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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22307

FusionGeneSummary for MORF4L2_GLRA4

check button Fusion gene summary
Fusion gene informationFusion gene name: MORF4L2_GLRA4
Fusion gene ID: 22307
HgeneTgene
Gene symbol

MORF4L2

GLRA4

Gene ID

9643

441509

Gene namemortality factor 4 like 2glycine receptor alpha 4
SynonymsMORFL2|MRGX-
Cytomap

Xq22.2

Xq22.2

Type of geneprotein-codingprotein-coding
Descriptionmortality factor 4-like protein 2MORF-related gene X proteinMSL3-2 proteinprotein MSL3-2transcription factor-like protein MRGXglycine receptor subunit alpha-4
Modification date2018052320180523
UniProtAcc

Q15014

Q5JXX5

Ensembl transtripts involved in fusion geneENST00000360458, ENST00000422154, 
ENST00000451301, ENST00000433176, 
ENST00000423833, ENST00000441076, 
ENST00000492116, 
ENST00000372617, 
ENST00000469567, 
Fusion gene scores* DoF score3 X 3 X 2=181 X 1 X 1=1
# samples 31
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: MORF4L2 [Title/Abstract] AND GLRA4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-44-7660-01AMORF4L2chrX

102933427

-GLRA4chrX

102974199

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000360458ENST00000372617MORF4L2chrX

102933427

-GLRA4chrX

102974199

-
5UTR-intronENST00000360458ENST00000469567MORF4L2chrX

102933427

-GLRA4chrX

102974199

-
5UTR-3CDSENST00000422154ENST00000372617MORF4L2chrX

102933427

-GLRA4chrX

102974199

-
5UTR-intronENST00000422154ENST00000469567MORF4L2chrX

102933427

-GLRA4chrX

102974199

-
intron-3CDSENST00000451301ENST00000372617MORF4L2chrX

102933427

-GLRA4chrX

102974199

-
intron-intronENST00000451301ENST00000469567MORF4L2chrX

102933427

-GLRA4chrX

102974199

-
5UTR-3CDSENST00000433176ENST00000372617MORF4L2chrX

102933427

-GLRA4chrX

102974199

-
5UTR-intronENST00000433176ENST00000469567MORF4L2chrX

102933427

-GLRA4chrX

102974199

-
5UTR-3CDSENST00000423833ENST00000372617MORF4L2chrX

102933427

-GLRA4chrX

102974199

-
5UTR-intronENST00000423833ENST00000469567MORF4L2chrX

102933427

-GLRA4chrX

102974199

-
5UTR-3CDSENST00000441076ENST00000372617MORF4L2chrX

102933427

-GLRA4chrX

102974199

-
5UTR-intronENST00000441076ENST00000469567MORF4L2chrX

102933427

-GLRA4chrX

102974199

-
intron-3CDSENST00000492116ENST00000372617MORF4L2chrX

102933427

-GLRA4chrX

102974199

-
intron-intronENST00000492116ENST00000469567MORF4L2chrX

102933427

-GLRA4chrX

102974199

-

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FusionProtFeatures for MORF4L2_GLRA4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MORF4L2

Q15014

GLRA4

Q5JXX5

Component of the NuA4 histone acetyltransferase complexwhich is involved in transcriptional activation of select genesprincipally by acetylation of nucleosomal histone H4 and H2A. Thismodification may both alter nucleosome - DNA interactions andpromote interaction of the modified histones with other proteinswhich positively regulate transcription. This complex may berequired for the activation of transcriptional programs associatedwith oncogene and proto-oncogene mediated growth induction, tumorsuppressor mediated growth arrest and replicative senescence,apoptosis, and DNA repair. The NuA4 complex ATPase and helicaseactivities seem to be, at least in part, contributed by theassociation of RUVBL1 and RUVBL2 with EP400. NuA4 may also play adirect role in DNA repair when directly recruited to sites of DNAdamage. Also component of the MSIN3A complex which acts to represstranscription by deacetylation of nucleosomal histones. Glycine receptors are ligand-gated chloride channels.Channel opening is triggered by extracellular glycine. Channelopening is also triggered by taurine and beta-alanine. Plays arole in the down-regulation of neuronal excitability. Contributesto the generation of inhibitory postsynaptic currents.{ECO:0000250|UniProtKB:Q61603}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MORF4L2_GLRA4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MORF4L2_GLRA4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MORF4L2MPDU1, PITPNA, RB1, MRFAP1, HDAC9, SIN3A, MRGBP, SRCAP, KDM5A, BRD8, SIN3B, PHF12, EPC1, EPC2, KPNB1, HNRNPU, ZNF131, MBTD1, HSPA4, HNRNPM, LMNA, HDAC1, HDAC2, DMAP1, HNRNPK, TUBB2A, TUBA1A, KPNA2, KAT5, RBBP7, RUVBL1, RUVBL2, ACTL6A, ACTA1, ACTB, ACTG1, H2AFV, HIST2H2BE, PALB2, TRRAP, EP400, RBP2, HIST2H2AC, MORF4L1, TAB1, CDR2, RPA3, RPA2, RPA1, ITGB1BP2, AES, PHC2, GOLGA2, TNNT2, ZBTB14, TNIP1, IKZF1, PNMA2, ZBTB43, KLHL3, ZBTB7B, THAP1, CEP55, GRAMD3, ZBTB10, LZTS2, L3MBTL3, MRFAP1L1, DDIT4L, FAM9B, BEND7, BRCA1, GATAD1, FOXR2, HIST1H2BA, YEATS4, HNRNPR, KPNA1, KPNA6, PDIA5, SYNCRIP, VAPB, BLM, HIST1H2BG, EXOSC1, FBXW7, FOXO1, FOXR1, UBXN7, C11orf30, EP400NL, ASH1L, SATB2, MEAF6, VPS72, ING3, JAZF1, BRCA2GLRA4SRPK2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MORF4L2_GLRA4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MORF4L2_GLRA4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource