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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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RelatedDiseases

Fusion gene ID: 22334

FusionGeneSummary for MPDZ_ITPK1

check button Fusion gene summary
Fusion gene informationFusion gene name: MPDZ_ITPK1
Fusion gene ID: 22334
HgeneTgene
Gene symbol

MPDZ

ITPK1

Gene ID

84708

3705

Gene nameligand of numb-protein X 1inositol-tetrakisphosphate 1-kinase
SynonymsLNX|MPDZ|PDZRN2ITRPK1
Cytomap

4q12

14q32.12

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase LNXPDZ domain-containing ring finger protein 2RING-type E3 ubiquitin transferase LNXligand of numb-protein X 1, E3 ubiquitin protein ligasemulti-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNXnumb-binding prinositol-tetrakisphosphate 1-kinaseinositol 1,3,4-trisphosphate 5/6-kinaseins(1,3,4)P(3) 5/6-kinase
Modification date2018052220180529
UniProtAcc

O75970

Q13572

Ensembl transtripts involved in fusion geneENST00000319217, ENST00000541718, 
ENST00000381022, ENST00000541093, 
ENST00000538841, ENST00000536827, 
ENST00000447879, ENST00000381015, 
ENST00000546205, ENST00000540202, 
ENST00000267615, ENST00000354313, 
ENST00000556603, ENST00000555495, 
ENST00000556954, 
Fusion gene scores* DoF score6 X 5 X 5=1506 X 6 X 5=180
# samples 67
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MPDZ [Title/Abstract] AND ITPK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-PG-A7D5-01AMPDZchr9

13247634

-ITPK1chr14

93408249

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000319217ENST00000267615MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000319217ENST00000354313MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000319217ENST00000556603MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000319217ENST00000555495MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000319217ENST00000556954MPDZchr9

13247634

-ITPK1chr14

93408249

-
Frame-shiftENST00000541718ENST00000267615MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000541718ENST00000354313MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000541718ENST00000556603MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000541718ENST00000555495MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000541718ENST00000556954MPDZchr9

13247634

-ITPK1chr14

93408249

-
In-frameENST00000381022ENST00000267615MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000381022ENST00000354313MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000381022ENST00000556603MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000381022ENST00000555495MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000381022ENST00000556954MPDZchr9

13247634

-ITPK1chr14

93408249

-
intron-3CDSENST00000541093ENST00000267615MPDZchr9

13247634

-ITPK1chr14

93408249

-
intron-intronENST00000541093ENST00000354313MPDZchr9

13247634

-ITPK1chr14

93408249

-
intron-intronENST00000541093ENST00000556603MPDZchr9

13247634

-ITPK1chr14

93408249

-
intron-intronENST00000541093ENST00000555495MPDZchr9

13247634

-ITPK1chr14

93408249

-
intron-intronENST00000541093ENST00000556954MPDZchr9

13247634

-ITPK1chr14

93408249

-
intron-3CDSENST00000538841ENST00000267615MPDZchr9

13247634

-ITPK1chr14

93408249

-
intron-intronENST00000538841ENST00000354313MPDZchr9

13247634

-ITPK1chr14

93408249

-
intron-intronENST00000538841ENST00000556603MPDZchr9

13247634

-ITPK1chr14

93408249

-
intron-intronENST00000538841ENST00000555495MPDZchr9

13247634

-ITPK1chr14

93408249

-
intron-intronENST00000538841ENST00000556954MPDZchr9

13247634

-ITPK1chr14

93408249

-
In-frameENST00000536827ENST00000267615MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000536827ENST00000354313MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000536827ENST00000556603MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000536827ENST00000555495MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000536827ENST00000556954MPDZchr9

13247634

-ITPK1chr14

93408249

-
In-frameENST00000447879ENST00000267615MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000447879ENST00000354313MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000447879ENST00000556603MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000447879ENST00000555495MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000447879ENST00000556954MPDZchr9

13247634

-ITPK1chr14

93408249

-
In-frameENST00000381015ENST00000267615MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000381015ENST00000354313MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000381015ENST00000556603MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000381015ENST00000555495MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000381015ENST00000556954MPDZchr9

13247634

-ITPK1chr14

93408249

-
Frame-shiftENST00000546205ENST00000267615MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000546205ENST00000354313MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000546205ENST00000556603MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000546205ENST00000555495MPDZchr9

13247634

-ITPK1chr14

93408249

-
5CDS-intronENST00000546205ENST00000556954MPDZchr9

13247634

-ITPK1chr14

93408249

-
intron-3CDSENST00000540202ENST00000267615MPDZchr9

13247634

-ITPK1chr14

93408249

-
intron-intronENST00000540202ENST00000354313MPDZchr9

13247634

-ITPK1chr14

93408249

-
intron-intronENST00000540202ENST00000556603MPDZchr9

13247634

-ITPK1chr14

93408249

-
intron-intronENST00000540202ENST00000555495MPDZchr9

13247634

-ITPK1chr14

93408249

-
intron-intronENST00000540202ENST00000556954MPDZchr9

13247634

-ITPK1chr14

93408249

-

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FusionProtFeatures for MPDZ_ITPK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPDZ

O75970

ITPK1

Q13572

Kinase that can phosphorylate various inositolpolyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.Phosphorylates Ins(3,4,5,6)P4 at position 1 to formIns(1,3,4,5,6)P5. This reaction is thought to have regulatoryimportance, since Ins(3,4,5,6)P4 is an inhibitor of plasmamembrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to formIns(1,3,4,6)P4, an essential molecule in the hexakisphosphate(InsP6) pathway. Also acts as an inositol polyphosphatephosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May alsoact as an isomerase that interconverts the inositoltetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in thepresence of ADP and magnesium. Probably acts as the rate-limitingenzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosisby interfering with the activation of TNFRSF1A-associated deathdomain. {ECO:0000269|PubMed:11909533, ECO:0000269|PubMed:12925536,ECO:0000269|PubMed:17616525}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MPDZ_ITPK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MPDZ_ENST00000381022_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_175aa
MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQATRAXASSSQTSXTTSPLSCRARAQPWQP

>In-frame_MPDZ_ENST00000536827_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_175aa
MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQATRAXASSSQTSXTTSPLSCRARAQPWQP

>In-frame_MPDZ_ENST00000447879_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_175aa
MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQATRAXASSSQTSXTTSPLSCRARAQPWQP

