![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 22152 |
FusionGeneSummary for MLLT10_SKIDA1 |
![]() |
Fusion gene information | Fusion gene name: MLLT10_SKIDA1 | Fusion gene ID: 22152 | Hgene | Tgene | Gene symbol | MLLT10 | SKIDA1 | Gene ID | 8028 | 387640 |
Gene name | MLLT10, histone lysine methyltransferase DOT1L cofactor | SKI/DACH domain containing 1 | |
Synonyms | AF10 | C10orf140|DLN-1 | |
Cytomap | 10p12.31 | 10p12.31 | |
Type of gene | protein-coding | protein-coding | |
Description | protein AF-10ALL1-fused gene from chromosome 10 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10type I AF10 proteintype III AF10 prot | SKI/DACH domain-containing protein 1protein DLN-1 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | P55197 | Q1XH10 | |
Ensembl transtripts involved in fusion gene | ENST00000446906, ENST00000377072, ENST00000307729, ENST00000377059, ENST00000495130, ENST00000377100, ENST00000377091, | ENST00000449193, ENST00000444772, ENST00000487107, | |
Fusion gene scores | * DoF score | 13 X 10 X 8=1040 | 3 X 1 X 4=12 |
# samples | 20 | 5 | |
** MAII score | log2(20/1040*10)=-2.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/12*10)=2.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MLLT10 [Title/Abstract] AND SKIDA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MLLT10 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17868029 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LIHC | TCGA-DD-A73G-01A | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000446906 | ENST00000449193 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
5CDS-intron | ENST00000446906 | ENST00000444772 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
5CDS-5UTR | ENST00000446906 | ENST00000487107 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
5CDS-5UTR | ENST00000377072 | ENST00000449193 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
5CDS-intron | ENST00000377072 | ENST00000444772 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
5CDS-5UTR | ENST00000377072 | ENST00000487107 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
5CDS-5UTR | ENST00000307729 | ENST00000449193 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
5CDS-intron | ENST00000307729 | ENST00000444772 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
5CDS-5UTR | ENST00000307729 | ENST00000487107 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
5CDS-5UTR | ENST00000377059 | ENST00000449193 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
5CDS-intron | ENST00000377059 | ENST00000444772 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
5CDS-5UTR | ENST00000377059 | ENST00000487107 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
intron-5UTR | ENST00000495130 | ENST00000449193 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
intron-intron | ENST00000495130 | ENST00000444772 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
intron-5UTR | ENST00000495130 | ENST00000487107 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
intron-5UTR | ENST00000377100 | ENST00000449193 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
intron-intron | ENST00000377100 | ENST00000444772 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
intron-5UTR | ENST00000377100 | ENST00000487107 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
intron-5UTR | ENST00000377091 | ENST00000449193 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
intron-intron | ENST00000377091 | ENST00000444772 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
intron-5UTR | ENST00000377091 | ENST00000487107 | MLLT10 | chr10 | 21906136 | + | SKIDA1 | chr10 | 21812800 | - |
Top |
FusionProtFeatures for MLLT10_SKIDA1 |
![]() |
Hgene | Tgene |
MLLT10 | SKIDA1 |
Probably involved in transcriptional regulation. Invitro or as fusion protein with KMT2A/MLL1 has transactivationactivity. Binds to cruciform DNA. In cells, binding to unmodifiedhistone H3 regulates DOT1L functions including histone H3 'Lys-79'dimethylation (H3K79me2) and gene activation (PubMed:26439302).{ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MLLT10_SKIDA1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for MLLT10_SKIDA1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MLLT10 | YEATS4, SMARCB1, SS18, MLLT10, DOT1L, MLLT1, MLLT3, AFF1, DISC1, NDEL1, ELAVL1, CENPJ, TMPO, ZNF526, MLLT6, TCP10L, KIF6, PMF1 | SKIDA1 | ELAVL1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MLLT10_SKIDA1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MLLT10_SKIDA1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MLLT10 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | MLLT10 | C0025202 | melanoma | 1 | CTD_human |
Hgene | MLLT10 | C0025286 | Meningioma | 1 | CTD_human |