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Fusion gene ID: 22305 |
FusionGeneSummary for MORF4L1_RAB21 |
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Fusion gene information | Fusion gene name: MORF4L1_RAB21 | Fusion gene ID: 22305 | Hgene | Tgene | Gene symbol | MORF4L1 | RAB21 | Gene ID | 10933 | 23011 |
Gene name | mortality factor 4 like 1 | RAB21, member RAS oncogene family | |
Synonyms | Eaf3|FWP006|HsT17725|MEAF3|MORFRG15|MRG15|S863-6 | - | |
Cytomap | 15q25.1 | 12q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | mortality factor 4-like protein 1Esa1p-associated factor 3 homologMORF-related gene 15 proteinMORF-related gene on chromosome 15protein MSL3-1transcription factor-like protein MRG15 | ras-related protein Rab-21GTP-binding protein RAB21 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UBU8 | Q9UL25 | |
Ensembl transtripts involved in fusion gene | ENST00000379535, ENST00000426013, ENST00000331268, ENST00000558746, ENST00000559345, ENST00000561171, ENST00000558502, | ENST00000261263, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 2=18 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MORF4L1 [Title/Abstract] AND RAB21 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MORF4L1 | GO:0000724 | double-strand break repair via homologous recombination | 20332121 |
Hgene | MORF4L1 | GO:0016575 | histone deacetylation | 14966270 |
Hgene | MORF4L1 | GO:0043967 | histone H4 acetylation | 14966270 |
Hgene | MORF4L1 | GO:0043968 | histone H2A acetylation | 14966270 |
Tgene | RAB21 | GO:0017157 | regulation of exocytosis | 22705394 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ430384 | MORF4L1 | chr15 | 79190513 | + | RAB21 | chr12 | 72179939 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000379535 | ENST00000261263 | MORF4L1 | chr15 | 79190513 | + | RAB21 | chr12 | 72179939 | + |
intron-3UTR | ENST00000426013 | ENST00000261263 | MORF4L1 | chr15 | 79190513 | + | RAB21 | chr12 | 72179939 | + |
intron-3UTR | ENST00000331268 | ENST00000261263 | MORF4L1 | chr15 | 79190513 | + | RAB21 | chr12 | 72179939 | + |
intron-3UTR | ENST00000558746 | ENST00000261263 | MORF4L1 | chr15 | 79190513 | + | RAB21 | chr12 | 72179939 | + |
intron-3UTR | ENST00000559345 | ENST00000261263 | MORF4L1 | chr15 | 79190513 | + | RAB21 | chr12 | 72179939 | + |
intron-3UTR | ENST00000561171 | ENST00000261263 | MORF4L1 | chr15 | 79190513 | + | RAB21 | chr12 | 72179939 | + |
intron-3UTR | ENST00000558502 | ENST00000261263 | MORF4L1 | chr15 | 79190513 | + | RAB21 | chr12 | 72179939 | + |
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FusionProtFeatures for MORF4L1_RAB21 |
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Hgene | Tgene |
MORF4L1 | RAB21 |
Regulates integrin internalization and recycling, butdoes not influence the traffic of endosomally translocatedreceptors in general. As a result, may regulate cell adhesion andmigration (By similarity). During the mitosis of adherent cells,controls the endosomal trafficking of integrins which is requiredfor the successful completion of cytokinesis. Involved in neuritegrowth (By similarity). {ECO:0000250,ECO:0000250|UniProtKB:Q6AXT5, ECO:0000269|PubMed:18804435}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MORF4L1_RAB21 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MORF4L1_RAB21 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MORF4L1_RAB21 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MORF4L1_RAB21 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MORF4L1 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |