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Fusion gene ID: 22217 |
FusionGeneSummary for MMP14_PPM1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MMP14_PPM1A | Fusion gene ID: 22217 | Hgene | Tgene | Gene symbol | MMP14 | PPM1A | Gene ID | 4323 | 5494 |
| Gene name | matrix metallopeptidase 14 | protein phosphatase, Mg2+/Mn2+ dependent 1A | |
| Synonyms | MMP-14|MMP-X1|MT-MMP|MT-MMP 1|MT1-MMP|MT1MMP|MTMMP1|WNCHRS | PP2C-ALPHA|PP2CA|PP2Calpha | |
| Cytomap | 14q11.2 | 14q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | matrix metalloproteinase-14matrix metallopeptidase 14 (membrane-inserted)membrane type 1 metalloproteasemembrane-type-1 matrix metalloproteinase | protein phosphatase 1Aprotein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P50281 | P35813 | |
| Ensembl transtripts involved in fusion gene | ENST00000311852, ENST00000548162, | ENST00000325642, ENST00000529574, ENST00000395076, ENST00000325658, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 4 X 4 X 2=32 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MMP14 [Title/Abstract] AND PPM1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MMP14 | GO:0006508 | proteolysis | 15863497|24970228 |
| Hgene | MMP14 | GO:0030307 | positive regulation of cell growth | 22065321 |
| Hgene | MMP14 | GO:0030335 | positive regulation of cell migration | 22065321 |
| Tgene | PPM1A | GO:0010991 | negative regulation of SMAD protein complex assembly | 16751101 |
| Tgene | PPM1A | GO:0016055 | Wnt signaling pathway | 10644691 |
| Tgene | PPM1A | GO:0016311 | dephosphorylation | 10644691 |
| Tgene | PPM1A | GO:0030177 | positive regulation of Wnt signaling pathway | 10644691 |
| Tgene | PPM1A | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 16751101 |
| Tgene | PPM1A | GO:0035970 | peptidyl-threonine dephosphorylation | 11559703|20801214 |
| Tgene | PPM1A | GO:0045893 | positive regulation of transcription, DNA-templated | 10644691 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-XF-AAMW-01A | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000311852 | ENST00000325642 | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
| 5CDS-5UTR | ENST00000311852 | ENST00000529574 | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
| 5CDS-5UTR | ENST00000311852 | ENST00000395076 | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
| 5CDS-5UTR | ENST00000311852 | ENST00000325658 | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
| 3UTR-3CDS | ENST00000548162 | ENST00000325642 | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
| 3UTR-5UTR | ENST00000548162 | ENST00000529574 | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
| 3UTR-5UTR | ENST00000548162 | ENST00000395076 | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
| 3UTR-5UTR | ENST00000548162 | ENST00000325658 | MMP14 | chr14 | 23314575 | + | PPM1A | chr14 | 60749402 | + |
