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Fusion gene ID: 22273 |
FusionGeneSummary for MOCOS_MEI4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MOCOS_MEI4 | Fusion gene ID: 22273 | Hgene | Tgene | Gene symbol | MOCOS | MEI4 | Gene ID | 55034 | 101928601 |
| Gene name | molybdenum cofactor sulfurase | meiotic double-stranded break formation protein 4 | |
| Synonyms | HMCS|MCS|MOS | - | |
| Cytomap | 18q12.2 | 6q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | molybdenum cofactor sulfurase | meiosis-specific protein MEI4meiosis-specific 4 homologmeiosis-specific protein MEI4-like | |
| Modification date | 20180519 | 20180329 | |
| UniProtAcc | Q96EN8 | A8MW99 | |
| Ensembl transtripts involved in fusion gene | ENST00000261326, ENST00000588132, | ENST00000602452, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: MOCOS [Title/Abstract] AND MEI4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-AB2T-01A | MOCOS | chr18 | 33785239 | + | MEI4 | chr6 | 78632806 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000261326 | ENST00000602452 | MOCOS | chr18 | 33785239 | + | MEI4 | chr6 | 78632806 | + |
| intron-3CDS | ENST00000588132 | ENST00000602452 | MOCOS | chr18 | 33785239 | + | MEI4 | chr6 | 78632806 | + |
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FusionProtFeatures for MOCOS_MEI4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MOCOS | MEI4 |
| Sulfurates the molybdenum cofactor. Sulfation ofmolybdenum is essential for xanthine dehydrogenase (XDH) andaldehyde oxidase (ADO) enzymes in which molybdenum cofactor isliganded by 1 oxygen and 1 sulfur atom in active form. In vitro,the C-terminal domain is able to reduce N-hydroxylated prodrugs,such as benzamidoxime. {ECO:0000255|HAMAP-Rule:MF_03050,ECO:0000269|PubMed:16973608}. | Required for DNA double-strand breaks (DSBs) formationin unsynapsed regions during meiotic recombination. Probably actsby forming a complex with IHO1/CCDC36 and REC114, which activatesDSBs formation in unsynapsed regions, an essential step to ensurecompletion of synapsis. {ECO:0000250|UniProtKB:Q8BRM6}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MOCOS_MEI4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MOCOS_MEI4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MOCOS | APOA1, PARVA, RAB3A, KLK11, TSHR, HSD17B8, HDAC7, CHIA, PLAU, RIMKLA, PSAT1, SEPT8, XPO1, MRPL50, CNTROB, IFIT1B, RGS20, IRF3, DOCK5, TKT, DNAJC7, IQCF1, CRTAC1, TULP2 | MEI4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MOCOS_MEI4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | MOCOS | Q96EN8 | DB00114 | Pyridoxal Phosphate | Molybdenum cofactor sulfurase {ECO:0000255|HAMAP-Rule:MF_03050} | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for MOCOS_MEI4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MOCOS | C1863688 | Xanthinuria, Type II | 2 | ORPHANET;UNIPROT |
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