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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 22335

FusionGeneSummary for MPDZ_LURAP1L

check button Fusion gene summary
Fusion gene informationFusion gene name: MPDZ_LURAP1L
Fusion gene ID: 22335
HgeneTgene
Gene symbol

MPDZ

LURAP1L

Gene ID

84708

286343

Gene nameligand of numb-protein X 1leucine rich adaptor protein 1 like
SynonymsLNX|MPDZ|PDZRN2C9orf150|HYST0841|LRAP35b|bA3L8.2
Cytomap

4q12

9p23

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase LNXPDZ domain-containing ring finger protein 2RING-type E3 ubiquitin transferase LNXligand of numb-protein X 1, E3 ubiquitin protein ligasemulti-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNXnumb-binding prleucine rich adaptor protein 1-likeleucine repeat adaptor protein 35b
Modification date2018052220180519
UniProtAcc

O75970

Q8IV03

Ensembl transtripts involved in fusion geneENST00000319217, ENST00000541718, 
ENST00000381022, ENST00000541093, 
ENST00000538841, ENST00000536827, 
ENST00000447879, ENST00000381015, 
ENST00000546205, ENST00000540202, 
ENST00000319264, ENST00000489107, 
Fusion gene scores* DoF score6 X 5 X 5=1503 X 2 X 3=18
# samples 63
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MPDZ [Title/Abstract] AND LURAP1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E2-A150-01AMPDZchr9

13247634

-LURAP1Lchr9

12821385

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000319217ENST00000319264MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
5CDS-intronENST00000319217ENST00000489107MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
In-frameENST00000541718ENST00000319264MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
5CDS-intronENST00000541718ENST00000489107MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
Frame-shiftENST00000381022ENST00000319264MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
5CDS-intronENST00000381022ENST00000489107MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
intron-3CDSENST00000541093ENST00000319264MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
intron-intronENST00000541093ENST00000489107MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
intron-3CDSENST00000538841ENST00000319264MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
intron-intronENST00000538841ENST00000489107MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
Frame-shiftENST00000536827ENST00000319264MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
5CDS-intronENST00000536827ENST00000489107MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
Frame-shiftENST00000447879ENST00000319264MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
5CDS-intronENST00000447879ENST00000489107MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
Frame-shiftENST00000381015ENST00000319264MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
5CDS-intronENST00000381015ENST00000489107MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
In-frameENST00000546205ENST00000319264MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
5CDS-intronENST00000546205ENST00000489107MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
intron-3CDSENST00000540202ENST00000319264MPDZchr9

13247634

-LURAP1Lchr9

12821385

+
intron-intronENST00000540202ENST00000489107MPDZchr9

13247634

-LURAP1Lchr9

12821385

+

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FusionProtFeatures for MPDZ_LURAP1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPDZ

O75970

LURAP1L

Q8IV03


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMPDZchr9:13247634chr9:12821385ENST00000319217-3471_63612071DomainL27
HgeneMPDZchr9:13247634chr9:12821385ENST00000381015-2461_63612071DomainL27
HgeneMPDZchr9:13247634chr9:12821385ENST00000381022-2451_63612042DomainL27
HgeneMPDZchr9:13247634chr9:12821385ENST00000447879-2451_63612038DomainL27
HgeneMPDZchr9:13247634chr9:12821385ENST00000536827-2441_63612009DomainL27
HgeneMPDZchr9:13247634chr9:12821385ENST00000541718-3461_63612042DomainL27