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FusionProtFeatures for MMP14_PPM1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MMP14 | PPM1A |
| Endopeptidase that degrades various components of theextracellular matrix such as collagen. Activates progelatinase A.Essential for pericellular collagenolysis and modeling of skeletaland extraskeletal connective tissues during development (Bysimilarity). May be involved in actin cytoskeleton reorganizationby cleaving PTK7 (PubMed:20837484). Acts as a positive regulatorof cell growth and migration via activation of MMP15. Involved inthe formation of the fibrovascular tissues in association withpro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to releasevasculostatin-40 which inhibits angiogenesis (PubMed:22330140).{ECO:0000250|UniProtKB:P53690, ECO:0000269|PubMed:12714657,ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:22065321,ECO:0000269|PubMed:22330140}. | Enzyme with a broad specificity. Negatively regulatesTGF-beta signaling through dephosphorylating SMAD2 and SMAD3,resulting in their dissociation from SMAD4, nuclear export of theSMADs and termination of the TGF-beta-mediated signaling.Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in thetermination of TNF-alpha-mediated NF-kappa-B activation throughdephosphorylating and inactivating IKBKB/IKKB.{ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:18930133}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MMP14 | chr14:23314575 | chr14:60749402 | ENST00000311852 | + | 9 | 10 | 91_98 | 472 | 583 | Motif | Cysteine switch |
| Hgene | MMP14 | chr14:23314575 | chr14:60749402 | ENST00000311852 | + | 9 | 10 | 316_364 | 472 | 583 | Repeat | Note=Hemopexin 1 |
| Hgene | MMP14 | chr14:23314575 | chr14:60749402 | ENST00000311852 | + | 9 | 10 | 365_410 | 472 | 583 | Repeat | Note=Hemopexin 2 |
| Hgene | MMP14 | chr14:23314575 | chr14:60749402 | ENST00000311852 | + | 9 | 10 | 412_460 | 472 | 583 | Repeat | Note=Hemopexin 3 |
| Tgene | >PPM1A | chr14:23314575 | chr14:60749402 | ENST00000325658 | + | 1 | 4 | 23_291 | -7 | 325 | Domain | PPM-type phosphatase |
| Tgene | >PPM1A | chr14:23314575 | chr14:60749402 | ENST00000395076 | + | 0 | 6 | 23_291 | -7 | 383 | Domain | PPM-type phosphatase |
| Tgene | >PPM1A | chr14:23314575 | chr14:60749402 | ENST00000529574 | + | 1 | 7 | 23_291 | -7 | 383 | Domain | PPM-type phosphatase |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MMP14 | chr14:23314575 | chr14:60749402 | ENST00000311852 | + | 9 | 10 | 461_508 | 472 | 583 | Repeat | Note=Hemopexin 4 |
| Hgene | >MMP14 | chr14:23314575 | chr14:60749402 | ENST00000311852 | + | 9 | 10 | 112_541 | 472 | 583 | Topological domain | Extracellular |
| Hgene | >MMP14 | chr14:23314575 | chr14:60749402 | ENST00000311852 | + | 9 | 10 | 563_582 | 472 | 583 | Topological domain | Cytoplasmic |
