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Fusion gene ID: 22250 |
FusionGeneSummary for MOB1B_RUFY3 |
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Fusion gene information | Fusion gene name: MOB1B_RUFY3 | Fusion gene ID: 22250 | Hgene | Tgene | Gene symbol | MOB1B | RUFY3 | Gene ID | 92597 | 79443 |
Gene name | MOB kinase activator 1B | FYVE and coiled-coil domain containing 1 | |
Synonyms | MATS2|MOB4A|MOBKL1A | CATC2|CTRCT18|RUFY3|ZFYVE7 | |
Cytomap | 4q13.3 | 3p21.31 | |
Type of gene | protein-coding | protein-coding | |
Description | MOB kinase activator 1BMOB1 Mps One Binder homolog BMOB1, Mps One Binder kinase activator-like 1Amob1 homolog 1Amob1Amps one binder kinase activator-like 1A | FYVE and coiled-coil domain-containing protein 1RUN and FYVE domain containing 3zinc finger FYVE domain-containing protein 7 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q7L9L4 | Q7L099 | |
Ensembl transtripts involved in fusion gene | ENST00000309395, ENST00000396051, ENST00000511449, | ENST00000417478, ENST00000381006, ENST00000226328, ENST00000536664, ENST00000502653, ENST00000512331, | |
Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 3 X 3 X 3=27 |
# samples | 4 | 4 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MOB1B [Title/Abstract] AND RUFY3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MOB1B | GO:0031952 | regulation of protein autophosphorylation | 15197186 |
Hgene | MOB1B | GO:0035329 | hippo signaling | 19739119 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BLCA | TCGA-4Z-AA82-01A | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000309395 | ENST00000417478 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
5CDS-intron | ENST00000309395 | ENST00000381006 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
5CDS-intron | ENST00000309395 | ENST00000226328 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
5CDS-intron | ENST00000309395 | ENST00000536664 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
5CDS-intron | ENST00000309395 | ENST00000502653 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
5CDS-3UTR | ENST00000309395 | ENST00000512331 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
5UTR-intron | ENST00000396051 | ENST00000417478 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
5UTR-intron | ENST00000396051 | ENST00000381006 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
5UTR-intron | ENST00000396051 | ENST00000226328 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
5UTR-intron | ENST00000396051 | ENST00000536664 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
5UTR-intron | ENST00000396051 | ENST00000502653 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
5UTR-3UTR | ENST00000396051 | ENST00000512331 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
3UTR-intron | ENST00000511449 | ENST00000417478 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
3UTR-intron | ENST00000511449 | ENST00000381006 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
3UTR-intron | ENST00000511449 | ENST00000226328 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
3UTR-intron | ENST00000511449 | ENST00000536664 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
3UTR-intron | ENST00000511449 | ENST00000502653 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
3UTR-3UTR | ENST00000511449 | ENST00000512331 | MOB1B | chr4 | 71768267 | + | RUFY3 | chr4 | 71672233 | + |
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FusionProtFeatures for MOB1B_RUFY3 |
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Hgene | Tgene |
MOB1B | RUFY3 |
Activator of LATS1/2 in the Hippo signaling pathwaywhich plays a pivotal role in organ size control and tumorsuppression by restricting proliferation and promoting apoptosis.The core of this pathway is composed of a kinase cascade whereinSTK3/MST2 and STK4/MST1, in complex with its regulatory proteinSAV1, phosphorylates and activates LATS1/2 in complex with itsregulatory protein MOB1, which in turn phosphorylates andinactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation ofYAP1 by LATS1/2 inhibits its translocation into the nucleus toregulate cellular genes important for cell proliferation, celldeath, and cell migration. Stimulates the kinase activity ofSTK38L. {ECO:0000269|PubMed:15067004,ECO:0000269|PubMed:19739119}. | Plays a role in the generation of neuronal polarityformation and axon growth (By similarity). Implicated in theformation of a single axon by developing neurons (By similarity).May inhibit the formation of additional axons by inhibition ofPI3K in minor neuronal processes (By similarity). Plays a role inthe formation of F-actin-enriched protrusive structures at thecell periphery (PubMed:25766321). Plays a role in cytoskeletalorganization by regulating the subcellular localization of FSCN1and DBN1 at axonal growth cones (By similarity). Promotes gastriccancer cell migration and invasion in a PAK1-dependent manner(PubMed:25766321). {ECO:0000250|UniProtKB:Q5FVJ0,ECO:0000250|UniProtKB:Q9D394, ECO:0000269|PubMed:25766321}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MOB1B_RUFY3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MOB1B_RUFY3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MOB1B | LATS1, LATS2, STK3, STK38, APP, STK38L, ANKRD28, ANKRD52, CRLF3, DOCK6, DOCK7, DOCK8, DST, IPO11, LRCH1, LRCH2, LRCH3, MAP4K4, MOB2, PPP6C, PPP6R1, PPP6R2, PPP6R3, PTPN14, RASSF2, RASSF5, SAV1, STK4, TNIP1, NT5C2, CCDC53, MOB1A, SKI, CYLD, HSD17B10, SOD1 | RUFY3 | UNC119, APP, CTTNBP2NL, KIAA1456, DCAF15, NTRK1, RUFY1, RUFY2, GLT1D1, ADAMTS12, CHIA, GANAB, ASB8 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MOB1B_RUFY3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MOB1B_RUFY3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | RUFY3 | C0037274 | Dermatologic disorders | 1 | CTD_human |
Tgene | RUFY3 | C0311375 | Arsenic Poisoning | 1 | CTD_human |