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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 22159

FusionGeneSummary for MLLT1_MAD1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: MLLT1_MAD1L1
Fusion gene ID: 22159
HgeneTgene
Gene symbol

MLLT1

MAD1L1

Gene ID

4298

8379

Gene nameMLLT1, super elongation complex subunitmitotic arrest deficient 1 like 1
SynonymsENL|LTG19|YEATS1MAD1|PIG9|TP53I9|TXBP181
Cytomap

19p13.3

7p22.3

Type of geneprotein-codingprotein-coding
Descriptionprotein ENLCTC-503J8.6ENL/MLL fusionMLL/ENL fusion proteinMLLT1/MLL fusionYEATS domain-containing protein 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolmitotic spindle assembly checkpoint protein MAD1MAD1 mitotic arrest deficient like 1MAD1-like protein 1mitotic arrest deficient 1-like protein 1mitotic checkpoint MAD1 protein homologmitotic-arrest deficient 1, yeast, homolog-like 1tax-binding prote
Modification date2018051920180523
UniProtAcc

Q03111

Q9Y6D9

Ensembl transtripts involved in fusion geneENST00000252674, ENST00000585588, 
ENST00000402746, ENST00000399654, 
ENST00000406869, ENST00000265854, 
ENST00000486340, 
Fusion gene scores* DoF score6 X 8 X 4=19210 X 12 X 9=1080
# samples 918
** MAII scorelog2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/1080*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MLLT1 [Title/Abstract] AND MAD1L1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAD1L1

GO:0090235

regulation of metaphase plate congression

20133940


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-FS-A1Z4-06AMLLT1chr19

6230581

-MAD1L1chr7

2041756

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000252674ENST00000402746MLLT1chr19

6230581

-MAD1L1chr7

2041756

-
In-frameENST00000252674ENST00000399654MLLT1chr19

6230581

-MAD1L1chr7

2041756

-
In-frameENST00000252674ENST00000406869MLLT1chr19

6230581

-MAD1L1chr7

2041756

-
In-frameENST00000252674ENST00000265854MLLT1chr19

6230581

-MAD1L1chr7

2041756

-
5CDS-intronENST00000252674ENST00000486340MLLT1chr19

6230581

-MAD1L1chr7

2041756

-
intron-3CDSENST00000585588ENST00000402746MLLT1chr19

6230581

-MAD1L1chr7

2041756

-
intron-3CDSENST00000585588ENST00000399654MLLT1chr19

6230581

-MAD1L1chr7

2041756

-
intron-3CDSENST00000585588ENST00000406869MLLT1chr19

6230581

-MAD1L1chr7

2041756

-
intron-3CDSENST00000585588ENST00000265854MLLT1chr19

6230581

-MAD1L1chr7

2041756

-
intron-intronENST00000585588ENST00000486340MLLT1chr19

6230581

-MAD1L1chr7

2041756

-

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FusionProtFeatures for MLLT1_MAD1L1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MLLT1

Q03111

MAD1L1

Q9Y6D9

Component of the super elongation complex (SEC), acomplex required to increase the catalytic rate of RNA polymeraseII transcription by suppressing transient pausing by thepolymerase at multiple sites along the DNA.{ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948}. Component of the spindle-assembly checkpoint thatprevents the onset of anaphase until all chromosomes are properlyaligned at the metaphase plate. May recruit MAD2L1 to unattachedkinetochores. Has a role in the correct positioning of the septum.Required for anchoring MAD2L1 to the nuclear periphery. Binds tothe TERT promoter and represses telomerase expression, possibly byinterfering with MYC binding. {ECO:0000269|PubMed:10049595,ECO:0000269|PubMed:12837246, ECO:0000269|PubMed:20133940}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMLLT1chr19:6230581chr7:2041756ENST00000252674-4128_112140560DomainYEATS