| Hgene | >MMP14 | chr14:23314575 | chr14:60749402 | ENST00000311852 | + | 9 | 10 | 542_562 | 472 | 583 | Transmembrane | Helical |
| Tgene | PPM1A | chr14:23314575 | chr14:60749402 | ENST00000325642 | + | 0 | 6 | 23_291 | 66 | 456 | Domain | PPM-type phosphatase |
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FusionGeneSequence for MMP14_PPM1A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MMP14_ENST00000311852_chr14_23314575_+_PPM1A_ENST00000325642_chr14_60749402_+_862aa MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRR PRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIF FAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFV LPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQF WRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYP KNIKVWEGIPESPRGSFMGSDEDLEDQDIMGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDG HAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLL CRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGI WDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAVKKEAELDKYLECRVEEIIKKQGEGVPDLV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MMP14_ENST00000311852_chr14_23314575_+_PPM1A_ENST00000325642_chr14_60749402_+_2586nt ATGTCTCCCGCCCCAAGACCCCCCCGTTGTCTCCTGCTCCCCCTGCTCACGCTCGGCACCGCGCTCGCCTCCCTCGGCTCGGCCCAAAGC AGCAGCTTCAGCCCCGAAGCCTGGCTACAGCAATATGGCTACCTGCCTCCCGGGGACCTACGTACCCACACACAGCGCTCACCCCAGTCA CTCTCAGCGGCCATCGCTGCCATGCAGAAGTTTTACGGCTTGCAAGTAACAGGCAAAGCTGATGCAGACACCATGAAGGCCATGAGGCGC CCCCGATGTGGTGTTCCAGACAAGTTTGGGGCTGAGATCAAGGCCAATGTTCGAAGGAAGCGCTACGCCATCCAGGGTCTCAAATGGCAA CATAATGAAATCACTTTCTGCATCCAGAATTACACCCCCAAGGTGGGCGAGTATGCCACATACGAGGCCATTCGCAAGGCGTTCCGCGTG TGGGAGAGTGCCACACCACTGCGCTTCCGCGAGGTGCCCTATGCCTACATCCGTGAGGGCCATGAGAAGCAGGCCGACATCATGATCTTC TTTGCCGAGGGCTTCCATGGCGACAGCACGCCCTTCGATGGTGAGGGCGGCTTCCTGGCCCATGCCTACTTCCCAGGCCCCAACATTGGA GGAGACACCCACTTTGACTCTGCCGAGCCTTGGACTGTCAGGAATGAGGATCTGAATGGAAATGACATCTTCCTGGTGGCTGTGCACGAG CTGGGCCATGCCCTGGGGCTCGAGCATTCCAGTGACCCCTCGGCCATCATGGCACCCTTTTACCAGTGGATGGACACGGAGAATTTTGTG CTGCCCGATGATGACCGCCGGGGCATCCAGCAACTTTATGGGGGTGAGTCAGGGTTCCCCACCAAGATGCCCCCTCAACCCAGGACTACC TCCCGGCCTTCTGTTCCTGATAAACCCAAAAACCCCACCTATGGGCCCAACATCTGTGACGGGAACTTTGACACCGTGGCCATGCTCCGA GGGGAGATGTTTGTCTTCAAGGAGCGCTGGTTCTGGCGGGTGAGGAATAACCAAGTGATGGATGGATACCCAATGCCCATTGGCCAGTTC TGGCGGGGCCTGCCTGCGTCCATCAACACTGCCTACGAGAGGAAGGATGGCAAATTCGTCTTCTTCAAAGGAGACAAGCATTGGGTGTTT GATGAGGCGTCCCTGGAACCTGGCTACCCCAAGCACATTAAGGAGCTGGGCCGAGGGCTGCCTACCGACAAGATTGATGCTGCTCTCTTC TGGATGCCCAATGGAAAGACCTACTTCTTCCGTGGAAACAAGTACTACCGTTTCAACGAAGAGCTCAGGGCAGTGGATAGCGAGTACCCC AAGAACATCAAAGTCTGGGAAGGGATCCCTGAGTCTCCCAGAGGGTCATTCATGGGCAGCGATGAAGACCTAGAGGATCAAGACATAATG GGAGCATTTTTAGACAAGCCAAAGATGGAAAAGCATAATGCCCAGGGGCAGGGTAATGGGTTGCGATATGGGCTAAGCAGCATGCAAGGC TGGCGTGTTGAAATGGAGGATGCACATACGGCTGTGATCGGTTTGCCAAGTGGACTTGAATCGTGGTCATTCTTTGCTGTGTATGATGGG