>In-frame_MPDZ_ENST00000381015_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_175aa
MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQATRAXASSSQTSXTTSPLSCRARAQPWQP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MPDZ_ENST00000381022_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_527nt
ATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCGCTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAA
GACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAGTCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGAC
CAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCACATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCA
CAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCGGCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCG
GCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAGGCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCG

>In-frame_MPDZ_ENST00000536827_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_527nt
ATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCGCTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAA
GACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAGTCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGAC
CAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCACATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCA
CAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCGGCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCG
GCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAGGCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCG

>In-frame_MPDZ_ENST00000447879_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_527nt
ATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCGCTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAA
GACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAGTCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGAC
CAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCACATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCA
CAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCGGCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCG
GCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAGGCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCG

>In-frame_MPDZ_ENST00000381015_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_527nt
ATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCGCTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAA
GACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAGTCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGAC
CAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCACATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCA
CAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCGGCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCG
GCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAGGCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCG


* Fusion transcript sequences (Full-length transcript).
>In-frame_MPDZ_ENST00000381022_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_5225nt
ATTTTAATTGCTGTTAATCATTTCAGAGAAGAACACTGAACTTTGAAAAAAATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCA
GCAGAGCGCTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAAGACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCT
CTCTTCAGTCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGACCAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCC
TGAACCACATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCACAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGG
CCGAGCCGGCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCGGCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGA
AGGCTGAGGCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCGGCTGCAACGCCGGCGTGTCGCCCAGCTTCCAGCAGCATT
GTGTGGCCTCCCTGGCCACCAAGGCCTCCTCCCAGTAGCCACGGAGCCGGGACCCAGAGGGGCAGCGCAGGGCGCAGAGCACACCCGCTG
GGCCAGCAGCTCCCAACGGCGATGCTACTACTAAGAATCCCCAGTGATCTGATTCTTCTGTTTTTTAATTTTTAACCTGATTCTCTGATG
TCATGATCTAAATGAGGGGTAGTGGGGGATGGAAGAGAGTACCAGGTGGTCCACCGTTGGGGAGTGGGGCCGTCCGCCTGCTCTCTACTG
TGCAGACCTCCTAACTGAGTTTACACACGCTTGTGTTTGCAACACTAGGTCTGGATGGGAGGTGAGGGGTGTGCGTATGGCTGCCATGCC
AGTGTCTGTGCACATCCCTGTCTGTTGGTCTCCATGGCCACTGTGGACCGGGACCCTTGGGGGAAGCCTGCCCATGTCGGGCTGTGGGAG
GCTGATCGGTGCATGTGAGAGTGGCTTCCCTTCTGCCTGACTCCCCACTCCCTGACCTGCCCCTTCCTTGTTTTTCCTCCTACTGGTCTC