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMLLT1chr19:6230581chr7:2041756ENST00000252674-412272_280140560Compositional biasNote=Poly-Pro
HgeneMLLT1chr19:6230581chr7:2041756ENST00000252674-412319_325140560Compositional biasNote=Poly-Ser
HgeneMLLT1chr19:6230581chr7:2041756ENST00000252674-412374_389140560Compositional biasNote=Poly-Ser
HgeneMLLT1chr19:6230581chr7:2041756ENST00000252674-412457_460140560Compositional biasNote=Poly-Pro
HgeneMLLT1chr19:6230581chr7:2041756ENST00000252674-412463_466140560Compositional biasNote=Poly-Pro
TgeneMAD1L1chr19:6230581chr7:2041756ENST00000265854-111846_632453719Coiled coilOntology_term=ECO:0000255
TgeneMAD1L1chr19:6230581chr7:2041756ENST00000399654-121946_632453719Coiled coilOntology_term=ECO:0000255
TgeneMAD1L1chr19:6230581chr7:2041756ENST00000406869-121946_632453719Coiled coilOntology_term=ECO:0000255


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FusionGeneSequence for MLLT1_MAD1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MLLT1_ENST00000252674_chr19_6230581_-_MAD1L1_ENST00000402746_chr7_2041756_-_406aa
MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFK
NKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLF
SREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDTDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGT
VPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGS

>In-frame_MLLT1_ENST00000252674_chr19_6230581_-_MAD1L1_ENST00000399654_chr7_2041756_-_406aa
MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFK
NKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLF
SREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDTDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGT
VPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGS

>In-frame_MLLT1_ENST00000252674_chr19_6230581_-_MAD1L1_ENST00000406869_chr7_2041756_-_406aa
MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFK
NKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLF
SREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDTDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGT
VPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGS

>In-frame_MLLT1_ENST00000252674_chr19_6230581_-_MAD1L1_ENST00000265854_chr7_2041756_-_406aa
MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFK
NKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLF
SREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDTDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGT
VPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MLLT1_ENST00000252674_chr19_6230581_-_MAD1L1_ENST00000402746_chr7_2041756_-_1218nt
ATGGACAATCAGTGCACCGTCCAGGTGAGGTTAGAGCTGGGGCATCGCGCCCAACTGCGCAAGAAGCCCACCACGGAGGGGTTCACTCAC
GACTGGATGGTGTTTGTCCGCGGCCCCGAGCAATGTGACATCCAGCACTTCGTGGAGAAGGTGGTCTTCTGGCTGCACGACAGCTTCCCC
AAGCCCAGACGCGTGTGCAAGGAGCCCCCCTACAAAGTAGAGGAGTCGGGGTACGCTGGCTTCATCATGCCCATCGAGGTGCACTTCAAA
AACAAGGAGGAGCCGAGGAAGGTCTGCTTCACCTACGACCTGTTCCTGAACCTGGAAGGCAACCCGCCCGTGAACCACCTGCGCTGCGAG
AAGCTCACCTTCAACAACCCCACCACGGAGTTCCGGTACAAGCTCCTGCGGGCCGGCGGGGCTCAGCTGTCGCAGGCCCTGGAGGAGCTG
GGAGGCCAGAAACAAAGAGCAGACATGCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTCCTGTTC
TCCAGGGAGGAGGCGGACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATGCTGGAG
GCACAGCTGGAGCGGCGAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCC
AGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACC
GTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTG
AAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATC
ACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCC
AAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTC

