|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 22240 |
FusionGeneSummary for MND1_ARFIP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MND1_ARFIP1 | Fusion gene ID: 22240 | Hgene | Tgene | Gene symbol | MND1 | ARFIP1 | Gene ID | 84057 | 27236 |
| Gene name | meiotic nuclear divisions 1 | ADP ribosylation factor interacting protein 1 | |
| Synonyms | GAJ | HSU52521 | |
| Cytomap | 4q31.3 | 4q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | meiotic nuclear division protein 1 homologhomolog of yeast MND1meiotic nuclear divisions 1 homolog | arfaptin-1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9BWT6 | P53367 | |
| Ensembl transtripts involved in fusion gene | ENST00000240488, ENST00000503967, ENST00000504860, | ENST00000451320, ENST00000429148, ENST00000353617, ENST00000405727, ENST00000356064, ENST00000511289, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 7 X 6 X 7=294 |
| # samples | 2 | 10 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(10/294*10)=-1.55581615506164 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MND1 [Title/Abstract] AND ARFIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ARFIP1 | GO:0006886 | intracellular protein transport | 12606037 |
| Tgene | ARFIP1 | GO:0050708 | regulation of protein secretion | 12606037 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A7-A13D-01A | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000240488 | ENST00000451320 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000240488 | ENST00000429148 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000240488 | ENST00000353617 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000240488 | ENST00000405727 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000240488 | ENST00000356064 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-3UTR | ENST00000240488 | ENST00000511289 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| intron-3CDS | ENST00000503967 | ENST00000451320 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| intron-intron | ENST00000503967 | ENST00000429148 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| intron-intron | ENST00000503967 | ENST00000353617 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| intron-intron | ENST00000503967 | ENST00000405727 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| intron-intron | ENST00000503967 | ENST00000356064 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| intron-3UTR | ENST00000503967 | ENST00000511289 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| In-frame | ENST00000504860 | ENST00000451320 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000504860 | ENST00000429148 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000504860 | ENST00000353617 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000504860 | ENST00000405727 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000504860 | ENST00000356064 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-3UTR | ENST00000504860 | ENST00000511289 | MND1 | chr4 | 154279774 | + | ARFIP1 | chr4 | 153784758 | + |
Top |
FusionProtFeatures for MND1_ARFIP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MND1 | ARFIP1 |
| Required for proper homologous chromosome pairing andefficient cross-over and intragenic recombination during meiosis(By similarity). Stimulates both DMC1- and RAD51-mediatedhomologous strand assimilation, which is required for theresolution of meiotic double-strand breaks.{ECO:0000250|UniProtKB:Q8K396, ECO:0000269|PubMed:16407260}. | Putative target protein of ADP-ribosylation factor. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ARFIP1 | chr4:154279774 | chr4:153784758 | ENST00000353617 | + | 1 | 9 | 153_353 | 31 | 374 | Domain | AH |
| Tgene | >ARFIP1 | chr4:154279774 | chr4:153784758 | ENST00000356064 | + | 1 | 8 | 153_353 | 31 | 342 | Domain | AH |
| Tgene | >ARFIP1 | chr4:154279774 | chr4:153784758 | ENST00000405727 | + | 1 | 8 | 153_353 | 31 | 342 | Domain | AH |
| Tgene | >ARFIP1 | chr4:154279774 | chr4:153784758 | ENST00000451320 | + | 1 | 9 | 153_353 | 31 | 374 | Domain | AH |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MND1 | chr4:154279774 | chr4:153784758 | ENST00000240488 | + | 4 | 8 | 84_173 | 92 | 206 | Coiled coil | Ontology_term=ECO:0000255 |
Top |
FusionGeneSequence for MND1_ARFIP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MND1_ENST00000240488_chr4_154279774_+_ARFIP1_ENST00000451320_chr4_153784758_+_435aa MSKKKGLSAEEKRTRMMEIFSETKDVFQLKDLEKIAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKHKLEVLE SQDLKHSLPSGLGLSETQITSHGFDNTKEGVIEAGAFQGSPAPPLPSVMSPSRVAASRLAQQGSDLIVPAGGQRTQTKSGPVILADEIKN PAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLE LHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQA >In-frame_MND1_ENST00000504860_chr4_154279774_+_ARFIP1_ENST00000451320_chr4_153784758_+_420aa MMEIFSETKDVFQLKDLEKIAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKHKLEVLESQDLKHSLPSGLGLS ETQITSHGFDNTKEGVIEAGAFQGSPAPPLPSVMSPSRVAASRLAQQGSDLIVPAGGQRTQTKSGPVILADEIKNPAMEKLELVRKWSLN TYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLL AKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MND1_ENST00000240488_chr4_154279774_+_ARFIP1_ENST00000451320_chr4_153784758_+_1305nt ATGTCAAAGAAAAAAGGACTGAGTGCAGAAGAAAAGAGAACTCGCATGATGGAAATATTTTCTGAAACAAAAGATGTATTTCAATTAAAA