CACCAAGGCTTTGTTAGCCCCCACCCTGCCTGGTGTGCAGCTAACCCCTCCCTCCCCACAGCCAGAGGAGGCCACAGACCCCTCAGGGGA
GTTCCGCGCTGGGGTCTGGGCTGTGCTCCCTCACTAAAGGGAAGGAAAGGAAGCTGGGCGTCCTCTGGGCCCCCCAACACACGTCCCATT
TAGCCCTGCACAGCGGTCTCCTTCCCCTAAGCCAGCACTGCTGCTCCCTGGAGCCCGGGAAGGAGGCTGCCTGGCTGGAGGCCCGAGCCG
ATGGCGCCTGTGCTGAGGATTTGTGCTGTGATTTGGGCAAATCATTCCAGGTCTTTGGGCCTCCACCCCCTTGTCTCTAGTGGACATTTG
AGATCAGAGAGCACCACAGGGCTGGCTTTGTGCCCTAACCCCTGGGATGCAGCCTGCCTTTCCATAAAGTCACCTAGGTGAGGATAGGCG
CGGGAGCCTCGGCATGACACCATGGAGATCGGGGCCCTCTTCCCAGTGGGTTCACTCCTTTTCACACCTGCTGGGTCCCTCCTCACCCAG
CAGGCCTGGTCCACCTCTCATTGCAAGCCCCAAGCACTGAGCCAGCAGGTGCCAGGGAGCCACCCGCCCCCCATCGCTTCTGCACACCTC
AGACTCACCCCATCACCTTGGCAGCAAAGCACTGGCTCTGCCGTCTGACCCCTGATCCAGGCAGCCCCCTCTGCAGAGAAAAGGGTTGGG
GAGAAGCCTCTGCAGTCCTGGAAGATGTGGGGTGCTGGGTGAGAGGCATCAGCCCCCACAAGTATGTTTTTGTGTCTTAAGATAGCAGTT
TACTTTGAAAAAGTGAAAAAGGCTTCCGGGCTGTCCTCTGCCCAGTGAGATGGAGGACGCTAGAGAAAGTGCTGAGTGTCCCGAGAGAGG
CCCCCGAGCCAGTGCATGGAGGTCCTTCGGCCTGGCTCAGCTGGGCTGCAGGATGCCCACTTTGAGGAGGGAGGCACAGGGCTTGGGCGA
GGGGCAGAGGCCATCAGAACTGCCCGGCTTTTTTGGAAACTGAGGACCCAACAACTAACCACGTTTACACGACTTGAGTTTTGAACCCCG
ATTAATGTCTGTACGTCACCTTTCCTAGTTCTGACCCTGAGCCCTGGGGAACAGGAAAGCGTGGCTGGCCTCTTGCACTGCTTTGTCTCC
AAAATAAACTACTGAAATCAAACCGCATTTCACACGTGTTTACACATGTTGCTCAAGTTTGTTATGTCATACTCCCAGTCCTTAAAAGAC
GTTTAATAAAACAGCTTTACCTTTTAAAAATAAAATTTCAATCCCAGTCTGCCTCAGGTACGGGTGGGGGTGTGCAGCGTGACTCCTGGC
TGTGTTCCTGTACCGTTTGTGGCCTCCGGGGTCTTGCGCGTCCAGGGCCCAGATACCGAGTAACTGCCATGTGGTGTCGTGGTGGCGTCC
ATAGGCCTCCGTGGTGGGGCGGGGGCGGGGCTGTGGGTGTGCAGGGCAGCTGCATTTTCCAAGAGTGGAGATGGAGGATGGAGATTTGCT
TCGTAAAGGCCTGGGAGCTACATGGGAGGTAGGGAGGGGCCAGCCACACCCAGGGCTGGGGGGCCGGTGGACTCTGCCCAGTGAAGCCAG
GGGAGTGTCAGCAATGAGGGGCCTGGACAGCGACGCGGGACCCGCACCTGGGAGCGGCAGAGATGGAGCCCAGCTCGCTAAACGTACCCT
AAGGGTGCACGCTGACCATCTTTGATCCCTGGACAGTGTCCATAGAGTTGTCTCCCCTTCGGTCACATTGTCCCTGGCCTTGGAGTTTCT
GCCTCAGGGAAAGACCCACTAAAACCACCCGGGCTCTGGCGGCCTCCTCTTCTCCAGAGCATGGTGGCGCTGCCTCCTGAGCAGAGTCAC
TGAGAGTGTCTGGGTCCAAGGAAGGGACCCACTTAGCAAAGGTTGTTGTGTGGTGCTGTGCAGGCACGGCGCCTGGAGTTGGCCCCGCCA
GCATCGGGGTGGCTTGGGGCTCTGGTTCCTAAGCTTCTGCTTCTGAGTTGGTCAGCACGTTGGCTCTGCGCCCTGCAGTGCCTGTCTTGA
TGGTGGTCCCTGGATGTGCTGAAGGGCTCCAGGAGCAAGGGGCCAGACCACACTTTGGCTGAGTCCTTGGGTAGTTTCAGAGGGTCACCT
GCACAGTCTGCATTGAGCACCCTGGGGCTGAGGCCGTGGGTCAAGTTCTGCCTGACAGTGCTTTGATTATATGGTGATGTGATTCTGCAA
ACATAACCCCCCAACTGAGTGCCAGCTGCTGGGTGTCCCCACCCCAAGAGCCAAGGGGAGGCCACCCTGGAACTGGTGCTTTGCCCTTGG
TGTCATGGAGGTGTCTGGGTCCACACGTGGTGGGTGGGCTGGGCCTGCAGTCACCCAGCATGGCCGGCGGGATTGGACCCAGCTGCAACC
TGGCAGGTTCCATGGGGCTTCCTGTGCCTGGGCCTGCCTGTGTCTCATGCCTGTCAATAAAGGAGAAAGCAACCTGGGAAAAACATTCCT
CTCTGTACCCAGGGGACTGCCAAGTGTGCTTTATAGAAGGCTGGAAGACCGACTGAAGTAGGAAGCTGTCACATGTTTGAGCCAACTGAG
CAAAGCAGCTGTTGCCTGCCAGACAGCCACCCCAAGACCAAGGGAGCCAGCCTGTCGTTTGTCCTTCTAGCCTGGAAGACCAGTTCTTGG
CTCTTGGGCACTCACATTGGCCACTGGCCACAACTGCTGAATGGCTTCACTAATGTCCCTGGGGTCTGTATCTGCCCTCTCTTCTATTCC
CTAGAAACTCTGGCCGGGCATGGCGGCTCACGCCTGTCATCCCAGCACTTAGGGAGGCTGAGGCAGGTGGATCACAAGGTCAAGAGATCG
ACACCATCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGACATGGTGGTGGGCGCCTGTAGTCCCAGCT
ACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACTCGGGAGGCGTAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGCA
ACAGAGCAAGACTCCTCAAAAAACAAACAAACAAACAAACAAACTCTGATCATTCACCCGGTGGGATCCCCGGCAGCTCCTTCTCCTTCC
CGAGCTGTGGCTCATGGGCCATTGGATTCAGAGACCTTGAGCTGGGTGCTGGCTGCCCTAAAGGAGCACGACCCCTCCAGCCTGGTGACC
GGGAGGCAGAGAAGTGCAGCTGTCCTTGACAAAGGCCCAGCCTCTGCTGCCTCAGGCCAGCCTGGCCACACCCCGATGCCACAGTCATCT
GCCCCGCCCAGGCATAAGCCTGACTCAGGTGATACAGGCGAGGCTTCTCCCATGGGTCCTCCCCTTGTGAGAAAGGGTCTGTGCTGTGTA
CCTTCTCTCTGCACAGCCATTGTCAGTGTGGTTTGGAGTGAGTGAGCCTCCCGCACTGCTCAGGGGAGAGCTGGTGAGCATGACTCCATG
GCCTCCTGCTGGTTGGGGTCTTCTTCTGATTCTCACCCGCAGGAGCACCCAGACCCCCCCTTTTCAGAAATGATTACATTTTCCCTTCAA
GAGTCATCTGTGACCTGGTGGTGTGGAGGGACTGTCCCCTCCTGCAGCCTGGCCGACCCCCTTCCTCCAGGGCTGTGTGGAATCACCTCT
CAGAAGCTCACTCTGAAAAGCCACTCACAGGGATTTCACCAGGATGTTGCTGTTCCTGCCGACACCTGGGCTTTGTGACAAATGCTGTTT
GCTTCAAGCTGTTCACAAGCAACTTCACCAGAATCCCAAGCTGGTTCGTACTTAATTTGTGTACATACATATGCATAATATACATGACCA
TGTATGAGATACAGACACCATGGCTTCTGTCCATTGGCTCATTCGCCTGGTCGCATGTTCACTCCATGAGGTTAGGACACTGCGGGTGGC
TTTGGGATGGGTGGTTTCAGGGACAAGGTGTCGCTATGATCTCTGTATTTGCTAACTAGTCTTGTTTTGATTTCTAACGGTCTAGTGGAG
TACAGTTAATGTTGTGTTTATTTCTGTAACTGTAGGGGTGGAGTATAAACCTAACTTTTGGAAACATGAAGAAATAAACAATAGCGCCAG