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMPDZchr9:13247634chr9:12821385ENST00000319217-3471818_1848612071Compositional biasNote=Ser-rich
HgeneMPDZchr9:13247634chr9:12821385ENST00000381015-2461818_1848612071Compositional biasNote=Ser-rich
HgeneMPDZchr9:13247634chr9:12821385ENST00000381022-2451818_1848612042Compositional biasNote=Ser-rich
HgeneMPDZchr9:13247634chr9:12821385ENST00000447879-2451818_1848612038Compositional biasNote=Ser-rich
HgeneMPDZchr9:13247634chr9:12821385ENST00000536827-2441818_1848612009Compositional biasNote=Ser-rich
HgeneMPDZchr9:13247634chr9:12821385ENST00000541718-3461818_1848612042Compositional biasNote=Ser-rich
HgeneMPDZchr9:13247634chr9:12821385ENST00000319217-3471008_1089612071DomainPDZ 6
HgeneMPDZchr9:13247634chr9:12821385ENST00000319217-3471151_1243612071DomainPDZ 7
HgeneMPDZchr9:13247634chr9:12821385ENST00000319217-3471350_1433612071DomainPDZ 8
HgeneMPDZchr9:13247634chr9:12821385ENST00000319217-347137_224612071DomainPDZ 1
HgeneMPDZchr9:13247634chr9:12821385ENST00000319217-3471483_1564612071DomainPDZ 9
HgeneMPDZchr9:13247634chr9:12821385ENST00000319217-3471629_1712612071DomainPDZ 10
HgeneMPDZchr9:13247634chr9:12821385ENST00000319217-3471725_1807612071DomainPDZ 11
HgeneMPDZchr9:13247634chr9:12821385ENST00000319217-3471862_1948612071DomainPDZ 12
HgeneMPDZchr9:13247634chr9:12821385ENST00000319217-3471987_2070612071DomainPDZ 13
HgeneMPDZchr9:13247634chr9:12821385ENST00000319217-347257_337612071DomainPDZ 2
HgeneMPDZchr9:13247634chr9:12821385ENST00000319217-347377_463612071DomainPDZ 3
HgeneMPDZchr9:13247634chr9:12821385ENST00000319217-347553_634612071DomainPDZ 4
HgeneMPDZchr9:13247634chr9:12821385ENST00000319217-347700_786612071DomainPDZ 5
HgeneMPDZchr9:13247634chr9:12821385ENST00000381015-2461008_1089612071DomainPDZ 6
HgeneMPDZchr9:13247634chr9:12821385ENST00000381015-2461151_1243612071DomainPDZ 7
HgeneMPDZchr9:13247634chr9:12821385ENST00000381015-2461350_1433612071DomainPDZ 8
HgeneMPDZchr9:13247634chr9:12821385ENST00000381015-246137_224612071DomainPDZ 1
HgeneMPDZchr9:13247634chr9:12821385ENST00000381015-2461483_1564612071DomainPDZ 9
HgeneMPDZchr9:13247634chr9:12821385ENST00000381015-2461629_1712612071DomainPDZ 10
HgeneMPDZchr9:13247634chr9:12821385ENST00000381015-2461725_1807612071DomainPDZ 11
HgeneMPDZchr9:13247634chr9:12821385ENST00000381015-2461862_1948612071DomainPDZ 12
HgeneMPDZchr9:13247634chr9:12821385ENST00000381015-2461987_2070612071DomainPDZ 13
HgeneMPDZchr9:13247634chr9:12821385ENST00000381015-246257_337612071DomainPDZ 2
HgeneMPDZchr9:13247634chr9:12821385ENST00000381015-246377_463612071DomainPDZ 3
HgeneMPDZchr9:13247634chr9:12821385ENST00000381015-246553_634612071DomainPDZ 4
HgeneMPDZchr9:13247634chr9:12821385ENST00000381015-246700_786612071DomainPDZ 5
HgeneMPDZchr9:13247634chr9:12821385ENST00000381022-2451008_1089612042DomainPDZ 6
HgeneMPDZchr9:13247634chr9:12821385ENST00000381022-2451151_1243612042DomainPDZ 7
HgeneMPDZchr9:13247634chr9:12821385ENST00000381022-2451350_1433612042DomainPDZ 8
HgeneMPDZchr9:13247634chr9:12821385ENST00000381022-245137_224612042DomainPDZ 1
HgeneMPDZchr9:13247634chr9:12821385ENST00000381022-2451483_1564612042DomainPDZ 9
HgeneMPDZchr9:13247634chr9:12821385ENST00000381022-2451629_1712612042DomainPDZ 10
HgeneMPDZchr9:13247634chr9:12821385ENST00000381022-2451725_1807612042DomainPDZ 11
HgeneMPDZchr9:13247634chr9:12821385ENST00000381022-2451862_1948612042DomainPDZ 12
HgeneMPDZchr9:13247634chr9:12821385ENST00000381022-2451987_2070612042DomainPDZ 13
HgeneMPDZchr9:13247634chr9:12821385ENST00000381022-245257_337612042DomainPDZ 2
