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Fusion gene ID: 2228 |
FusionGeneSummary for APOL2_SNCA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: APOL2_SNCA | Fusion gene ID: 2228 | Hgene | Tgene | Gene symbol | APOL2 | SNCA | Gene ID | 23780 | 6622 |
| Gene name | apolipoprotein L2 | synuclein alpha | |
| Synonyms | APOL-II|APOL3 | NACP|PARK1|PARK4|PD1 | |
| Cytomap | 22q12.3 | 4q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | apolipoprotein L2apolipoprotein L, 2apolipoprotein L-II | alpha-synucleinI+/--synucleinnon A-beta component of AD amyloidsynuclein alpha-140synuclein, alpha (non A4 component of amyloid precursor) | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9BQE5 | P37840 | |
| Ensembl transtripts involved in fusion gene | ENST00000358502, ENST00000249066, ENST00000451256, ENST00000476579, | ENST00000420646, ENST00000394989, ENST00000345009, ENST00000394986, ENST00000394991, ENST00000336904, ENST00000508895, ENST00000506244, ENST00000505199, ENST00000502987, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: APOL2 [Title/Abstract] AND SNCA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SNCA | GO:0001921 | positive regulation of receptor recycling | 18980610 |
| Tgene | SNCA | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 21050448 |
| Tgene | SNCA | GO:0010040 | response to iron(II) ion | 11850416 |
| Tgene | SNCA | GO:0010517 | regulation of phospholipase activity | 15641770 |
| Tgene | SNCA | GO:0010642 | negative regulation of platelet-derived growth factor receptor signaling pathway | 12239163 |
| Tgene | SNCA | GO:0031115 | negative regulation of microtubule polymerization | 21127069 |
| Tgene | SNCA | GO:0031623 | receptor internalization | 18980610 |
| Tgene | SNCA | GO:0031648 | protein destabilization | 21320589 |
| Tgene | SNCA | GO:0032026 | response to magnesium ion | 11850416 |
| Tgene | SNCA | GO:0032410 | negative regulation of transporter activity | 16882008 |
| Tgene | SNCA | GO:0032496 | response to lipopolysaccharide | 12406186 |
| Tgene | SNCA | GO:0032769 | negative regulation of monooxygenase activity | 11943812 |
| Tgene | SNCA | GO:0034341 | response to interferon-gamma | 19157893 |
| Tgene | SNCA | GO:0035067 | negative regulation of histone acetylation | 16959795 |
| Tgene | SNCA | GO:0045807 | positive regulation of endocytosis | 18980610 |
| Tgene | SNCA | GO:0050729 | positive regulation of inflammatory response | 25533483 |
| Tgene | SNCA | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 15641770 |
| Tgene | SNCA | GO:0051585 | negative regulation of dopamine uptake involved in synaptic transmission | 12958153 |
| Tgene | SNCA | GO:0051612 | negative regulation of serotonin uptake | 16882008 |
| Tgene | SNCA | GO:0051622 | negative regulation of norepinephrine uptake | 17156375 |
| Tgene | SNCA | GO:0055074 | calcium ion homeostasis | 12239163 |
| Tgene | SNCA | GO:0055114 | oxidation-reduction process | 21320589 |
| Tgene | SNCA | GO:0060732 | positive regulation of inositol phosphate biosynthetic process | 15641770 |
| Tgene | SNCA | GO:0070495 | negative regulation of thrombin-activated receptor signaling pathway | 12239163 |
| Tgene | SNCA | GO:0070555 | response to interleukin-1 | 12406186 |
| Tgene | SNCA | GO:0071280 | cellular response to copper ion | 21320589 |
| Tgene | SNCA | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 21127069 |
| Tgene | SNCA | GO:1901215 | negative regulation of neuron death | 15863497 |
| Tgene | SNCA | GO:1901216 | positive regulation of neuron death | 25533483 |
| Tgene | SNCA | GO:1903284 | positive regulation of glutathione peroxidase activity | 23507046 |
| Tgene | SNCA | GO:1903285 | positive regulation of hydrogen peroxide catabolic process | 23507046 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA153823 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000358502 | ENST00000420646 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000358502 | ENST00000394989 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000358502 | ENST00000345009 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000358502 | ENST00000394986 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000358502 | ENST00000394991 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000358502 | ENST00000336904 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000358502 | ENST00000508895 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000358502 | ENST00000506244 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000358502 | ENST00000505199 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000358502 | ENST00000502987 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000249066 | ENST00000420646 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000249066 | ENST00000394989 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000249066 | ENST00000345009 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000249066 | ENST00000394986 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000249066 | ENST00000394991 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000249066 | ENST00000336904 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000249066 | ENST00000508895 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000249066 | ENST00000506244 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000249066 | ENST00000505199 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000249066 | ENST00000502987 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000451256 | ENST00000420646 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000451256 | ENST00000394989 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000451256 | ENST00000345009 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000451256 | ENST00000394986 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000451256 | ENST00000394991 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000451256 | ENST00000336904 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000451256 | ENST00000508895 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000451256 | ENST00000506244 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000451256 | ENST00000505199 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000451256 | ENST00000502987 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000476579 | ENST00000420646 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000476579 | ENST00000394989 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000476579 | ENST00000345009 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000476579 | ENST00000394986 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000476579 | ENST00000394991 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000476579 | ENST00000336904 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000476579 | ENST00000508895 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000476579 | ENST00000506244 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000476579 | ENST00000505199 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
| intron-intron | ENST00000476579 | ENST00000502987 | APOL2 | chr22 | 36635515 | - | SNCA | chr4 | 90650416 | - |
Top |
FusionProtFeatures for APOL2_SNCA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| APOL2 | SNCA |
| May be involved in the regulation of dopamine releaseand transport. Induces fibrillization of microtubule-associatedprotein tau. Reduces neuronal responsiveness to various apoptoticstimuli, leading to a decreased caspase-3 activation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for APOL2_SNCA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for APOL2_SNCA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for APOL2_SNCA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for APOL2_SNCA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | APOL2 | C0024809 | Marijuana Abuse | 1 | CTD_human |
| Hgene | APOL2 | C0031391 | Phencyclidine Abuse | 1 | CTD_human |
| Hgene | APOL2 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| Tgene | SNCA | C0030567 | Parkinson Disease | 27 | CTD_human |
| Tgene | SNCA | C1868595 | PARKINSON DISEASE 1, AUTOSOMAL DOMINANT (disorder) | 9 | CTD_human;UNIPROT |
| Tgene | SNCA | C0001973 | Alcoholic Intoxication, Chronic | 6 | CTD_human;PSYGENET |
| Tgene | SNCA | C0242422 | Parkinsonian Disorders | 4 | CTD_human;HPO |
| Tgene | SNCA | C0524851 | Neurodegenerative Disorders | 4 | CTD_human |
| Tgene | SNCA | C0027746 | Nerve Degeneration | 2 | CTD_human |
| Tgene | SNCA | C0752347 | Lewy Body Disease | 2 | CTD_human;HPO;UNIPROT |
| Tgene | SNCA | C0017205 | Gaucher Disease | 1 | CTD_human |
| Tgene | SNCA | C0019202 | Hepatolenticular Degeneration | 1 | CTD_human |
| Tgene | SNCA | C0033941 | Psychoses, Substance-Induced | 1 | CTD_human |
| Tgene | SNCA | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| Tgene | SNCA | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| Tgene | SNCA | C0677050 | Manganese Poisoning | 1 | CTD_human |
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