>In-frame_MLLT1_ENST00000252674_chr19_6230581_-_MAD1L1_ENST00000399654_chr7_2041756_-_1218nt
ATGGACAATCAGTGCACCGTCCAGGTGAGGTTAGAGCTGGGGCATCGCGCCCAACTGCGCAAGAAGCCCACCACGGAGGGGTTCACTCAC
GACTGGATGGTGTTTGTCCGCGGCCCCGAGCAATGTGACATCCAGCACTTCGTGGAGAAGGTGGTCTTCTGGCTGCACGACAGCTTCCCC
AAGCCCAGACGCGTGTGCAAGGAGCCCCCCTACAAAGTAGAGGAGTCGGGGTACGCTGGCTTCATCATGCCCATCGAGGTGCACTTCAAA
AACAAGGAGGAGCCGAGGAAGGTCTGCTTCACCTACGACCTGTTCCTGAACCTGGAAGGCAACCCGCCCGTGAACCACCTGCGCTGCGAG
AAGCTCACCTTCAACAACCCCACCACGGAGTTCCGGTACAAGCTCCTGCGGGCCGGCGGGGCTCAGCTGTCGCAGGCCCTGGAGGAGCTG
GGAGGCCAGAAACAAAGAGCAGACATGCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTCCTGTTC
TCCAGGGAGGAGGCGGACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATGCTGGAG
GCACAGCTGGAGCGGCGAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCC
AGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACC
GTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTG
AAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATC
ACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCC
AAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTC

>In-frame_MLLT1_ENST00000252674_chr19_6230581_-_MAD1L1_ENST00000406869_chr7_2041756_-_1218nt
ATGGACAATCAGTGCACCGTCCAGGTGAGGTTAGAGCTGGGGCATCGCGCCCAACTGCGCAAGAAGCCCACCACGGAGGGGTTCACTCAC
GACTGGATGGTGTTTGTCCGCGGCCCCGAGCAATGTGACATCCAGCACTTCGTGGAGAAGGTGGTCTTCTGGCTGCACGACAGCTTCCCC
AAGCCCAGACGCGTGTGCAAGGAGCCCCCCTACAAAGTAGAGGAGTCGGGGTACGCTGGCTTCATCATGCCCATCGAGGTGCACTTCAAA
AACAAGGAGGAGCCGAGGAAGGTCTGCTTCACCTACGACCTGTTCCTGAACCTGGAAGGCAACCCGCCCGTGAACCACCTGCGCTGCGAG
AAGCTCACCTTCAACAACCCCACCACGGAGTTCCGGTACAAGCTCCTGCGGGCCGGCGGGGCTCAGCTGTCGCAGGCCCTGGAGGAGCTG
GGAGGCCAGAAACAAAGAGCAGACATGCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTCCTGTTC
TCCAGGGAGGAGGCGGACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATGCTGGAG
GCACAGCTGGAGCGGCGAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCC
AGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACC
GTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTG
AAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATC
ACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCC
AAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTC

>In-frame_MLLT1_ENST00000252674_chr19_6230581_-_MAD1L1_ENST00000265854_chr7_2041756_-_1218nt
ATGGACAATCAGTGCACCGTCCAGGTGAGGTTAGAGCTGGGGCATCGCGCCCAACTGCGCAAGAAGCCCACCACGGAGGGGTTCACTCAC
GACTGGATGGTGTTTGTCCGCGGCCCCGAGCAATGTGACATCCAGCACTTCGTGGAGAAGGTGGTCTTCTGGCTGCACGACAGCTTCCCC
AAGCCCAGACGCGTGTGCAAGGAGCCCCCCTACAAAGTAGAGGAGTCGGGGTACGCTGGCTTCATCATGCCCATCGAGGTGCACTTCAAA
AACAAGGAGGAGCCGAGGAAGGTCTGCTTCACCTACGACCTGTTCCTGAACCTGGAAGGCAACCCGCCCGTGAACCACCTGCGCTGCGAG
AAGCTCACCTTCAACAACCCCACCACGGAGTTCCGGTACAAGCTCCTGCGGGCCGGCGGGGCTCAGCTGTCGCAGGCCCTGGAGGAGCTG
GGAGGCCAGAAACAAAGAGCAGACATGCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTCCTGTTC
TCCAGGGAGGAGGCGGACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATGCTGGAG
GCACAGCTGGAGCGGCGAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCC
AGGCAGCGCCTGCGCGAGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACC
GTCCCAGCCGACCTTGAGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTG
AAGAACCAGCGGCTCAAGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATC
ACCACGGAGAACCAGTACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCC
AAGATGCAGCTACTGGAGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_MLLT1_ENST00000252674_chr19_6230581_-_MAD1L1_ENST00000402746_chr7_2041756_-_1658nt
GGTTCCGCGGGGCTGGCGGGCGAGCGGGCGGCCGGGATCGGCGGCGGCGGCGGCGGCGGCGGCGCTTGACAGACAATGAGGGCGGCGGGG
CGGCGTTGAGCGGCGGCGGCGGCGGCGGCGGCGGCGAGCGACGCGGGGCCCGGGGGCGGGGCGGGGCGCCAGCCATGGACAATCAGTGCA
CCGTCCAGGTGAGGTTAGAGCTGGGGCATCGCGCCCAACTGCGCAAGAAGCCCACCACGGAGGGGTTCACTCACGACTGGATGGTGTTTG
TCCGCGGCCCCGAGCAATGTGACATCCAGCACTTCGTGGAGAAGGTGGTCTTCTGGCTGCACGACAGCTTCCCCAAGCCCAGACGCGTGT
GCAAGGAGCCCCCCTACAAAGTAGAGGAGTCGGGGTACGCTGGCTTCATCATGCCCATCGAGGTGCACTTCAAAAACAAGGAGGAGCCGA
GGAAGGTCTGCTTCACCTACGACCTGTTCCTGAACCTGGAAGGCAACCCGCCCGTGAACCACCTGCGCTGCGAGAAGCTCACCTTCAACA
ACCCCACCACGGAGTTCCGGTACAAGCTCCTGCGGGCCGGCGGGGCTCAGCTGTCGCAGGCCCTGGAGGAGCTGGGAGGCCAGAAACAAA
GAGCAGACATGCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTCCTGTTCTCCAGGGAGGAGGCGG
ACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATGCTGGAGGCACAGCTGGAGCGGC
GAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCG
AGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTG
AGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCA
AGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGT
ACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGG
AGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCC
TCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCC
TGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTC
GGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTGTGGGCGTCGGCCACCAGCCTGG

>In-frame_MLLT1_ENST00000252674_chr19_6230581_-_MAD1L1_ENST00000399654_chr7_2041756_-_1658nt
GGTTCCGCGGGGCTGGCGGGCGAGCGGGCGGCCGGGATCGGCGGCGGCGGCGGCGGCGGCGGCGCTTGACAGACAATGAGGGCGGCGGGG
CGGCGTTGAGCGGCGGCGGCGGCGGCGGCGGCGGCGAGCGACGCGGGGCCCGGGGGCGGGGCGGGGCGCCAGCCATGGACAATCAGTGCA
CCGTCCAGGTGAGGTTAGAGCTGGGGCATCGCGCCCAACTGCGCAAGAAGCCCACCACGGAGGGGTTCACTCACGACTGGATGGTGTTTG
TCCGCGGCCCCGAGCAATGTGACATCCAGCACTTCGTGGAGAAGGTGGTCTTCTGGCTGCACGACAGCTTCCCCAAGCCCAGACGCGTGT
GCAAGGAGCCCCCCTACAAAGTAGAGGAGTCGGGGTACGCTGGCTTCATCATGCCCATCGAGGTGCACTTCAAAAACAAGGAGGAGCCGA
GGAAGGTCTGCTTCACCTACGACCTGTTCCTGAACCTGGAAGGCAACCCGCCCGTGAACCACCTGCGCTGCGAGAAGCTCACCTTCAACA
ACCCCACCACGGAGTTCCGGTACAAGCTCCTGCGGGCCGGCGGGGCTCAGCTGTCGCAGGCCCTGGAGGAGCTGGGAGGCCAGAAACAAA
GAGCAGACATGCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTCCTGTTCTCCAGGGAGGAGGCGG
ACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATGCTGGAGGCACAGCTGGAGCGGC
GAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCG
AGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTG
AGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCA
AGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGT
ACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGG
AGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCC
TCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCC
TGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTC
GGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTGTGGGCGTCGGCCACCAGCCTGG

