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Fusion gene ID: 22334 |
FusionGeneSummary for MPDZ_ITPK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MPDZ_ITPK1 | Fusion gene ID: 22334 | Hgene | Tgene | Gene symbol | MPDZ | ITPK1 | Gene ID | 84708 | 3705 |
| Gene name | ligand of numb-protein X 1 | inositol-tetrakisphosphate 1-kinase | |
| Synonyms | LNX|MPDZ|PDZRN2 | ITRPK1 | |
| Cytomap | 4q12 | 14q32.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase LNXPDZ domain-containing ring finger protein 2RING-type E3 ubiquitin transferase LNXligand of numb-protein X 1, E3 ubiquitin protein ligasemulti-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNXnumb-binding pr | inositol-tetrakisphosphate 1-kinaseinositol 1,3,4-trisphosphate 5/6-kinaseins(1,3,4)P(3) 5/6-kinase | |
| Modification date | 20180522 | 20180529 | |
| UniProtAcc | O75970 | Q13572 | |
| Ensembl transtripts involved in fusion gene | ENST00000319217, ENST00000541718, ENST00000381022, ENST00000541093, ENST00000538841, ENST00000536827, ENST00000447879, ENST00000381015, ENST00000546205, ENST00000540202, | ENST00000267615, ENST00000354313, ENST00000556603, ENST00000555495, ENST00000556954, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 6 X 6 X 5=180 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MPDZ [Title/Abstract] AND ITPK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-PG-A7D5-01A | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000319217 | ENST00000267615 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000319217 | ENST00000354313 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000319217 | ENST00000556603 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000319217 | ENST00000555495 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000319217 | ENST00000556954 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| Frame-shift | ENST00000541718 | ENST00000267615 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000541718 | ENST00000354313 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000541718 | ENST00000556603 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000541718 | ENST00000555495 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000541718 | ENST00000556954 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| In-frame | ENST00000381022 | ENST00000267615 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000381022 | ENST00000354313 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000381022 | ENST00000556603 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000381022 | ENST00000555495 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000381022 | ENST00000556954 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| intron-3CDS | ENST00000541093 | ENST00000267615 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| intron-intron | ENST00000541093 | ENST00000354313 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| intron-intron | ENST00000541093 | ENST00000556603 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| intron-intron | ENST00000541093 | ENST00000555495 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| intron-intron | ENST00000541093 | ENST00000556954 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| intron-3CDS | ENST00000538841 | ENST00000267615 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| intron-intron | ENST00000538841 | ENST00000354313 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| intron-intron | ENST00000538841 | ENST00000556603 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| intron-intron | ENST00000538841 | ENST00000555495 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| intron-intron | ENST00000538841 | ENST00000556954 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| In-frame | ENST00000536827 | ENST00000267615 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000536827 | ENST00000354313 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000536827 | ENST00000556603 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000536827 | ENST00000555495 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000536827 | ENST00000556954 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| In-frame | ENST00000447879 | ENST00000267615 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000447879 | ENST00000354313 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000447879 | ENST00000556603 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000447879 | ENST00000555495 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000447879 | ENST00000556954 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| In-frame | ENST00000381015 | ENST00000267615 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000381015 | ENST00000354313 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000381015 | ENST00000556603 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000381015 | ENST00000555495 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000381015 | ENST00000556954 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| Frame-shift | ENST00000546205 | ENST00000267615 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000546205 | ENST00000354313 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000546205 | ENST00000556603 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000546205 | ENST00000555495 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| 5CDS-intron | ENST00000546205 | ENST00000556954 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| intron-3CDS | ENST00000540202 | ENST00000267615 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| intron-intron | ENST00000540202 | ENST00000354313 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| intron-intron | ENST00000540202 | ENST00000556603 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| intron-intron | ENST00000540202 | ENST00000555495 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
| intron-intron | ENST00000540202 | ENST00000556954 | MPDZ | chr9 | 13247634 | - | ITPK1 | chr14 | 93408249 | - |
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FusionProtFeatures for MPDZ_ITPK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MPDZ | ITPK1 |
| Kinase that can phosphorylate various inositolpolyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.Phosphorylates Ins(3,4,5,6)P4 at position 1 to formIns(1,3,4,5,6)P5. This reaction is thought to have regulatoryimportance, since Ins(3,4,5,6)P4 is an inhibitor of plasmamembrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to formIns(1,3,4,6)P4, an essential molecule in the hexakisphosphate(InsP6) pathway. Also acts as an inositol polyphosphatephosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May alsoact as an isomerase that interconverts the inositoltetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in thepresence of ADP and magnesium. Probably acts as the rate-limitingenzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosisby interfering with the activation of TNFRSF1A-associated deathdomain. {ECO:0000269|PubMed:11909533, ECO:0000269|PubMed:12925536,ECO:0000269|PubMed:17616525}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MPDZ_ITPK1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MPDZ_ENST00000381022_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_175aa MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQATRAXASSSQTSXTTSPLSCRARAQPWQP >In-frame_MPDZ_ENST00000536827_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_175aa MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQATRAXASSSQTSXTTSPLSCRARAQPWQP >In-frame_MPDZ_ENST00000447879_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_175aa MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQATRAXASSSQTSXTTSPLSCRARAQPWQP >In-frame_MPDZ_ENST00000381015_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_175aa MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQATRAXASSSQTSXTTSPLSCRARAQPWQP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MPDZ_ENST00000381022_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_527nt ATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCGCTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAA GACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAGTCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGAC CAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCACATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCA CAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCGGCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCG GCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAGGCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCG >In-frame_MPDZ_ENST00000536827_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_527nt ATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCGCTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAA GACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAGTCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGAC CAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCACATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCA CAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCGGCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCG GCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAGGCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCG >In-frame_MPDZ_ENST00000447879_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_527nt ATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCGCTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAA GACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAGTCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGAC CAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCACATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCA CAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCGGCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCG GCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAGGCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCG >In-frame_MPDZ_ENST00000381015_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_527nt ATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCGCTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAA GACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAGTCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGAC CAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCACATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCA CAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCGGCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCG GCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAGGCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MPDZ_ENST00000381022_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_5225nt ATTTTAATTGCTGTTAATCATTTCAGAGAAGAACACTGAACTTTGAAAAAAATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCA GCAGAGCGCTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAAGACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCT CTCTTCAGTCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGACCAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCC TGAACCACATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCACAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGG CCGAGCCGGCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCGGCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGA AGGCTGAGGCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCGGCTGCAACGCCGGCGTGTCGCCCAGCTTCCAGCAGCATT GTGTGGCCTCCCTGGCCACCAAGGCCTCCTCCCAGTAGCCACGGAGCCGGGACCCAGAGGGGCAGCGCAGGGCGCAGAGCACACCCGCTG GGCCAGCAGCTCCCAACGGCGATGCTACTACTAAGAATCCCCAGTGATCTGATTCTTCTGTTTTTTAATTTTTAACCTGATTCTCTGATG TCATGATCTAAATGAGGGGTAGTGGGGGATGGAAGAGAGTACCAGGTGGTCCACCGTTGGGGAGTGGGGCCGTCCGCCTGCTCTCTACTG TGCAGACCTCCTAACTGAGTTTACACACGCTTGTGTTTGCAACACTAGGTCTGGATGGGAGGTGAGGGGTGTGCGTATGGCTGCCATGCC AGTGTCTGTGCACATCCCTGTCTGTTGGTCTCCATGGCCACTGTGGACCGGGACCCTTGGGGGAAGCCTGCCCATGTCGGGCTGTGGGAG GCTGATCGGTGCATGTGAGAGTGGCTTCCCTTCTGCCTGACTCCCCACTCCCTGACCTGCCCCTTCCTTGTTTTTCCTCCTACTGGTCTC CACCAAGGCTTTGTTAGCCCCCACCCTGCCTGGTGTGCAGCTAACCCCTCCCTCCCCACAGCCAGAGGAGGCCACAGACCCCTCAGGGGA GTTCCGCGCTGGGGTCTGGGCTGTGCTCCCTCACTAAAGGGAAGGAAAGGAAGCTGGGCGTCCTCTGGGCCCCCCAACACACGTCCCATT TAGCCCTGCACAGCGGTCTCCTTCCCCTAAGCCAGCACTGCTGCTCCCTGGAGCCCGGGAAGGAGGCTGCCTGGCTGGAGGCCCGAGCCG ATGGCGCCTGTGCTGAGGATTTGTGCTGTGATTTGGGCAAATCATTCCAGGTCTTTGGGCCTCCACCCCCTTGTCTCTAGTGGACATTTG AGATCAGAGAGCACCACAGGGCTGGCTTTGTGCCCTAACCCCTGGGATGCAGCCTGCCTTTCCATAAAGTCACCTAGGTGAGGATAGGCG CGGGAGCCTCGGCATGACACCATGGAGATCGGGGCCCTCTTCCCAGTGGGTTCACTCCTTTTCACACCTGCTGGGTCCCTCCTCACCCAG CAGGCCTGGTCCACCTCTCATTGCAAGCCCCAAGCACTGAGCCAGCAGGTGCCAGGGAGCCACCCGCCCCCCATCGCTTCTGCACACCTC