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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22258

FusionGeneSummary for MOB2_TNFAIP8

check button Fusion gene summary
Fusion gene informationFusion gene name: MOB2_TNFAIP8
Fusion gene ID: 22258
HgeneTgene
Gene symbol

MOB2

TNFAIP8

Gene ID

81532

25816

Gene nameMOB kinase activator 2TNF alpha induced protein 8
SynonymsHCCA2GG2-1|MDC-3.13|NDED|SCC-S2|SCCS2
Cytomap

11p15.5

5q23.1

Type of geneprotein-codingprotein-coding
DescriptionMOB kinase activator 2MOB2 Mps One Binder homologMps one binder kinase activator-like 2tumor necrosis factor alpha-induced protein 8NF-kappa-B-inducible DED-containing proteinTNF-induced protein GG2-1head and neck tumor and metastasis-related proteintumor necrosis factor, alpha induced protein 8
Modification date2018051920180523
UniProtAcc

Q70IA6

O95379

Ensembl transtripts involved in fusion geneENST00000329957, ENST00000526462, 
ENST00000274456, ENST00000513374, 
ENST00000504771, ENST00000503646, 
ENST00000504642, ENST00000415806, 
Fusion gene scores* DoF score9 X 12 X 2=2165 X 4 X 4=80
# samples 126
** MAII scorelog2(12/216*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MOB2 [Title/Abstract] AND TNFAIP8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF868816MOB2chr11

1774494

+TNFAIP8chr5

118704541

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000329957ENST00000274456MOB2chr11

1774494

+TNFAIP8chr5

118704541

+
intron-intronENST00000329957ENST00000513374MOB2chr11

1774494

+TNFAIP8chr5

118704541

+
intron-intronENST00000329957ENST00000504771MOB2chr11

1774494

+TNFAIP8chr5

118704541

+
intron-intronENST00000329957ENST00000503646MOB2chr11

1774494

+TNFAIP8chr5

118704541

+
intron-intronENST00000329957ENST00000504642MOB2chr11

1774494

+TNFAIP8chr5

118704541

+
intron-intronENST00000329957ENST00000415806MOB2chr11

1774494

+TNFAIP8chr5

118704541

+
intron-intronENST00000526462ENST00000274456MOB2chr11

1774494

+TNFAIP8chr5

118704541

+
intron-intronENST00000526462ENST00000513374MOB2chr11

1774494

+TNFAIP8chr5

118704541

+
intron-intronENST00000526462ENST00000504771MOB2chr11

1774494

+TNFAIP8chr5

118704541

+
intron-intronENST00000526462ENST00000503646MOB2chr11

1774494

+TNFAIP8chr5

118704541

+
intron-intronENST00000526462ENST00000504642MOB2chr11

1774494

+TNFAIP8chr5

118704541

+
intron-intronENST00000526462ENST00000415806MOB2chr11

1774494

+TNFAIP8chr5

118704541

+

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FusionProtFeatures for MOB2_TNFAIP8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MOB2

Q70IA6

TNFAIP8

O95379

Stimulates the autophosphorylation and kinase activityof STK38 and STK38L. {ECO:0000269|PubMed:15067004}. Acts as a negative mediator of apoptosis and may play arole in tumor progression. Suppresses the TNF-mediated apoptosisby inhibiting caspase-8 activity but not the processing ofprocaspase-8, subsequently resulting in inhibition of BID cleavageand caspase-3 activation. {ECO:0000269|PubMed:10644768,ECO:0000269|PubMed:11346652, ECO:0000269|PubMed:14724590}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MOB2_TNFAIP8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MOB2_TNFAIP8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MOB2_TNFAIP8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MOB2_TNFAIP8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTNFAIP8C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTNFAIP8C0027627Neoplasm Metastasis1CTD_human
TgeneTNFAIP8C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneTNFAIP8C3495559Juvenile arthritis1CTD_human