>In-frame_MLLT1_ENST00000252674_chr19_6230581_-_MAD1L1_ENST00000406869_chr7_2041756_-_1658nt
GGTTCCGCGGGGCTGGCGGGCGAGCGGGCGGCCGGGATCGGCGGCGGCGGCGGCGGCGGCGGCGCTTGACAGACAATGAGGGCGGCGGGG
CGGCGTTGAGCGGCGGCGGCGGCGGCGGCGGCGGCGAGCGACGCGGGGCCCGGGGGCGGGGCGGGGCGCCAGCCATGGACAATCAGTGCA
CCGTCCAGGTGAGGTTAGAGCTGGGGCATCGCGCCCAACTGCGCAAGAAGCCCACCACGGAGGGGTTCACTCACGACTGGATGGTGTTTG
TCCGCGGCCCCGAGCAATGTGACATCCAGCACTTCGTGGAGAAGGTGGTCTTCTGGCTGCACGACAGCTTCCCCAAGCCCAGACGCGTGT
GCAAGGAGCCCCCCTACAAAGTAGAGGAGTCGGGGTACGCTGGCTTCATCATGCCCATCGAGGTGCACTTCAAAAACAAGGAGGAGCCGA
GGAAGGTCTGCTTCACCTACGACCTGTTCCTGAACCTGGAAGGCAACCCGCCCGTGAACCACCTGCGCTGCGAGAAGCTCACCTTCAACA
ACCCCACCACGGAGTTCCGGTACAAGCTCCTGCGGGCCGGCGGGGCTCAGCTGTCGCAGGCCCTGGAGGAGCTGGGAGGCCAGAAACAAA
GAGCAGACATGCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTCCTGTTCTCCAGGGAGGAGGCGG
ACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATGCTGGAGGCACAGCTGGAGCGGC
GAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCG
AGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTG
AGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCA
AGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGT
ACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGG
AGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCC
TCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCC
TGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTC
GGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTGTGGGCGTCGGCCACCAGCCTGG