AGACTCACCCCATCACCTTGGCAGCAAAGCACTGGCTCTGCCGTCTGACCCCTGATCCAGGCAGCCCCCTCTGCAGAGAAAAGGGTTGGG GAGAAGCCTCTGCAGTCCTGGAAGATGTGGGGTGCTGGGTGAGAGGCATCAGCCCCCACAAGTATGTTTTTGTGTCTTAAGATAGCAGTT TACTTTGAAAAAGTGAAAAAGGCTTCCGGGCTGTCCTCTGCCCAGTGAGATGGAGGACGCTAGAGAAAGTGCTGAGTGTCCCGAGAGAGG CCCCCGAGCCAGTGCATGGAGGTCCTTCGGCCTGGCTCAGCTGGGCTGCAGGATGCCCACTTTGAGGAGGGAGGCACAGGGCTTGGGCGA GGGGCAGAGGCCATCAGAACTGCCCGGCTTTTTTGGAAACTGAGGACCCAACAACTAACCACGTTTACACGACTTGAGTTTTGAACCCCG ATTAATGTCTGTACGTCACCTTTCCTAGTTCTGACCCTGAGCCCTGGGGAACAGGAAAGCGTGGCTGGCCTCTTGCACTGCTTTGTCTCC AAAATAAACTACTGAAATCAAACCGCATTTCACACGTGTTTACACATGTTGCTCAAGTTTGTTATGTCATACTCCCAGTCCTTAAAAGAC GTTTAATAAAACAGCTTTACCTTTTAAAAATAAAATTTCAATCCCAGTCTGCCTCAGGTACGGGTGGGGGTGTGCAGCGTGACTCCTGGC TGTGTTCCTGTACCGTTTGTGGCCTCCGGGGTCTTGCGCGTCCAGGGCCCAGATACCGAGTAACTGCCATGTGGTGTCGTGGTGGCGTCC ATAGGCCTCCGTGGTGGGGCGGGGGCGGGGCTGTGGGTGTGCAGGGCAGCTGCATTTTCCAAGAGTGGAGATGGAGGATGGAGATTTGCT TCGTAAAGGCCTGGGAGCTACATGGGAGGTAGGGAGGGGCCAGCCACACCCAGGGCTGGGGGGCCGGTGGACTCTGCCCAGTGAAGCCAG GGGAGTGTCAGCAATGAGGGGCCTGGACAGCGACGCGGGACCCGCACCTGGGAGCGGCAGAGATGGAGCCCAGCTCGCTAAACGTACCCT AAGGGTGCACGCTGACCATCTTTGATCCCTGGACAGTGTCCATAGAGTTGTCTCCCCTTCGGTCACATTGTCCCTGGCCTTGGAGTTTCT GCCTCAGGGAAAGACCCACTAAAACCACCCGGGCTCTGGCGGCCTCCTCTTCTCCAGAGCATGGTGGCGCTGCCTCCTGAGCAGAGTCAC TGAGAGTGTCTGGGTCCAAGGAAGGGACCCACTTAGCAAAGGTTGTTGTGTGGTGCTGTGCAGGCACGGCGCCTGGAGTTGGCCCCGCCA GCATCGGGGTGGCTTGGGGCTCTGGTTCCTAAGCTTCTGCTTCTGAGTTGGTCAGCACGTTGGCTCTGCGCCCTGCAGTGCCTGTCTTGA TGGTGGTCCCTGGATGTGCTGAAGGGCTCCAGGAGCAAGGGGCCAGACCACACTTTGGCTGAGTCCTTGGGTAGTTTCAGAGGGTCACCT GCACAGTCTGCATTGAGCACCCTGGGGCTGAGGCCGTGGGTCAAGTTCTGCCTGACAGTGCTTTGATTATATGGTGATGTGATTCTGCAA ACATAACCCCCCAACTGAGTGCCAGCTGCTGGGTGTCCCCACCCCAAGAGCCAAGGGGAGGCCACCCTGGAACTGGTGCTTTGCCCTTGG TGTCATGGAGGTGTCTGGGTCCACACGTGGTGGGTGGGCTGGGCCTGCAGTCACCCAGCATGGCCGGCGGGATTGGACCCAGCTGCAACC TGGCAGGTTCCATGGGGCTTCCTGTGCCTGGGCCTGCCTGTGTCTCATGCCTGTCAATAAAGGAGAAAGCAACCTGGGAAAAACATTCCT CTCTGTACCCAGGGGACTGCCAAGTGTGCTTTATAGAAGGCTGGAAGACCGACTGAAGTAGGAAGCTGTCACATGTTTGAGCCAACTGAG CAAAGCAGCTGTTGCCTGCCAGACAGCCACCCCAAGACCAAGGGAGCCAGCCTGTCGTTTGTCCTTCTAGCCTGGAAGACCAGTTCTTGG CTCTTGGGCACTCACATTGGCCACTGGCCACAACTGCTGAATGGCTTCACTAATGTCCCTGGGGTCTGTATCTGCCCTCTCTTCTATTCC CTAGAAACTCTGGCCGGGCATGGCGGCTCACGCCTGTCATCCCAGCACTTAGGGAGGCTGAGGCAGGTGGATCACAAGGTCAAGAGATCG ACACCATCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGACATGGTGGTGGGCGCCTGTAGTCCCAGCT ACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACTCGGGAGGCGTAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGCA ACAGAGCAAGACTCCTCAAAAAACAAACAAACAAACAAACAAACTCTGATCATTCACCCGGTGGGATCCCCGGCAGCTCCTTCTCCTTCC CGAGCTGTGGCTCATGGGCCATTGGATTCAGAGACCTTGAGCTGGGTGCTGGCTGCCCTAAAGGAGCACGACCCCTCCAGCCTGGTGACC GGGAGGCAGAGAAGTGCAGCTGTCCTTGACAAAGGCCCAGCCTCTGCTGCCTCAGGCCAGCCTGGCCACACCCCGATGCCACAGTCATCT GCCCCGCCCAGGCATAAGCCTGACTCAGGTGATACAGGCGAGGCTTCTCCCATGGGTCCTCCCCTTGTGAGAAAGGGTCTGTGCTGTGTA CCTTCTCTCTGCACAGCCATTGTCAGTGTGGTTTGGAGTGAGTGAGCCTCCCGCACTGCTCAGGGGAGAGCTGGTGAGCATGACTCCATG GCCTCCTGCTGGTTGGGGTCTTCTTCTGATTCTCACCCGCAGGAGCACCCAGACCCCCCCTTTTCAGAAATGATTACATTTTCCCTTCAA GAGTCATCTGTGACCTGGTGGTGTGGAGGGACTGTCCCCTCCTGCAGCCTGGCCGACCCCCTTCCTCCAGGGCTGTGTGGAATCACCTCT CAGAAGCTCACTCTGAAAAGCCACTCACAGGGATTTCACCAGGATGTTGCTGTTCCTGCCGACACCTGGGCTTTGTGACAAATGCTGTTT GCTTCAAGCTGTTCACAAGCAACTTCACCAGAATCCCAAGCTGGTTCGTACTTAATTTGTGTACATACATATGCATAATATACATGACCA TGTATGAGATACAGACACCATGGCTTCTGTCCATTGGCTCATTCGCCTGGTCGCATGTTCACTCCATGAGGTTAGGACACTGCGGGTGGC TTTGGGATGGGTGGTTTCAGGGACAAGGTGTCGCTATGATCTCTGTATTTGCTAACTAGTCTTGTTTTGATTTCTAACGGTCTAGTGGAG TACAGTTAATGTTGTGTTTATTTCTGTAACTGTAGGGGTGGAGTATAAACCTAACTTTTGGAAACATGAAGAAATAAACAATAGCGCCAG >In-frame_MPDZ_ENST00000536827_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_5217nt TGCTGTTAATCATTTCAGAGAAGAACACTGAACTTTGAAAAAAATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCG CTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAAGACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAG TCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGACCAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCAC ATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCACAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCG GCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCGGCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAG GCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCGGCTGCAACGCCGGCGTGTCGCCCAGCTTCCAGCAGCATTGTGTGGCC TCCCTGGCCACCAAGGCCTCCTCCCAGTAGCCACGGAGCCGGGACCCAGAGGGGCAGCGCAGGGCGCAGAGCACACCCGCTGGGCCAGCA GCTCCCAACGGCGATGCTACTACTAAGAATCCCCAGTGATCTGATTCTTCTGTTTTTTAATTTTTAACCTGATTCTCTGATGTCATGATC TAAATGAGGGGTAGTGGGGGATGGAAGAGAGTACCAGGTGGTCCACCGTTGGGGAGTGGGGCCGTCCGCCTGCTCTCTACTGTGCAGACC TCCTAACTGAGTTTACACACGCTTGTGTTTGCAACACTAGGTCTGGATGGGAGGTGAGGGGTGTGCGTATGGCTGCCATGCCAGTGTCTG TGCACATCCCTGTCTGTTGGTCTCCATGGCCACTGTGGACCGGGACCCTTGGGGGAAGCCTGCCCATGTCGGGCTGTGGGAGGCTGATCG GTGCATGTGAGAGTGGCTTCCCTTCTGCCTGACTCCCCACTCCCTGACCTGCCCCTTCCTTGTTTTTCCTCCTACTGGTCTCCACCAAGG CTTTGTTAGCCCCCACCCTGCCTGGTGTGCAGCTAACCCCTCCCTCCCCACAGCCAGAGGAGGCCACAGACCCCTCAGGGGAGTTCCGCG CTGGGGTCTGGGCTGTGCTCCCTCACTAAAGGGAAGGAAAGGAAGCTGGGCGTCCTCTGGGCCCCCCAACACACGTCCCATTTAGCCCTG CACAGCGGTCTCCTTCCCCTAAGCCAGCACTGCTGCTCCCTGGAGCCCGGGAAGGAGGCTGCCTGGCTGGAGGCCCGAGCCGATGGCGCC TGTGCTGAGGATTTGTGCTGTGATTTGGGCAAATCATTCCAGGTCTTTGGGCCTCCACCCCCTTGTCTCTAGTGGACATTTGAGATCAGA GAGCACCACAGGGCTGGCTTTGTGCCCTAACCCCTGGGATGCAGCCTGCCTTTCCATAAAGTCACCTAGGTGAGGATAGGCGCGGGAGCC TCGGCATGACACCATGGAGATCGGGGCCCTCTTCCCAGTGGGTTCACTCCTTTTCACACCTGCTGGGTCCCTCCTCACCCAGCAGGCCTG GTCCACCTCTCATTGCAAGCCCCAAGCACTGAGCCAGCAGGTGCCAGGGAGCCACCCGCCCCCCATCGCTTCTGCACACCTCAGACTCAC CCCATCACCTTGGCAGCAAAGCACTGGCTCTGCCGTCTGACCCCTGATCCAGGCAGCCCCCTCTGCAGAGAAAAGGGTTGGGGAGAAGCC TCTGCAGTCCTGGAAGATGTGGGGTGCTGGGTGAGAGGCATCAGCCCCCACAAGTATGTTTTTGTGTCTTAAGATAGCAGTTTACTTTGA AAAAGTGAAAAAGGCTTCCGGGCTGTCCTCTGCCCAGTGAGATGGAGGACGCTAGAGAAAGTGCTGAGTGTCCCGAGAGAGGCCCCCGAG CCAGTGCATGGAGGTCCTTCGGCCTGGCTCAGCTGGGCTGCAGGATGCCCACTTTGAGGAGGGAGGCACAGGGCTTGGGCGAGGGGCAGA GGCCATCAGAACTGCCCGGCTTTTTTGGAAACTGAGGACCCAACAACTAACCACGTTTACACGACTTGAGTTTTGAACCCCGATTAATGT CTGTACGTCACCTTTCCTAGTTCTGACCCTGAGCCCTGGGGAACAGGAAAGCGTGGCTGGCCTCTTGCACTGCTTTGTCTCCAAAATAAA CTACTGAAATCAAACCGCATTTCACACGTGTTTACACATGTTGCTCAAGTTTGTTATGTCATACTCCCAGTCCTTAAAAGACGTTTAATA AAACAGCTTTACCTTTTAAAAATAAAATTTCAATCCCAGTCTGCCTCAGGTACGGGTGGGGGTGTGCAGCGTGACTCCTGGCTGTGTTCC TGTACCGTTTGTGGCCTCCGGGGTCTTGCGCGTCCAGGGCCCAGATACCGAGTAACTGCCATGTGGTGTCGTGGTGGCGTCCATAGGCCT CCGTGGTGGGGCGGGGGCGGGGCTGTGGGTGTGCAGGGCAGCTGCATTTTCCAAGAGTGGAGATGGAGGATGGAGATTTGCTTCGTAAAG GCCTGGGAGCTACATGGGAGGTAGGGAGGGGCCAGCCACACCCAGGGCTGGGGGGCCGGTGGACTCTGCCCAGTGAAGCCAGGGGAGTGT CAGCAATGAGGGGCCTGGACAGCGACGCGGGACCCGCACCTGGGAGCGGCAGAGATGGAGCCCAGCTCGCTAAACGTACCCTAAGGGTGC ACGCTGACCATCTTTGATCCCTGGACAGTGTCCATAGAGTTGTCTCCCCTTCGGTCACATTGTCCCTGGCCTTGGAGTTTCTGCCTCAGG GAAAGACCCACTAAAACCACCCGGGCTCTGGCGGCCTCCTCTTCTCCAGAGCATGGTGGCGCTGCCTCCTGAGCAGAGTCACTGAGAGTG TCTGGGTCCAAGGAAGGGACCCACTTAGCAAAGGTTGTTGTGTGGTGCTGTGCAGGCACGGCGCCTGGAGTTGGCCCCGCCAGCATCGGG GTGGCTTGGGGCTCTGGTTCCTAAGCTTCTGCTTCTGAGTTGGTCAGCACGTTGGCTCTGCGCCCTGCAGTGCCTGTCTTGATGGTGGTC CCTGGATGTGCTGAAGGGCTCCAGGAGCAAGGGGCCAGACCACACTTTGGCTGAGTCCTTGGGTAGTTTCAGAGGGTCACCTGCACAGTC TGCATTGAGCACCCTGGGGCTGAGGCCGTGGGTCAAGTTCTGCCTGACAGTGCTTTGATTATATGGTGATGTGATTCTGCAAACATAACC CCCCAACTGAGTGCCAGCTGCTGGGTGTCCCCACCCCAAGAGCCAAGGGGAGGCCACCCTGGAACTGGTGCTTTGCCCTTGGTGTCATGG AGGTGTCTGGGTCCACACGTGGTGGGTGGGCTGGGCCTGCAGTCACCCAGCATGGCCGGCGGGATTGGACCCAGCTGCAACCTGGCAGGT TCCATGGGGCTTCCTGTGCCTGGGCCTGCCTGTGTCTCATGCCTGTCAATAAAGGAGAAAGCAACCTGGGAAAAACATTCCTCTCTGTAC CCAGGGGACTGCCAAGTGTGCTTTATAGAAGGCTGGAAGACCGACTGAAGTAGGAAGCTGTCACATGTTTGAGCCAACTGAGCAAAGCAG CTGTTGCCTGCCAGACAGCCACCCCAAGACCAAGGGAGCCAGCCTGTCGTTTGTCCTTCTAGCCTGGAAGACCAGTTCTTGGCTCTTGGG CACTCACATTGGCCACTGGCCACAACTGCTGAATGGCTTCACTAATGTCCCTGGGGTCTGTATCTGCCCTCTCTTCTATTCCCTAGAAAC TCTGGCCGGGCATGGCGGCTCACGCCTGTCATCCCAGCACTTAGGGAGGCTGAGGCAGGTGGATCACAAGGTCAAGAGATCGACACCATC CTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGACATGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGA GGCTGAGGCAGGAGAATTGCTTGAACTCGGGAGGCGTAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGCAACAGAGCA AGACTCCTCAAAAAACAAACAAACAAACAAACAAACTCTGATCATTCACCCGGTGGGATCCCCGGCAGCTCCTTCTCCTTCCCGAGCTGT GGCTCATGGGCCATTGGATTCAGAGACCTTGAGCTGGGTGCTGGCTGCCCTAAAGGAGCACGACCCCTCCAGCCTGGTGACCGGGAGGCA GAGAAGTGCAGCTGTCCTTGACAAAGGCCCAGCCTCTGCTGCCTCAGGCCAGCCTGGCCACACCCCGATGCCACAGTCATCTGCCCCGCC CAGGCATAAGCCTGACTCAGGTGATACAGGCGAGGCTTCTCCCATGGGTCCTCCCCTTGTGAGAAAGGGTCTGTGCTGTGTACCTTCTCT