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Fusion gene ID: 22161 |
FusionGeneSummary for MLLT1_PRLR |
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Fusion gene information | Fusion gene name: MLLT1_PRLR | Fusion gene ID: 22161 | Hgene | Tgene | Gene symbol | MLLT1 | PRLR | Gene ID | 4298 | 5618 |
Gene name | MLLT1, super elongation complex subunit | prolactin receptor | |
Synonyms | ENL|LTG19|YEATS1 | HPRL|MFAB|RI-PRLR|hPRLrI | |
Cytomap | 19p13.3 | 5p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | protein ENLCTC-503J8.6ENL/MLL fusionMLL/ENL fusion proteinMLLT1/MLL fusionYEATS domain-containing protein 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homol | prolactin receptorhPRL receptorsecreted prolactin binding protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q03111 | P16471 | |
Ensembl transtripts involved in fusion gene | ENST00000252674, ENST00000585588, | ENST00000342362, ENST00000382002, ENST00000231423, ENST00000513753, ENST00000397391, ENST00000348262, ENST00000542609, ENST00000310101, ENST00000511486, ENST00000509934, | |
Fusion gene scores | * DoF score | 6 X 8 X 4=192 | 6 X 5 X 4=120 |
# samples | 9 | 6 | |
** MAII score | log2(9/192*10)=-1.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MLLT1 [Title/Abstract] AND PRLR [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PRLR | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity | 10585417 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | ACC | TCGA-OR-A5K9-01A | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000252674 | ENST00000342362 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
5CDS-5UTR | ENST00000252674 | ENST00000382002 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
5CDS-intron | ENST00000252674 | ENST00000231423 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
5CDS-intron | ENST00000252674 | ENST00000513753 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
5CDS-intron | ENST00000252674 | ENST00000397391 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
5CDS-intron | ENST00000252674 | ENST00000348262 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
5CDS-intron | ENST00000252674 | ENST00000542609 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
5CDS-intron | ENST00000252674 | ENST00000310101 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
5CDS-intron | ENST00000252674 | ENST00000511486 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
5CDS-intron | ENST00000252674 | ENST00000509934 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
intron-5UTR | ENST00000585588 | ENST00000342362 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
intron-5UTR | ENST00000585588 | ENST00000382002 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
intron-intron | ENST00000585588 | ENST00000231423 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
intron-intron | ENST00000585588 | ENST00000513753 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
intron-intron | ENST00000585588 | ENST00000397391 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
intron-intron | ENST00000585588 | ENST00000348262 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
intron-intron | ENST00000585588 | ENST00000542609 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
intron-intron | ENST00000585588 | ENST00000310101 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
intron-intron | ENST00000585588 | ENST00000511486 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
intron-intron | ENST00000585588 | ENST00000509934 | MLLT1 | chr19 | 6270590 | - | PRLR | chr5 | 35118224 | - |
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FusionProtFeatures for MLLT1_PRLR |
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Hgene | Tgene |
MLLT1 | PRLR |
Component of the super elongation complex (SEC), acomplex required to increase the catalytic rate of RNA polymeraseII transcription by suppressing transient pausing by thepolymerase at multiple sites along the DNA.{ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MLLT1_PRLR |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MLLT1_PRLR |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MLLT1 | CBX8, AFF1, CDK9, WDR5, DOT1L, MLLT3, RFX5, AFF4, CSNK2A1, BCOR, RFXAP, MLLT10, ACACA, CHD1, ELL, SIRT1, MLLT6, CCNT1, KMT2A, BRD4, ELL2, PAF1, POLR2A, MED26, HIST3H3, HIST1H1B, EAF1, ELL3, RNF2, RPL12, MRPL12, HIST2H2AC, H2AFX, HIST2H2BE, HIST4H4, BMI1, PIP4K2A, EPB41L2, CAMKV, BPIFB1, YAF2, RYBP, DENND2D, ARRB2, TRIM25 | PRLR | PPIA, SOCS3, TEC, VAV1, SOCS2, JAK2, PTPN11, GTF3A, FBXW11, CREBBP, PRLR, STAT5B, BTRC |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MLLT1_PRLR |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PRLR | P16471 | DB01185 | Fluoxymesterone | Prolactin receptor | small molecule | approved|illicit |
Tgene | PRLR | P16471 | DB00052 | Somatotropin | Prolactin receptor | biotech | approved|investigational |
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RelatedDiseases for MLLT1_PRLR |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PRLR | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
Tgene | PRLR | C0000786 | Spontaneous abortion | 1 | CTD_human |
Tgene | PRLR | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | PRLR | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | PRLR | C0020514 | Hyperprolactinemia | 1 | HPO;ORPHANET;UNIPROT |
Tgene | PRLR | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | PRLR | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | PRLR | C3809918 | MULTIPLE FIBROADENOMAS OF THE BREAST | 1 | ORPHANET;UNIPROT |