HgeneMPDZchr9:13247634chr9:12821385ENST00000381022-245377_463612042DomainPDZ 3
HgeneMPDZchr9:13247634chr9:12821385ENST00000381022-245553_634612042DomainPDZ 4
HgeneMPDZchr9:13247634chr9:12821385ENST00000381022-245700_786612042DomainPDZ 5
HgeneMPDZchr9:13247634chr9:12821385ENST00000447879-2451008_1089612038DomainPDZ 6
HgeneMPDZchr9:13247634chr9:12821385ENST00000447879-2451151_1243612038DomainPDZ 7
HgeneMPDZchr9:13247634chr9:12821385ENST00000447879-2451350_1433612038DomainPDZ 8
HgeneMPDZchr9:13247634chr9:12821385ENST00000447879-245137_224612038DomainPDZ 1
HgeneMPDZchr9:13247634chr9:12821385ENST00000447879-2451483_1564612038DomainPDZ 9
HgeneMPDZchr9:13247634chr9:12821385ENST00000447879-2451629_1712612038DomainPDZ 10
HgeneMPDZchr9:13247634chr9:12821385ENST00000447879-2451725_1807612038DomainPDZ 11
HgeneMPDZchr9:13247634chr9:12821385ENST00000447879-2451862_1948612038DomainPDZ 12
HgeneMPDZchr9:13247634chr9:12821385ENST00000447879-2451987_2070612038DomainPDZ 13
HgeneMPDZchr9:13247634chr9:12821385ENST00000447879-245257_337612038DomainPDZ 2
HgeneMPDZchr9:13247634chr9:12821385ENST00000447879-245377_463612038DomainPDZ 3
HgeneMPDZchr9:13247634chr9:12821385ENST00000447879-245553_634612038DomainPDZ 4
HgeneMPDZchr9:13247634chr9:12821385ENST00000447879-245700_786612038DomainPDZ 5
HgeneMPDZchr9:13247634chr9:12821385ENST00000536827-2441008_1089612009DomainPDZ 6
HgeneMPDZchr9:13247634chr9:12821385ENST00000536827-2441151_1243612009DomainPDZ 7
HgeneMPDZchr9:13247634chr9:12821385ENST00000536827-2441350_1433612009DomainPDZ 8
HgeneMPDZchr9:13247634chr9:12821385ENST00000536827-244137_224612009DomainPDZ 1
HgeneMPDZchr9:13247634chr9:12821385ENST00000536827-2441483_1564612009DomainPDZ 9
HgeneMPDZchr9:13247634chr9:12821385ENST00000536827-2441629_1712612009DomainPDZ 10
HgeneMPDZchr9:13247634chr9:12821385ENST00000536827-2441725_1807612009DomainPDZ 11
HgeneMPDZchr9:13247634chr9:12821385ENST00000536827-2441862_1948612009DomainPDZ 12
HgeneMPDZchr9:13247634chr9:12821385ENST00000536827-2441987_2070612009DomainPDZ 13
HgeneMPDZchr9:13247634chr9:12821385ENST00000536827-244257_337612009DomainPDZ 2
HgeneMPDZchr9:13247634chr9:12821385ENST00000536827-244377_463612009DomainPDZ 3
HgeneMPDZchr9:13247634chr9:12821385ENST00000536827-244553_634612009DomainPDZ 4
HgeneMPDZchr9:13247634chr9:12821385ENST00000536827-244700_786612009DomainPDZ 5
HgeneMPDZchr9:13247634chr9:12821385ENST00000541718-3461008_1089612042DomainPDZ 6
HgeneMPDZchr9:13247634chr9:12821385ENST00000541718-3461151_1243612042DomainPDZ 7
HgeneMPDZchr9:13247634chr9:12821385ENST00000541718-3461350_1433612042DomainPDZ 8
HgeneMPDZchr9:13247634chr9:12821385ENST00000541718-346137_224612042DomainPDZ 1
HgeneMPDZchr9:13247634chr9:12821385ENST00000541718-3461483_1564612042DomainPDZ 9
HgeneMPDZchr9:13247634chr9:12821385ENST00000541718-3461629_1712612042DomainPDZ 10
HgeneMPDZchr9:13247634chr9:12821385ENST00000541718-3461725_1807612042DomainPDZ 11
HgeneMPDZchr9:13247634chr9:12821385ENST00000541718-3461862_1948612042DomainPDZ 12
HgeneMPDZchr9:13247634chr9:12821385ENST00000541718-3461987_2070612042DomainPDZ 13
HgeneMPDZchr9:13247634chr9:12821385ENST00000541718-346257_337612042DomainPDZ 2
HgeneMPDZchr9:13247634chr9:12821385ENST00000541718-346377_463612042DomainPDZ 3
HgeneMPDZchr9:13247634chr9:12821385ENST00000541718-346553_634612042DomainPDZ 4
HgeneMPDZchr9:13247634chr9:12821385ENST00000541718-346700_786612042DomainPDZ 5
TgeneLURAP1Lchr9:13247634chr9:12821385ENST00000319264+0244_62104229Compositional biasNote=Gly-rich
TgeneLURAP1Lchr9:13247634chr9:12821385ENST00000319264+0260_91104229Compositional biasNote=Ser-rich