>In-frame_MLLT1_ENST00000252674_chr19_6230581_-_MAD1L1_ENST00000265854_chr7_2041756_-_1641nt
GGTTCCGCGGGGCTGGCGGGCGAGCGGGCGGCCGGGATCGGCGGCGGCGGCGGCGGCGGCGGCGCTTGACAGACAATGAGGGCGGCGGGG
CGGCGTTGAGCGGCGGCGGCGGCGGCGGCGGCGGCGAGCGACGCGGGGCCCGGGGGCGGGGCGGGGCGCCAGCCATGGACAATCAGTGCA
CCGTCCAGGTGAGGTTAGAGCTGGGGCATCGCGCCCAACTGCGCAAGAAGCCCACCACGGAGGGGTTCACTCACGACTGGATGGTGTTTG
TCCGCGGCCCCGAGCAATGTGACATCCAGCACTTCGTGGAGAAGGTGGTCTTCTGGCTGCACGACAGCTTCCCCAAGCCCAGACGCGTGT
GCAAGGAGCCCCCCTACAAAGTAGAGGAGTCGGGGTACGCTGGCTTCATCATGCCCATCGAGGTGCACTTCAAAAACAAGGAGGAGCCGA
GGAAGGTCTGCTTCACCTACGACCTGTTCCTGAACCTGGAAGGCAACCCGCCCGTGAACCACCTGCGCTGCGAGAAGCTCACCTTCAACA
ACCCCACCACGGAGTTCCGGTACAAGCTCCTGCGGGCCGGCGGGGCTCAGCTGTCGCAGGCCCTGGAGGAGCTGGGAGGCCAGAAACAAA
GAGCAGACATGCTGGAGATGGAGCTGAAGATGCTGAAGTCTCAGTCCAGCTCTGCCGAACAGAGCTTCCTGTTCTCCAGGGAGGAGGCGG
ACACGCTCAGGTTGAAGGTCGAGGAGCTGGAAGGCGAGCGGAGTCGGCTGGAGGAGGAAAAGAGGATGCTGGAGGCACAGCTGGAGCGGC
GAGCTCTGCAGGGTGACTATGACCAGAGCAGGACCAAAGTGCTGCACATGAGCCTGAACCCCACCAGTGTGGCCAGGCAGCGCCTGCGCG
AGGACCACAGCCAGCTGCAGGCGGAGTGCGAGCGACTGCGCGGGCTCCTGCGCGCCATGGAGAGAGGAGGCACCGTCCCAGCCGACCTTG
AGGCTGCCGCCGCGAGTCTGCCATCGTCCAAGGAGGTGGCAGAGCTGAAGAAGCAGGTGGAGAGTGCCGAGCTGAAGAACCAGCGGCTCA
AGGAGGTTTTCCAGACCAAGATCCAGGAGTTCCGCAAGGCCTGCTACACGCTCACCGGCTACCAGATCGACATCACCACGGAGAACCAGT
ACCGGCTGACCTCGCTGTACGCCGAGCACCCAGGCGACTGCCTCATCTTCAAGGCCACCAGCCCCTCGGGTTCCAAGATGCAGCTACTGG
AGACAGAGTTCTCACACACCGTGGGCGAGCTCATCGAGGTGCACCTGCGGCGCCAGGACAGCATCCCTGCCTTCCTCAGCTCGCTCACCC
TCGAGCTCTTCAGCCGCCAGACCGTGGCGTAGCCTGCAGGCTCGGGGGCATAGCCGGAGCCACTCTGCTTGGCCTGACCTGCAGGTCCCC
TGCCCCGCCAGCCACAGGCTGGGTGCACGTCCTGCCTCTCCAGCCCCACAGGGCAGCAGCATGACTGACAGACACGCTGGGACCTACGTC
GGGCTTCCTGCTGGGGCGGCCAGCACCCTCTCCACGTGCAGACCCCATGCGTCCCGGAGCCTGGTGTGTGGGCGTCGGCCACCAGCCTGG


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FusionGenePPI for MLLT1_MAD1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MLLT1CBX8, AFF1, CDK9, WDR5, DOT1L, MLLT3, RFX5, AFF4, CSNK2A1, BCOR, RFXAP, MLLT10, ACACA, CHD1, ELL, SIRT1, MLLT6, CCNT1, KMT2A, BRD4, ELL2, PAF1, POLR2A, MED26, HIST3H3, HIST1H1B, EAF1, ELL3, RNF2, RPL12, MRPL12, HIST2H2AC, H2AFX, HIST2H2BE, HIST4H4, BMI1, PIP4K2A, EPB41L2, CAMKV, BPIFB1, YAF2, RYBP, DENND2D, ARRB2, TRIM25MAD1L1TEX11, NINL, NONO, FAM131C, TRIM29, AMOTL2, TUBGCP4, MAD1L1, MAD2L1, HDAC1, HDAC2, MNT, NRD1, MAD2L1BP, CDC27, COIL, UBC, METTL21C, ZW10, SIN3A, BAG5, FLNB, ZZEF1, CDC20, TPR, TRIP13, ALOX5, TSC22D3, MFAP1, PSMA1, TPM1, TPM3, RNF8, SPATA2, USP15, NEBL, LGALSL, CCHCR1, ZSCAN32, CCDC94, TSHZ3, HAUS1, CWF19L2, CLEC11A, KCNAB3, VPS28, SCARA3, IKZF3, NUDC, STK24, NTRK1, APC, FOXJ2, SNW1, CDC5L, SENP3, PTRF, ZADH2, BMP1, ASB7, HSPA8, C6orf141


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MLLT1_MAD1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MLLT1_MAD1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMAD1L1C0036341Schizophrenia1PSYGENET
TgeneMAD1L1C1336708Testicular Germ Cell Tumor1CTD_human
TgeneMAD1L1C3495559Juvenile arthritis1CTD_human