteinteraction during fertilization (By similarity).{ECO:0000250|UniProtKB:Q62522, ECO:0000269|PubMed:21911476}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MPDZ_ZPBP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MPDZ_ZPBP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MPDZ | HTR2C, DRD3, KIT, PLEKHA1, PLEKHA2, AMOT, SSTR3, AMOTL2, LATS2, YAP1, WWOX, ENO1, SHMT2, NXF1, RNF166, LIN7C, LIN7A, MPP5, KRAS, CRK, KIF22, VCL, XRCC5, SNX3, VPS26A, TSC22D2, MTNR1A, WWC1 | ZPBP | CALU, ERRFI1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MPDZ_ZPBP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MPDZ_ZPBP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MPDZ | C0001973 | Alcoholic Intoxication, Chronic | 4 | PSYGENET |
Hgene | MPDZ | C0236663 | Alcohol withdrawal syndrome | 3 | PSYGENET |
Hgene | MPDZ | C0036572 | Seizures | 1 | CTD_human;HPO |
Hgene | MPDZ | C0085762 | Alcohol abuse | 1 | PSYGENET |
Hgene | MPDZ | C0149821 | ACUTE ALCOHOL WITHDRAWAL | 1 | PSYGENET |
Hgene | MPDZ | C0586323 | Alcohol Withdrawal Seizures | 1 | PSYGENET |