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FusionGeneSequence for MPDZ_LURAP1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MPDZ_ENST00000319217_chr9_13247634_-_LURAP1L_ENST00000319264_chr9_12821385_+_186aa
MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQVNLRATDVRLMRQLLVINESIESIKWMIE
EKATITSRGSSLSGSLCSLLESQSTSLRGSYNSLHDGSDGLDGISVGSYLDTLADDVPGHQTPSDLDQFSDSSLIEDSQALHKRPKLDSE

>In-frame_MPDZ_ENST00000541718_chr9_13247634_-_LURAP1L_ENST00000319264_chr9_12821385_+_186aa
MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQVNLRATDVRLMRQLLVINESIESIKWMIE
EKATITSRGSSLSGSLCSLLESQSTSLRGSYNSLHDGSDGLDGISVGSYLDTLADDVPGHQTPSDLDQFSDSSLIEDSQALHKRPKLDSE

>In-frame_MPDZ_ENST00000546205_chr9_13247634_-_LURAP1L_ENST00000319264_chr9_12821385_+_186aa
MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQVNLRATDVRLMRQLLVINESIESIKWMIE
EKATITSRGSSLSGSLCSLLESQSTSLRGSYNSLHDGSDGLDGISVGSYLDTLADDVPGHQTPSDLDQFSDSSLIEDSQALHKRPKLDSE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MPDZ_ENST00000319217_chr9_13247634_-_LURAP1L_ENST00000319264_chr9_12821385_+_558nt
ATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCGCTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAA
GACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAGTCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGAC
CAGGTTAACCTCAGAGCCACAGACGTCAGGCTCATGCGCCAGTTGCTTGTAATCAATGAGAGCATCGAGTCCATCAAGTGGATGATCGAA
GAAAAAGCCACCATTACCAGCAGAGGCAGCAGCCTCAGTGGCAGCCTGTGCAGTTTGTTGGAGAGTCAGAGCACCTCCTTACGTGGCAGC
TACAACAGCCTACACGATGGCAGTGATGGGCTGGATGGCATTTCCGTGGGAAGTTATCTGGACACGTTGGCGGATGATGTCCCAGGCCAT
CAGACCCCTTCAGACTTGGACCAATTCAGTGACAGCTCCCTCATAGAGGACTCACAGGCACTACACAAGCGTCCTAAATTGGATTCTGAA

>In-frame_MPDZ_ENST00000541718_chr9_13247634_-_LURAP1L_ENST00000319264_chr9_12821385_+_558nt
ATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCGCTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAA
GACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAGTCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGAC
CAGGTTAACCTCAGAGCCACAGACGTCAGGCTCATGCGCCAGTTGCTTGTAATCAATGAGAGCATCGAGTCCATCAAGTGGATGATCGAA
GAAAAAGCCACCATTACCAGCAGAGGCAGCAGCCTCAGTGGCAGCCTGTGCAGTTTGTTGGAGAGTCAGAGCACCTCCTTACGTGGCAGC
TACAACAGCCTACACGATGGCAGTGATGGGCTGGATGGCATTTCCGTGGGAAGTTATCTGGACACGTTGGCGGATGATGTCCCAGGCCAT
CAGACCCCTTCAGACTTGGACCAATTCAGTGACAGCTCCCTCATAGAGGACTCACAGGCACTACACAAGCGTCCTAAATTGGATTCTGAA

