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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22338

FusionGeneSummary for MPDZ_PLIN2

check button Fusion gene summary
Fusion gene informationFusion gene name: MPDZ_PLIN2
Fusion gene ID: 22338
HgeneTgene
Gene symbol

MPDZ

PLIN2

Gene ID

84708

123

Gene nameligand of numb-protein X 1perilipin 2
SynonymsLNX|MPDZ|PDZRN2ADFP|ADRP
Cytomap

4q12

9p22.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase LNXPDZ domain-containing ring finger protein 2RING-type E3 ubiquitin transferase LNXligand of numb-protein X 1, E3 ubiquitin protein ligasemulti-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNXnumb-binding prperilipin-2adipophilinadipose differentiation-related protein
Modification date2018052220180519
UniProtAcc

O75970

Q99541

Ensembl transtripts involved in fusion geneENST00000319217, ENST00000541718, 
ENST00000381022, ENST00000541093, 
ENST00000538841, ENST00000536827, 
ENST00000447879, ENST00000381015, 
ENST00000546205, ENST00000540202, 
ENST00000494753, ENST00000411567, 
ENST00000276914, ENST00000380465, 
ENST00000380464, 
Fusion gene scores* DoF score6 X 5 X 5=1505 X 4 X 5=100
# samples 67
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MPDZ [Title/Abstract] AND PLIN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-E1-A7Z2-01AMPDZchr9

13188783

-PLIN2chr9

19131269

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000319217ENST00000494753MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000319217ENST00000411567MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000319217ENST00000276914MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000319217ENST00000380465MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000319217ENST00000380464MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-5UTRENST00000541718ENST00000494753MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000541718ENST00000411567MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000541718ENST00000276914MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000541718ENST00000380465MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000541718ENST00000380464MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-5UTRENST00000381022ENST00000494753MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000381022ENST00000411567MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000381022ENST00000276914MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000381022ENST00000380465MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000381022ENST00000380464MPDZchr9

13188783

-PLIN2chr9

19131269

-
intron-5UTRENST00000541093ENST00000494753MPDZchr9

13188783

-PLIN2chr9

19131269

-
intron-intronENST00000541093ENST00000411567MPDZchr9

13188783

-PLIN2chr9

19131269

-
intron-intronENST00000541093ENST00000276914MPDZchr9

13188783

-PLIN2chr9

19131269

-
intron-intronENST00000541093ENST00000380465MPDZchr9

13188783

-PLIN2chr9

19131269

-
intron-intronENST00000541093ENST00000380464MPDZchr9

13188783

-PLIN2chr9

19131269

-
intron-5UTRENST00000538841ENST00000494753MPDZchr9

13188783

-PLIN2chr9

19131269

-
intron-intronENST00000538841ENST00000411567MPDZchr9

13188783

-PLIN2chr9

19131269

-
intron-intronENST00000538841ENST00000276914MPDZchr9

13188783

-PLIN2chr9

19131269

-
intron-intronENST00000538841ENST00000380465MPDZchr9

13188783

-PLIN2chr9

19131269

-
intron-intronENST00000538841ENST00000380464MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-5UTRENST00000536827ENST00000494753MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000536827ENST00000411567MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000536827ENST00000276914MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000536827ENST00000380465MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000536827ENST00000380464MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-5UTRENST00000447879ENST00000494753MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000447879ENST00000411567MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000447879ENST00000276914MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000447879ENST00000380465MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000447879ENST00000380464MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-5UTRENST00000381015ENST00000494753MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000381015ENST00000411567MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000381015ENST00000276914MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000381015ENST00000380465MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000381015ENST00000380464MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-5UTRENST00000546205ENST00000494753MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000546205ENST00000411567MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000546205ENST00000276914MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000546205ENST00000380465MPDZchr9

13188783

-PLIN2chr9

19131269

-
5CDS-intronENST00000546205ENST00000380464MPDZchr9

13188783

-PLIN2chr9

19131269

-
intron-5UTRENST00000540202ENST00000494753MPDZchr9

13188783

-PLIN2chr9

19131269

-
intron-intronENST00000540202ENST00000411567MPDZchr9

13188783

-PLIN2chr9

19131269

-
intron-intronENST00000540202ENST00000276914MPDZchr9

13188783

-PLIN2chr9

19131269

-
intron-intronENST00000540202ENST00000380465MPDZchr9

13188783

-PLIN2chr9

19131269

-
intron-intronENST00000540202ENST00000380464MPDZchr9

13188783

-PLIN2chr9

19131269

-

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FusionProtFeatures for MPDZ_PLIN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPDZ

O75970

PLIN2

Q99541

May be involved in development and maintenance ofadipose tissue. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MPDZ_PLIN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MPDZ_PLIN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MPDZHTR2C, DRD3, KIT, PLEKHA1, PLEKHA2, AMOT, SSTR3, AMOTL2, LATS2, YAP1, WWOX, ENO1, SHMT2, NXF1, RNF166, LIN7C, LIN7A, MPP5, KRAS, CRK, KIF22, VCL, XRCC5, SNX3, VPS26A, TSC22D2, MTNR1A, WWC1PLIN2MAPK10, APOB, LIPE


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MPDZ_PLIN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MPDZ_PLIN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMPDZC0001973Alcoholic Intoxication, Chronic4PSYGENET
HgeneMPDZC0236663Alcohol withdrawal syndrome3PSYGENET
HgeneMPDZC0036572Seizures1CTD_human;HPO
HgeneMPDZC0085762Alcohol abuse1PSYGENET
HgeneMPDZC0149821ACUTE ALCOHOL WITHDRAWAL1PSYGENET
HgeneMPDZC0586323Alcohol Withdrawal Seizures1PSYGENET
TgenePLIN2C0015695Fatty Liver1CTD_human
TgenePLIN2C0023893Liver Cirrhosis, Experimental1CTD_human
TgenePLIN2C0038356Stomach Neoplasms1CTD_human