>In-frame_MPDZ_ENST00000536827_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_5217nt
TGCTGTTAATCATTTCAGAGAAGAACACTGAACTTTGAAAAAAATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCG
CTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAAGACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAG
TCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGACCAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCAC
ATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCACAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCG
GCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCGGCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAG
GCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCGGCTGCAACGCCGGCGTGTCGCCCAGCTTCCAGCAGCATTGTGTGGCC
TCCCTGGCCACCAAGGCCTCCTCCCAGTAGCCACGGAGCCGGGACCCAGAGGGGCAGCGCAGGGCGCAGAGCACACCCGCTGGGCCAGCA
GCTCCCAACGGCGATGCTACTACTAAGAATCCCCAGTGATCTGATTCTTCTGTTTTTTAATTTTTAACCTGATTCTCTGATGTCATGATC
TAAATGAGGGGTAGTGGGGGATGGAAGAGAGTACCAGGTGGTCCACCGTTGGGGAGTGGGGCCGTCCGCCTGCTCTCTACTGTGCAGACC
TCCTAACTGAGTTTACACACGCTTGTGTTTGCAACACTAGGTCTGGATGGGAGGTGAGGGGTGTGCGTATGGCTGCCATGCCAGTGTCTG
TGCACATCCCTGTCTGTTGGTCTCCATGGCCACTGTGGACCGGGACCCTTGGGGGAAGCCTGCCCATGTCGGGCTGTGGGAGGCTGATCG
GTGCATGTGAGAGTGGCTTCCCTTCTGCCTGACTCCCCACTCCCTGACCTGCCCCTTCCTTGTTTTTCCTCCTACTGGTCTCCACCAAGG
CTTTGTTAGCCCCCACCCTGCCTGGTGTGCAGCTAACCCCTCCCTCCCCACAGCCAGAGGAGGCCACAGACCCCTCAGGGGAGTTCCGCG
CTGGGGTCTGGGCTGTGCTCCCTCACTAAAGGGAAGGAAAGGAAGCTGGGCGTCCTCTGGGCCCCCCAACACACGTCCCATTTAGCCCTG
CACAGCGGTCTCCTTCCCCTAAGCCAGCACTGCTGCTCCCTGGAGCCCGGGAAGGAGGCTGCCTGGCTGGAGGCCCGAGCCGATGGCGCC
TGTGCTGAGGATTTGTGCTGTGATTTGGGCAAATCATTCCAGGTCTTTGGGCCTCCACCCCCTTGTCTCTAGTGGACATTTGAGATCAGA
GAGCACCACAGGGCTGGCTTTGTGCCCTAACCCCTGGGATGCAGCCTGCCTTTCCATAAAGTCACCTAGGTGAGGATAGGCGCGGGAGCC
TCGGCATGACACCATGGAGATCGGGGCCCTCTTCCCAGTGGGTTCACTCCTTTTCACACCTGCTGGGTCCCTCCTCACCCAGCAGGCCTG
GTCCACCTCTCATTGCAAGCCCCAAGCACTGAGCCAGCAGGTGCCAGGGAGCCACCCGCCCCCCATCGCTTCTGCACACCTCAGACTCAC
CCCATCACCTTGGCAGCAAAGCACTGGCTCTGCCGTCTGACCCCTGATCCAGGCAGCCCCCTCTGCAGAGAAAAGGGTTGGGGAGAAGCC
TCTGCAGTCCTGGAAGATGTGGGGTGCTGGGTGAGAGGCATCAGCCCCCACAAGTATGTTTTTGTGTCTTAAGATAGCAGTTTACTTTGA
AAAAGTGAAAAAGGCTTCCGGGCTGTCCTCTGCCCAGTGAGATGGAGGACGCTAGAGAAAGTGCTGAGTGTCCCGAGAGAGGCCCCCGAG
CCAGTGCATGGAGGTCCTTCGGCCTGGCTCAGCTGGGCTGCAGGATGCCCACTTTGAGGAGGGAGGCACAGGGCTTGGGCGAGGGGCAGA
GGCCATCAGAACTGCCCGGCTTTTTTGGAAACTGAGGACCCAACAACTAACCACGTTTACACGACTTGAGTTTTGAACCCCGATTAATGT
CTGTACGTCACCTTTCCTAGTTCTGACCCTGAGCCCTGGGGAACAGGAAAGCGTGGCTGGCCTCTTGCACTGCTTTGTCTCCAAAATAAA
CTACTGAAATCAAACCGCATTTCACACGTGTTTACACATGTTGCTCAAGTTTGTTATGTCATACTCCCAGTCCTTAAAAGACGTTTAATA
AAACAGCTTTACCTTTTAAAAATAAAATTTCAATCCCAGTCTGCCTCAGGTACGGGTGGGGGTGTGCAGCGTGACTCCTGGCTGTGTTCC
TGTACCGTTTGTGGCCTCCGGGGTCTTGCGCGTCCAGGGCCCAGATACCGAGTAACTGCCATGTGGTGTCGTGGTGGCGTCCATAGGCCT
CCGTGGTGGGGCGGGGGCGGGGCTGTGGGTGTGCAGGGCAGCTGCATTTTCCAAGAGTGGAGATGGAGGATGGAGATTTGCTTCGTAAAG
GCCTGGGAGCTACATGGGAGGTAGGGAGGGGCCAGCCACACCCAGGGCTGGGGGGCCGGTGGACTCTGCCCAGTGAAGCCAGGGGAGTGT
CAGCAATGAGGGGCCTGGACAGCGACGCGGGACCCGCACCTGGGAGCGGCAGAGATGGAGCCCAGCTCGCTAAACGTACCCTAAGGGTGC
ACGCTGACCATCTTTGATCCCTGGACAGTGTCCATAGAGTTGTCTCCCCTTCGGTCACATTGTCCCTGGCCTTGGAGTTTCTGCCTCAGG
GAAAGACCCACTAAAACCACCCGGGCTCTGGCGGCCTCCTCTTCTCCAGAGCATGGTGGCGCTGCCTCCTGAGCAGAGTCACTGAGAGTG
TCTGGGTCCAAGGAAGGGACCCACTTAGCAAAGGTTGTTGTGTGGTGCTGTGCAGGCACGGCGCCTGGAGTTGGCCCCGCCAGCATCGGG
GTGGCTTGGGGCTCTGGTTCCTAAGCTTCTGCTTCTGAGTTGGTCAGCACGTTGGCTCTGCGCCCTGCAGTGCCTGTCTTGATGGTGGTC
CCTGGATGTGCTGAAGGGCTCCAGGAGCAAGGGGCCAGACCACACTTTGGCTGAGTCCTTGGGTAGTTTCAGAGGGTCACCTGCACAGTC
TGCATTGAGCACCCTGGGGCTGAGGCCGTGGGTCAAGTTCTGCCTGACAGTGCTTTGATTATATGGTGATGTGATTCTGCAAACATAACC
CCCCAACTGAGTGCCAGCTGCTGGGTGTCCCCACCCCAAGAGCCAAGGGGAGGCCACCCTGGAACTGGTGCTTTGCCCTTGGTGTCATGG
AGGTGTCTGGGTCCACACGTGGTGGGTGGGCTGGGCCTGCAGTCACCCAGCATGGCCGGCGGGATTGGACCCAGCTGCAACCTGGCAGGT
TCCATGGGGCTTCCTGTGCCTGGGCCTGCCTGTGTCTCATGCCTGTCAATAAAGGAGAAAGCAACCTGGGAAAAACATTCCTCTCTGTAC
CCAGGGGACTGCCAAGTGTGCTTTATAGAAGGCTGGAAGACCGACTGAAGTAGGAAGCTGTCACATGTTTGAGCCAACTGAGCAAAGCAG
CTGTTGCCTGCCAGACAGCCACCCCAAGACCAAGGGAGCCAGCCTGTCGTTTGTCCTTCTAGCCTGGAAGACCAGTTCTTGGCTCTTGGG
CACTCACATTGGCCACTGGCCACAACTGCTGAATGGCTTCACTAATGTCCCTGGGGTCTGTATCTGCCCTCTCTTCTATTCCCTAGAAAC
TCTGGCCGGGCATGGCGGCTCACGCCTGTCATCCCAGCACTTAGGGAGGCTGAGGCAGGTGGATCACAAGGTCAAGAGATCGACACCATC
CTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGACATGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGA
GGCTGAGGCAGGAGAATTGCTTGAACTCGGGAGGCGTAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGCAACAGAGCA
AGACTCCTCAAAAAACAAACAAACAAACAAACAAACTCTGATCATTCACCCGGTGGGATCCCCGGCAGCTCCTTCTCCTTCCCGAGCTGT
GGCTCATGGGCCATTGGATTCAGAGACCTTGAGCTGGGTGCTGGCTGCCCTAAAGGAGCACGACCCCTCCAGCCTGGTGACCGGGAGGCA
GAGAAGTGCAGCTGTCCTTGACAAAGGCCCAGCCTCTGCTGCCTCAGGCCAGCCTGGCCACACCCCGATGCCACAGTCATCTGCCCCGCC
CAGGCATAAGCCTGACTCAGGTGATACAGGCGAGGCTTCTCCCATGGGTCCTCCCCTTGTGAGAAAGGGTCTGTGCTGTGTACCTTCTCT
CTGCACAGCCATTGTCAGTGTGGTTTGGAGTGAGTGAGCCTCCCGCACTGCTCAGGGGAGAGCTGGTGAGCATGACTCCATGGCCTCCTG
CTGGTTGGGGTCTTCTTCTGATTCTCACCCGCAGGAGCACCCAGACCCCCCCTTTTCAGAAATGATTACATTTTCCCTTCAAGAGTCATC
TGTGACCTGGTGGTGTGGAGGGACTGTCCCCTCCTGCAGCCTGGCCGACCCCCTTCCTCCAGGGCTGTGTGGAATCACCTCTCAGAAGCT
CACTCTGAAAAGCCACTCACAGGGATTTCACCAGGATGTTGCTGTTCCTGCCGACACCTGGGCTTTGTGACAAATGCTGTTTGCTTCAAG
CTGTTCACAAGCAACTTCACCAGAATCCCAAGCTGGTTCGTACTTAATTTGTGTACATACATATGCATAATATACATGACCATGTATGAG
ATACAGACACCATGGCTTCTGTCCATTGGCTCATTCGCCTGGTCGCATGTTCACTCCATGAGGTTAGGACACTGCGGGTGGCTTTGGGAT
GGGTGGTTTCAGGGACAAGGTGTCGCTATGATCTCTGTATTTGCTAACTAGTCTTGTTTTGATTTCTAACGGTCTAGTGGAGTACAGTTA

