![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 22149 |
FusionGeneSummary for MLLT10_NAV1 |
![]() |
Fusion gene information | Fusion gene name: MLLT10_NAV1 | Fusion gene ID: 22149 | Hgene | Tgene | Gene symbol | MLLT10 | NAV1 | Gene ID | 8028 | 89796 |
Gene name | MLLT10, histone lysine methyltransferase DOT1L cofactor | neuron navigator 1 | |
Synonyms | AF10 | POMFIL3|STEERIN1|UNC53H1 | |
Cytomap | 10p12.31 | 1q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein AF-10ALL1-fused gene from chromosome 10 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10type I AF10 proteintype III AF10 prot | neuron navigator 1pore membrane and/or filament interacting like protein 3unc-53 homolog 1 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P55197 | Q8NEY1 | |
Ensembl transtripts involved in fusion gene | ENST00000446906, ENST00000377072, ENST00000307729, ENST00000377059, ENST00000495130, ENST00000377100, ENST00000377091, | ENST00000367302, ENST00000367296, ENST00000295624, ENST00000367297, ENST00000367300, ENST00000367295, ENST00000469130, | |
Fusion gene scores | * DoF score | 13 X 10 X 8=1040 | 7 X 6 X 3=126 |
# samples | 20 | 9 | |
** MAII score | log2(20/1040*10)=-2.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/126*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MLLT10 [Title/Abstract] AND NAV1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MLLT10 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17868029 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AN-A0AL-01A | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000446906 | ENST00000367302 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000446906 | ENST00000367296 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000446906 | ENST00000295624 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000446906 | ENST00000367297 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000446906 | ENST00000367300 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000446906 | ENST00000367295 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-intron | ENST00000446906 | ENST00000469130 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000377072 | ENST00000367302 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000377072 | ENST00000367296 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000377072 | ENST00000295624 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000377072 | ENST00000367297 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000377072 | ENST00000367300 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000377072 | ENST00000367295 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-intron | ENST00000377072 | ENST00000469130 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000307729 | ENST00000367302 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000307729 | ENST00000367296 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000307729 | ENST00000295624 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000307729 | ENST00000367297 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000307729 | ENST00000367300 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000307729 | ENST00000367295 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-intron | ENST00000307729 | ENST00000469130 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000377059 | ENST00000367302 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000377059 | ENST00000367296 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000377059 | ENST00000295624 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000377059 | ENST00000367297 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000377059 | ENST00000367300 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-3UTR | ENST00000377059 | ENST00000367295 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
5CDS-intron | ENST00000377059 | ENST00000469130 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000495130 | ENST00000367302 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000495130 | ENST00000367296 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000495130 | ENST00000295624 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000495130 | ENST00000367297 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000495130 | ENST00000367300 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000495130 | ENST00000367295 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-intron | ENST00000495130 | ENST00000469130 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000377100 | ENST00000367302 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000377100 | ENST00000367296 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000377100 | ENST00000295624 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000377100 | ENST00000367297 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000377100 | ENST00000367300 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000377100 | ENST00000367295 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-intron | ENST00000377100 | ENST00000469130 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000377091 | ENST00000367302 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000377091 | ENST00000367296 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000377091 | ENST00000295624 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000377091 | ENST00000367297 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000377091 | ENST00000367300 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-3UTR | ENST00000377091 | ENST00000367295 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
intron-intron | ENST00000377091 | ENST00000469130 | MLLT10 | chr10 | 21906136 | + | NAV1 | chr1 | 201790755 | + |
Top |
FusionProtFeatures for MLLT10_NAV1 |
![]() |
Hgene | Tgene |
MLLT10 | NAV1 |
Probably involved in transcriptional regulation. Invitro or as fusion protein with KMT2A/MLL1 has transactivationactivity. Binds to cruciform DNA. In cells, binding to unmodifiedhistone H3 regulates DOT1L functions including histone H3 'Lys-79'dimethylation (H3K79me2) and gene activation (PubMed:26439302).{ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for MLLT10_NAV1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for MLLT10_NAV1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MLLT10 | YEATS4, SMARCB1, SS18, MLLT10, DOT1L, MLLT1, MLLT3, AFF1, DISC1, NDEL1, ELAVL1, CENPJ, TMPO, ZNF526, MLLT6, TCP10L, KIF6, PMF1 | NAV1 | APC, ELAVL1, APP, MAPK1, YWHAB, MAPRE1, TRIO, KRT31, GCC1, DTNBP1, RCC1, FBXW11, PPA1, PPA2, MED4, PCM1, FGFR1OP, CEP128, CEP135, CEP89, RNF41, CCDC53, COG6, PDCD1, MAP3K14, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, CGN, LRFN1, DENND1A, RTKN, SH3PXD2A, MAST3, SRGAP2, EIF4E2, SIPA1L1, PPM1H, LIMA1, MAGI1, DENND4C, TESK2, DCLK1, ZNF638, NF1, HDAC4, CBY1, SRSF12, CDC25C, SYDE1, MAPKAP1, NADK, AGAP1, GIGYF2, CDC25B, INPP5E |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for MLLT10_NAV1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MLLT10_NAV1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MLLT10 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | MLLT10 | C0025202 | melanoma | 1 | CTD_human |
Hgene | MLLT10 | C0025286 | Meningioma | 1 | CTD_human |
Tgene | NAV1 | C0036341 | Schizophrenia | 1 | PSYGENET |