CATGCTGGTTCTCAGGTTGCCAAATACTGCTGTGAGCATTTGTTAGATCACATCACCAATAACCAGGATTTTAAAGGGTCTGCAGGAGCA CCTTCTGTGGAAAATGTAAAGAATGGAATCAGAACAGGTTTTCTGGAGATTGATGAACACATGAGAGTTATGTCAGAGAAGAAACATGGT GCAGATAGAAGTGGGTCAACAGCTGTAGGTGTCTTAATTTCTCCCCAACATACTTATTTCATTAACTGTGGAGACTCAAGAGGTTTACTT TGTAGGAACAGGAAAGTTCATTTCTTCACACAAGATCACAAACCAAGTAATCCGCTGGAGAAAGAACGAATTCAGAATGCAGGTGGCTCT GTAATGATTCAGCGTGTGAATGGCTCTCTGGCTGTATCGAGGGCCCTTGGGGATTTTGATTACAAATGTGTCCATGGAAAAGGTCCTACT GAGCAGCTTGTCTCACCAGAGCCTGAAGTCCATGATATTGAAAGATCTGAAGAAGATGATCAGTTCATTATCCTTGCATGTGATGGTATC TGGGATGTTATGGGAAATGAAGAGCTCTGTGATTTTGTAAGATCCAGACTTGAAGTCACTGATGACCTTGAGAAAGTTTGCAATGAAGTA GTCGACACCTGTTTGTATAAGGGAAGTCGAGACAACATGAGTGTGATTTTGATCTGTTTTCCAAATGCACCCAAAGTATCGCCAGAAGCA GTGAAGAAGGAGGCAGAGTTGGACAAGTACCTGGAATGCAGAGTAGAAGAAATCATAAAGAAGCAGGGGGAAGGCGTCCCCGACTTAGTC CATGTGATGCGCACATTAGCGAGTGAGAACATCCCCAGCCTCCCACCAGGGGGTGAATTGGCAAGCAAGAGGAATGTTATTGAAGCCGTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MMP14_ENST00000311852_chr14_23314575_+_PPM1A_ENST00000325642_chr14_60749402_+_3096nt ACCAGAGGAGAGAGCGAGAGAGGGAACCAGACCCCAGTTCGCCGACTAAGCAGAAGAAAGATCAAAAACCGGAAAAGAGGAGAAGAGCAA ACAGGCACTTTGAGGAACAATCCCCTTTAACTCCAAGCCGACAGCGGTCTAGGAATTCAAGTTCAGTGCCTACCGAAGACAAAGGCGCCC CGAGGGAGTGGCGGTGCGACCCCAGGGCGTGGGCCCGGCCGCGGAGCCCACACTGCCCGGCTGACCCGGTGGTCTCGGACCATGTCTCCC GCCCCAAGACCCCCCCGTTGTCTCCTGCTCCCCCTGCTCACGCTCGGCACCGCGCTCGCCTCCCTCGGCTCGGCCCAAAGCAGCAGCTTC AGCCCCGAAGCCTGGCTACAGCAATATGGCTACCTGCCTCCCGGGGACCTACGTACCCACACACAGCGCTCACCCCAGTCACTCTCAGCG GCCATCGCTGCCATGCAGAAGTTTTACGGCTTGCAAGTAACAGGCAAAGCTGATGCAGACACCATGAAGGCCATGAGGCGCCCCCGATGT GGTGTTCCAGACAAGTTTGGGGCTGAGATCAAGGCCAATGTTCGAAGGAAGCGCTACGCCATCCAGGGTCTCAAATGGCAACATAATGAA ATCACTTTCTGCATCCAGAATTACACCCCCAAGGTGGGCGAGTATGCCACATACGAGGCCATTCGCAAGGCGTTCCGCGTGTGGGAGAGT GCCACACCACTGCGCTTCCGCGAGGTGCCCTATGCCTACATCCGTGAGGGCCATGAGAAGCAGGCCGACATCATGATCTTCTTTGCCGAG GGCTTCCATGGCGACAGCACGCCCTTCGATGGTGAGGGCGGCTTCCTGGCCCATGCCTACTTCCCAGGCCCCAACATTGGAGGAGACACC CACTTTGACTCTGCCGAGCCTTGGACTGTCAGGAATGAGGATCTGAATGGAAATGACATCTTCCTGGTGGCTGTGCACGAGCTGGGCCAT GCCCTGGGGCTCGAGCATTCCAGTGACCCCTCGGCCATCATGGCACCCTTTTACCAGTGGATGGACACGGAGAATTTTGTGCTGCCCGAT GATGACCGCCGGGGCATCCAGCAACTTTATGGGGGTGAGTCAGGGTTCCCCACCAAGATGCCCCCTCAACCCAGGACTACCTCCCGGCCT TCTGTTCCTGATAAACCCAAAAACCCCACCTATGGGCCCAACATCTGTGACGGGAACTTTGACACCGTGGCCATGCTCCGAGGGGAGATG TTTGTCTTCAAGGAGCGCTGGTTCTGGCGGGTGAGGAATAACCAAGTGATGGATGGATACCCAATGCCCATTGGCCAGTTCTGGCGGGGC CTGCCTGCGTCCATCAACACTGCCTACGAGAGGAAGGATGGCAAATTCGTCTTCTTCAAAGGAGACAAGCATTGGGTGTTTGATGAGGCG TCCCTGGAACCTGGCTACCCCAAGCACATTAAGGAGCTGGGCCGAGGGCTGCCTACCGACAAGATTGATGCTGCTCTCTTCTGGATGCCC AATGGAAAGACCTACTTCTTCCGTGGAAACAAGTACTACCGTTTCAACGAAGAGCTCAGGGCAGTGGATAGCGAGTACCCCAAGAACATC AAAGTCTGGGAAGGGATCCCTGAGTCTCCCAGAGGGTCATTCATGGGCAGCGATGAAGACCTAGAGGATCAAGACATAATGGGAGCATTT TTAGACAAGCCAAAGATGGAAAAGCATAATGCCCAGGGGCAGGGTAATGGGTTGCGATATGGGCTAAGCAGCATGCAAGGCTGGCGTGTT