>In-frame_MPDZ_ENST00000447879_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_5217nt
TGCTGTTAATCATTTCAGAGAAGAACACTGAACTTTGAAAAAAATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCG
CTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAAGACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAG
TCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGACCAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCAC
ATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCACAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCG
GCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCGGCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAG
GCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCGGCTGCAACGCCGGCGTGTCGCCCAGCTTCCAGCAGCATTGTGTGGCC
TCCCTGGCCACCAAGGCCTCCTCCCAGTAGCCACGGAGCCGGGACCCAGAGGGGCAGCGCAGGGCGCAGAGCACACCCGCTGGGCCAGCA
GCTCCCAACGGCGATGCTACTACTAAGAATCCCCAGTGATCTGATTCTTCTGTTTTTTAATTTTTAACCTGATTCTCTGATGTCATGATC
TAAATGAGGGGTAGTGGGGGATGGAAGAGAGTACCAGGTGGTCCACCGTTGGGGAGTGGGGCCGTCCGCCTGCTCTCTACTGTGCAGACC
TCCTAACTGAGTTTACACACGCTTGTGTTTGCAACACTAGGTCTGGATGGGAGGTGAGGGGTGTGCGTATGGCTGCCATGCCAGTGTCTG
TGCACATCCCTGTCTGTTGGTCTCCATGGCCACTGTGGACCGGGACCCTTGGGGGAAGCCTGCCCATGTCGGGCTGTGGGAGGCTGATCG
GTGCATGTGAGAGTGGCTTCCCTTCTGCCTGACTCCCCACTCCCTGACCTGCCCCTTCCTTGTTTTTCCTCCTACTGGTCTCCACCAAGG
CTTTGTTAGCCCCCACCCTGCCTGGTGTGCAGCTAACCCCTCCCTCCCCACAGCCAGAGGAGGCCACAGACCCCTCAGGGGAGTTCCGCG
CTGGGGTCTGGGCTGTGCTCCCTCACTAAAGGGAAGGAAAGGAAGCTGGGCGTCCTCTGGGCCCCCCAACACACGTCCCATTTAGCCCTG
CACAGCGGTCTCCTTCCCCTAAGCCAGCACTGCTGCTCCCTGGAGCCCGGGAAGGAGGCTGCCTGGCTGGAGGCCCGAGCCGATGGCGCC
TGTGCTGAGGATTTGTGCTGTGATTTGGGCAAATCATTCCAGGTCTTTGGGCCTCCACCCCCTTGTCTCTAGTGGACATTTGAGATCAGA
GAGCACCACAGGGCTGGCTTTGTGCCCTAACCCCTGGGATGCAGCCTGCCTTTCCATAAAGTCACCTAGGTGAGGATAGGCGCGGGAGCC
TCGGCATGACACCATGGAGATCGGGGCCCTCTTCCCAGTGGGTTCACTCCTTTTCACACCTGCTGGGTCCCTCCTCACCCAGCAGGCCTG
GTCCACCTCTCATTGCAAGCCCCAAGCACTGAGCCAGCAGGTGCCAGGGAGCCACCCGCCCCCCATCGCTTCTGCACACCTCAGACTCAC
CCCATCACCTTGGCAGCAAAGCACTGGCTCTGCCGTCTGACCCCTGATCCAGGCAGCCCCCTCTGCAGAGAAAAGGGTTGGGGAGAAGCC
TCTGCAGTCCTGGAAGATGTGGGGTGCTGGGTGAGAGGCATCAGCCCCCACAAGTATGTTTTTGTGTCTTAAGATAGCAGTTTACTTTGA
AAAAGTGAAAAAGGCTTCCGGGCTGTCCTCTGCCCAGTGAGATGGAGGACGCTAGAGAAAGTGCTGAGTGTCCCGAGAGAGGCCCCCGAG
CCAGTGCATGGAGGTCCTTCGGCCTGGCTCAGCTGGGCTGCAGGATGCCCACTTTGAGGAGGGAGGCACAGGGCTTGGGCGAGGGGCAGA
GGCCATCAGAACTGCCCGGCTTTTTTGGAAACTGAGGACCCAACAACTAACCACGTTTACACGACTTGAGTTTTGAACCCCGATTAATGT
CTGTACGTCACCTTTCCTAGTTCTGACCCTGAGCCCTGGGGAACAGGAAAGCGTGGCTGGCCTCTTGCACTGCTTTGTCTCCAAAATAAA
CTACTGAAATCAAACCGCATTTCACACGTGTTTACACATGTTGCTCAAGTTTGTTATGTCATACTCCCAGTCCTTAAAAGACGTTTAATA
AAACAGCTTTACCTTTTAAAAATAAAATTTCAATCCCAGTCTGCCTCAGGTACGGGTGGGGGTGTGCAGCGTGACTCCTGGCTGTGTTCC
TGTACCGTTTGTGGCCTCCGGGGTCTTGCGCGTCCAGGGCCCAGATACCGAGTAACTGCCATGTGGTGTCGTGGTGGCGTCCATAGGCCT