CTGCACAGCCATTGTCAGTGTGGTTTGGAGTGAGTGAGCCTCCCGCACTGCTCAGGGGAGAGCTGGTGAGCATGACTCCATGGCCTCCTG CTGGTTGGGGTCTTCTTCTGATTCTCACCCGCAGGAGCACCCAGACCCCCCCTTTTCAGAAATGATTACATTTTCCCTTCAAGAGTCATC TGTGACCTGGTGGTGTGGAGGGACTGTCCCCTCCTGCAGCCTGGCCGACCCCCTTCCTCCAGGGCTGTGTGGAATCACCTCTCAGAAGCT CACTCTGAAAAGCCACTCACAGGGATTTCACCAGGATGTTGCTGTTCCTGCCGACACCTGGGCTTTGTGACAAATGCTGTTTGCTTCAAG CTGTTCACAAGCAACTTCACCAGAATCCCAAGCTGGTTCGTACTTAATTTGTGTACATACATATGCATAATATACATGACCATGTATGAG ATACAGACACCATGGCTTCTGTCCATTGGCTCATTCGCCTGGTCGCATGTTCACTCCATGAGGTTAGGACACTGCGGGTGGCTTTGGGAT GGGTGGTTTCAGGGACAAGGTGTCGCTATGATCTCTGTATTTGCTAACTAGTCTTGTTTTGATTTCTAACGGTCTAGTGGAGTACAGTTA >In-frame_MPDZ_ENST00000447879_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_5217nt TGCTGTTAATCATTTCAGAGAAGAACACTGAACTTTGAAAAAAATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCG CTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAAGACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAG TCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGACCAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCAC ATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCACAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCG GCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCGGCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAG GCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCGGCTGCAACGCCGGCGTGTCGCCCAGCTTCCAGCAGCATTGTGTGGCC TCCCTGGCCACCAAGGCCTCCTCCCAGTAGCCACGGAGCCGGGACCCAGAGGGGCAGCGCAGGGCGCAGAGCACACCCGCTGGGCCAGCA GCTCCCAACGGCGATGCTACTACTAAGAATCCCCAGTGATCTGATTCTTCTGTTTTTTAATTTTTAACCTGATTCTCTGATGTCATGATC TAAATGAGGGGTAGTGGGGGATGGAAGAGAGTACCAGGTGGTCCACCGTTGGGGAGTGGGGCCGTCCGCCTGCTCTCTACTGTGCAGACC TCCTAACTGAGTTTACACACGCTTGTGTTTGCAACACTAGGTCTGGATGGGAGGTGAGGGGTGTGCGTATGGCTGCCATGCCAGTGTCTG TGCACATCCCTGTCTGTTGGTCTCCATGGCCACTGTGGACCGGGACCCTTGGGGGAAGCCTGCCCATGTCGGGCTGTGGGAGGCTGATCG GTGCATGTGAGAGTGGCTTCCCTTCTGCCTGACTCCCCACTCCCTGACCTGCCCCTTCCTTGTTTTTCCTCCTACTGGTCTCCACCAAGG CTTTGTTAGCCCCCACCCTGCCTGGTGTGCAGCTAACCCCTCCCTCCCCACAGCCAGAGGAGGCCACAGACCCCTCAGGGGAGTTCCGCG CTGGGGTCTGGGCTGTGCTCCCTCACTAAAGGGAAGGAAAGGAAGCTGGGCGTCCTCTGGGCCCCCCAACACACGTCCCATTTAGCCCTG CACAGCGGTCTCCTTCCCCTAAGCCAGCACTGCTGCTCCCTGGAGCCCGGGAAGGAGGCTGCCTGGCTGGAGGCCCGAGCCGATGGCGCC TGTGCTGAGGATTTGTGCTGTGATTTGGGCAAATCATTCCAGGTCTTTGGGCCTCCACCCCCTTGTCTCTAGTGGACATTTGAGATCAGA GAGCACCACAGGGCTGGCTTTGTGCCCTAACCCCTGGGATGCAGCCTGCCTTTCCATAAAGTCACCTAGGTGAGGATAGGCGCGGGAGCC TCGGCATGACACCATGGAGATCGGGGCCCTCTTCCCAGTGGGTTCACTCCTTTTCACACCTGCTGGGTCCCTCCTCACCCAGCAGGCCTG GTCCACCTCTCATTGCAAGCCCCAAGCACTGAGCCAGCAGGTGCCAGGGAGCCACCCGCCCCCCATCGCTTCTGCACACCTCAGACTCAC CCCATCACCTTGGCAGCAAAGCACTGGCTCTGCCGTCTGACCCCTGATCCAGGCAGCCCCCTCTGCAGAGAAAAGGGTTGGGGAGAAGCC TCTGCAGTCCTGGAAGATGTGGGGTGCTGGGTGAGAGGCATCAGCCCCCACAAGTATGTTTTTGTGTCTTAAGATAGCAGTTTACTTTGA AAAAGTGAAAAAGGCTTCCGGGCTGTCCTCTGCCCAGTGAGATGGAGGACGCTAGAGAAAGTGCTGAGTGTCCCGAGAGAGGCCCCCGAG CCAGTGCATGGAGGTCCTTCGGCCTGGCTCAGCTGGGCTGCAGGATGCCCACTTTGAGGAGGGAGGCACAGGGCTTGGGCGAGGGGCAGA GGCCATCAGAACTGCCCGGCTTTTTTGGAAACTGAGGACCCAACAACTAACCACGTTTACACGACTTGAGTTTTGAACCCCGATTAATGT CTGTACGTCACCTTTCCTAGTTCTGACCCTGAGCCCTGGGGAACAGGAAAGCGTGGCTGGCCTCTTGCACTGCTTTGTCTCCAAAATAAA CTACTGAAATCAAACCGCATTTCACACGTGTTTACACATGTTGCTCAAGTTTGTTATGTCATACTCCCAGTCCTTAAAAGACGTTTAATA AAACAGCTTTACCTTTTAAAAATAAAATTTCAATCCCAGTCTGCCTCAGGTACGGGTGGGGGTGTGCAGCGTGACTCCTGGCTGTGTTCC TGTACCGTTTGTGGCCTCCGGGGTCTTGCGCGTCCAGGGCCCAGATACCGAGTAACTGCCATGTGGTGTCGTGGTGGCGTCCATAGGCCT CCGTGGTGGGGCGGGGGCGGGGCTGTGGGTGTGCAGGGCAGCTGCATTTTCCAAGAGTGGAGATGGAGGATGGAGATTTGCTTCGTAAAG GCCTGGGAGCTACATGGGAGGTAGGGAGGGGCCAGCCACACCCAGGGCTGGGGGGCCGGTGGACTCTGCCCAGTGAAGCCAGGGGAGTGT CAGCAATGAGGGGCCTGGACAGCGACGCGGGACCCGCACCTGGGAGCGGCAGAGATGGAGCCCAGCTCGCTAAACGTACCCTAAGGGTGC ACGCTGACCATCTTTGATCCCTGGACAGTGTCCATAGAGTTGTCTCCCCTTCGGTCACATTGTCCCTGGCCTTGGAGTTTCTGCCTCAGG GAAAGACCCACTAAAACCACCCGGGCTCTGGCGGCCTCCTCTTCTCCAGAGCATGGTGGCGCTGCCTCCTGAGCAGAGTCACTGAGAGTG TCTGGGTCCAAGGAAGGGACCCACTTAGCAAAGGTTGTTGTGTGGTGCTGTGCAGGCACGGCGCCTGGAGTTGGCCCCGCCAGCATCGGG GTGGCTTGGGGCTCTGGTTCCTAAGCTTCTGCTTCTGAGTTGGTCAGCACGTTGGCTCTGCGCCCTGCAGTGCCTGTCTTGATGGTGGTC CCTGGATGTGCTGAAGGGCTCCAGGAGCAAGGGGCCAGACCACACTTTGGCTGAGTCCTTGGGTAGTTTCAGAGGGTCACCTGCACAGTC TGCATTGAGCACCCTGGGGCTGAGGCCGTGGGTCAAGTTCTGCCTGACAGTGCTTTGATTATATGGTGATGTGATTCTGCAAACATAACC