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Fusion gene ID: 22237 |
FusionGeneSummary for MNAT1_RASGEF1B |
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Fusion gene information | Fusion gene name: MNAT1_RASGEF1B | Fusion gene ID: 22237 | Hgene | Tgene | Gene symbol | MNAT1 | RASGEF1B | Gene ID | 4331 | 153020 |
Gene name | MNAT1, CDK activating kinase assembly factor | RasGEF domain family member 1B | |
Synonyms | CAP35|MAT1|RNF66|TFB3 | GPIG4 | |
Cytomap | 14q23.1 | 4q21.21 | |
Type of gene | protein-coding | protein-coding | |
Description | CDK-activating kinase assembly factor MAT1CDK7/cyclin-H assembly factorMNAT CDK-activating kinase assembly factor 1RING finger protein 66RING finger protein MAT1cyclin G1 interacting proteinmenage a trois 1 (CAK assembly factor)menage a trois homol | ras-GEF domain-containing family member 1BGPI gamma-4 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P51948 | Q0VAM2 | |
Ensembl transtripts involved in fusion gene | ENST00000555545, ENST00000261245, ENST00000539616, | ENST00000509081, ENST00000264400, ENST00000335927, ENST00000436139, ENST00000514889, | |
Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 6 X 4 X 5=120 |
# samples | 5 | 6 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MNAT1 [Title/Abstract] AND RASGEF1B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MNAT1 | GO:0006357 | regulation of transcription by RNA polymerase II | 10801852 |
Hgene | MNAT1 | GO:0006366 | transcription by RNA polymerase II | 9852112 |
Hgene | MNAT1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 8692841 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-KK-A6E1-01A | MNAT1 | chr14 | 61201669 | + | RASGEF1B | chr4 | 82380668 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-5UTR | ENST00000555545 | ENST00000509081 | MNAT1 | chr14 | 61201669 | + | RASGEF1B | chr4 | 82380668 | - |
3UTR-5UTR | ENST00000555545 | ENST00000264400 | MNAT1 | chr14 | 61201669 | + | RASGEF1B | chr4 | 82380668 | - |
3UTR-5UTR | ENST00000555545 | ENST00000335927 | MNAT1 | chr14 | 61201669 | + | RASGEF1B | chr4 | 82380668 | - |
3UTR-5UTR | ENST00000555545 | ENST00000436139 | MNAT1 | chr14 | 61201669 | + | RASGEF1B | chr4 | 82380668 | - |
3UTR-intron | ENST00000555545 | ENST00000514889 | MNAT1 | chr14 | 61201669 | + | RASGEF1B | chr4 | 82380668 | - |
5CDS-5UTR | ENST00000261245 | ENST00000509081 | MNAT1 | chr14 | 61201669 | + | RASGEF1B | chr4 | 82380668 | - |
5CDS-5UTR | ENST00000261245 | ENST00000264400 | MNAT1 | chr14 | 61201669 | + | RASGEF1B | chr4 | 82380668 | - |
5CDS-5UTR | ENST00000261245 | ENST00000335927 | MNAT1 | chr14 | 61201669 | + | RASGEF1B | chr4 | 82380668 | - |
5CDS-5UTR | ENST00000261245 | ENST00000436139 | MNAT1 | chr14 | 61201669 | + | RASGEF1B | chr4 | 82380668 | - |
5CDS-intron | ENST00000261245 | ENST00000514889 | MNAT1 | chr14 | 61201669 | + | RASGEF1B | chr4 | 82380668 | - |
5CDS-5UTR | ENST00000539616 | ENST00000509081 | MNAT1 | chr14 | 61201669 | + | RASGEF1B | chr4 | 82380668 | - |
5CDS-5UTR | ENST00000539616 | ENST00000264400 | MNAT1 | chr14 | 61201669 | + | RASGEF1B | chr4 | 82380668 | - |
5CDS-5UTR | ENST00000539616 | ENST00000335927 | MNAT1 | chr14 | 61201669 | + | RASGEF1B | chr4 | 82380668 | - |
5CDS-5UTR | ENST00000539616 | ENST00000436139 | MNAT1 | chr14 | 61201669 | + | RASGEF1B | chr4 | 82380668 | - |
5CDS-intron | ENST00000539616 | ENST00000514889 | MNAT1 | chr14 | 61201669 | + | RASGEF1B | chr4 | 82380668 | - |
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FusionProtFeatures for MNAT1_RASGEF1B |
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Hgene | Tgene |
MNAT1 | RASGEF1B |
Stabilizes the cyclin H-CDK7 complex to form afunctional CDK-activating kinase (CAK) enzymatic complex. CAKactivates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6by threonine phosphorylation. CAK complexed to the core-TFIIHbasal transcription factor activates RNA polymerase II by serinephosphorylation of the repetitive C-terminal domain (CTD) of itslarge subunit (POLR2A), allowing its escape from the promoter andelongation of the transcripts. Involved in cell cycle control andin RNA transcription by RNA polymerase II.{ECO:0000269|PubMed:10024882}. | Guanine nucleotide exchange factor (GEF) withspecificity for RAP2A, it doesn't seems to activate other Rasfamily proteins (in vitro). {ECO:0000269|PubMed:19645719,ECO:0000269|PubMed:23894443}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MNAT1_RASGEF1B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MNAT1_RASGEF1B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MNAT1 | CCNH, ERCC3, MTA1, ESR1, CDK7, HPS6, COPS6, RBM48, EEF1A1, LRIF1, POU5F1, POU2F2, POU2F1, MCM7, RB1, TP53, DMAP1, GTF2H2, GTF2H1, SP1, ERCC2, XBP1P1, ICK, BRCA1, GTF2H3, GTF2H4, USP2, POLR2A, SUPT5H, NKX3-1, TRIM2, TRIM9, TRIML1, MKRN3, TRIM31, TRIM34, RNF32, TRIM17, RNF7, RNF41, TRIM21, TRIM39, TRIM5, MDM4, TRIM26, NGFRAP1, RPA3, RPA2, RPA1, CDK2, SFR1, HIST1H2BG, PCIF1, GTF2H5, MAGEC2, MAGEE2, SIRT6 | RASGEF1B | EGFR, COL1A1, GAPDHS |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MNAT1_RASGEF1B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MNAT1_RASGEF1B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | RASGEF1B | C3495559 | Juvenile arthritis | 1 | CTD_human |