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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22269

FusionGeneSummary for MOB3C_ATPAF1

check button Fusion gene summary
Fusion gene informationFusion gene name: MOB3C_ATPAF1
Fusion gene ID: 22269
HgeneTgene
Gene symbol

MOB3C

ATPAF1

Gene ID

148932

64756

Gene nameMOB kinase activator 3CATP synthase mitochondrial F1 complex assembly factor 1
SynonymsMOB1E|MOBKL2CATP11|ATP11p
Cytomap

1p33

1p33

Type of geneprotein-codingprotein-coding
DescriptionMOB kinase activator 3CMOB1, Mps One Binder kinase activator-like 2Cmob1 homolog 2CATP synthase mitochondrial F1 complex assembly factor 1homolog of yeast ATP11
Modification date2018051920180523
UniProtAcc

Q70IA8

Q5TC12

Ensembl transtripts involved in fusion geneENST00000319928, ENST00000271139, 
ENST00000371940, ENST00000477318, 
ENST00000576409, ENST00000574428, 
ENST00000371937, ENST00000542495, 
ENST00000329231, ENST00000532925, 
ENST00000525633, 
Fusion gene scores* DoF score2 X 1 X 2=43 X 3 X 2=18
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MOB3C [Title/Abstract] AND ATPAF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-0893-01BMOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000319928ENST00000576409MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
5UTR-3CDSENST00000319928ENST00000574428MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
5UTR-3CDSENST00000319928ENST00000371937MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
5UTR-5UTRENST00000319928ENST00000542495MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
5UTR-5UTRENST00000319928ENST00000329231MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
5UTR-5UTRENST00000319928ENST00000532925MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
5UTR-5UTRENST00000319928ENST00000525633MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
intron-3CDSENST00000271139ENST00000576409MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
intron-3CDSENST00000271139ENST00000574428MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
intron-3CDSENST00000271139ENST00000371937MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
intron-5UTRENST00000271139ENST00000542495MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
intron-5UTRENST00000271139ENST00000329231MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
intron-5UTRENST00000271139ENST00000532925MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
intron-5UTRENST00000271139ENST00000525633MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
intron-3CDSENST00000371940ENST00000576409MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
intron-3CDSENST00000371940ENST00000574428MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
intron-3CDSENST00000371940ENST00000371937MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
intron-5UTRENST00000371940ENST00000542495MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
intron-5UTRENST00000371940ENST00000329231MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
intron-5UTRENST00000371940ENST00000532925MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
intron-5UTRENST00000371940ENST00000525633MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
5UTR-3CDSENST00000477318ENST00000576409MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
5UTR-3CDSENST00000477318ENST00000574428MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
5UTR-3CDSENST00000477318ENST00000371937MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
5UTR-5UTRENST00000477318ENST00000542495MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
5UTR-5UTRENST00000477318ENST00000329231MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
5UTR-5UTRENST00000477318ENST00000532925MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-
5UTR-5UTRENST00000477318ENST00000525633MOB3Cchr1

47082383

-ATPAF1chr1

47131036

-

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FusionProtFeatures for MOB3C_ATPAF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MOB3C

Q70IA8

ATPAF1

Q5TC12

May regulate the activity of kinases. {ECO:0000250}. May play an essential role for the assembly of themitochondrial F1-F0 complex. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MOB3C_ATPAF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MOB3C_ATPAF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MOB3CLATS1, LATS2, APP, SIAH1, TDO2, TFCP2, TNIP1, NT5C2, FAM118A, ZBTB10, CMTM3, KRT40, C10orf107, MAU2, TRIM25ATPAF1ATP5B, ERAL1, RAD18, OTC, NDUFS7, RPUSD3, OXCT2, YBEY


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MOB3C_ATPAF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MOB3C_ATPAF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneATPAF1C0028754Obesity1CTD_human