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Fusion gene ID: 22258 |
FusionGeneSummary for MOB2_TNFAIP8 |
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Fusion gene information | Fusion gene name: MOB2_TNFAIP8 | Fusion gene ID: 22258 | Hgene | Tgene | Gene symbol | MOB2 | TNFAIP8 | Gene ID | 81532 | 25816 |
Gene name | MOB kinase activator 2 | TNF alpha induced protein 8 | |
Synonyms | HCCA2 | GG2-1|MDC-3.13|NDED|SCC-S2|SCCS2 | |
Cytomap | 11p15.5 | 5q23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | MOB kinase activator 2MOB2 Mps One Binder homologMps one binder kinase activator-like 2 | tumor necrosis factor alpha-induced protein 8NF-kappa-B-inducible DED-containing proteinTNF-induced protein GG2-1head and neck tumor and metastasis-related proteintumor necrosis factor, alpha induced protein 8 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q70IA6 | O95379 | |
Ensembl transtripts involved in fusion gene | ENST00000329957, ENST00000526462, | ENST00000274456, ENST00000513374, ENST00000504771, ENST00000503646, ENST00000504642, ENST00000415806, | |
Fusion gene scores | * DoF score | 9 X 12 X 2=216 | 5 X 4 X 4=80 |
# samples | 12 | 6 | |
** MAII score | log2(12/216*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MOB2 [Title/Abstract] AND TNFAIP8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF868816 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000329957 | ENST00000274456 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
intron-intron | ENST00000329957 | ENST00000513374 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
intron-intron | ENST00000329957 | ENST00000504771 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
intron-intron | ENST00000329957 | ENST00000503646 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
intron-intron | ENST00000329957 | ENST00000504642 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
intron-intron | ENST00000329957 | ENST00000415806 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
intron-intron | ENST00000526462 | ENST00000274456 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
intron-intron | ENST00000526462 | ENST00000513374 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
intron-intron | ENST00000526462 | ENST00000504771 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
intron-intron | ENST00000526462 | ENST00000503646 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
intron-intron | ENST00000526462 | ENST00000504642 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
intron-intron | ENST00000526462 | ENST00000415806 | MOB2 | chr11 | 1774494 | + | TNFAIP8 | chr5 | 118704541 | + |
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FusionProtFeatures for MOB2_TNFAIP8 |
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Hgene | Tgene |
MOB2 | TNFAIP8 |
Stimulates the autophosphorylation and kinase activityof STK38 and STK38L. {ECO:0000269|PubMed:15067004}. | Acts as a negative mediator of apoptosis and may play arole in tumor progression. Suppresses the TNF-mediated apoptosisby inhibiting caspase-8 activity but not the processing ofprocaspase-8, subsequently resulting in inhibition of BID cleavageand caspase-3 activation. {ECO:0000269|PubMed:10644768,ECO:0000269|PubMed:11346652, ECO:0000269|PubMed:14724590}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MOB2_TNFAIP8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MOB2_TNFAIP8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MOB2_TNFAIP8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MOB2_TNFAIP8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TNFAIP8 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | TNFAIP8 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | TNFAIP8 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Tgene | TNFAIP8 | C3495559 | Juvenile arthritis | 1 | CTD_human |