![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 22241 |
FusionGeneSummary for MND1_TRIM2 |
![]() |
Fusion gene information | Fusion gene name: MND1_TRIM2 | Fusion gene ID: 22241 | Hgene | Tgene | Gene symbol | MND1 | TRIM2 | Gene ID | 84057 | 23321 |
Gene name | meiotic nuclear divisions 1 | tripartite motif containing 2 | |
Synonyms | GAJ | CMT2R|RNF86 | |
Cytomap | 4q31.3 | 4q31.3 | |
Type of gene | protein-coding | protein-coding | |
Description | meiotic nuclear division protein 1 homologhomolog of yeast MND1meiotic nuclear divisions 1 homolog | tripartite motif-containing protein 2E3 ubiquitin-protein ligase TRIM2RING finger protein 86RING-type E3 ubiquitin transferase TRIM2tripartite motif protein TRIM2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9BWT6 | Q9C040 | |
Ensembl transtripts involved in fusion gene | ENST00000240488, ENST00000503967, ENST00000504860, | ENST00000437508, ENST00000494872, ENST00000338700, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 2=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MND1 [Title/Abstract] AND TRIM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-D8-A1JL-01A | MND1 | chr4 | 154265892 | + | TRIM2 | chr4 | 154249682 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000240488 | ENST00000437508 | MND1 | chr4 | 154265892 | + | TRIM2 | chr4 | 154249682 | + |
5CDS-intron | ENST00000240488 | ENST00000494872 | MND1 | chr4 | 154265892 | + | TRIM2 | chr4 | 154249682 | + |
5CDS-intron | ENST00000240488 | ENST00000338700 | MND1 | chr4 | 154265892 | + | TRIM2 | chr4 | 154249682 | + |
3UTR-3CDS | ENST00000503967 | ENST00000437508 | MND1 | chr4 | 154265892 | + | TRIM2 | chr4 | 154249682 | + |
3UTR-intron | ENST00000503967 | ENST00000494872 | MND1 | chr4 | 154265892 | + | TRIM2 | chr4 | 154249682 | + |
3UTR-intron | ENST00000503967 | ENST00000338700 | MND1 | chr4 | 154265892 | + | TRIM2 | chr4 | 154249682 | + |
intron-3CDS | ENST00000504860 | ENST00000437508 | MND1 | chr4 | 154265892 | + | TRIM2 | chr4 | 154249682 | + |
intron-intron | ENST00000504860 | ENST00000494872 | MND1 | chr4 | 154265892 | + | TRIM2 | chr4 | 154249682 | + |
intron-intron | ENST00000504860 | ENST00000338700 | MND1 | chr4 | 154265892 | + | TRIM2 | chr4 | 154249682 | + |
Top |
FusionProtFeatures for MND1_TRIM2 |
![]() |
Hgene | Tgene |
MND1 | TRIM2 |
Required for proper homologous chromosome pairing andefficient cross-over and intragenic recombination during meiosis(By similarity). Stimulates both DMC1- and RAD51-mediatedhomologous strand assimilation, which is required for theresolution of meiotic double-strand breaks.{ECO:0000250|UniProtKB:Q8K396, ECO:0000269|PubMed:16407260}. | UBE2D1-dependent E3 ubiquitin-protein ligase thatmediates the ubiquitination of NEFL and of phosphorylated BCL2L11.Plays a neuroprotective function. May play a role in neuronalrapid ischemic tolerance. {ECO:0000250|UniProtKB:Q9ESN6}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000338700 | + | 9 | 12 | 700_743 | 674 | 772 | Repeat | Note=NHL 6 |
Tgene | >TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000437508 | + | 9 | 12 | 656_699 | 647 | 745 | Repeat | Note=NHL 5 |
Tgene | >TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000437508 | + | 9 | 12 | 700_743 | 647 | 745 | Repeat | Note=NHL 6 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >MND1 | chr4:154265892 | chr4:154249682 | ENST00000240488 | + | 1 | 8 | 84_173 | 1 | 206 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000338700 | + | 9 | 12 | 320_421 | 674 | 772 | Repeat | Note=Filamin |
Tgene | TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000338700 | + | 9 | 12 | 473_516 | 674 | 772 | Repeat | Note=NHL 1 |
Tgene | TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000338700 | + | 9 | 12 | 520_563 | 674 | 772 | Repeat | Note=NHL 2 |
Tgene | TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000338700 | + | 9 | 12 | 564_605 | 674 | 772 | Repeat | Note=NHL 3 |
Tgene | TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000338700 | + | 9 | 12 | 609_652 | 674 | 772 | Repeat | Note=NHL 4 |
Tgene | TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000338700 | + | 9 | 12 | 656_699 | 674 | 772 | Repeat | Note=NHL 5 |
Tgene | TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000437508 | + | 9 | 12 | 320_421 | 647 | 745 | Repeat | Note=Filamin |
Tgene | TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000437508 | + | 9 | 12 | 473_516 | 647 | 745 | Repeat | Note=NHL 1 |
Tgene | TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000437508 | + | 9 | 12 | 520_563 | 647 | 745 | Repeat | Note=NHL 2 |
Tgene | TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000437508 | + | 9 | 12 | 564_605 | 647 | 745 | Repeat | Note=NHL 3 |
Tgene | TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000437508 | + | 9 | 12 | 609_652 | 647 | 745 | Repeat | Note=NHL 4 |
Tgene | TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000338700 | + | 9 | 12 | 113_154 | 674 | 772 | Zinc finger | B box-type |
Tgene | TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000338700 | + | 9 | 12 | 23_64 | 674 | 772 | Zinc finger | RING-type |
Tgene | TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000437508 | + | 9 | 12 | 113_154 | 647 | 745 | Zinc finger | B box-type |
Tgene | TRIM2 | chr4:154265892 | chr4:154249682 | ENST00000437508 | + | 9 | 12 | 23_64 | 647 | 745 | Zinc finger | RING-type |
Top |
FusionGeneSequence for MND1_TRIM2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for MND1_TRIM2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MND1 | APP, PSMC3IP, IK, MTERF4, NSUN4, ALOX5, SPAG9 | TRIM2 | SIRPA, UBE2U, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2H, UBE2K, UBE2W, UBE2E2, DTNBP1, TNIK, BCL2L11, ELAVL1, MTRNR2L1, OTUB2, TNFAIP3, HSP90AA1, MNAT1, TRIM8, GJB5, UBAC1, CIB3, NUFIP1, PDHA1, LCA5, LRRC8E, TRIM3 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MND1_TRIM2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MND1_TRIM2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TRIM2 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | TRIM2 | C3809655 | CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R | 1 | ORPHANET;UNIPROT |