>In-frame_MPDZ_ENST00000546205_chr9_13247634_-_LURAP1L_ENST00000319264_chr9_12821385_+_558nt
ATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCGCTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAA
GACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAGTCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGAC
CAGGTTAACCTCAGAGCCACAGACGTCAGGCTCATGCGCCAGTTGCTTGTAATCAATGAGAGCATCGAGTCCATCAAGTGGATGATCGAA
GAAAAAGCCACCATTACCAGCAGAGGCAGCAGCCTCAGTGGCAGCCTGTGCAGTTTGTTGGAGAGTCAGAGCACCTCCTTACGTGGCAGC
TACAACAGCCTACACGATGGCAGTGATGGGCTGGATGGCATTTCCGTGGGAAGTTATCTGGACACGTTGGCGGATGATGTCCCAGGCCAT
CAGACCCCTTCAGACTTGGACCAATTCAGTGACAGCTCCCTCATAGAGGACTCACAGGCACTACACAAGCGTCCTAAATTGGATTCTGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_MPDZ_ENST00000319217_chr9_13247634_-_LURAP1L_ENST00000319264_chr9_12821385_+_1177nt
CCGCGGGATTAAGTTTCTCAGTCACGCGTGAGTGTCTGTGCGTTTTGATCCGAAGCTCCTCGCCGGGTCGTTACTTCAGAAGAGAAGACA
GTGAGCGTGGGCGAGGCGAGGCATCCAGAGGCCCCGGCGACCCCTGCTCCCCAGTCCTCCGCCCCCTCGCGTCGCGGCCCTGGGCGGGCG
CCGCGAGCCGGAGTTCCATTTTAATTGCTGTTAATCATTTCAGAGAAGAACACTGAACTTTGAAAAAAATGTTGGAAGCCATTGACAAAA
ATCGGGCCCTGCATGCAGCAGAGCGCTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAAGACAAACTGAGCCTTCTGAAGT
CAGTCCTGCAGAGCCCTCTCTTCAGTCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGACCAGGTTAACCTCAGAGCCACAG
ACGTCAGGCTCATGCGCCAGTTGCTTGTAATCAATGAGAGCATCGAGTCCATCAAGTGGATGATCGAAGAAAAAGCCACCATTACCAGCA
GAGGCAGCAGCCTCAGTGGCAGCCTGTGCAGTTTGTTGGAGAGTCAGAGCACCTCCTTACGTGGCAGCTACAACAGCCTACACGATGGCA
GTGATGGGCTGGATGGCATTTCCGTGGGAAGTTATCTGGACACGTTGGCGGATGATGTCCCAGGCCATCAGACCCCTTCAGACTTGGACC
AATTCAGTGACAGCTCCCTCATAGAGGACTCACAGGCACTACACAAGCGTCCTAAATTGGATTCTGAATACTACTGCTTTGGCTAGTGAC
AGTTTTTTGCATGGGACTGGTGTGCAATGAACTTGTATTTATCCTTCTTCTCCGCTGCTATATTTTTGGTGTGATTTTTATTTTAATAAG
ATGACCTTTTTAAAAGAAGCTGATTTTGAAACTGCTTAATGGTATTGCTGTTGCTCCTAATACTTCTCATCTGAGCTGATTTATTTTTCT
CTGTTACATCTCTATTTTTTATTTATTACAATGATTTTCTCCCTTCTTTTACAGTAGCACAAACAAAGTAGGGGGAAAAGAATAAGCAAT
AATTATGTTTTTGCTTTTGTTTTCAGAGCAATGGGTCAGGGATTACAAGAAAAACTTTGCTAAATTTTACAATAAACCAAAGTCTGATAA

>In-frame_MPDZ_ENST00000541718_chr9_13247634_-_LURAP1L_ENST00000319264_chr9_12821385_+_1151nt
CGTGAGTGTCTGTGCGTTTTGATCCGAAGCTCCTCGCCGGGTCGTTACTTCAGAAGAGAAGACAGTGAGCGTGGGCGAGGCGAGGCATCC
AGAGGCCCCGGCGACCCCTGCTCCCCAGTCCTCCGCCCCCTCGCGTCGCGGCCCTGGGCGGGCGCCGCGAGCCGGAGTTCCATTTTAATT
GCTGTTAATCATTTCAGAGAAGAACACTGAACTTTGAAAAAAATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCGC
TTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAAGACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAGT
CAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGACCAGGTTAACCTCAGAGCCACAGACGTCAGGCTCATGCGCCAGTTGCTT
GTAATCAATGAGAGCATCGAGTCCATCAAGTGGATGATCGAAGAAAAAGCCACCATTACCAGCAGAGGCAGCAGCCTCAGTGGCAGCCTG
TGCAGTTTGTTGGAGAGTCAGAGCACCTCCTTACGTGGCAGCTACAACAGCCTACACGATGGCAGTGATGGGCTGGATGGCATTTCCGTG
GGAAGTTATCTGGACACGTTGGCGGATGATGTCCCAGGCCATCAGACCCCTTCAGACTTGGACCAATTCAGTGACAGCTCCCTCATAGAG
GACTCACAGGCACTACACAAGCGTCCTAAATTGGATTCTGAATACTACTGCTTTGGCTAGTGACAGTTTTTTGCATGGGACTGGTGTGCA
ATGAACTTGTATTTATCCTTCTTCTCCGCTGCTATATTTTTGGTGTGATTTTTATTTTAATAAGATGACCTTTTTAAAAGAAGCTGATTT
TGAAACTGCTTAATGGTATTGCTGTTGCTCCTAATACTTCTCATCTGAGCTGATTTATTTTTCTCTGTTACATCTCTATTTTTTATTTAT
TACAATGATTTTCTCCCTTCTTTTACAGTAGCACAAACAAAGTAGGGGGAAAAGAATAAGCAATAATTATGTTTTTGCTTTTGTTTTCAG