GACTTGGAGAAGATTGCTCCCAAAGAGAAAGGCATTACTGCTATGTCAGTAAAAGAAGTCCTTCAAAGCTTAGTTGATGATGGTATGGTT GACTGTGAGAGGATCGGAACTTCTAATTATTATTGGGCTTTTCCAAGTAAAGCTCTTCATGCAAGGAAACATAAGTTGGAGGTTCTGGAA TCTCAGGATTTGAAGCATTCATTACCATCTGGACTTGGTCTCTCAGAAACCCAAATTACATCTCATGGCTTTGACAATACCAAAGAGGGT GTTATTGAAGCAGGAGCATTTCAAGGTTCCCCAGCACCGCCACTGCCATCTGTTATGTCTCCTAGCAGGGTTGCAGCTAGTCGACTGGCT CAGCAAGGAAGTGATTTAATTGTTCCTGCAGGTGGCCAGAGAACACAGACAAAAAGTGGACCAGTTATTCTAGCAGATGAAATTAAAAAT CCTGCAATGGAAAAGTTAGAACTTGTTAGAAAATGGAGTCTAAACACCTATAAGTGTACTCGACAGATTATCTCTGAGAAGCTAGGCCGT GGCTCAAGAACTGTGGACCTTGAACTTGAAGCTCAGATTGATATATTAAGGGATAACAAGAAAAAATATGAAAATATTTTAAAACTGGCT CAAACATTGTCGACCCAGCTTTTCCAGATGGTACATACCCAAAGGCAACTTGGAGATGCATTTGCTGACCTGAGTTTGAAGTCACTAGAA CTTCATGAAGAATTTGGCTATAATGCCGATACCCAGAAACTGCTGGCTAAAAATGGAGAGACTCTTCTTGGGGCCATTAATTTTTTCATT GCTAGTGTGAACACTTTGGTGAATAAAACCATTGAAGATACATTAATGACTGTGAAACAGTATGAAAGTGCCAGGATTGAATATGATGCA TATCGCACTGATTTGGAAGAACTGAATCTTGGACCACGTGACGCAAACACTCTGCCAAAGATTGAGCAGTCACAGCATCTCTTCCAAGCA CATAAGGAAAAATATGATAAAATGCGCAATGATGTTTCTGTCAAATTGAAATTTCTAGAAGAAAATAAGGTTAAAGTATTGCACAATCAG CTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGACACTTAAACAGTTCCATATCAAATTG >In-frame_MND1_ENST00000504860_chr4_154279774_+_ARFIP1_ENST00000451320_chr4_153784758_+_1260nt ATGATGGAAATATTTTCTGAAACAAAAGATGTATTTCAATTAAAAGACTTGGAGAAGATTGCTCCCAAAGAGAAAGGCATTACTGCTATG TCAGTAAAAGAAGTCCTTCAAAGCTTAGTTGATGATGGTATGGTTGACTGTGAGAGGATCGGAACTTCTAATTATTATTGGGCTTTTCCA AGTAAAGCTCTTCATGCAAGGAAACATAAGTTGGAGGTTCTGGAATCTCAGGATTTGAAGCATTCATTACCATCTGGACTTGGTCTCTCA GAAACCCAAATTACATCTCATGGCTTTGACAATACCAAAGAGGGTGTTATTGAAGCAGGAGCATTTCAAGGTTCCCCAGCACCGCCACTG CCATCTGTTATGTCTCCTAGCAGGGTTGCAGCTAGTCGACTGGCTCAGCAAGGAAGTGATTTAATTGTTCCTGCAGGTGGCCAGAGAACA CAGACAAAAAGTGGACCAGTTATTCTAGCAGATGAAATTAAAAATCCTGCAATGGAAAAGTTAGAACTTGTTAGAAAATGGAGTCTAAAC ACCTATAAGTGTACTCGACAGATTATCTCTGAGAAGCTAGGCCGTGGCTCAAGAACTGTGGACCTTGAACTTGAAGCTCAGATTGATATA TTAAGGGATAACAAGAAAAAATATGAAAATATTTTAAAACTGGCTCAAACATTGTCGACCCAGCTTTTCCAGATGGTACATACCCAAAGG CAACTTGGAGATGCATTTGCTGACCTGAGTTTGAAGTCACTAGAACTTCATGAAGAATTTGGCTATAATGCCGATACCCAGAAACTGCTG GCTAAAAATGGAGAGACTCTTCTTGGGGCCATTAATTTTTTCATTGCTAGTGTGAACACTTTGGTGAATAAAACCATTGAAGATACATTA ATGACTGTGAAACAGTATGAAAGTGCCAGGATTGAATATGATGCATATCGCACTGATTTGGAAGAACTGAATCTTGGACCACGTGACGCA AACACTCTGCCAAAGATTGAGCAGTCACAGCATCTCTTCCAAGCACATAAGGAAAAATATGATAAAATGCGCAATGATGTTTCTGTCAAA TTGAAATTTCTAGAAGAAAATAAGGTTAAAGTATTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAAT CAGAAGCAGCTTGAACAGACACTTAAACAGTTCCATATCAAATTGAAAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MND1_ENST00000240488_chr4_154279774_+_ARFIP1_ENST00000451320_chr4_153784758_+_3532nt