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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22153

FusionGeneSummary for MLLT10_SLC16A1

check button Fusion gene summary
Fusion gene informationFusion gene name: MLLT10_SLC16A1
Fusion gene ID: 22153
HgeneTgene
Gene symbol

MLLT10

SLC16A1

Gene ID

8028

6566

Gene nameMLLT10, histone lysine methyltransferase DOT1L cofactorsolute carrier family 16 member 1
SynonymsAF10HHF7|MCT|MCT1|MCT1D
Cytomap

10p12.31

1p13.2

Type of geneprotein-codingprotein-coding
Descriptionprotein AF-10ALL1-fused gene from chromosome 10 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10type I AF10 proteintype III AF10 protmonocarboxylate transporter 1MCT 1solute carrier family 16 (monocarboxylate transporter), member 1solute carrier family 16 (monocarboxylic acid transporters), member 1solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
Modification date2018052220180527
UniProtAcc

P55197

P53985

Ensembl transtripts involved in fusion geneENST00000446906, ENST00000377072, 
ENST00000307729, ENST00000377059, 
ENST00000495130, ENST00000377100, 
ENST00000377091, 
ENST00000369626, 
ENST00000538576, ENST00000433570, 
ENST00000478835, 
Fusion gene scores* DoF score13 X 10 X 8=10403 X 3 X 2=18
# samples 203
** MAII scorelog2(20/1040*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MLLT10 [Title/Abstract] AND SLC16A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMLLT10

GO:0045944

positive regulation of transcription by RNA polymerase II

17868029


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-RP-A695-06AMLLT10chr10

21823733

+SLC16A1chr1

113471974

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000446906ENST00000369626MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000446906ENST00000538576MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000446906ENST00000433570MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000446906ENST00000478835MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000377072ENST00000369626MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000377072ENST00000538576MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000377072ENST00000433570MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000377072ENST00000478835MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000307729ENST00000369626MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000307729ENST00000538576MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000307729ENST00000433570MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000307729ENST00000478835MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000377059ENST00000369626MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000377059ENST00000538576MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000377059ENST00000433570MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000377059ENST00000478835MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
3UTR-5UTRENST00000495130ENST00000369626MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
3UTR-5UTRENST00000495130ENST00000538576MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
3UTR-5UTRENST00000495130ENST00000433570MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
3UTR-5UTRENST00000495130ENST00000478835MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000377100ENST00000369626MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000377100ENST00000538576MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000377100ENST00000433570MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000377100ENST00000478835MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000377091ENST00000369626MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000377091ENST00000538576MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000377091ENST00000433570MLLT10chr10

21823733

+SLC16A1chr1

113471974

-
5CDS-5UTRENST00000377091ENST00000478835MLLT10chr10

21823733

+SLC16A1chr1

113471974

-

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FusionProtFeatures for MLLT10_SLC16A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MLLT10

P55197

SLC16A1

P53985

Probably involved in transcriptional regulation. Invitro or as fusion protein with KMT2A/MLL1 has transactivationactivity. Binds to cruciform DNA. In cells, binding to unmodifiedhistone H3 regulates DOT1L functions including histone H3 'Lys-79'dimethylation (H3K79me2) and gene activation (PubMed:26439302).{ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. Proton-coupled monocarboxylate transporter. Catalyzesthe rapid transport across the plasma membrane of manymonocarboxylates such as lactate, pyruvate, branched-chain oxoacids derived from leucine, valine and isoleucine, and the ketonebodies acetoacetate, beta-hydroxybutyrate and acetate. Dependingon the tissue and on cicumstances, mediates the import or exportof lactic acid and ketone bodies. Required for normal nutrientassimilation, increase of white adipose tissue and body weightgain when on a high-fat diet. Plays a role in cellular responsesto a high-fat diet by modulating the cellular levels of lactateand pyruvate, small molecules that contribute to the regulation ofcentral metabolic pathways and insulin secretion, with concomitanteffects on plasma insulin levels and blood glucose homeostasis.{ECO:0000269|PubMed:17701893}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MLLT10_SLC16A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MLLT10_SLC16A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MLLT10YEATS4, SMARCB1, SS18, MLLT10, DOT1L, MLLT1, MLLT3, AFF1, DISC1, NDEL1, ELAVL1, CENPJ, TMPO, ZNF526, MLLT6, TCP10L, KIF6, PMF1SLC16A1DEGS1, SERINC3, AP1S1, BSG, MME, CUL3, CUL2, CYSTM1, LGR4, ILK, UNK, NTRK1, FAM46A, OTUB1, COQ9, PTPMT1, NDUFA4, C15orf48, C17orf89, CISD3, NDUFS3, CHCHD10, CRBN, NR3C1, SOAT1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MLLT10_SLC16A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSLC16A1P53985DB09338MersalylMonocarboxylate transporter 1small moleculeapproved

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RelatedDiseases for MLLT10_SLC16A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMLLT10C0007134Renal Cell Carcinoma1CTD_human
HgeneMLLT10C0025202melanoma1CTD_human
HgeneMLLT10C0025286Meningioma1CTD_human
TgeneSLC16A1C0007621Neoplastic Cell Transformation1CTD_human
TgeneSLC16A1C0009375Colonic Neoplasms1CTD_human
TgeneSLC16A1C1855577Erythrocyte Lactate Transporter Defect1CTD_human;ORPHANET;UNIPROT
TgeneSLC16A1C4015186MONOCARBOXYLATE TRANSPORTER 1 DEFICIENCY1ORPHANET;UNIPROT