CCCCAACTGAGTGCCAGCTGCTGGGTGTCCCCACCCCAAGAGCCAAGGGGAGGCCACCCTGGAACTGGTGCTTTGCCCTTGGTGTCATGG AGGTGTCTGGGTCCACACGTGGTGGGTGGGCTGGGCCTGCAGTCACCCAGCATGGCCGGCGGGATTGGACCCAGCTGCAACCTGGCAGGT TCCATGGGGCTTCCTGTGCCTGGGCCTGCCTGTGTCTCATGCCTGTCAATAAAGGAGAAAGCAACCTGGGAAAAACATTCCTCTCTGTAC CCAGGGGACTGCCAAGTGTGCTTTATAGAAGGCTGGAAGACCGACTGAAGTAGGAAGCTGTCACATGTTTGAGCCAACTGAGCAAAGCAG CTGTTGCCTGCCAGACAGCCACCCCAAGACCAAGGGAGCCAGCCTGTCGTTTGTCCTTCTAGCCTGGAAGACCAGTTCTTGGCTCTTGGG CACTCACATTGGCCACTGGCCACAACTGCTGAATGGCTTCACTAATGTCCCTGGGGTCTGTATCTGCCCTCTCTTCTATTCCCTAGAAAC TCTGGCCGGGCATGGCGGCTCACGCCTGTCATCCCAGCACTTAGGGAGGCTGAGGCAGGTGGATCACAAGGTCAAGAGATCGACACCATC CTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGACATGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGA GGCTGAGGCAGGAGAATTGCTTGAACTCGGGAGGCGTAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGCAACAGAGCA AGACTCCTCAAAAAACAAACAAACAAACAAACAAACTCTGATCATTCACCCGGTGGGATCCCCGGCAGCTCCTTCTCCTTCCCGAGCTGT GGCTCATGGGCCATTGGATTCAGAGACCTTGAGCTGGGTGCTGGCTGCCCTAAAGGAGCACGACCCCTCCAGCCTGGTGACCGGGAGGCA GAGAAGTGCAGCTGTCCTTGACAAAGGCCCAGCCTCTGCTGCCTCAGGCCAGCCTGGCCACACCCCGATGCCACAGTCATCTGCCCCGCC CAGGCATAAGCCTGACTCAGGTGATACAGGCGAGGCTTCTCCCATGGGTCCTCCCCTTGTGAGAAAGGGTCTGTGCTGTGTACCTTCTCT CTGCACAGCCATTGTCAGTGTGGTTTGGAGTGAGTGAGCCTCCCGCACTGCTCAGGGGAGAGCTGGTGAGCATGACTCCATGGCCTCCTG CTGGTTGGGGTCTTCTTCTGATTCTCACCCGCAGGAGCACCCAGACCCCCCCTTTTCAGAAATGATTACATTTTCCCTTCAAGAGTCATC TGTGACCTGGTGGTGTGGAGGGACTGTCCCCTCCTGCAGCCTGGCCGACCCCCTTCCTCCAGGGCTGTGTGGAATCACCTCTCAGAAGCT CACTCTGAAAAGCCACTCACAGGGATTTCACCAGGATGTTGCTGTTCCTGCCGACACCTGGGCTTTGTGACAAATGCTGTTTGCTTCAAG CTGTTCACAAGCAACTTCACCAGAATCCCAAGCTGGTTCGTACTTAATTTGTGTACATACATATGCATAATATACATGACCATGTATGAG ATACAGACACCATGGCTTCTGTCCATTGGCTCATTCGCCTGGTCGCATGTTCACTCCATGAGGTTAGGACACTGCGGGTGGCTTTGGGAT GGGTGGTTTCAGGGACAAGGTGTCGCTATGATCTCTGTATTTGCTAACTAGTCTTGTTTTGATTTCTAACGGTCTAGTGGAGTACAGTTA >In-frame_MPDZ_ENST00000381015_chr9_13247634_-_ITPK1_ENST00000267615_chr14_93408249_-_5217nt TGCTGTTAATCATTTCAGAGAAGAACACTGAACTTTGAAAAAAATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCG CTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAAGACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAG TCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGACCAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCAC ATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCACAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCG GCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCGGCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAG GCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCGGCTGCAACGCCGGCGTGTCGCCCAGCTTCCAGCAGCATTGTGTGGCC TCCCTGGCCACCAAGGCCTCCTCCCAGTAGCCACGGAGCCGGGACCCAGAGGGGCAGCGCAGGGCGCAGAGCACACCCGCTGGGCCAGCA GCTCCCAACGGCGATGCTACTACTAAGAATCCCCAGTGATCTGATTCTTCTGTTTTTTAATTTTTAACCTGATTCTCTGATGTCATGATC TAAATGAGGGGTAGTGGGGGATGGAAGAGAGTACCAGGTGGTCCACCGTTGGGGAGTGGGGCCGTCCGCCTGCTCTCTACTGTGCAGACC TCCTAACTGAGTTTACACACGCTTGTGTTTGCAACACTAGGTCTGGATGGGAGGTGAGGGGTGTGCGTATGGCTGCCATGCCAGTGTCTG TGCACATCCCTGTCTGTTGGTCTCCATGGCCACTGTGGACCGGGACCCTTGGGGGAAGCCTGCCCATGTCGGGCTGTGGGAGGCTGATCG GTGCATGTGAGAGTGGCTTCCCTTCTGCCTGACTCCCCACTCCCTGACCTGCCCCTTCCTTGTTTTTCCTCCTACTGGTCTCCACCAAGG CTTTGTTAGCCCCCACCCTGCCTGGTGTGCAGCTAACCCCTCCCTCCCCACAGCCAGAGGAGGCCACAGACCCCTCAGGGGAGTTCCGCG CTGGGGTCTGGGCTGTGCTCCCTCACTAAAGGGAAGGAAAGGAAGCTGGGCGTCCTCTGGGCCCCCCAACACACGTCCCATTTAGCCCTG CACAGCGGTCTCCTTCCCCTAAGCCAGCACTGCTGCTCCCTGGAGCCCGGGAAGGAGGCTGCCTGGCTGGAGGCCCGAGCCGATGGCGCC TGTGCTGAGGATTTGTGCTGTGATTTGGGCAAATCATTCCAGGTCTTTGGGCCTCCACCCCCTTGTCTCTAGTGGACATTTGAGATCAGA GAGCACCACAGGGCTGGCTTTGTGCCCTAACCCCTGGGATGCAGCCTGCCTTTCCATAAAGTCACCTAGGTGAGGATAGGCGCGGGAGCC TCGGCATGACACCATGGAGATCGGGGCCCTCTTCCCAGTGGGTTCACTCCTTTTCACACCTGCTGGGTCCCTCCTCACCCAGCAGGCCTG GTCCACCTCTCATTGCAAGCCCCAAGCACTGAGCCAGCAGGTGCCAGGGAGCCACCCGCCCCCCATCGCTTCTGCACACCTCAGACTCAC CCCATCACCTTGGCAGCAAAGCACTGGCTCTGCCGTCTGACCCCTGATCCAGGCAGCCCCCTCTGCAGAGAAAAGGGTTGGGGAGAAGCC TCTGCAGTCCTGGAAGATGTGGGGTGCTGGGTGAGAGGCATCAGCCCCCACAAGTATGTTTTTGTGTCTTAAGATAGCAGTTTACTTTGA AAAAGTGAAAAAGGCTTCCGGGCTGTCCTCTGCCCAGTGAGATGGAGGACGCTAGAGAAAGTGCTGAGTGTCCCGAGAGAGGCCCCCGAG CCAGTGCATGGAGGTCCTTCGGCCTGGCTCAGCTGGGCTGCAGGATGCCCACTTTGAGGAGGGAGGCACAGGGCTTGGGCGAGGGGCAGA GGCCATCAGAACTGCCCGGCTTTTTTGGAAACTGAGGACCCAACAACTAACCACGTTTACACGACTTGAGTTTTGAACCCCGATTAATGT