AGTCGGCGCCAAAATCAAACGCGTCCTGGCCTGTCCCGCCCCTCTCCCCAAGCGCGGGCCCGGCCAGCGGAAGCCCCTGCGCCCGCGCCA TGTCAAAGAAAAAAGGACTGAGTGCAGAAGAAAAGAGAACTCGCATGATGGAAATATTTTCTGAAACAAAAGATGTATTTCAATTAAAAG ACTTGGAGAAGATTGCTCCCAAAGAGAAAGGCATTACTGCTATGTCAGTAAAAGAAGTCCTTCAAAGCTTAGTTGATGATGGTATGGTTG ACTGTGAGAGGATCGGAACTTCTAATTATTATTGGGCTTTTCCAAGTAAAGCTCTTCATGCAAGGAAACATAAGTTGGAGGTTCTGGAAT CTCAGGATTTGAAGCATTCATTACCATCTGGACTTGGTCTCTCAGAAACCCAAATTACATCTCATGGCTTTGACAATACCAAAGAGGGTG TTATTGAAGCAGGAGCATTTCAAGGTTCCCCAGCACCGCCACTGCCATCTGTTATGTCTCCTAGCAGGGTTGCAGCTAGTCGACTGGCTC AGCAAGGAAGTGATTTAATTGTTCCTGCAGGTGGCCAGAGAACACAGACAAAAAGTGGACCAGTTATTCTAGCAGATGAAATTAAAAATC CTGCAATGGAAAAGTTAGAACTTGTTAGAAAATGGAGTCTAAACACCTATAAGTGTACTCGACAGATTATCTCTGAGAAGCTAGGCCGTG GCTCAAGAACTGTGGACCTTGAACTTGAAGCTCAGATTGATATATTAAGGGATAACAAGAAAAAATATGAAAATATTTTAAAACTGGCTC AAACATTGTCGACCCAGCTTTTCCAGATGGTACATACCCAAAGGCAACTTGGAGATGCATTTGCTGACCTGAGTTTGAAGTCACTAGAAC TTCATGAAGAATTTGGCTATAATGCCGATACCCAGAAACTGCTGGCTAAAAATGGAGAGACTCTTCTTGGGGCCATTAATTTTTTCATTG CTAGTGTGAACACTTTGGTGAATAAAACCATTGAAGATACATTAATGACTGTGAAACAGTATGAAAGTGCCAGGATTGAATATGATGCAT ATCGCACTGATTTGGAAGAACTGAATCTTGGACCACGTGACGCAAACACTCTGCCAAAGATTGAGCAGTCACAGCATCTCTTCCAAGCAC ATAAGGAAAAATATGATAAAATGCGCAATGATGTTTCTGTCAAATTGAAATTTCTAGAAGAAAATAAGGTTAAAGTATTGCACAATCAGC TGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGACACTTAAACAGTTCCATATCAAATTGA AAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCGGAAAATAAAAAGAAAGTCGCGTTGTTATATTTCTAA ACCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCATTATAGTGATTCTTGCACAAACAGCTTTAATTTTTC CCTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATAGTTTCTATAATCTGAACACAATAATTTTCCTTTTTG AGAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACATCTAATAGAGATTTGCACTGACAAGATAAAAATTCAA GGTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTACATGATTTGTATCAACATCAGATATTTTATATGTGA ATATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAACTATTTTGCAGAGTAAAGTTATATGGTGTTCCTGCAG CGTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCAAATACCTTTTTAAAAATGAATCTGTACCACTGTAAT TTTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGGCTTTTAAGCTTATGAATTTGCTTCACCCGAAGTCAT TGGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGAATTTTTTTTTTTGACAGGTGGACGTGGGAATGGAAA TTCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTCAGTTCCATTTTGATAGAAGTGAATACATAGACAGCT TTTATTGACTTCCATATGTAACAATACCGTTTAAGCCTTAAATCACAGATATGTGCCTTCTCAGATACAGTAATTCTTGTTCAACCAATG TACAAAATCCATAAAGAAACCCCTGTTGGATAATGTTTGATGTGTCTATTCCTTCCATGGAATGGAGCACTATGTATGAATGTTGGGTTT CTTTGTACTTGTTAAGCCACATTTGAGGTTTATGGTAAAAATCATCTTTTGAGTTTGCTCTTTGGTTTTTCTTCATTCCTTTTGAGGATT