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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22327

FusionGeneSummary for MPDU1_DNAH9

check button Fusion gene summary
Fusion gene informationFusion gene name: MPDU1_DNAH9
Fusion gene ID: 22327
HgeneTgene
Gene symbol

MPDU1

DNAH9

Gene ID

9526

1770

Gene namemannose-P-dolichol utilization defect 1dynein axonemal heavy chain 9
SynonymsCDGIF|HBEBP2BPA|Lec35|My008|PP3958|PQLC5|SL15DNAH17L|DNEL1|DYH9|Dnahc9|HL-20|HL20
Cytomap

17p13.1

17p12

Type of geneprotein-codingprotein-coding
Descriptionmannose-P-dolichol utilization defect 1 proteinHBeAg-binding protein 2 binding protein Asuppressor of Lec15 and Lec35 glycosylation mutation homologdynein heavy chain 9, axonemalDNAH9 variant proteinaxonemal beta dynein heavy chain 9ciliary dynein heavy chain 9dynein, axonemal, heavy polypeptide 9
Modification date2018051920180523
UniProtAcc

O75352

Q9NYC9

Ensembl transtripts involved in fusion geneENST00000582151, ENST00000250124, 
ENST00000396501, ENST00000423172, 
ENST00000262442, ENST00000454412, 
ENST00000608377, ENST00000396001, 
ENST00000579828, 
Fusion gene scores* DoF score7 X 7 X 4=1963 X 4 X 3=36
# samples 104
** MAII scorelog2(10/196*10)=-0.970853654340483
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MPDU1 [Title/Abstract] AND DNAH9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMPDU1

GO:0009312

oligosaccharide biosynthetic process

11179430


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-X6-A8C4-01AMPDU1chr17

7487283

+DNAH9chr17

11790142

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000582151ENST00000262442MPDU1chr17

7487283

+DNAH9chr17

11790142

+
Frame-shiftENST00000582151ENST00000454412MPDU1chr17

7487283

+DNAH9chr17

11790142

+
5CDS-5UTRENST00000582151ENST00000608377MPDU1chr17

7487283

+DNAH9chr17

11790142

+
5CDS-3UTRENST00000582151ENST00000396001MPDU1chr17

7487283

+DNAH9chr17

11790142

+
5CDS-intronENST00000582151ENST00000579828MPDU1chr17

7487283

+DNAH9chr17

11790142

+
Frame-shiftENST00000250124ENST00000262442MPDU1chr17

7487283

+DNAH9chr17

11790142

+
Frame-shiftENST00000250124ENST00000454412MPDU1chr17

7487283

+DNAH9chr17

11790142

+
5CDS-5UTRENST00000250124ENST00000608377MPDU1chr17

7487283

+DNAH9chr17

11790142

+
5CDS-3UTRENST00000250124ENST00000396001MPDU1chr17

7487283

+DNAH9chr17

11790142

+
5CDS-intronENST00000250124ENST00000579828MPDU1chr17

7487283

+DNAH9chr17

11790142

+
Frame-shiftENST00000396501ENST00000262442MPDU1chr17

7487283

+DNAH9chr17

11790142

+
Frame-shiftENST00000396501ENST00000454412MPDU1chr17

7487283

+DNAH9chr17

11790142

+
5CDS-5UTRENST00000396501ENST00000608377MPDU1chr17

7487283

+DNAH9chr17

11790142

+
5CDS-3UTRENST00000396501ENST00000396001MPDU1chr17

7487283

+DNAH9chr17

11790142

+
5CDS-intronENST00000396501ENST00000579828MPDU1chr17

7487283

+DNAH9chr17

11790142

+
Frame-shiftENST00000423172ENST00000262442MPDU1chr17

7487283

+DNAH9chr17

11790142

+
Frame-shiftENST00000423172ENST00000454412MPDU1chr17

7487283

+DNAH9chr17

11790142

+
5CDS-5UTRENST00000423172ENST00000608377MPDU1chr17

7487283

+DNAH9chr17

11790142

+
5CDS-3UTRENST00000423172ENST00000396001MPDU1chr17

7487283

+DNAH9chr17

11790142

+
5CDS-intronENST00000423172ENST00000579828MPDU1chr17

7487283

+DNAH9chr17

11790142

+

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FusionProtFeatures for MPDU1_DNAH9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPDU1

O75352

DNAH9

Q9NYC9

Required for normal utilization of mannose-dolicholphosphate (Dol-P-Man) in the synthesis of N-linked and O-linkedoligosaccharides and GPI anchors. {ECO:0000250}. Force generating protein of respiratory cilia. Producesforce towards the minus ends of microtubules. Dynein has ATPaseactivity; the force-producing power stroke is thought to occur onrelease of ADP.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MPDU1_DNAH9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MPDU1_DNAH9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MPDU1MORF4L2, PMVK, SLC1A5, QRICH2, RPS3A, HERC2, SHBG, LSM1, MOV10, NXF1DNAH9BCL6, FAM103A1, SRPK2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MPDU1_DNAH9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MPDU1_DNAH9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMPDU1C1836669CONGENITAL DISORDER OF GLYCOSYLATION, TYPE If2CTD_human;ORPHANET;UNIPROT