CTGTACGTCACCTTTCCTAGTTCTGACCCTGAGCCCTGGGGAACAGGAAAGCGTGGCTGGCCTCTTGCACTGCTTTGTCTCCAAAATAAA CTACTGAAATCAAACCGCATTTCACACGTGTTTACACATGTTGCTCAAGTTTGTTATGTCATACTCCCAGTCCTTAAAAGACGTTTAATA AAACAGCTTTACCTTTTAAAAATAAAATTTCAATCCCAGTCTGCCTCAGGTACGGGTGGGGGTGTGCAGCGTGACTCCTGGCTGTGTTCC TGTACCGTTTGTGGCCTCCGGGGTCTTGCGCGTCCAGGGCCCAGATACCGAGTAACTGCCATGTGGTGTCGTGGTGGCGTCCATAGGCCT CCGTGGTGGGGCGGGGGCGGGGCTGTGGGTGTGCAGGGCAGCTGCATTTTCCAAGAGTGGAGATGGAGGATGGAGATTTGCTTCGTAAAG GCCTGGGAGCTACATGGGAGGTAGGGAGGGGCCAGCCACACCCAGGGCTGGGGGGCCGGTGGACTCTGCCCAGTGAAGCCAGGGGAGTGT CAGCAATGAGGGGCCTGGACAGCGACGCGGGACCCGCACCTGGGAGCGGCAGAGATGGAGCCCAGCTCGCTAAACGTACCCTAAGGGTGC ACGCTGACCATCTTTGATCCCTGGACAGTGTCCATAGAGTTGTCTCCCCTTCGGTCACATTGTCCCTGGCCTTGGAGTTTCTGCCTCAGG GAAAGACCCACTAAAACCACCCGGGCTCTGGCGGCCTCCTCTTCTCCAGAGCATGGTGGCGCTGCCTCCTGAGCAGAGTCACTGAGAGTG TCTGGGTCCAAGGAAGGGACCCACTTAGCAAAGGTTGTTGTGTGGTGCTGTGCAGGCACGGCGCCTGGAGTTGGCCCCGCCAGCATCGGG GTGGCTTGGGGCTCTGGTTCCTAAGCTTCTGCTTCTGAGTTGGTCAGCACGTTGGCTCTGCGCCCTGCAGTGCCTGTCTTGATGGTGGTC CCTGGATGTGCTGAAGGGCTCCAGGAGCAAGGGGCCAGACCACACTTTGGCTGAGTCCTTGGGTAGTTTCAGAGGGTCACCTGCACAGTC TGCATTGAGCACCCTGGGGCTGAGGCCGTGGGTCAAGTTCTGCCTGACAGTGCTTTGATTATATGGTGATGTGATTCTGCAAACATAACC CCCCAACTGAGTGCCAGCTGCTGGGTGTCCCCACCCCAAGAGCCAAGGGGAGGCCACCCTGGAACTGGTGCTTTGCCCTTGGTGTCATGG AGGTGTCTGGGTCCACACGTGGTGGGTGGGCTGGGCCTGCAGTCACCCAGCATGGCCGGCGGGATTGGACCCAGCTGCAACCTGGCAGGT TCCATGGGGCTTCCTGTGCCTGGGCCTGCCTGTGTCTCATGCCTGTCAATAAAGGAGAAAGCAACCTGGGAAAAACATTCCTCTCTGTAC CCAGGGGACTGCCAAGTGTGCTTTATAGAAGGCTGGAAGACCGACTGAAGTAGGAAGCTGTCACATGTTTGAGCCAACTGAGCAAAGCAG CTGTTGCCTGCCAGACAGCCACCCCAAGACCAAGGGAGCCAGCCTGTCGTTTGTCCTTCTAGCCTGGAAGACCAGTTCTTGGCTCTTGGG CACTCACATTGGCCACTGGCCACAACTGCTGAATGGCTTCACTAATGTCCCTGGGGTCTGTATCTGCCCTCTCTTCTATTCCCTAGAAAC TCTGGCCGGGCATGGCGGCTCACGCCTGTCATCCCAGCACTTAGGGAGGCTGAGGCAGGTGGATCACAAGGTCAAGAGATCGACACCATC CTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGACATGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGA GGCTGAGGCAGGAGAATTGCTTGAACTCGGGAGGCGTAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGCAACAGAGCA AGACTCCTCAAAAAACAAACAAACAAACAAACAAACTCTGATCATTCACCCGGTGGGATCCCCGGCAGCTCCTTCTCCTTCCCGAGCTGT GGCTCATGGGCCATTGGATTCAGAGACCTTGAGCTGGGTGCTGGCTGCCCTAAAGGAGCACGACCCCTCCAGCCTGGTGACCGGGAGGCA GAGAAGTGCAGCTGTCCTTGACAAAGGCCCAGCCTCTGCTGCCTCAGGCCAGCCTGGCCACACCCCGATGCCACAGTCATCTGCCCCGCC CAGGCATAAGCCTGACTCAGGTGATACAGGCGAGGCTTCTCCCATGGGTCCTCCCCTTGTGAGAAAGGGTCTGTGCTGTGTACCTTCTCT CTGCACAGCCATTGTCAGTGTGGTTTGGAGTGAGTGAGCCTCCCGCACTGCTCAGGGGAGAGCTGGTGAGCATGACTCCATGGCCTCCTG CTGGTTGGGGTCTTCTTCTGATTCTCACCCGCAGGAGCACCCAGACCCCCCCTTTTCAGAAATGATTACATTTTCCCTTCAAGAGTCATC TGTGACCTGGTGGTGTGGAGGGACTGTCCCCTCCTGCAGCCTGGCCGACCCCCTTCCTCCAGGGCTGTGTGGAATCACCTCTCAGAAGCT CACTCTGAAAAGCCACTCACAGGGATTTCACCAGGATGTTGCTGTTCCTGCCGACACCTGGGCTTTGTGACAAATGCTGTTTGCTTCAAG CTGTTCACAAGCAACTTCACCAGAATCCCAAGCTGGTTCGTACTTAATTTGTGTACATACATATGCATAATATACATGACCATGTATGAG ATACAGACACCATGGCTTCTGTCCATTGGCTCATTCGCCTGGTCGCATGTTCACTCCATGAGGTTAGGACACTGCGGGTGGCTTTGGGAT GGGTGGTTTCAGGGACAAGGTGTCGCTATGATCTCTGTATTTGCTAACTAGTCTTGTTTTGATTTCTAACGGTCTAGTGGAGTACAGTTA |
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FusionGenePPI for MPDZ_ITPK1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MPDZ | HTR2C, DRD3, KIT, PLEKHA1, PLEKHA2, AMOT, SSTR3, AMOTL2, LATS2, YAP1, WWOX, ENO1, SHMT2, NXF1, RNF166, LIN7C, LIN7A, MPP5, KRAS, CRK, KIF22, VCL, XRCC5, SNX3, VPS26A, TSC22D2, MTNR1A, WWC1 | ITPK1 | TRAF2, GPS1, TP53, JUN, ITPK1, NFKBIA, MOV10, TRAC, CRYZL1, SCN2B, DNAAF5, MAPK1, CDC5L, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MPDZ_ITPK1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MPDZ_ITPK1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MPDZ | C0001973 | Alcoholic Intoxication, Chronic | 4 | PSYGENET |
| Hgene | MPDZ | C0236663 | Alcohol withdrawal syndrome | 3 | PSYGENET |
| Hgene | MPDZ | C0036572 | Seizures | 1 | CTD_human;HPO |
| Hgene | MPDZ | C0085762 | Alcohol abuse | 1 | PSYGENET |
| Hgene | MPDZ | C0149821 | ACUTE ALCOHOL WITHDRAWAL | 1 | PSYGENET |
| Hgene | MPDZ | C0586323 | Alcohol Withdrawal Seizures | 1 | PSYGENET |
| Tgene | ITPK1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
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