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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22339

FusionGeneSummary for MPDZ_ZPBP

check button Fusion gene summary
Fusion gene informationFusion gene name: MPDZ_ZPBP
Fusion gene ID: 22339
HgeneTgene
Gene symbol

MPDZ

ZPBP

Gene ID

84708

11055

Gene nameligand of numb-protein X 1zona pellucida binding protein
SynonymsLNX|MPDZ|PDZRN2ZPBP1
Cytomap

4q12

7p12.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase LNXPDZ domain-containing ring finger protein 2RING-type E3 ubiquitin transferase LNXligand of numb-protein X 1, E3 ubiquitin protein ligasemulti-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNXnumb-binding przona pellucida-binding protein 1inner acrosomal membrane IAM38
Modification date2018052220180519
UniProtAcc

O75970

Q9BS86

Ensembl transtripts involved in fusion geneENST00000319217, ENST00000541718, 
ENST00000381022, ENST00000541093, 
ENST00000538841, ENST00000536827, 
ENST00000447879, ENST00000381015, 
ENST00000546205, ENST00000540202, 
ENST00000491129, ENST00000046087, 
ENST00000419417, 
Fusion gene scores* DoF score6 X 5 X 5=1503 X 3 X 3=27
# samples 63
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MPDZ [Title/Abstract] AND ZPBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-22-4591-01AMPDZchr9

13150510

-ZPBPchr7

50023115

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000319217ENST00000491129MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000319217ENST00000046087MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000319217ENST00000419417MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000541718ENST00000491129MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000541718ENST00000046087MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000541718ENST00000419417MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000381022ENST00000491129MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000381022ENST00000046087MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000381022ENST00000419417MPDZchr9

13150510

-ZPBPchr7

50023115

-
intron-5UTRENST00000541093ENST00000491129MPDZchr9

13150510

-ZPBPchr7

50023115

-
intron-5UTRENST00000541093ENST00000046087MPDZchr9

13150510

-ZPBPchr7

50023115

-
intron-5UTRENST00000541093ENST00000419417MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000538841ENST00000491129MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000538841ENST00000046087MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000538841ENST00000419417MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000536827ENST00000491129MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000536827ENST00000046087MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000536827ENST00000419417MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000447879ENST00000491129MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000447879ENST00000046087MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000447879ENST00000419417MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000381015ENST00000491129MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000381015ENST00000046087MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000381015ENST00000419417MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000546205ENST00000491129MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000546205ENST00000046087MPDZchr9

13150510

-ZPBPchr7

50023115

-
5CDS-5UTRENST00000546205ENST00000419417MPDZchr9

13150510

-ZPBPchr7

50023115

-
intron-5UTRENST00000540202ENST00000491129MPDZchr9

13150510

-ZPBPchr7

50023115

-
intron-5UTRENST00000540202ENST00000046087MPDZchr9

13150510

-ZPBPchr7

50023115

-
intron-5UTRENST00000540202ENST00000419417MPDZchr9

13150510

-ZPBPchr7

50023115

-

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FusionProtFeatures for MPDZ_ZPBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPDZ

O75970

ZPBP

Q9BS86

Plays a role in acrosome compaction and spermmorphogenesis (PubMed:21911476). Is implicated in sperm-oocyteinteraction during fertilization (By similarity).{ECO:0000250|UniProtKB:Q62522, ECO:0000269|PubMed:21911476}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MPDZ_ZPBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MPDZ_ZPBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MPDZHTR2C, DRD3, KIT, PLEKHA1, PLEKHA2, AMOT, SSTR3, AMOTL2, LATS2, YAP1, WWOX, ENO1, SHMT2, NXF1, RNF166, LIN7C, LIN7A, MPP5, KRAS, CRK, KIF22, VCL, XRCC5, SNX3, VPS26A, TSC22D2, MTNR1A, WWC1ZPBPCALU, ERRFI1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MPDZ_ZPBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MPDZ_ZPBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMPDZC0001973Alcoholic Intoxication, Chronic4PSYGENET
HgeneMPDZC0236663Alcohol withdrawal syndrome3PSYGENET
HgeneMPDZC0036572Seizures1CTD_human;HPO
HgeneMPDZC0085762Alcohol abuse1PSYGENET
HgeneMPDZC0149821ACUTE ALCOHOL WITHDRAWAL1PSYGENET
HgeneMPDZC0586323Alcohol Withdrawal Seizures1PSYGENET