>In-frame_MPDZ_ENST00000546205_chr9_13247634_-_LURAP1L_ENST00000319264_chr9_12821385_+_994nt
CGAGCCGGAGTTCCATTTTAATTGCTGTTAATCATTTCAGAGAAGAACACTGAACTTTGAAAAAAATGTTGGAAGCCATTGACAAAAATC
GGGCCCTGCATGCAGCAGAGCGCTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAAGACAAACTGAGCCTTCTGAAGTCAG
TCCTGCAGAGCCCTCTCTTCAGTCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGACCAGGTTAACCTCAGAGCCACAGACG
TCAGGCTCATGCGCCAGTTGCTTGTAATCAATGAGAGCATCGAGTCCATCAAGTGGATGATCGAAGAAAAAGCCACCATTACCAGCAGAG
GCAGCAGCCTCAGTGGCAGCCTGTGCAGTTTGTTGGAGAGTCAGAGCACCTCCTTACGTGGCAGCTACAACAGCCTACACGATGGCAGTG
ATGGGCTGGATGGCATTTCCGTGGGAAGTTATCTGGACACGTTGGCGGATGATGTCCCAGGCCATCAGACCCCTTCAGACTTGGACCAAT
TCAGTGACAGCTCCCTCATAGAGGACTCACAGGCACTACACAAGCGTCCTAAATTGGATTCTGAATACTACTGCTTTGGCTAGTGACAGT
TTTTTGCATGGGACTGGTGTGCAATGAACTTGTATTTATCCTTCTTCTCCGCTGCTATATTTTTGGTGTGATTTTTATTTTAATAAGATG
ACCTTTTTAAAAGAAGCTGATTTTGAAACTGCTTAATGGTATTGCTGTTGCTCCTAATACTTCTCATCTGAGCTGATTTATTTTTCTCTG
TTACATCTCTATTTTTTATTTATTACAATGATTTTCTCCCTTCTTTTACAGTAGCACAAACAAAGTAGGGGGAAAAGAATAAGCAATAAT
TATGTTTTTGCTTTTGTTTTCAGAGCAATGGGTCAGGGATTACAAGAAAAACTTTGCTAAATTTTACAATAAACCAAAGTCTGATAACAG


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FusionGenePPI for MPDZ_LURAP1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MPDZHTR2C, DRD3, KIT, PLEKHA1, PLEKHA2, AMOT, SSTR3, AMOTL2, LATS2, YAP1, WWOX, ENO1, SHMT2, NXF1, RNF166, LIN7C, LIN7A, MPP5, KRAS, CRK, KIF22, VCL, XRCC5, SNX3, VPS26A, TSC22D2, MTNR1A, WWC1LURAP1LAPP, KIAA1598, NEFM, SNTB2, CDC42BPA, CDC42BPB, FBXO28, HSF1, SNAP29, TP53RK


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MPDZ_LURAP1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MPDZ_LURAP1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMPDZC0001973Alcoholic Intoxication, Chronic4PSYGENET
HgeneMPDZC0236663Alcohol withdrawal syndrome3PSYGENET
HgeneMPDZC0036572Seizures1CTD_human;HPO
HgeneMPDZC0085762Alcohol abuse1PSYGENET
HgeneMPDZC0149821ACUTE ALCOHOL WITHDRAWAL1PSYGENET
HgeneMPDZC0586323Alcohol Withdrawal Seizures1PSYGENET
TgeneLURAP1LC0023893Liver Cirrhosis, Experimental1CTD_human