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Fusion gene ID: 22153 |
FusionGeneSummary for MLLT10_SLC16A1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MLLT10_SLC16A1 | Fusion gene ID: 22153 | Hgene | Tgene | Gene symbol | MLLT10 | SLC16A1 | Gene ID | 8028 | 6566 |
| Gene name | MLLT10, histone lysine methyltransferase DOT1L cofactor | solute carrier family 16 member 1 | |
| Synonyms | AF10 | HHF7|MCT|MCT1|MCT1D | |
| Cytomap | 10p12.31 | 1p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein AF-10ALL1-fused gene from chromosome 10 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10type I AF10 proteintype III AF10 prot | monocarboxylate transporter 1MCT 1solute carrier family 16 (monocarboxylate transporter), member 1solute carrier family 16 (monocarboxylic acid transporters), member 1solute carrier family 16, member 1 (monocarboxylic acid transporter 1) | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | P55197 | P53985 | |
| Ensembl transtripts involved in fusion gene | ENST00000446906, ENST00000377072, ENST00000307729, ENST00000377059, ENST00000495130, ENST00000377100, ENST00000377091, | ENST00000369626, ENST00000538576, ENST00000433570, ENST00000478835, | |
| Fusion gene scores | * DoF score | 13 X 10 X 8=1040 | 3 X 3 X 2=18 |
| # samples | 20 | 3 | |
| ** MAII score | log2(20/1040*10)=-2.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MLLT10 [Title/Abstract] AND SLC16A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MLLT10 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17868029 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-RP-A695-06A | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000446906 | ENST00000369626 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000446906 | ENST00000538576 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000446906 | ENST00000433570 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000446906 | ENST00000478835 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000377072 | ENST00000369626 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000377072 | ENST00000538576 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000377072 | ENST00000433570 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000377072 | ENST00000478835 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000307729 | ENST00000369626 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000307729 | ENST00000538576 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000307729 | ENST00000433570 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000307729 | ENST00000478835 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000377059 | ENST00000369626 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000377059 | ENST00000538576 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000377059 | ENST00000433570 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000377059 | ENST00000478835 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 3UTR-5UTR | ENST00000495130 | ENST00000369626 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 3UTR-5UTR | ENST00000495130 | ENST00000538576 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 3UTR-5UTR | ENST00000495130 | ENST00000433570 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 3UTR-5UTR | ENST00000495130 | ENST00000478835 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000377100 | ENST00000369626 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000377100 | ENST00000538576 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000377100 | ENST00000433570 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000377100 | ENST00000478835 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000377091 | ENST00000369626 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000377091 | ENST00000538576 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000377091 | ENST00000433570 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
| 5CDS-5UTR | ENST00000377091 | ENST00000478835 | MLLT10 | chr10 | 21823733 | + | SLC16A1 | chr1 | 113471974 | - |
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FusionProtFeatures for MLLT10_SLC16A1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MLLT10 | SLC16A1 |
| Probably involved in transcriptional regulation. Invitro or as fusion protein with KMT2A/MLL1 has transactivationactivity. Binds to cruciform DNA. In cells, binding to unmodifiedhistone H3 regulates DOT1L functions including histone H3 'Lys-79'dimethylation (H3K79me2) and gene activation (PubMed:26439302).{ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. | Proton-coupled monocarboxylate transporter. Catalyzesthe rapid transport across the plasma membrane of manymonocarboxylates such as lactate, pyruvate, branched-chain oxoacids derived from leucine, valine and isoleucine, and the ketonebodies acetoacetate, beta-hydroxybutyrate and acetate. Dependingon the tissue and on cicumstances, mediates the import or exportof lactic acid and ketone bodies. Required for normal nutrientassimilation, increase of white adipose tissue and body weightgain when on a high-fat diet. Plays a role in cellular responsesto a high-fat diet by modulating the cellular levels of lactateand pyruvate, small molecules that contribute to the regulation ofcentral metabolic pathways and insulin secretion, with concomitanteffects on plasma insulin levels and blood glucose homeostasis.{ECO:0000269|PubMed:17701893}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MLLT10_SLC16A1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MLLT10_SLC16A1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MLLT10 | YEATS4, SMARCB1, SS18, MLLT10, DOT1L, MLLT1, MLLT3, AFF1, DISC1, NDEL1, ELAVL1, CENPJ, TMPO, ZNF526, MLLT6, TCP10L, KIF6, PMF1 | SLC16A1 | DEGS1, SERINC3, AP1S1, BSG, MME, CUL3, CUL2, CYSTM1, LGR4, ILK, UNK, NTRK1, FAM46A, OTUB1, COQ9, PTPMT1, NDUFA4, C15orf48, C17orf89, CISD3, NDUFS3, CHCHD10, CRBN, NR3C1, SOAT1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MLLT10_SLC16A1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | SLC16A1 | P53985 | DB09338 | Mersalyl | Monocarboxylate transporter 1 | small molecule | approved |
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RelatedDiseases for MLLT10_SLC16A1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MLLT10 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Hgene | MLLT10 | C0025202 | melanoma | 1 | CTD_human |
| Hgene | MLLT10 | C0025286 | Meningioma | 1 | CTD_human |
| Tgene | SLC16A1 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Tgene | SLC16A1 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Tgene | SLC16A1 | C1855577 | Erythrocyte Lactate Transporter Defect | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | SLC16A1 | C4015186 | MONOCARBOXYLATE TRANSPORTER 1 DEFICIENCY | 1 | ORPHANET;UNIPROT |
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