GGGAAAACAGAAAGATTCTTTGATTTGGGTAATGAAGAGGTAATTTGGGACAGTGTGGTGGTACCAGGAAGAAAGAGGATTGGAAAGGCC AGTACTGTTTTAGTTGCTCGGCACTGTTGGTTTTGTTTTAATGTGGTTGCCCTGTCCACTACATGGTTCTATCAGTAGTGTAATCCATTT TCAATGTAAAGCTCTTTTAGTTTTTGTCATAGACATAAATTAATATTTTGAGAGGCATCCCTCACCTGTTCATTTCTTCTGTGTTGAAAT GAAGTACTTAAAATTACCGTTATACATGAACTTTGTGGACTGTAAGATTTGTTATATATGTTCAAATGCCTTTTAGCTGGCTTTTTAATT AATATGCCTGTTTTGAGTGCTTAATACAATGTAATGTGATTGTAAATCATACCTATTTTAAATCATTCCTTCCTGTATATTTGTACTCAG AGAGCCTTATTTTATTCTTCCAGCAGAATTACTACTTGTGATAGTTCATTTACATTCCCCAGAATGTGCCTCTAGTGTGAATTTTGTATT CTTATTAAACGTGTTTGCTGCAGTAAATCGTTTCTCTGGACCTTCATAGTTTAAGAAGTAACTATTTGGAAATTCTGAAGACACATAATT TGCGTTTTCTGAACCTTAAAAAAAAAGGTACTTCTGTCACTTATAATTGTTTTAGCTCAGTAAGCTATTTTTTTTCAATGTGAATCTCTT TTGAGAGCTGAACATGTCCATTCTTAACCACATTTCAATAACAGTTACTGTAGCTAAGGAGCTAAATAGTTTCATGGATTAATTTTTTTC AGAATAAATTTAAAATATCCATGATTCTGATAGTGGGCACATGACCAAAAGAAAAAAGTAAATCAATATATTTAGCCAATGGTACATTTA CTTTGTTAGGAATGTAATTTATGTTCATTATAGAAAAGAATTAGAAGAAAATTTCAAGTAATAGAAGATAAGTACCTTCCCAAGTGAATA >In-frame_MND1_ENST00000504860_chr4_154279774_+_ARFIP1_ENST00000451320_chr4_153784758_+_3441nt GTCAAAGAAAAAAGGACTGAGTGCAGAAGAAAAGAGAACTCGCATGATGGAAATATTTTCTGAAACAAAAGATGTATTTCAATTAAAAGA CTTGGAGAAGATTGCTCCCAAAGAGAAAGGCATTACTGCTATGTCAGTAAAAGAAGTCCTTCAAAGCTTAGTTGATGATGGTATGGTTGA CTGTGAGAGGATCGGAACTTCTAATTATTATTGGGCTTTTCCAAGTAAAGCTCTTCATGCAAGGAAACATAAGTTGGAGGTTCTGGAATC TCAGGATTTGAAGCATTCATTACCATCTGGACTTGGTCTCTCAGAAACCCAAATTACATCTCATGGCTTTGACAATACCAAAGAGGGTGT TATTGAAGCAGGAGCATTTCAAGGTTCCCCAGCACCGCCACTGCCATCTGTTATGTCTCCTAGCAGGGTTGCAGCTAGTCGACTGGCTCA GCAAGGAAGTGATTTAATTGTTCCTGCAGGTGGCCAGAGAACACAGACAAAAAGTGGACCAGTTATTCTAGCAGATGAAATTAAAAATCC TGCAATGGAAAAGTTAGAACTTGTTAGAAAATGGAGTCTAAACACCTATAAGTGTACTCGACAGATTATCTCTGAGAAGCTAGGCCGTGG CTCAAGAACTGTGGACCTTGAACTTGAAGCTCAGATTGATATATTAAGGGATAACAAGAAAAAATATGAAAATATTTTAAAACTGGCTCA AACATTGTCGACCCAGCTTTTCCAGATGGTACATACCCAAAGGCAACTTGGAGATGCATTTGCTGACCTGAGTTTGAAGTCACTAGAACT TCATGAAGAATTTGGCTATAATGCCGATACCCAGAAACTGCTGGCTAAAAATGGAGAGACTCTTCTTGGGGCCATTAATTTTTTCATTGC TAGTGTGAACACTTTGGTGAATAAAACCATTGAAGATACATTAATGACTGTGAAACAGTATGAAAGTGCCAGGATTGAATATGATGCATA TCGCACTGATTTGGAAGAACTGAATCTTGGACCACGTGACGCAAACACTCTGCCAAAGATTGAGCAGTCACAGCATCTCTTCCAAGCACA TAAGGAAAAATATGATAAAATGCGCAATGATGTTTCTGTCAAATTGAAATTTCTAGAAGAAAATAAGGTTAAAGTATTGCACAATCAGCT GGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGACACTTAAACAGTTCCATATCAAATTGAA AACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCGGAAAATAAAAAGAAAGTCGCGTTGTTATATTTCTAAA CCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCATTATAGTGATTCTTGCACAAACAGCTTTAATTTTTCC CTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATAGTTTCTATAATCTGAACACAATAATTTTCCTTTTTGA GAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACATCTAATAGAGATTTGCACTGACAAGATAAAAATTCAAG GTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTACATGATTTGTATCAACATCAGATATTTTATATGTGAA TATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAACTATTTTGCAGAGTAAAGTTATATGGTGTTCCTGCAGC GTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCAAATACCTTTTTAAAAATGAATCTGTACCACTGTAATT TTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGGCTTTTAAGCTTATGAATTTGCTTCACCCGAAGTCATT GGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGAATTTTTTTTTTTGACAGGTGGACGTGGGAATGGAAAT TCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTCAGTTCCATTTTGATAGAAGTGAATACATAGACAGCTT TTATTGACTTCCATATGTAACAATACCGTTTAAGCCTTAAATCACAGATATGTGCCTTCTCAGATACAGTAATTCTTGTTCAACCAATGT ACAAAATCCATAAAGAAACCCCTGTTGGATAATGTTTGATGTGTCTATTCCTTCCATGGAATGGAGCACTATGTATGAATGTTGGGTTTC TTTGTACTTGTTAAGCCACATTTGAGGTTTATGGTAAAAATCATCTTTTGAGTTTGCTCTTTGGTTTTTCTTCATTCCTTTTGAGGATTG GGAAAACAGAAAGATTCTTTGATTTGGGTAATGAAGAGGTAATTTGGGACAGTGTGGTGGTACCAGGAAGAAAGAGGATTGGAAAGGCCA GTACTGTTTTAGTTGCTCGGCACTGTTGGTTTTGTTTTAATGTGGTTGCCCTGTCCACTACATGGTTCTATCAGTAGTGTAATCCATTTT CAATGTAAAGCTCTTTTAGTTTTTGTCATAGACATAAATTAATATTTTGAGAGGCATCCCTCACCTGTTCATTTCTTCTGTGTTGAAATG AAGTACTTAAAATTACCGTTATACATGAACTTTGTGGACTGTAAGATTTGTTATATATGTTCAAATGCCTTTTAGCTGGCTTTTTAATTA ATATGCCTGTTTTGAGTGCTTAATACAATGTAATGTGATTGTAAATCATACCTATTTTAAATCATTCCTTCCTGTATATTTGTACTCAGA GAGCCTTATTTTATTCTTCCAGCAGAATTACTACTTGTGATAGTTCATTTACATTCCCCAGAATGTGCCTCTAGTGTGAATTTTGTATTC TTATTAAACGTGTTTGCTGCAGTAAATCGTTTCTCTGGACCTTCATAGTTTAAGAAGTAACTATTTGGAAATTCTGAAGACACATAATTT GCGTTTTCTGAACCTTAAAAAAAAAGGTACTTCTGTCACTTATAATTGTTTTAGCTCAGTAAGCTATTTTTTTTCAATGTGAATCTCTTT TGAGAGCTGAACATGTCCATTCTTAACCACATTTCAATAACAGTTACTGTAGCTAAGGAGCTAAATAGTTTCATGGATTAATTTTTTTCA GAATAAATTTAAAATATCCATGATTCTGATAGTGGGCACATGACCAAAAGAAAAAAGTAAATCAATATATTTAGCCAATGGTACATTTAC TTTGTTAGGAATGTAATTTATGTTCATTATAGAAAAGAATTAGAAGAAAATTTCAAGTAATAGAAGATAAGTACCTTCCCAAGTGAATAA |
Top |
FusionGenePPI for MND1_ARFIP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MND1 | APP, PSMC3IP, IK, MTERF4, NSUN4, ALOX5, SPAG9 | ARFIP1 | ARF3, ARF1, ARF5, SLC2A4, ATP6V1C1, TBC1D15, TSNAX, YAP1, DNM1L, HIST1H4A, IDE, LUC7L2, PRMT3, PSMG3, SEC24A, SHMT2, STAT3, ARFIP2, PICK1, AACS, AKR1A1, ADSS, DPYSL2, G6PD, GART, HSD17B8, MVB12A, PFKM, PFKP, PPP3CA, PROSC, SARS, SEC24D, SHMT1, TSTA3, TXNDC9, USP14, ATOX1, ECH1, FLNB, LYPLA1, PAFAH1B2, PDCD6, PGM2L1, QDPR, STIP1, TBCA, DYNLT1, TMEM17, TMEM216, CDC5L, CDH1, CLPB, HSPA8, HSPBP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MND1_ARFIP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MND1_ARFIP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|