CCGTGGTGGGGCGGGGGCGGGGCTGTGGGTGTGCAGGGCAGCTGCATTTTCCAAGAGTGGAGATGGAGGATGGAGATTTGCTTCGTAAAG
GCCTGGGAGCTACATGGGAGGTAGGGAGGGGCCAGCCACACCCAGGGCTGGGGGGCCGGTGGACTCTGCCCAGTGAAGCCAGGGGAGTGT
CAGCAATGAGGGGCCTGGACAGCGACGCGGGACCCGCACCTGGGAGCGGCAGAGATGGAGCCCAGCTCGCTAAACGTACCCTAAGGGTGC
ACGCTGACCATCTTTGATCCCTGGACAGTGTCCATAGAGTTGTCTCCCCTTCGGTCACATTGTCCCTGGCCTTGGAGTTTCTGCCTCAGG
GAAAGACCCACTAAAACCACCCGGGCTCTGGCGGCCTCCTCTTCTCCAGAGCATGGTGGCGCTGCCTCCTGAGCAGAGTCACTGAGAGTG
TCTGGGTCCAAGGAAGGGACCCACTTAGCAAAGGTTGTTGTGTGGTGCTGTGCAGGCACGGCGCCTGGAGTTGGCCCCGCCAGCATCGGG
GTGGCTTGGGGCTCTGGTTCCTAAGCTTCTGCTTCTGAGTTGGTCAGCACGTTGGCTCTGCGCCCTGCAGTGCCTGTCTTGATGGTGGTC
CCTGGATGTGCTGAAGGGCTCCAGGAGCAAGGGGCCAGACCACACTTTGGCTGAGTCCTTGGGTAGTTTCAGAGGGTCACCTGCACAGTC
TGCATTGAGCACCCTGGGGCTGAGGCCGTGGGTCAAGTTCTGCCTGACAGTGCTTTGATTATATGGTGATGTGATTCTGCAAACATAACC
CCCCAACTGAGTGCCAGCTGCTGGGTGTCCCCACCCCAAGAGCCAAGGGGAGGCCACCCTGGAACTGGTGCTTTGCCCTTGGTGTCATGG
AGGTGTCTGGGTCCACACGTGGTGGGTGGGCTGGGCCTGCAGTCACCCAGCATGGCCGGCGGGATTGGACCCAGCTGCAACCTGGCAGGT
TCCATGGGGCTTCCTGTGCCTGGGCCTGCCTGTGTCTCATGCCTGTCAATAAAGGAGAAAGCAACCTGGGAAAAACATTCCTCTCTGTAC
CCAGGGGACTGCCAAGTGTGCTTTATAGAAGGCTGGAAGACCGACTGAAGTAGGAAGCTGTCACATGTTTGAGCCAACTGAGCAAAGCAG
CTGTTGCCTGCCAGACAGCCACCCCAAGACCAAGGGAGCCAGCCTGTCGTTTGTCCTTCTAGCCTGGAAGACCAGTTCTTGGCTCTTGGG
CACTCACATTGGCCACTGGCCACAACTGCTGAATGGCTTCACTAATGTCCCTGGGGTCTGTATCTGCCCTCTCTTCTATTCCCTAGAAAC
TCTGGCCGGGCATGGCGGCTCACGCCTGTCATCCCAGCACTTAGGGAGGCTGAGGCAGGTGGATCACAAGGTCAAGAGATCGACACCATC
CTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGACATGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGA
GGCTGAGGCAGGAGAATTGCTTGAACTCGGGAGGCGTAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGCAACAGAGCA
AGACTCCTCAAAAAACAAACAAACAAACAAACAAACTCTGATCATTCACCCGGTGGGATCCCCGGCAGCTCCTTCTCCTTCCCGAGCTGT
GGCTCATGGGCCATTGGATTCAGAGACCTTGAGCTGGGTGCTGGCTGCCCTAAAGGAGCACGACCCCTCCAGCCTGGTGACCGGGAGGCA
GAGAAGTGCAGCTGTCCTTGACAAAGGCCCAGCCTCTGCTGCCTCAGGCCAGCCTGGCCACACCCCGATGCCACAGTCATCTGCCCCGCC
CAGGCATAAGCCTGACTCAGGTGATACAGGCGAGGCTTCTCCCATGGGTCCTCCCCTTGTGAGAAAGGGTCTGTGCTGTGTACCTTCTCT
CTGCACAGCCATTGTCAGTGTGGTTTGGAGTGAGTGAGCCTCCCGCACTGCTCAGGGGAGAGCTGGTGAGCATGACTCCATGGCCTCCTG
CTGGTTGGGGTCTTCTTCTGATTCTCACCCGCAGGAGCACCCAGACCCCCCCTTTTCAGAAATGATTACATTTTCCCTTCAAGAGTCATC
TGTGACCTGGTGGTGTGGAGGGACTGTCCCCTCCTGCAGCCTGGCCGACCCCCTTCCTCCAGGGCTGTGTGGAATCACCTCTCAGAAGCT
CACTCTGAAAAGCCACTCACAGGGATTTCACCAGGATGTTGCTGTTCCTGCCGACACCTGGGCTTTGTGACAAATGCTGTTTGCTTCAAG
CTGTTCACAAGCAACTTCACCAGAATCCCAAGCTGGTTCGTACTTAATTTGTGTACATACATATGCATAATATACATGACCATGTATGAG
ATACAGACACCATGGCTTCTGTCCATTGGCTCATTCGCCTGGTCGCATGTTCACTCCATGAGGTTAGGACACTGCGGGTGGCTTTGGGAT
GGGTGGTTTCAGGGACAAGGTGTCGCTATGATCTCTGTATTTGCTAACTAGTCTTGTTTTGATTTCTAACGGTCTAGTGGAGTACAGTTA