GAAATGGAGGATGCACATACGGCTGTGATCGGTTTGCCAAGTGGACTTGAATCGTGGTCATTCTTTGCTGTGTATGATGGGCATGCTGGT TCTCAGGTTGCCAAATACTGCTGTGAGCATTTGTTAGATCACATCACCAATAACCAGGATTTTAAAGGGTCTGCAGGAGCACCTTCTGTG GAAAATGTAAAGAATGGAATCAGAACAGGTTTTCTGGAGATTGATGAACACATGAGAGTTATGTCAGAGAAGAAACATGGTGCAGATAGA AGTGGGTCAACAGCTGTAGGTGTCTTAATTTCTCCCCAACATACTTATTTCATTAACTGTGGAGACTCAAGAGGTTTACTTTGTAGGAAC AGGAAAGTTCATTTCTTCACACAAGATCACAAACCAAGTAATCCGCTGGAGAAAGAACGAATTCAGAATGCAGGTGGCTCTGTAATGATT CAGCGTGTGAATGGCTCTCTGGCTGTATCGAGGGCCCTTGGGGATTTTGATTACAAATGTGTCCATGGAAAAGGTCCTACTGAGCAGCTT GTCTCACCAGAGCCTGAAGTCCATGATATTGAAAGATCTGAAGAAGATGATCAGTTCATTATCCTTGCATGTGATGGTATCTGGGATGTT ATGGGAAATGAAGAGCTCTGTGATTTTGTAAGATCCAGACTTGAAGTCACTGATGACCTTGAGAAAGTTTGCAATGAAGTAGTCGACACC TGTTTGTATAAGGGAAGTCGAGACAACATGAGTGTGATTTTGATCTGTTTTCCAAATGCACCCAAAGTATCGCCAGAAGCAGTGAAGAAG GAGGCAGAGTTGGACAAGTACCTGGAATGCAGAGTAGAAGAAATCATAAAGAAGCAGGGGGAAGGCGTCCCCGACTTAGTCCATGTGATG CGCACATTAGCGAGTGAGAACATCCCCAGCCTCCCACCAGGGGGTGAATTGGCAAGCAAGAGGAATGTTATTGAAGCCGTTTACAATAGA CTGAATCCTTACAAAAATGACGACACTGACTCTACATCAACAGATGATATGTGGTAAAACTGCTCATCTAGCCATGGAGTTTACCTTCAC CTCCAAAGGAGAGTACAGCTCAACTTTGTTGAAACTTTTAACATCCATCCTCAACTTTAAGGAAGGGGATATGACATGGGTGAGAATGAT TACATCAGAGAACTTCAGCAGTACAACAGCTAGCCCAGAACTGATTTTTTTTTTTTTTTTTGTAAATTTGAGACTTATGTAAGCGTGATT |
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FusionGenePPI for MMP14_PPM1A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MMP14 | LUM, LRP1, TIMP2, C1QBP, SPOCK3, BCAR1, RRAD, PLLP, CCDC155, FURIN, MMP3, TIMP1 | PPM1A | LXN, GRM3, ARRB1, ARRB2, SMAD1, SMURF1, FGFR2, NR4A1, HSPB1, RPLP0, ASB2, DCP1B, HSFY1, PRKAA1, FBXW11, CER1, PRSS22, ADAMTS12, CHST10, VWA9, INPPL1, PPM1B, RTEL1, GDF3, RNASE13, CHEK1, MAP4K5, NAA10, MAPK9, PKN1, PRKCI, HNRNPD, XRCC5, TOR1AIP1, ACTR5, PIGS, NEDD1, AKT1, EGFR, IGF1R, INSR, BCKDK, FANCI, GCN1L1, HSD17B4, HSDL2, IWS1, LETM1, PAK4, SLC25A5, SLFN11, UGGT1, DUSP12, DUSP22, HAO2, CERKL, TECPR2, QARS, INSL6, PDDC1, HIP1R, CCL22, ZDHHC11, UBE3D, ALDH3B1, FBXL14, MTERF2, LMTK2, AATK, ERBB4, ERBB2, ERBB3, KDR, ROR2, ALK, PTK7, PAK1, PAK2, CDC42BPA, CDC42BPB, PRKCA, CYLD, COQ2, SOAT1, SOD1, VDAC1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MMP14_PPM1A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MMP14_PPM1A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MMP14 | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Hgene | MMP14 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Hgene | MMP14 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| Hgene | MMP14 | C0024117 | Chronic Obstructive Airway Disease | 1 | CTD_human |
| Hgene | MMP14 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Hgene | MMP14 | C0162871 | Aortic Aneurysm, Abdominal | 1 | CTD_human |
| Hgene | MMP14 | C0432289 | Winchester syndrome (disorder) | 1 | UNIPROT |
| Hgene | MMP14 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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