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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22272

FusionGeneSummary for MOBP_BOLA2

check button Fusion gene summary
Fusion gene informationFusion gene name: MOBP_BOLA2
Fusion gene ID: 22272
HgeneTgene
Gene symbol

MOBP

BOLA2

Gene ID

4336

654483

Gene namemyelin-associated oligodendrocyte basic proteinbolA family member 2B
Synonyms-BOLA2
Cytomap

3p22.1

16p11.2

Type of geneprotein-codingprotein-coding
Descriptionmyelin-associated oligodendrocyte basic proteinbolA-like protein 2BolA-like protein 2 member BbolA homolog 2BbolA-like protein 2B
Modification date2018052320180519
UniProtAcc

Q13875

Q9H3K6

Ensembl transtripts involved in fusion geneENST00000354668, ENST00000428261, 
ENST00000420739, ENST00000415443, 
ENST00000447324, ENST00000383754, 
ENST00000441980, ENST00000311042, 
ENST00000396228, ENST00000479860, 
ENST00000330978, 
Fusion gene scores* DoF score1 X 1 X 1=119 X 26 X 1=494
# samples 128
** MAII scorelog2(1/1*10)=3.32192809488736log2(28/494*10)=-0.819084214639711
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MOBP [Title/Abstract] AND BOLA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBOLA2

GO:0044571

[2Fe-2S] cluster assembly

27519415

TgeneBOLA2

GO:0097428

protein maturation by iron-sulfur cluster transfer

27519415


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF932390MOBPchr3

39567238

+BOLA2chr16

30078851

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000354668ENST00000330978MOBPchr3

39567238

+BOLA2chr16

30078851

+
intron-intronENST00000428261ENST00000330978MOBPchr3

39567238

+BOLA2chr16

30078851

+
intron-intronENST00000420739ENST00000330978MOBPchr3

39567238

+BOLA2chr16

30078851

+
intron-intronENST00000415443ENST00000330978MOBPchr3

39567238

+BOLA2chr16

30078851

+
intron-intronENST00000447324ENST00000330978MOBPchr3

39567238

+BOLA2chr16

30078851

+
intron-intronENST00000383754ENST00000330978MOBPchr3

39567238

+BOLA2chr16

30078851

+
intron-intronENST00000441980ENST00000330978MOBPchr3

39567238

+BOLA2chr16

30078851

+
intron-intronENST00000311042ENST00000330978MOBPchr3

39567238

+BOLA2chr16

30078851

+
intron-intronENST00000396228ENST00000330978MOBPchr3

39567238

+BOLA2chr16

30078851

+
intron-intronENST00000479860ENST00000330978MOBPchr3

39567238

+BOLA2chr16

30078851

+

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FusionProtFeatures for MOBP_BOLA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MOBP

Q13875

BOLA2

Q9H3K6

May play a role in compacting or stabilizing the myelinsheath, possibly by binding the negatively charged acidicphospholipids of the cytoplasmic membrane. {ECO:0000250}. Acts as a cytosolic iron-sulfur (Fe-S) cluster assemblyfactor that facilitates [2Fe-2S] cluster insertion into a subsetof cytosolic proteins (PubMed:26613676, PubMed:27519415). Actstogether with the monothiol glutaredoxin GLRX3 (PubMed:26613676,PubMed:27519415). {ECO:0000269|PubMed:26613676,ECO:0000269|PubMed:27519415}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MOBP_BOLA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MOBP_BOLA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MOBP_BOLA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MOBP_BOLA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMOBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneMOBPC0002736Amyotrophic Lateral Sclerosis1CTD_human
HgeneMOBPC0036341Schizophrenia1PSYGENET
HgeneMOBPC0038868Progressive supranuclear palsy1CTD_human