>In-frame_MPDZ_ENST00000381015_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_5217nt
TGCTGTTAATCATTTCAGAGAAGAACACTGAACTTTGAAAAAAATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCG
CTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAAGACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAG
TCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGACCAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCAC
ATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCACAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCG
GCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCGGCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAG
GCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCGGCTGCAACGCCGGCGTGTCGCCCAGCTTCCAGCAGCATTGTGTGGCC
TCCCTGGCCACCAAGGCCTCCTCCCAGTAGCCACGGAGCCGGGACCCAGAGGGGCAGCGCAGGGCGCAGAGCACACCCGCTGGGCCAGCA
GCTCCCAACGGCGATGCTACTACTAAGAATCCCCAGTGATCTGATTCTTCTGTTTTTTAATTTTTAACCTGATTCTCTGATGTCATGATC
TAAATGAGGGGTAGTGGGGGATGGAAGAGAGTACCAGGTGGTCCACCGTTGGGGAGTGGGGCCGTCCGCCTGCTCTCTACTGTGCAGACC
TCCTAACTGAGTTTACACACGCTTGTGTTTGCAACACTAGGTCTGGATGGGAGGTGAGGGGTGTGCGTATGGCTGCCATGCCAGTGTCTG
TGCACATCCCTGTCTGTTGGTCTCCATGGCCACTGTGGACCGGGACCCTTGGGGGAAGCCTGCCCATGTCGGGCTGTGGGAGGCTGATCG
GTGCATGTGAGAGTGGCTTCCCTTCTGCCTGACTCCCCACTCCCTGACCTGCCCCTTCCTTGTTTTTCCTCCTACTGGTCTCCACCAAGG
CTTTGTTAGCCCCCACCCTGCCTGGTGTGCAGCTAACCCCTCCCTCCCCACAGCCAGAGGAGGCCACAGACCCCTCAGGGGAGTTCCGCG
CTGGGGTCTGGGCTGTGCTCCCTCACTAAAGGGAAGGAAAGGAAGCTGGGCGTCCTCTGGGCCCCCCAACACACGTCCCATTTAGCCCTG
CACAGCGGTCTCCTTCCCCTAAGCCAGCACTGCTGCTCCCTGGAGCCCGGGAAGGAGGCTGCCTGGCTGGAGGCCCGAGCCGATGGCGCC
TGTGCTGAGGATTTGTGCTGTGATTTGGGCAAATCATTCCAGGTCTTTGGGCCTCCACCCCCTTGTCTCTAGTGGACATTTGAGATCAGA
GAGCACCACAGGGCTGGCTTTGTGCCCTAACCCCTGGGATGCAGCCTGCCTTTCCATAAAGTCACCTAGGTGAGGATAGGCGCGGGAGCC
TCGGCATGACACCATGGAGATCGGGGCCCTCTTCCCAGTGGGTTCACTCCTTTTCACACCTGCTGGGTCCCTCCTCACCCAGCAGGCCTG
GTCCACCTCTCATTGCAAGCCCCAAGCACTGAGCCAGCAGGTGCCAGGGAGCCACCCGCCCCCCATCGCTTCTGCACACCTCAGACTCAC
CCCATCACCTTGGCAGCAAAGCACTGGCTCTGCCGTCTGACCCCTGATCCAGGCAGCCCCCTCTGCAGAGAAAAGGGTTGGGGAGAAGCC
TCTGCAGTCCTGGAAGATGTGGGGTGCTGGGTGAGAGGCATCAGCCCCCACAAGTATGTTTTTGTGTCTTAAGATAGCAGTTTACTTTGA
AAAAGTGAAAAAGGCTTCCGGGCTGTCCTCTGCCCAGTGAGATGGAGGACGCTAGAGAAAGTGCTGAGTGTCCCGAGAGAGGCCCCCGAG
CCAGTGCATGGAGGTCCTTCGGCCTGGCTCAGCTGGGCTGCAGGATGCCCACTTTGAGGAGGGAGGCACAGGGCTTGGGCGAGGGGCAGA
GGCCATCAGAACTGCCCGGCTTTTTTGGAAACTGAGGACCCAACAACTAACCACGTTTACACGACTTGAGTTTTGAACCCCGATTAATGT
CTGTACGTCACCTTTCCTAGTTCTGACCCTGAGCCCTGGGGAACAGGAAAGCGTGGCTGGCCTCTTGCACTGCTTTGTCTCCAAAATAAA
CTACTGAAATCAAACCGCATTTCACACGTGTTTACACATGTTGCTCAAGTTTGTTATGTCATACTCCCAGTCCTTAAAAGACGTTTAATA
AAACAGCTTTACCTTTTAAAAATAAAATTTCAATCCCAGTCTGCCTCAGGTACGGGTGGGGGTGTGCAGCGTGACTCCTGGCTGTGTTCC
TGTACCGTTTGTGGCCTCCGGGGTCTTGCGCGTCCAGGGCCCAGATACCGAGTAACTGCCATGTGGTGTCGTGGTGGCGTCCATAGGCCT
CCGTGGTGGGGCGGGGGCGGGGCTGTGGGTGTGCAGGGCAGCTGCATTTTCCAAGAGTGGAGATGGAGGATGGAGATTTGCTTCGTAAAG
GCCTGGGAGCTACATGGGAGGTAGGGAGGGGCCAGCCACACCCAGGGCTGGGGGGCCGGTGGACTCTGCCCAGTGAAGCCAGGGGAGTGT
CAGCAATGAGGGGCCTGGACAGCGACGCGGGACCCGCACCTGGGAGCGGCAGAGATGGAGCCCAGCTCGCTAAACGTACCCTAAGGGTGC
ACGCTGACCATCTTTGATCCCTGGACAGTGTCCATAGAGTTGTCTCCCCTTCGGTCACATTGTCCCTGGCCTTGGAGTTTCTGCCTCAGG
GAAAGACCCACTAAAACCACCCGGGCTCTGGCGGCCTCCTCTTCTCCAGAGCATGGTGGCGCTGCCTCCTGAGCAGAGTCACTGAGAGTG
TCTGGGTCCAAGGAAGGGACCCACTTAGCAAAGGTTGTTGTGTGGTGCTGTGCAGGCACGGCGCCTGGAGTTGGCCCCGCCAGCATCGGG
GTGGCTTGGGGCTCTGGTTCCTAAGCTTCTGCTTCTGAGTTGGTCAGCACGTTGGCTCTGCGCCCTGCAGTGCCTGTCTTGATGGTGGTC
CCTGGATGTGCTGAAGGGCTCCAGGAGCAAGGGGCCAGACCACACTTTGGCTGAGTCCTTGGGTAGTTTCAGAGGGTCACCTGCACAGTC
TGCATTGAGCACCCTGGGGCTGAGGCCGTGGGTCAAGTTCTGCCTGACAGTGCTTTGATTATATGGTGATGTGATTCTGCAAACATAACC
CCCCAACTGAGTGCCAGCTGCTGGGTGTCCCCACCCCAAGAGCCAAGGGGAGGCCACCCTGGAACTGGTGCTTTGCCCTTGGTGTCATGG
AGGTGTCTGGGTCCACACGTGGTGGGTGGGCTGGGCCTGCAGTCACCCAGCATGGCCGGCGGGATTGGACCCAGCTGCAACCTGGCAGGT
TCCATGGGGCTTCCTGTGCCTGGGCCTGCCTGTGTCTCATGCCTGTCAATAAAGGAGAAAGCAACCTGGGAAAAACATTCCTCTCTGTAC
CCAGGGGACTGCCAAGTGTGCTTTATAGAAGGCTGGAAGACCGACTGAAGTAGGAAGCTGTCACATGTTTGAGCCAACTGAGCAAAGCAG
CTGTTGCCTGCCAGACAGCCACCCCAAGACCAAGGGAGCCAGCCTGTCGTTTGTCCTTCTAGCCTGGAAGACCAGTTCTTGGCTCTTGGG
CACTCACATTGGCCACTGGCCACAACTGCTGAATGGCTTCACTAATGTCCCTGGGGTCTGTATCTGCCCTCTCTTCTATTCCCTAGAAAC
TCTGGCCGGGCATGGCGGCTCACGCCTGTCATCCCAGCACTTAGGGAGGCTGAGGCAGGTGGATCACAAGGTCAAGAGATCGACACCATC
CTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGACATGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGA
GGCTGAGGCAGGAGAATTGCTTGAACTCGGGAGGCGTAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGCAACAGAGCA
AGACTCCTCAAAAAACAAACAAACAAACAAACAAACTCTGATCATTCACCCGGTGGGATCCCCGGCAGCTCCTTCTCCTTCCCGAGCTGT
GGCTCATGGGCCATTGGATTCAGAGACCTTGAGCTGGGTGCTGGCTGCCCTAAAGGAGCACGACCCCTCCAGCCTGGTGACCGGGAGGCA
GAGAAGTGCAGCTGTCCTTGACAAAGGCCCAGCCTCTGCTGCCTCAGGCCAGCCTGGCCACACCCCGATGCCACAGTCATCTGCCCCGCC
CAGGCATAAGCCTGACTCAGGTGATACAGGCGAGGCTTCTCCCATGGGTCCTCCCCTTGTGAGAAAGGGTCTGTGCTGTGTACCTTCTCT
CTGCACAGCCATTGTCAGTGTGGTTTGGAGTGAGTGAGCCTCCCGCACTGCTCAGGGGAGAGCTGGTGAGCATGACTCCATGGCCTCCTG
CTGGTTGGGGTCTTCTTCTGATTCTCACCCGCAGGAGCACCCAGACCCCCCCTTTTCAGAAATGATTACATTTTCCCTTCAAGAGTCATC
TGTGACCTGGTGGTGTGGAGGGACTGTCCCCTCCTGCAGCCTGGCCGACCCCCTTCCTCCAGGGCTGTGTGGAATCACCTCTCAGAAGCT
CACTCTGAAAAGCCACTCACAGGGATTTCACCAGGATGTTGCTGTTCCTGCCGACACCTGGGCTTTGTGACAAATGCTGTTTGCTTCAAG
CTGTTCACAAGCAACTTCACCAGAATCCCAAGCTGGTTCGTACTTAATTTGTGTACATACATATGCATAATATACATGACCATGTATGAG
ATACAGACACCATGGCTTCTGTCCATTGGCTCATTCGCCTGGTCGCATGTTCACTCCATGAGGTTAGGACACTGCGGGTGGCTTTGGGAT
GGGTGGTTTCAGGGACAAGGTGTCGCTATGATCTCTGTATTTGCTAACTAGTCTTGTTTTGATTTCTAACGGTCTAGTGGAGTACAGTTA


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FusionGenePPI for MPDZ_ITPK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MPDZHTR2C, DRD3, KIT, PLEKHA1, PLEKHA2, AMOT, SSTR3, AMOTL2, LATS2, YAP1, WWOX, ENO1, SHMT2, NXF1, RNF166, LIN7C, LIN7A, MPP5, KRAS, CRK, KIF22, VCL, XRCC5, SNX3, VPS26A, TSC22D2, MTNR1A, WWC1ITPK1TRAF2, GPS1, TP53, JUN, ITPK1, NFKBIA, MOV10, TRAC, CRYZL1, SCN2B, DNAAF5, MAPK1, CDC5L, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MPDZ_ITPK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MPDZ_ITPK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMPDZC0001973Alcoholic Intoxication, Chronic4PSYGENET
HgeneMPDZC0236663Alcohol withdrawal syndrome3PSYGENET
HgeneMPDZC0036572Seizures1CTD_human;HPO
HgeneMPDZC0085762Alcohol abuse1PSYGENET
HgeneMPDZC0149821ACUTE ALCOHOL WITHDRAWAL1PSYGENET
HgeneMPDZC0586323Alcohol Withdrawal Seizures1PSYGENET
TgeneITPK1C0027626Neoplasm Invasiveness1CTD_human